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001-es BibID:BIBFORM066337
035-os BibID:(Cikkazonosító)33307 (WOS)000383710400001 (scopus)84988640540
Első szerző:Chen, Jie
Cím:Spatial Distribution of the Cannabinoid Type 1 and Capsaicin Receptors May Contribute to the Complexity of Their Crosstalk / Jie Chen, Angelika Varga, Srikumaran Selvarajah, Agnes Jenes, Beatrix Dienes, Joao Sousa-Valente, Akos Kulik, Gabor Veress, Susan D. Brain, David Baker, Laszlo Urban, Ken Mackie, Istvan Nagy
Dátum:2016
ISSN:2045-2322
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 6 (2016), p. 33307. -
További szerzők:Varga Angelika (1977-) (biológus) Selvarajah, Srikumaran Jenes Ágnes (1980-) (élettanász) Dienes Beatrix (1972-) (élettanász, molekuláris biológus) Sousa-Valente, Joao Kulik Ákos Veress Gábor (1971-) (neurobiológus) Brain, Susan D. Baker, David Urbán László (1960-) Mackie, Ken Nagy István Péter (1964-) (vegyész, kémikus)
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2.

001-es BibID:BIBFORM069011
Első szerző:Sousa-Valente, Joao
Cím:Inflammation of peripheral tissues and injury to peripheral nerves induce differing effects in the expression of the calcium-sensitive N-arachydonoylethanolamine-synthesizing enzyme and related molecules in rat primary sensory neurons / Sousa-Valente Joao, Varga Angelika, Torres-Perez Jose Vicente, Jenes Agnes, Wahba John, Mackie Ken, Cravatt Benjamin, Ueda Natsuo, Tsuboi Kazuhito, Santha Peter, Jancso Gabor, Tailor Hiren, Avelino António, Nagy Istvan
Dátum:2017
ISSN:0021-9967
Megjegyzések:Elevation of intracellular Ca2+ concentration induces the synthesis of N-arachydonoylethanolamine (anandamide) in a subpopulation of primary sensory neurons. N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) is the only known enzyme that synthesizes anandamide in a Ca2+ -dependent manner. NAPE-PLD mRNA as well as anandamide's main targets, the excitatory transient receptor potential vanilloid type 1 ion channel (TRPV1), the inhibitory cannabinoid type 1 (CB1) receptor, and the main anandamide-hydrolyzing enzyme fatty acid amide hydrolase (FAAH), are all expressed by subpopulations of nociceptive primary sensory neurons. Thus, NAPE-PLD, TRPV1, the CB1 receptor, and FAAH could form an autocrine signaling system that could shape the activity of a major subpopulation of nociceptive primary sensory neurons, contributing to the development of pain. Although the expression patterns of TRPV1, the CB1 receptor, and FAAH have been comprehensively elucidated, little is known about NAPE-PLD expression in primary sensory neurons under physiological and pathological conditions. This study shows that NAPE-PLD is expressed by about one-third of primary sensory neurons, the overwhelming majority of which also express nociceptive markers as well as the CB1 receptor, TRPV1, and FAAH. Inflammation of peripheral tissues and injury to peripheral nerves induce differing but concerted changes in the expression pattern of NAPE-PLD, the CB1 receptor, TRPV1, and FAAH. Together these data indicate the existence of the anatomical basis for an autocrine signaling system in a major proportion of nociceptive primary sensory neurons and that alterations in that autocrine signaling by peripheral pathologies could contribute to the development of both inflammatory and neuropathic pain.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
cannabinoid type 1 receptor
fatty acid amide hydrolase
inflammation
neuropathy
pain
transient receptor potential vanilloid type 1 ion channel
Megjelenés:Journal Of Comparative Neurology 525 : 8 (2017), p. 1778-1796. -
További szerzők:Varga Angelika (1977-) (biológus) Torres-Pérez, Jose Vicente Jenes Ágnes (1980-) (élettanász) Wahba, John Mackie, Ken Cravatt, Benjamin Ueda, Natsuo Tsuboi, Kazuhito Sántha Péter Jancsó Gábor Tailor, Hiren Avelino, Antonio Nagy István (orvos)
Pályázati támogatás:TAMOP 4.1.2. E-13/1/KONV-2013-0010
TÁMOP
K-101873
OTKA
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3.

001-es BibID:BIBFORM060177
Első szerző:Sousa-Valente, Joao
Cím:Anandamide in primary sensory neurons: too much of a good thing? / Joao Sousa-Valente, Angelika Varga, Kajaluxy Ananthan, Ankur Khajuria, Istvan Nagy
Dátum:2014
ISSN:0953-816X
Megjegyzések:The quest for possible targets for the development of novel analgesics has identified the activation of the cannabinoid type 1 (CB1) receptor outside the CNS as a potential means of providing relief from persistent pain, which currently constitutes an unmet medical need. Increasing tissue levels of the CB1 receptor endogenous ligand N-arachidonoylethanolamine (anandamide), by inhibiting anandamide degradation through blocking the anandamide-hydrolysing enzyme fatty acid amide hydrolase, has been suggested to be used to activate the CB1 receptor. However, recent clinical trials revealed that this approach does not deliver the expected relief from pain. Here, we discuss one of the possible reasons, the activation of the transient receptor potential vanilloid type 1 ion channel (TRPV1) on nociceptive primary sensory neurons (PSNs) by anandamide, which may compromise the benefi- cial effects of increased tissue levels of anandamide. We conclude that better design such as concomitant blocking of anandamide hydrolysis and anandamide uptake into PSNs, to inhibit TRPV1 activation, could overcome these problems.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
analgesics
cannabinoid
dorsal root ganglia
endogenous cannabinoids
TRPV1
Megjelenés:European Journal Of Neuroscience. - 39 : 3 (2014), p. 409-418. -
További szerzők:Varga Angelika (1977-) (biológus) Ananthan, Kajaluxy Khajuria, Ankur Nagy István
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4.

001-es BibID:BIBFORM050561
035-os BibID:PMID:24114173
Első szerző:Varga Angelika (biológus)
Cím:Anandamide produced by Ca2+-insensitive enzymes induces excitation in primary sensory neurons / Angelika Varga, Agnes Jenes, Timothy H. Marczylo, Joao Sousa-Valente, Jie Chen, Jonothan Austin, Srikumaran Selvarajah, Fabiana Piscitelli, Anna P. Andreou, Anthony H. Taylor, Fiona Kyle, Mohammed Yaqoob, Sue Brain, John P. M. White, Laszlo Csernoch, Vincenzo Di Marzo, Laki Buluwela, Istvan Nagy
Dátum:2014
ISSN:0031-6768
Megjegyzések:The endogenous lipid agent N-arachidonoylethanolamine (anandamide), among other effects, has been shown to be involved in nociceptive processing both in the central and peripheral nervous systems. Anandamide is thought to be synthesised by several enzymatic pathways both in a Ca2+-sensitive and Ca2+-insensitive manner, and rat primary sensory neurons produce anandamide. Here, we show for the first time, that cultured rat primary sensory neurons express at least four of the five known Ca2+-insensitive enzymes implicated in the synthesis of anandamide, and that application of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-arachidonoyl, the common substrate of the anandamide-synthesising pathways, results in anandamide production which is not changed by the removal of extracellular Ca2+. We also show that anandamide, which has been synthesised in primary sensory neurons following the application of 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine-N-arachidonoyl induces a transient receptor potential vanilloid type 1 ion channel-mediated excitatory effect that is not inhibited by concomitant activation of the cannabinoid type 1 receptor. Finally, we show that sub-populations of transient receptor potential vanilloid type 1 ion channel-expressing primary sensory neurons also express some of the putative Ca2+-insensitive anandamide-synthesising enzymes. Together, these findings indicate that anandamide synthesised by primary sensory neuron via a Ca2+-insensitive manner has an excitatory rather than an inhibitory role in primary sensory neurons and that excitation is mediated predominantly through autocrine signalling. Regulation of the activity of the Ca2+-insensitive anandamide-synthesising enzymes in these neurons may be capable of regulating the activity of these cells, with potential relevance to controlling nociceptive processing.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Pflugers Archiv. - 466 : 7 (2014), p. 1421-1435. -
További szerzők:Jenes Ágnes (1980-) (élettanász) Marczylo, Timothy H. Sousa-Valente, Joao Chen, Jie Austin, Jonothan Selvarajah, Srikumaran Piscitelli, Fabiana Andreou, Anna P. Taylor, Anthony H. Kyle, Fiona Yaqoob, Mohammed Brain, Sue White, John P. M. Csernoch László (1961-) (élettanász) Di Marzo, Vincenzo Buluwela, Laki Nagy István
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