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1.

001-es BibID:BIBFORM054138
Első szerző:Duró Edina
Cím:Adenosine A3 receptors negatively regulate the engulfment-dependent apoptotic cell suppression of inflammation / Edina Duró, Anna Pallai, Krisztina Köröskényi, Zsolt Sarang, Zsuzsa Szondy
Dátum:2014
ISSN:0165-2478
Megjegyzések:Timed initiation of apoptotic cell death followed by efficient removal mediated by professional macrophages is a key mechanism in maintaining tissue homeostasis. Besides phagocytosis, clearance of apoptotic cells also involves suppression of inflammatory responses by apoptotic cells mediated by both direct inhibition of pro-inflammatory cytokine production and release of soluble anti-inflammatory factors, which act in a paracrine or autocrine fashion to amplify or sustain the anti-inflammatory response. Previous work has demonstrated that during engulfment of apoptotic cells adenosine is produced in sufficient amounts to trigger both adenosine A2A receptors (A2ARs) and A3 receptors (A3Rs). Adenosine bound to A2ARs of macrophages activated the adenylate cyclase pathway to suppress the apoptotic-cell induced, NO-dependent formation of neutrophil migration factors. Here we show by using A3R null engulfing macrophages that the adenosine produced triggers the A3Rs as well, which attenuate the A2AR signaling by inhibiting adenylate cyclase. As a result, the balance in the activation of A2ARs and A3Rs determines the amounts of NO and consequently the levels of neutrophil chemoattractants formed. Since during phagocytosis of apoptotic cells the expression of A2ARs increases, while that of A3Rs decreases, on long term adenosine suppresses the proinflammatory responses in engulfing macrophages.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Immunology Letters 162 : 2 Part B (2014), p. 292-301. -
További szerzők:Pallai Anna (1983-) (biokémikus, molekuláris biológus) Köröskényi Krisztina (1979-) (biokémikus, molekuláris biológus) Sarang Zsolt (1976-) (mikrobiológus) Szondy Zsuzsanna (1959-) (molekuláris sejtbiológus, biokémikus)
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2.

001-es BibID:BIBFORM068300
Első szerző:Joós Gergely
Cím:Involvement of adenosine A3 receptors in the chemotactic navigation of macrophages towards apoptotic cells / Joós Gergely, Jákim Judit, Kiss Beáta, Szamosi Regina, Papp Tamás, Felszeghy Szabolcs, Sághy Tibor, Nagy Gábor, Szondy Zsuzsa
Dátum:2017
ISSN:0165-2478
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Adenosine
Adenosine A3 receptor
Apoptotic thymocyte
Chemotactic migration
Macrophage
Megjelenés:Immunology Letters 183 (2017), p. 62-72. -
További szerzők:Jakim Judit Kiss Beáta (1984-) (biokémikus, molekuláris biológus) Szamosi Regina Papp Tamás (1987-) (orvos) Felszeghy Szabolcs Béla (1972-) (fogorvos, anatómus, kötőszövetbiológus) Sághy Tibor Szemán-Nagy Gábor (1975-) (biológia tanár-molekuláris biológus) Szondy Zsuzsanna (1959-) (molekuláris sejtbiológus, biokémikus)
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3.

001-es BibID:BIBFORM028776
Első szerző:Ludányi Katalin (immunológus)
Cím:Ligation of RARgamma inhibits proliferation of phytohaemagglutinin-stimulated T-cells via down-regulating JAK3 protein levels / Katalin Ludányi, Zsuzsanna S. Nagy, Magdolna Alexa, Uwe Reichert, Serge Michel, László Fésüs, Zsuzsa Szondy
Dátum:2005
ISSN:0165-2478
Megjegyzések:The mechanisms whereby Vitamin A regulates the immune system are poorly understood. We have shown previously that retinoic acids, the Vitamin A derivatives, promote both apoptosis of neglected thymocytes and the activation-induced cell death of peripheral T-cells via ligating the nuclear retinoid receptor (RAR) gamma. In the present study, we found that human peripheral T-cells express RARalpha and gamma, but not RARbeta. Increasing concentrations of 9-cis RA inhibited phytohaemagglutinin (PHA)-induced proliferation of T-cells, an effect that could be mimicked only by addition of RARgamma agonists and could be inhibited by an RARgamma antagonist. Interleukin-2 (IL-2) produced is known to mediate PHA-induced proliferation of T lymphocytes. Ligation of RARgamma did not affect the PHA-induced high affinity IL-2 receptor expression, slightly reduced the PHA-induced IL-2 production, but interfered with the IL-2-mediated signal transduction resulting in inhibition of PHA-induced phosphorylation of retinoblastoma protein and of up-regulation of Bcl-2. Janus kinases JAK1 and JAK3 play a determinant role in IL-2-dependent signal transduction. Ligation of RARgamma did not affect the levels of JAK1, but prevented IL-2-induced expression of JAK3 resulting in inhibition of PHA-induced phosphorylation of Stat5 molecules. Our data suggest that the previously observed toxic effect of high concentrations of retinoids on the immune system might be mediated via formation of 9-cis RA, which via ligation of RARgamma not only induces cell death in immature thymocytes, but inhibits proliferation of T-cells as well.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Immunology Letters. - 98 : 1 (2005), p. 103-113. -
További szerzők:Nagy Zsuzsanna (1973-) (okleveles középiskolai kémia-fizika szakos tanár) Alexa Magdolna Reichert, Uwe Michel, Serge Fésüs László (1947-) (orvos biokémikus) Szondy Zsuzsanna (1959-) (molekuláris sejtbiológus, biokémikus)
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4.

001-es BibID:BIBFORM014108
Első szerző:Sarang Zsolt (mikrobiológus)
Cím:Transglutaminase 2 null macrophages respond to lipopolysaccharide stimulation by elevated proinflammatory cytokine production due to an enhanced [alfa](v)[béta](3) integrin-induced Src tyrosine kinase signaling / Zsolt Sarang, Krisztina Köröskényi, Anna Pallai, Edina Duró, Gerry Melino, Martin Griffin, László Fésüs, Zsuzsa Szondy
Dátum:2011
Megjegyzések:Transglutaminase 2 (TG2) is a protein crosslinking enzyme with several additional biochemical functions. Loss of TG2 in vivo results in impaired phagocytosis of apoptotic cells and altered proinflammatory cytokine production by macrophages engulfing apoptotic cells leading to autoimmunity. It has been proposed that TG2 acts as an integrin beta3 coreceptor in the engulfment process, while altered proinflammatory cytokine production is related to the lack of latent TGFbeta activation by TG2 null macrophages. Here we report that TG2 null macrophages respond to lipopolysaccharide treatment by elevated IL-6 and TNFalfa production. Though TGFβ has been proposed to act as a feed back regulator of proinflammatory cytokine production in LPS-stimulated macrophages, this phenomenon is not related to the lack of active TGFbeta production. Instead, in the absence of TG2 integrin beta3 maintains an elevated basal Src family kinase activity in macrophages, which leads to enhanced phosphorylation and degradation of the IkBalfa. Low basal levels of IkBalfa explain the enhanced sensitivity of TG2 null macrophages to signals that regulate NF-kB. Our data suggest that TG2 null macrophages bear a proinflammatory phenotype, which might contribute to the enhanced susceptibility of these mice to develop autoimmunity and atherosclerosis.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Immunology Letters. - 138 : 1 (2011), p. 71-78. -
További szerzők:Köröskényi Krisztina (1979-) (biokémikus, molekuláris biológus) Pallai Anna (1983-) (biokémikus, molekuláris biológus) Duró Edina Melino, Gerry Griffin, Martin Fésüs László (1947-) (orvos biokémikus) Szondy Zsuzsanna (1959-) (molekuláris sejtbiológus, biokémikus)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Az apoptózis és a fagocitózis folyamatának összehangolása a szövetet tönkretevő gyulladási reakciók elkerülésére
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5.

001-es BibID:BIBFORM028763
Első szerző:Szondy Zsuzsanna (molekuláris sejtbiológus, biokémikus)
Cím:Methylprednisolone and 2-chloroadenosine induce DNA fragmentation at different stages of human T-lymphocyte development / Zsuzsa Szondy
Dátum:1997
ISSN:0165-2478
Megjegyzések:Both methylprednisolone (MPS) and 2-chloroadenosine (2-CA) were shown previously to induce DNA fragmentation and cell death in human thymocytes at an optimum concentration of 1 and 40 microM, respectively. Though both compounds affected the CD4+CD8+ population, 2-CA depleted primarily thymocytes expressing medium or high levels of CD3-T-cell receptor molecule, while the glucocorticoid treatment affected cells expressing a lower level of CD3-T-cell receptor. Their effect on thymocyte viability and DNA fragmentation was observed already at day 1 of culture and involved the bcl-2 negative thymocytes. Incubation of peripheral T-lymphocytes (which express bcl-2) with the same concentration of MPS did not affect the viability for up to 5 days, while 2-CA induced 100% cell death and DNA fragmentation by day 5. If T-cells were stimulated with concanavalin A in the presence of MPS or 2-CA the cell proliferation was inhibited and a decrease in cell viability with a concomittant increase in DNA fragmentation was observed. If MPS was added at 24 h or later after mitogenic stimulation, it was not able to induce apoptosis and the inhibition of proliferation was less pronounced. 2-CA, on the other hand, inhibited proliferation and induced cell death whenever it was added to the culture. The decreased sensitivity towards the apoptosis induction effects of glucocorticoids at later phases of mitogenic stimulation can not be explained by an increased bcl-2 expression, since its expression level remained constant up to 48 h after mitogenic stimulation. Our data presented in this paper suggest: (1) that T-cells may show different sensitivity towards the same apoptosis inducer signals at different stages of the T-cell development; (2) the apoptotic sensitivity towards various signals may be different at the same stage of T-cell differentiation; and (3) their apoptotic sensitivity does not always correlate with the bcl-2 expression alone.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Immunology Letters. - 58 : 1 (1997), p. 59-65. -
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6.

001-es BibID:BIBFORM028718
Első szerző:Szondy Zsuzsanna (molekuláris sejtbiológus, biokémikus)
Cím:The effects of cell number, concentrations of mitogen and glutamine and time of culture on [3H]thymidine incorporation into cervical lymph node lymphocytes stimulated by concanavalin-A / Zsuzsa Szondy
Dátum:1995
ISSN:0165-2478
Megjegyzések:The amount of [3H]thymidine incorporated into DNA in lymphocytes stimulated with Concanavalin-A increases exponentially with time at different concentrations of glutamine, reaches a peak value, then gradually decreases. When the value (log10 thymidine incorporation glutamine present -log10 thymidine incorporation glutamine absent) obtained from the exponential phase is plotted against time, a linear plot is obtained for each glutamine concentration. When these linear rates of incorporation are plotted against glutamine concentration, hyperbolic curves are obtained for different times of culture. The peak value of incorporation (which reflects the final number of cells which entered the cell cycle) is determined by the concentration of mitogen and occurs at an earlier time as the number of cells in culture is increased and as the concentration of glutamine is increased. These findings suggest that increasing the plasma glutamine concentration above the normal physiological level may be of value in increasing the proliferation of lymphocytes in conditions of lymphopenia. Adenosine, a fuel of purine nucleotide synthesis, which may affect the lymphoproliferative response also via specific adenosine receptors, increases the rate of incorporation of [3H]thymidine but this effect depends upon the concentration of glutamine; at low concentrations of glutamine, the stimulation by adenosine is apparent whereas at high concentrations of glutamine adenosine appeared to inhibit proliferation.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Immunology Letters. - 45 : 3 (1995), p. 167-171. -
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7.

001-es BibID:BIBFORM008379
Első szerző:Tóth Beáta
Cím:Over-expression of integrin β3 can partially overcome the defect of integrin β3 signaling in transglutaminase 2 null macrophages / Tóth, B., Sarang, Zs., Vereb, Gy., Zhang, A., Tanaka, S., Melino, G., Fésüs, L., Szondy, Zs.
Dátum:2009
ISSN:0165-2478
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Immunology Letters. - 126 : 1-2 (2009), p. 22-28. -
További szerzők:Sarang Zsolt (1976-) (mikrobiológus) Vereb György (1965-) (biofizikus, orvos) Zhang, Ailiang Tanaka, Sakae Melino, Gerry Fésüs László (1947-) (orvos biokémikus) Szondy Zsuzsanna (1959-) (molekuláris sejtbiológus, biokémikus)
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