CCL

Összesen 1 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM093148
Első szerző:Pohóczky Krisztina
Cím:Pituitary adenylate cyclase activating polypeptide concentrations in the sheep mammary gland, milk, and in the lamb blood plasma after suckling / Pohóczky Krisztina, Tamás Andrea, Reglődi Dóra, Kemény Ágnes, Helyes Zsuzsanna, Czeglédi Levente
Dátum:2020
ISSN:2498-602X
Megjegyzések:Pituitary adenylate cyclase activating polypeptide (PACAP) is involved in development and reproduction. We previously described elevated PACAP levels in the milk compared to the plasma, and the presence of its specific PAC1 receptor in the mammary gland. This study aimed to determine PACAP and vasoactive intestinal peptide (VIP) levels in female suckling lambs compared to ewe plasma and mammary gland, as well as their age-dependent alterations. mRNA expressions of PACAP, VIP, PAC1 receptor and brain-derived neurotrophic factor (BDNF) were quantified in the milk whey and mammary gland. PACAP38-like immunoreactivity (PACAP38-LI) was measured in plasma, milk whey and mammary gland by radioimmunoassay, VIP-LI by enzyme-linked immunoassay. PACAP38-LI was 5, 6 times higher in the milk compared to the plasma of lactating sheep. It significantly increased in the lamb plasma 1 h, but returned to basal level 2 h after suckling. However, VIP mRNA was not present in the mammary gland, we detected the VIP protein in the milk whey. BDNF mRNA significantly decreased with age to approximately 60% and 25% in the 3- and 10-year-old sheep respectively, compared to the 3- month-old lambs. No differences were found between mammary and jugular vein plasma PACAP and VIP concentrations, or during the daily cycle. We propose a rapid absorption of PACAP38 from the milk and/or its release in suckling lambs. PACAP accumulated in the milk might be synthesized in the mammary gland or secreted from the plasma of the mothers. PACAP is suggested to have differentiation/proliferation promoting and immunomodulatory effects in the newborns and/or a local function in the mammary gland.
Tárgyszavak:Agrártudományok Állattenyésztési tudományok idegen nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
Megjelenés:Physiology International. - 107 : 1 (2020), p. 92-105. -
További szerzők:Tamás Andrea Reglődi Dóra (Idegtudományok) Kemény Ágnes Helyes Zsuzsanna Czeglédi Levente (1977-) (agrármérnök)
Pályázati támogatás:KTIA_NAP_13-2014-0022
Egyéb
EFOP-3.6.2-16-2017-00006
EFOP
EFOP-3.6.3-VEKOP-16-2017-00008
EFOP
FIKPII 20765/3/2018/FEKUTSTRAT
Egyéb
K115874
OTKA
K119759
Egyéb
GINOP-2.3.2-15-2016-00050
GINOP
PTE AOK KA-2019-30
Egyéb
KTIA_13_ NAP-A-III/5
Egyéb
TKI 14016
MTA
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1