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001-es BibID:	BIBFORM037279
Első szerző:	Csanaky Katalin
Cím:	Changes in PACAP Immunoreactivity in Human Milk and Presence of PAC1 Receptor in Mammary Gland during Lactation / Csanaky Katalin, Banki Eszter, Szabadfi Krisztina, Reglodi Dora, Tarcai Ibolya, Czegledi Levente, Helyes Zsuzsanna, Ertl Tibor, Gyarmati Judit, Szanto Zalan, Zapf Istvan, Sipos Erika, Shioda Seiji, Tamas Andrea
Dátum:	2012
ISSN:	0895-8696
Megjegyzések:	Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide with widespread occurrence in the nervous system and peripheral organs, including the mammary gland. Previously, we have shown that PACAP38 is present in the human milk at higher levels than in respective blood samples. However, it is not known how PACAP levels and the expression of PAC1 receptor change during lactation. Therefore, the aim of our study was to investigate PACAP38-like immunoreactivity (PACAP38-LI) in human colostrums and transitional and mature milk during lactation and to compare the expression of PAC1 receptors in lactating and non-lactating mammary glands. We found that PACAP38-LI was significantly higher in human colostrum samples than in the transitional and mature milk. PACAP38-LI did not show any significant changes within the first 10-month period of lactation, but a significant increase was observed thereafter, up to the examined 17th month. Weak expression of PAC1 receptors was detected in non-lactating sheep and human mammary glands, but a significant increase was observed in the lactating sheep samples. In summary, the present study is the first to show changes of PACAP levels in human milk during lactation. The presence of PACAP in the milk suggests a potential role in the development of newborn, while the increased expressions of PAC1 receptors on lactating breast may indicate a PACAP38/PAC1 interaction in the mammary gland during lactation.
Tárgyszavak:	Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény külföldi lapban sheep, PACAP Egészség- és Környezettudomány
Megjelenés:	Journal Of Molecular Neuroscience. - 48 : 3 (2012), p. 631-637. -
További szerzők:	Bánki Eszter Szabadfi Krisztina (Pécsi Egyetem) Reglődi Dóra (Idegtudományok) Tarcai Ibolya Czeglédi Levente (1977-) (agrármérnök) Helyes Zsuzsanna Ertl Tibor Gyarmati Judit Szántó Zalán Zapf István Sípos Erika Shioda, Seiji Tamás Andrea (Idegtudomány) (Pécs)
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Állati eredetű funkcionális élelmiszerek fejlesztése
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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