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1.

001-es BibID:BIBFORM119806
Első szerző:Ndunguru, Sawadi Fransisco (1980-)
Cím:Embryonic methionine triggers post-natal developmental programming in Japanese quail / Ndunguru, Sawadi F.; Reda, Gebrehaweria K.; Csernus, Brigitta; Knop, Renáta; Gulyás, Gabriella; Szabó, Csaba; Czeglédi, Levente; Lendvai, Ádám Z.
Dátum:2024
ISSN:0174-1578
Megjegyzések:Embryonic development is one of the most sensitive and critical stages when maternal effects may influence the offspring's phenotype. In birds and other oviparous species, embryonic development is confined to the eggs, therefore females must deposit resources into the eggs to prepare the offspring for the prevailing post-natal conditions. However, the mechanisms of such phenotypic adjustments remain poorly understood. We simulated a maternal nutritional transfer by injecting 1 mg of l-methionine solution into Japanese quail eggs before the onset of incubation. The increase in early methionine concentration in eggs activated the insulin/insulin-like signalling and mechanistic target of rapamycin (IIS/mTOR) signalling pathways and affected post-natal developmental trajectories. Chicks from methionine-supplemented eggs had higher expression of liver IGF1 and mTOR genes at hatching but were similar in size, and the phenotypic effects of increased growth became apparent only a week later and remained up to three weeks. Circulating levels of insulin-like growth factor-1 (IGF-1) and expression of ribosomal protein serine 6 kinase 1 (RPS6K1), the mTOR downstream effector, were elevated only three weeks after hatching. These results show that specific nutritional cues may have phenotypic programming effects by sequentially activating specific nutrient-sensing pathways and achieving transgenerational phenotypic plasticity.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
L-methionine
IGF1
mTOR
Growth
Amino acid
Megjelenés:Journal Of Comparative Physiology B-Biochemical Systemic And Environmental Physiology. - Epub (2024), p. 1-11. -
További szerzők:Reda, Gebrehaweria Kidane (Phd hallgató) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Knop Renáta (1983-) (állatorvos) Gulyás Gabriella (1985-) (agrár) Szabó Csaba (1968-) (agrármérnök) Czeglédi Levente (1977-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus)
Pályázati támogatás:K139021
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2.

001-es BibID:BIBFORM118739
Első szerző:Ndunguru, Sawadi Fransisco (1980-)
Cím:The prenatal window: Influence of leucine on growth and development of Japanese quail / Ndunguru Sawadi F., Reda Gebrehaweria K., Csernus Brigitta, Szabó Csaba, Lendvai Ádám Z., Czeglédi Levente
Dátum:2024
Megjegyzések:Nutrients acquired during embryonic developmental stages entail part of the adult energy budget. The crucial time is during the perinatal period in birds when embryos absorb residual yolk prehatch and during the first few days of post-hatch. During this fragile period, intestinal and skeletal development occurs expeditiously, and chicks experience a significant physiological shift. We collected freshly laid Japanese quail (Coturnix japonica) eggs, weighed them, and then incubated them under standard conditions. We injected 2.5 mg/egg of leucine amino acid solution the tenth day after incubation, and the second group was injected with a physiological saline solution to serve as a control. Leucine treatment increased the hatching success and grew faster with increased body mass, and influenced the increase of wing, head, tarsal length, and gastrointestinal development more than the control from 5-days old chicks, tarsal length 3-days old chicks and wing length from 7-days old chicks consistently up to 21-days old than the control. Leucine did not influence the gastrointestinal development of day-old chicks but increased gastrointestinal development in 21-day-old chicks with significant interaction between treatment and age of chicks. In Ovo, leucine supplementation improved growth and development and enhanced hormonal expression. The adaptive changes in hormonal expression stored lifetime nutritional memory of early dietary experience, which improved growth and development essential for increasing production efficiency.
ISBN:978-615-6457-43-1
Tárgyszavak:Agrártudományok Állattenyésztési tudományok előadáskivonat
könyvrészlet
Amino acid
growth
Japanese quail
Megjelenés:II. Magyar Agrártudományi Doktoranduszok Szimpóziuma : Absztraktkötet / szerk. Hajdú Péter. - p. 25. -
További szerzők:Reda, Gebrehaweria Kidane (Phd hallgató) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Szabó Csaba (1968-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus) Czeglédi Levente (1977-) (agrármérnök)
Pályázati támogatás:K139021
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3.

001-es BibID:BIBFORM120449
Első szerző:Reda, Gebrehaweria Kidane (Phd hallgató)
Cím:Expression of nutrient sensing genes mediate the effect of dietary unpredictability in Japanese quails / Reda Gebrehaweria K., Ndunguru Sawadi F., Csernus Brigitta, Szabó Csaba, Czeglédi Levente, Lendvai Ádám Z.
Dátum:2024
Megjegyzések:Dietary fluctuation is a common phenomenon in an organism's life and can compel them to change their mechanisms for growth, reproduction, immunity, and lifespan. These fluctuations hold evolutionary significance as they prompt diverse physiological and behavioural responses. Understanding animals' molecular mechanisms of adaptation to unpredictable changes in dietary availability is an essential question in animal research. Previous studies have proposed that one such signalling pathway, nutrient-sensing pathway, mediates systemic and cellular nutritional status hence regulates growth, reproduction and healthspan. Our previous study into varying degrees of dietary restriction in Japanese quails revealed significant changes in expression of nutrient sensing genes. To explore this further, we designed a study involved a combination of predictable feeding (control or 40% restricted feeding) and daily unpredictable feeding to Japanese quails, aimed to discern if unpredictable feed supply influence gene expression and fitness variables differently compared to control and consistently restricted birds. The research involved housing quails individually for 16 days and monitoring gene expression, body weight, egg laying, and egg morphology. Results revealed intriguing findings. Unpredictable feeding reduced body weight significantly in females but not in males, while a 40% dietary restriction lowered body weight in both sexes. However, only the 40% restriction notably affected egg laying and egg morphology. Gene expression analysis showed distinct patterns in nutrient-sensing genes. In the female groups, there was a notable reduction in the expression of insulin-like growth factor-1 and mechanistic target of rapamycin genes in both the unpredictable and restricted groups. Conversely, Forkhead box O1, Unc-51-like autophagy-activating kinases, autophagy genes (ATG9A and ATG5) and, unexpectedly, ribosomal protein S6 kinase 1 displayed an increasing trend in the constantly restricted and/or unpredictably fed groups. In males, all genes showed no significant variation although the trend mirrors what is observed in females. This study sheds light on how unpredictable dietary fluctuations impact gene expression and fitness traits. It also uncovers sex-specific variations in response to dietary changes.
ISBN:978-615-6457-43-1
Tárgyszavak:Agrártudományok Állattenyésztési tudományok előadáskivonat
könyvrészlet
Gene expression
Japanese quail
nutrient sensing pathway
unpredictable feeding
Megjelenés:II. Magyar Agrártudományi Doktoranduszok Szimpóziuma / szerk. Hajdú Péter. - p. 27. -
További szerzők:Ndunguru, Sawadi Fransisco (1980-) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Szabó Csaba (1968-) (agrármérnök) Czeglédi Levente (1977-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus)
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4.

001-es BibID:BIBFORM120370
Első szerző:Reda, Gebrehaweria Kidane (Phd hallgató)
Cím:Dietary restriction reveals sex-specifc expression of the mTOR pathway genes in Japanese quails / Gebrehaweria K. Reda, Sawadi F. Ndunguru, Brigitta Csernus, Renáta Knop, James K. Lugata, Csaba Szabó, Levente Czeglédi, Ádám Z. Lendvai
Dátum:2024
ISSN:2045-2322
Megjegyzések:Limited resources affect an organism's physiology through the conserved metabolic pathway, the mechanistic target of rapamycin (mTOR). Males and females often react differently to nutritional limitation, but whether it leads to differential mTOR pathway expression remains unknown. Recently, we found that dietary restriction (DR) induced significant changes in the expression of mTOR pathway genes in female Japanese quails (Coturnix japonica). We simultaneously exposed 32 male and female Japanese quails to either 20%, 30%, 40% restriction or ad libitum feeding for 14 days and determined the expression of six key genes of the mTOR pathway in the liver to investigate sex differences in the expression patterns. We found that DR significantly reduced body mass, albeit the effect was milder in males compared to females. We observed sex-specific liver gene expression. DR downregulated mTOR expression more in females than in males. Under moderate DR, ATG9A and RPS6K1 expressions were increased more in males than in females. Like females, body mass in males was correlated positively with mTOR and IGF1, but negatively with ATG9A and RS6K1 expressions. Our findings highlight that sexes may cope with nutritional deficits differently and emphasise the importance of considering sexual differences in studies of dietary restriction.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 14 : 1 (2024), p. 1-14. -
További szerzők:Ndunguru, Sawadi Fransisco (1980-) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Knop Renáta (1983-) (állatorvos) Lugata, James Kachungwa (1992-) (Ph.D hallgató) Szabó Csaba (1968-) (agrármérnök) Czeglédi Levente (1977-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus)
Pályázati támogatás:K139021
OTKA
Internet cím:Szerző által megadott URL
DOI
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5.

001-es BibID:BIBFORM120372
Első szerző:Reda, Gebrehaweria Kidane (Phd hallgató)
Cím:Dietary restriction and life-history trade-offs: insights into mTOR pathway regulation and reproductive investment in Japanese quails / Gebrehaweria K. Reda, Sawadi F Ndunguru, Brigitta Csernus, Gabriella Gulyás, Renáta Knop,Csaba Szabó, Levente Czeglédi, Ádám Z. Lendvai
Dátum:2024
ISSN:0022-0949
Megjegyzések:Resources are needed for growth, reproduction and survival, and organisms must trade-off limited resources among competing processes. Nutritional availability in organisms is sensed and monitored by nutrient-sensing pathways that can trigger physiological changes or alter gene expression. Previous studies have proposed that one such signalling pathway, the mechanistic target of rapamycin (mTOR), underpins a form of adaptive plasticity when individuals encounter constraints in their energy budget. Despite the fundamental importance of this process in evolutionary biology, how nutritional limitation is regulated through the expression of genes governing this pathway and its consequential effects on fitness remains understudied, particularly in birds. We used dietary restriction to simulate resource depletion and examined its effects on body mass, reproduction and gene expression in Japanese quails (Coturnix japonica). Quails were subjected to feeding 20%, 30%, 40% restriction levels or ad libitum for two weeks. All restricted groups exhibited reduced body mass, whereas reductions in the number and mass of eggs were observed only under more severe restrictions. Additionally, dietary restriction led to decreased expression of mTOR and insulin-like growth factor 1 (IGF1), whereas the ribosomal protein S6 kinase 1 (RPS6K1) and autophagy-related genes (ATG9A and ATG5) were upregulated. The pattern in which mTOR respond to restriction was similar to what has been seen in body mass. Regardless of the treatment, proportionally higher reproductive investment was associated with individual variation in mTOR expression. These findings reveal the connection between dietary intake and the expression of mTOR and related genes in this pathway.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal Of Experimental Biology. - [Epub ahead of print] : - (2024), p. -. -
További szerzők:Ndunguru, Sawadi Fransisco (1980-) Csernus Brigitta (1991-) (élelmiszerbiztonsági és -minőségi mérnök) Gulyás Gabriella Knop Renáta (1983-) (állatorvos) Szabó Csaba Czeglédi Levente (1977-) (agrármérnök) Lendvai Ádám Zoltán (1977-) (biológus)
Pályázati támogatás:K139021
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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