CCL

Összesen 6 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM037279
Első szerző:Csanaky Katalin
Cím:Changes in PACAP Immunoreactivity in Human Milk and Presence of PAC1 Receptor in Mammary Gland during Lactation / Csanaky Katalin, Banki Eszter, Szabadfi Krisztina, Reglodi Dora, Tarcai Ibolya, Czegledi Levente, Helyes Zsuzsanna, Ertl Tibor, Gyarmati Judit, Szanto Zalan, Zapf Istvan, Sipos Erika, Shioda Seiji, Tamas Andrea
Dátum:2012
ISSN:0895-8696
Megjegyzések:Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with widespread occurrence in the nervous system and peripheral organs, including the mammary gland. Previously, we have shown that PACAP38 is present in the human milk at higher levels than in respective blood samples. However, it is not known how PACAP levels and the expression of PAC1 receptor change during lactation. Therefore, the aim of our study was to investigate PACAP38-like immunoreactivity (PACAP38-LI) in human colostrums and transitional and mature milk during lactation and to compare the expression of PAC1 receptors in lactating and non-lactating mammary glands. We found that PACAP38-LI was significantly higher in human colostrum samples than in the transitional and mature milk. PACAP38-LI did not show any significant changes within the first 10-month period of lactation, but a significant increase was observed thereafter, up to the examined 17th month. Weak expression of PAC1 receptors was detected in non-lactating sheep and human mammary glands, but a significant increase was observed in the lactating sheep samples. In summary, the present study is the first to show changes of PACAP levels in human milk during lactation. The presence of PACAP in the milk suggests a potential role in the development of newborn, while the increased expressions of PAC1 receptors on lactating breast may indicate a PACAP38/PAC1 interaction in the mammary gland during lactation.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
sheep, PACAP
Egészség- és Környezettudomány
Megjelenés:Journal Of Molecular Neuroscience. - 48 : 3 (2012), p. 631-637. -
További szerzők:Bánki Eszter Szabadfi Krisztina (Pécsi Egyetem) Reglődi Dóra (Idegtudományok) Tarcai Ibolya Czeglédi Levente (1977-) (agrármérnök) Helyes Zsuzsanna Ertl Tibor Gyarmati Judit Szántó Zalán Zapf István Sípos Erika Shioda, Seiji Tamás Andrea (Idegtudomány) (Pécs)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Állati eredetű funkcionális élelmiszerek fejlesztése
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM061461
Első szerző:Csikós Ádám (molekuláris biológus)
Cím:Polimorfizmus keresése a szarvasmarha hipofízis adenilát-cikláz aktiváló polipeptid 5. exonjában / Csikós Ádám, Simon Ádám, Homonai Krisztina, Gulyás Gabriella, Tisza Ákos, Tamás Andrea, Reglődi Dóra, Jávor András, Czeglédi Levente
Dátum:2015
ISSN:1587-1282
Tárgyszavak:Agrártudományok Állattenyésztési tudományok magyar nyelvű folyóiratközlemény hazai lapban
Megjelenés:Agrártudományi közlemények = Acta agraria Debreceniensis. - 65 (2015), p. 17-20. -
További szerzők:Simon Ádám (1990-) (molekuláris biológus) Homonai Krisztina (molekuláris biológus) Gulyás Gabriella (1985-) (agrár) Tisza Ákos Tamás Andrea (Idegtudomány) (Pécs) Reglődi Dóra (Idegtudományok) Jávor András (1937-) (okleveles villamosmérnök) Czeglédi Levente (1977-) (agrármérnök)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM021890
Első szerző:Czeglédi Levente (agrármérnök)
Cím:Presence of pituitary adenylate cyclase-activating polypeptide (PACAP) in the plasma and milk of ruminant animals / Czeglédi Levente, Tamás Andrea, Borzsei Rita, Bagoly Teréz, Kiss Péter, Horváth Gabriella, Brubel Réka, Németh József, Szalontai Bálint, Szabadfi Krisztina, Jávor András, Reglódi Dóra, Helyes Zsuzsanna
Dátum:2011
Megjegyzések:Milk contains a variety of proteins and peptides that possess biological activity. Growth factors, such as growth hormone, insulin-like, epidermal and nerve growth factors are important milk components which may regulate growth and differentiation in various neonatal tissues and also those of the mammary gland itself. We have recently shown that pituitary adenylate cyclase-activating polypeptide (PACAP), an important neuropeptide with neurotrophic actions, is present in the human milk in much higher concentration than in the plasma of lactating women. Investigation of growth factors in the milk of domestic animals is of utmost importance for their nutritional values and agricultural significance. Therefore, the aim of the present study was to determine the presence and concentration of PACAP in the plasma and milk of three ruminant animal species. Furthermore, the presence of PACAP and its specific PAC1 receptor were investigated in the mammary glands. Radioimmunoassay measurements revealed that PACAP was present in the plasma and the milk of the sheep, goat and the cow in a similar concentration to that measured previously in humans. PACAP38-like immunoreactivity (PACAP38-LI) was 5-20-fold higher in the milk than in the plasma samples of the respective animals, a similar serum/milk ratio was found in all the three species. The levels did not show significant changes within the examined 3-month-period of lactation after delivery. Similar PACAP38-LI was measured in the homogenates of the sheep mammary gland samples taken 7 and 30 days after delivery. PAC1 receptor expression was detected in these udder biopsies by fluorescent immunohistochemistry suggesting that this peptide might have an effect on the mammary glands themselves. These data show that PACAP is present in the milk of various ruminant domestic animal species at high concentrations, the physiological implications of which awaits further investigation.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:General and Comparative Endocrinology. - 172 : 1 (2011), p. 115-119. -
További szerzők:Tamás Andrea (Idegtudomány) (Pécs) Borzsei Rita (agrár) Bagoly Teréz Kiss Péter Horváth Gabriella Brubel Réka Németh József (1954-) (vegyész, analitikus) Szalontai Bálint (Pécsi Egyetem) Szabadfi Krisztina (Pécsi Egyetem) Jávor András (1952-) (agrármérnök) Reglődi Dóra (Idegtudományok) Helyes Zsuzsanna
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

4.

001-es BibID:BIBFORM087705
Első szerző:Kiss Péter (Pécs)
Cím:Presence of PACAP-38 in mammalian plasma and milk : from guinea pig to humans / Kiss P., Csanaky K., Bánki E., Tamás A., Börzsei R., Márk L., Bagoly T., Bay Cs., Váczy A., Horváth G., Németh J., Czeglédi L., Szauer E., Helyes Zs., Reglődi D.
Dátum:2010
ISSN:0231-424X 1588-2683
Megjegyzések:PACAP is a pleiotropic and multifunctional neuropeptide widely distributed throughout the body. It is involved in the regulation of various physiological and pathophysiological processes, such as reproduction, thermoregulation, motor activity, brain development, neuronal survival, inflammation and pain. Since little is known about its distribution in humans, our aim was to examine PACAP-38 in human plasma. Furthermore, based on the presence of VIP, structurally the closest to PACAP, in milk, and presence of PACAP- and PACAP receptor-immunoreactive elements in the mammary gland, our aim was also to examine PACAP-38 in human milk. For comparative studies, we investigated presence of PACAP in plasma and milk of other species, including goat, sheep, cow and guinea pig. Methods. The presence of PACAP-38 was determined by mass spectrometry in plasma samples from healthy male and female volunteers (age: 20?40), in plasma and milk samples from lactating women (age: 20?35). PACAP concentration was measured with a specific and sensitive radioimmunoassay in human and other mammalian samples. Results. Our results revealed that PACAP-38 is present in human plasma, its concentration is relatively stable in healthy volunteers and it is not significantly altered by gender, age, food intake or the hormonal cycle in females. However, PACAP-38 plasma levels significantly increased in lactating women having 1?6-month-old babies. Moreover, this study is the first which provides evidence for the presence of PACAP-38 in the human milk with levels 5?20-fold greater in the milk whey than in the respective plasma samples. The same ratio was found in all other examined species. Conclusions. Based on the present findings and the literature, several important actions of milk-derived PACAP-38 can be suggested such as mammary gland proliferation, nutrient transfer as well as regulation of growth/differentiation of certain tissues of the neonates.
Tárgyszavak:Orvostudományok Egészségtudományok idézhető absztrakt
folyóiratcikk
PACAP-38
Megjelenés:Acta Physiologica Hungarica. - 97 : 1 (2010), p. 115. -
További szerzők:Csanaky Katalin Bánki Eszter Tamás Andrea (Idegtudomány) (Pécs) Börzsei Rita Márk László Bagoly Teréz Bay Csaba Váczy Alexandra Horváth Gabriella Németh József (1954-) (vegyész, analitikus) Czeglédi Levente (1977-) (agrármérnök) Szauer Edit Helyes Zsuzsanna Reglődi Dóra (Idegtudományok)
Pályázati támogatás:K72592
OTKA
K73044
OTKA
F67830
OTKA
78480
OTKA
K75965
OTKA
Gedeon Richter Centenary Foundation
Egyéb
Janos Bolyai Postdoctoral Research Fellowship
Egyéb
Internet cím:Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

5.

001-es BibID:BIBFORM093148
Első szerző:Pohóczky Krisztina
Cím:Pituitary adenylate cyclase activating polypeptide concentrations in the sheep mammary gland, milk, and in the lamb blood plasma after suckling / Pohóczky Krisztina, Tamás Andrea, Reglődi Dóra, Kemény Ágnes, Helyes Zsuzsanna, Czeglédi Levente
Dátum:2020
ISSN:2498-602X
Megjegyzések:Pituitary adenylate cyclase activating polypeptide (PACAP) is involved in development and reproduction. We previously described elevated PACAP levels in the milk compared to the plasma, and the presence of its specific PAC1 receptor in the mammary gland. This study aimed to determine PACAP and vasoactive intestinal peptide (VIP) levels in female suckling lambs compared to ewe plasma and mammary gland, as well as their age-dependent alterations. mRNA expressions of PACAP, VIP, PAC1 receptor and brain-derived neurotrophic factor (BDNF) were quantified in the milk whey and mammary gland. PACAP38-like immunoreactivity (PACAP38-LI) was measured in plasma, milk whey and mammary gland by radioimmunoassay, VIP-LI by enzyme-linked immunoassay. PACAP38-LI was 5, 6 times higher in the milk compared to the plasma of lactating sheep. It significantly increased in the lamb plasma 1 h, but returned to basal level 2 h after suckling. However, VIP mRNA was not present in the mammary gland, we detected the VIP protein in the milk whey. BDNF mRNA significantly decreased with age to approximately 60% and 25% in the 3- and 10-year-old sheep respectively, compared to the 3- month-old lambs. No differences were found between mammary and jugular vein plasma PACAP and VIP concentrations, or during the daily cycle. We propose a rapid absorption of PACAP38 from the milk and/or its release in suckling lambs. PACAP accumulated in the milk might be synthesized in the mammary gland or secreted from the plasma of the mothers. PACAP is suggested to have differentiation/proliferation promoting and immunomodulatory effects in the newborns and/or a local function in the mammary gland.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
Megjelenés:Physiology International. - 107 : 1 (2020), p. 92-105. -
További szerzők:Tamás Andrea Reglődi Dóra (Idegtudományok) Kemény Ágnes Helyes Zsuzsanna Czeglédi Levente (1977-) (agrármérnök)
Pályázati támogatás:KTIA_NAP_13-2014-0022
Egyéb
EFOP-3.6.2-16-2017-00006
EFOP
EFOP-3.6.3-VEKOP-16-2017-00008
EFOP
FIKPII 20765/3/2018/FEKUTSTRAT
Egyéb
K115874
OTKA
K119759
Egyéb
GINOP-2.3.2-15-2016-00050
GINOP
PTE AOK KA-2019-30
Egyéb
KTIA_13_ NAP-A-III/5
Egyéb
TKI 14016
MTA
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

6.

001-es BibID:BIBFORM074357
035-os BibID:(WOS)000410627800001 (Scopus)85029538367
Első szerző:Simon Ádám (molekuláris biológus)
Cím:Changes in expression of neuropeptides and their receptors in the hypothalamus and gastrointestinal tract of calorie restricted hens / Simon Ádám, Oláh János, Komlósi István, Jávor András, Németh József, Szilvássy Zoltán, Reglődi Dóra, Tamás Andrea, Czeglédi Levente
Dátum:2017
ISSN:0236-5383 1588-256X
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
Megjelenés:Acta Biologica Hungarica. - 68 : 3 (2017), p. 237-247. -
További szerzők:Oláh János (1976-) (állattenyésztés) Komlósi István (1960-) (agrármérnök) Jávor András (1952-) (agrármérnök) Németh József (1954-) (vegyész, analitikus) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Reglődi Dóra (Idegtudományok) Tamás Andrea Czeglédi Levente (1977-) (agrármérnök)
Pályázati támogatás:TÁMOP-4.2.2.D-15/1/KONV-2015-0016
TÁMOP
GINOP-2.3.2-15-2016-00050
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1