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1.

001-es BibID:BIBFORM065683
Első szerző:Aydemir, Gamze (biotechnológus)
Cím:Lycopene supplementation restores vitamin A deficiency in mice and possesses thereby partial pro-vitamin A activity transmitted via RAR-signaling / Gamze Aydemir, Yasamin Kasiri, Emöke-Márta Bartók, Eszter Birta, Kati Fröhlich, Volker Böhm, Johanna Mihaly, Ralph Rühl
Dátum:2016
ISSN:1613-4125
Megjegyzések:SCOPE:The aim of this study was to compare if lycopene also possesses pro-vitamin A (VA) activity comparable to known VA derivatives.MATERIALS AND METHODS:We used a transgenic retinoic acid response element reporter mouse model (n = 8, per group) for this study, and after the initial wash out of VA using a vitamin A deficient diet (VAD) for 18 weeks, the animals were supplemented further with (a) VAD-fed mice, (b) VAD-fed mice plus retinol (20 mg/kg bw), (c) VAD-fed mice plus ?-carotene (40 mg/kg bw), and (d) VAD-fed mice plus lycopene (40 mg/kg bw). Using ex vivo scanning and gene expression analysis of retinoid target and VA marker gene analysis in various organs of these supplemented mice (b, c, d), we found increased luciferase activity and normalized marker and target gene analysis compared to group a.CONCLUSIONS:Lycopene can restore VA deficiency and compensate VA for retinoic acid receptor (RAR)-mediated signaling as the major function of VA in the mammalian organism. Lycopene administration can initiate upregulation of RAR-mediated signaling in various organs in VAD-fed animals via potential novel bioactive lycopene metabolites. This indicates that lycopene possesses partial pro-VA activity in mice transmitted via RAR-mediated signaling.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Carotenoid
Retinoic acid receptor
Retinol
Tomato
Megjelenés:Molecular Nutrition & Food Research 60 : 11 (2016), p. 2413-2420. -
További szerzők:Kasiri, Yasamin Bartók Emőke Márta Birta Eszter Fröhlich Kati Böhm, Volker Mihály Johanna (1982-) (biológus, vegyész) Rühl, Ralph (1969-) (vegyész)
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2.

001-es BibID:BIBFORM052719
Első szerző:Aydemir, Gamze (biotechnológus)
Cím:Lycopene-derived bioactive retinoic acid receptors/retinoid-X receptors-activating metabolites may be relevant for lycopene's anti-cancer potential / Gamze Aydemir, Yasamin Kasiri, Eszter Birta, Gabriella Béke, Ada L. Garcia, Emőke-Márta Bartók, Ralph Rühl
Dátum:2013
ISSN:1613-4125
Megjegyzések:Dietary consumption of tomato products and especially the red tomato pigment lycopene has been associated with lower risk of cancer. New evidence is emerging toward metabolic pathways mediating the anti-cancer activities of lycopene. In this review, we explore associations between tomatoes and lycopene intake and cancer and relate this to the metabolic activation pathways of lycopene via carotene oxygenases and further carotenoid/retinoid-metabolizing enzymes to apo-lycopenoids. Several of these apo-lycopenoids have already been identified but up to date no direct connection between lycopene metabolism and apo-lycopenoids mediated receptor activation pathways has been established. Retinoic acid receptors/retinoid-X receptors activation pathways in particular, may be mediated via lycopene metabolites that are related to retinoic acids. Various studies have shown an association between lower concentration of insulin-like growth factor-1 upon lycopene treatment, cancer incidences, and retinoid-mediated signaling. In this review, we interrelate tomato/lycopene ingestion and cancer incidence, with metabolic activation of lycopene and retinoid-mediated signaling. The aim is to discuss a potential mechanism to explain lycopene related anti-cancer activities by modulation of insulin-like growth factor-1 concentrations via lycopene metabolite activation of retinoid-mediated signaling.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekuláris Medicina
Megjelenés:Molecular Nutrition & Food Research. - 57 : 5 (2013), p. 739-747. -
További szerzők:Kasiri, Yasamin Birta Eszter Béke Gabriella (1987-) (molekuláris biológus) Garcia, Ada L. Bartók Emőke Márta Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:TÁMOP-4.2.2.A-11/1/KONV-2012-0023
TÁMOP
TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Az apoptózis molekuláris mechanizmusa
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3.

001-es BibID:BIBFORM031277
Első szerző:Aydemir, Gamze (biotechnológus)
Cím:Lycopene induces retinoic acid receptor transcriptional activation in mice / Gamze Aydemir, Harald Carlsen, Rune Blomhoff, Ralph Rühl
Dátum:2012
ISSN:1613-4125
Megjegyzések:Lycopene is a lipophilic carotenoid and provides the red color to tomatoes and tomato product. Various studies indicated that lycopene and tomatoes / tomato products are able to positively influence various diseases associated with a chronic inflammation. The mechanism of action of lycopene to elicit these effects is partly unknown. A possible mechanism is that biological metabolites of lycopene may activate nuclear hormone receptors in mammalian cells. The aim of this study was to investigate the potential of orally administered lycopene and all-trans retinoic acid (ATRA) for the induction of the retinoic acid receptor (RAR) in a transgenic retinoic acid response-element (RARE)-reporter mouse system. Methods and Results:Orally administered lycopene (100 mg/kg bw in beadlets, n=6) and all-trans retinoic acid (ATRA) as an endogenous retinoic acid receptor (RAR)-ligand (50 mg/kg bw, n=6) for the induction of the retinoic acid receptor in male mice using a transgenic retinoic acid response-element (RARE)-reporter mouse system. Lycopene-treatments induced RARE-mediated cell signaling indicated by quantified bio-imaging, increased luciferase activity and up-regulated the retinoid target genes in selected organs of the mice. Conclusion:We conclude that lycopene can induce RAR-transcriptional activation in mice and lycopene might be a precursor of still non identified biologically active metabolites.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
lycopene
retinoid signalling
külföldön készült közlemény
Megjelenés:Molecular Nutrition and Food Research. - 56 : 5 (2012), p. 702-712. -
További szerzők:Carlsen, Harald Blomhoff, Rune Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:TÁMOP 4.2.1./B-09/1/KONV-2010-007
TÁMOP
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM113419
035-os BibID:(Scopus)85105164667 (WOS)000933681900005
Első szerző:Carlsen, Harald
Cím:A transgenic reporter mouse model for assessment of retinoic acid receptor transcriptional activation / Carlsen Harald, Ebihara Kanae, Kuwata Nobuyo H., Kuwata Kazuhisa, Aydemir Gamze, Rühl Ralph, Blomhoff Rune
Dátum:2023
ISSN:0300-9831
Megjegyzések:Background: Vitamin A is essential for a wide range of life processes throughout embryogenesis to adult life. With the aim of developing an in vivo model to monitor retinoic acid receptor (RAR) transactivation real-time in intact animals, we generated transgenic mice carrying a luciferase (luc) reporter gene under the control of retinoic acid response elements (RAREs) consisting of three copies of a direct repeat with five spacing nucleotides (DR5). Methods: Transgenic mice carrying a RARE dependent luciferase reporter flanked with insulator sequence were generated by pronuclear injection. RARE dependent luciferase activity was detected by in vivo imaging or in tissue extracts following manipulations with RAR/retinoid X receptor (RXR) agonists, RAR antagonists or in vitamin A deficient mice. Results: We found a strong induction of luciferase activity in a time and dose dependent manner by retinoic acid as well as RAR agonists, but not by the RXR agonist (using n=4-6 per group; 94 mice). In addition, luciferase activity was strongly reduced in vitamin A-deficient mice (n=6-9; 30 mice). These observations confirm that luciferase activity was controlled by RAR activation in the RARE-luc mouse. Luciferase activity was detectable in various organs, with high activity especially in brain and testis, indicating strong retinoid signalling in these tissues. Conclusion: The RARE-luc transgenic mice, which enabled real-time in vivo assessment of RAR activation, will be useful in understanding the normal physiology of vitamin A, the role of retinoid signalling in pathologies as well as to evaluate pharmacological ligands for RARs.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Animals
Luciferases
Male
Mice
Transgenic
Receptors, Retinoic Acid
Retinoid X Receptors
Retinoids
Transcriptional Activation
Tretinoin
Vitamin A
Megjelenés:International Journal For Vitamin And Nutrition Research. - 93 : 1 (2023), p. 29-41. -
További szerzők:Ebihara, Kanae Kuwata, Nobuyo H. Kuwata, Kazuhisa Aydemir, Gamze (1977-) (biotechnológus) Rühl, Ralph (1969-) (vegyész) Blomhoff, Rune
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5.

001-es BibID:BIBFORM036715
Első szerző:Garcia, Ada L.
Cím:Retinoid Concentrations in the Mouse during Postnatal Development and after Maternal Vitamin A Supplementation / Garcia A. L., Ruhl R., Schweigert F. J.
Dátum:2005
ISSN:0250-6807
Megjegyzések:BACKGROUND: Vitamin A (VA) and its derivates (retinoids) are important nutritional substances, which mediate their biological activity mainly via nuclear retinoid receptors. Maternal VA intake during lactation influences the VA content in milk and the VA status of the progeny. We investigated the effects of maternal supplementation during lactation and direct supplementation to the pups after weaning on the retinoid concentration in serum and liver of neonatal mice using high doses of VA. METHODS: Dams were fed a basal (4,500 retinol equivalents/kg diet) or a VA-supplemented (324,000 retinol equivalents/kg diet) diet during lactation. Pups kept receiving the same diet after weaning. Serum and liver samples of the pups were collected during lactation at days 1, 3, 5, 7, and 14 and post-weaning at days 21 and 65 after birth. Samples were analysed for retinoids by high-performance liquid chromatography. RESULTS: Maternal VA supplementation resulted in significantly higher concentrations of retinol, retinyl palmitate and retinyl stearate in serum of mice neonates at days 5, 7, 14, 21 and 65 after birth in comparison to the basal diet, whereas significantly higher concentrations were observed in liver at days 5, 14, 21 and 65 after birth. At day 7 after birth, a decrease in the liver retinoid concentrations occurred in the VA-supplemented diet. CONCLUSION: Our results show for the first time that supplementation with high doses of VA during the lactation period in mice can affect serum retinol concentrations in the neonates and report that day 7 after birth is a critical time in the tissue distribution of retinoids during postnatal development.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Annals Of Nutrition And Metabolism. - 49 : 5 (2005), p. 333-341. -
További szerzők:Rühl, Ralph (1969-) (vegyész) Schweigert, Florian J.
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6.

001-es BibID:BIBFORM065678
Első szerző:Grüber, Christoph
Cím:Serum Retinoic Acid and Atopy Among Children of Different Ethnic Origin Living in Germany / Christoph Grüber, Ceylan Taner, Johanna Mihály, Paolo M. Matricardi, Ulrich Wahn, Ralph Rühl
Dátum:2012
ISSN:0277-2116
Megjegyzések:We hypothesized that higher provitamin A carotenoid serum levels may be associated with higher concentrations of all-trans retinoic acid (ATRA) and atopy. Concentration of ATRA was measured by high-performance liquid chromatography in sera from German domestic and Turkish migrants' children. ATRA serum levels were significantly higher in German children if compared with Turkish children and correlated with those of ?-carotene (rs?=?0.692) and other provitamin A carotenoids. They did not differ significantly between atopic and nonatopic individuals. Serum levels of ATRA are related to those of provitamin A carotenoids but are not directly related to atopy in the present study.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
atopy
b-carotene
ethnicity
retinoic acid
vitamin a
Megjelenés:Journal Of Pediatric Gastroenterology And Nutrition. - 54 : 4 (2012), p. 558-560. -
További szerzők:Taner, Ceylan Mihály Johanna (1982-) (biológus, vegyész) Matricardi, Paolo M. Wahn, Ulrich Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
A szaruhártya és a retina betegségeinek kutatása
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7.

001-es BibID:BIBFORM087743
Első szerző:Lucas, Renata
Cím:Vitamin D signaling in a mouse allergic sensitization model / Renata Lucas, Johanna Mihály, Janine Gericke, Dániel Törőcsik, Ralph Rühl
Dátum:2020
ISSN:0300-9831
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:International Journal for Vitamin and Nutrition Research. - 90 : 5-6 (2020), p. 385-388. -
További szerzők:Mihály Johanna (1982-) (biológus, vegyész) Gericke, Janine (1982-) (táplálkozástudományi szakember) Töröcsik Dániel (1979-) (bőrgyógyász) Rühl, Ralph (1969-) (vegyész)
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8.

001-es BibID:BIBFORM036683
Első szerző:Rühl, Ralph (vegyész)
Cím:Modulation of Cytokine Production by Low and High Retinoid Diets in Ovalbumin-Sensitized Mice / Rühl, R., Garcia, A., Schweigert, F. J., Worm, M.
Dátum:2003
ISSN:0300-9831
Megjegyzések:Retinoids modulate many physiological processes such as the differentiation and growth of different cell types, including cells from the immune system. We have previously shown that retinoids modulate IgE production in vitro and in vivo. In the present study we investigated the effects of retinoids in non-sensitized and ovalbumin-sensitized mice that were fed for 11 weeks with three different vitamin A (VA) diets: a) VA-deficiency diet, b) base diet, and c) base diet supplemented with 0.5% all-trans-retinoic acid (ATRA). Phorbol-myristate-acetate (PMA)/ionomycin-stimulated SMC (splenic mononuclear cells) from mice fed with ATRA and the vitamin A-deficient diet group showed increased interleukin-4 (IL-4) responses in non-sensitized mice. After ovalbumin sensitization in the VA-deficient and the ATRA supplementation diet groups, no significant effects on IL-4 production were observed. By contrast, gamma interferon (IFN-gamma production from PMA/ionomycin-stimulated SMC was enhanced in the VA-deficient diet group in ovalbumin-sensitized mice, and also in non-sensitized mice compared to the base and the ATRA-supplemented diet group. The data indicate that VA and retinoid content in a diet influences the cytokine response in non-sensitized and also ovalbumin-sensitized mice. Therefore these molecules may serve as active modulators of cytokine production in vivo that are responsible for the induction and persistence of atopic diseases.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:International Journal For Vitamin And Nutrition Research. - 74 : 04 (2003), p. 279-284. -
További szerzők:Garcia, Ada L. Schweigert, Florian J. Worm, Margitta
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9.

001-es BibID:BIBFORM036652
Első szerző:Rühl, Ralph (vegyész)
Cím:Carotenoids and their metabolites are naturally occurring activators of gene expression via the pregnane X receptor / Rühl Ralph, Sczech Ronny, Landes Nico, Pfluger Paul, Kluth Dirk, Schweigert Florian J.
Dátum:2004
ISSN:1436-6207
Megjegyzések:Carotenoids are important micronutrients in the human diet and are present in human serum at micromolar concentrations. In addition to their antioxidant potential, carotenoids obtain physiologically relevant properties such as influencing cellular signal pathways, gene expression or induction of detoxifying enzymes. In this study, we determined the transactivation of PXR by cotransfection with the full-length receptor and a PXR-responsive reporter gene. Carotenoids and retinol revealed a 5-6 fold reporter gene activity in HepG2 cells in comparison to a 7-fold induction by the well-known PXR agonist rifampicin, whereas apo-carotenals and lycopene exerted less or no activation potential. The inductive efficacy was hereby concentration-dependent. In addition, carotenoid- or retinol-mediated gene expression of PXR-responsive genes like CYP3A4/CYP3A7, CYP3A5, MDR-1 and MRP-2 has been determined in HepG2 cells by RT-PCR with up-regulative properties of beta-carotene or retinol being comparable to or even higher than that of rifampicin. In conclusion, PXR-mediated up-regulation of CYP3A4/CYP3A7 and CYP3A5 as well as MDR1 and MRP2 by carotenoids points to a potential interference on the metabolism of xenobiotic and endogenous relevant compounds.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Journal Of Nutrition. - 43 : 6 (2004), p. 336-343. -
További szerzők:Sczech, Ronny Landes, Nico Pfluger, Paul Kluth, Dirk Schweigert, Florian J.
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10.

001-es BibID:BIBFORM012892
Első szerző:Rühl, Ralph (vegyész)
Cím:Fatty acid composition of serum lipid classes in mice following allergic sensitisation with or without dietary docosahexaenoic acid-enriched fish oil substitution / Ralph Rühl, Christin Koch, Tamás Marosvölgyi, Johanna Mihály, Florian J. Schweigert, Margitta Worm, Tamás Décsi
Dátum:2008
ISSN:0007-1145
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal Of Nutrition. - 99 : 6 (2008), p. 1239-1246. -
További szerzők:Koch, Christin Marosvölgyi Tamás Mihály Johanna (1982-) (biológus, vegyész) Schweigert, Florian J. Worm, Margitta Decsi Tamás
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11.

001-es BibID:BIBFORM003817
Első szerző:Rühl, Ralph (vegyész)
Cím:Modulation of plasma all-trans retinoic acid concentrations by the consumption of carotenoid-rich vegetables / Ralph Rühl, Achim Bub, Bernhard Watzl
Dátum:2008
Megjegyzések:A human intervention trial was conducted to determine the effects of consumption of carotenoid-rich vegetables on levels of retinol (ROL) and the active vitamin A metabolite all-trans retinoic acid (ATRA). METHODS: The study was divided into four periods, each lasting 2 wk: weeks 1-2, a low carotenoid period; weeks 3-4, daily consumption of 330 mL of tomato juice; weeks 5-6, 330 mL of carrot juice daily; and weeks 7-8, 10 g of dried spinach powder daily. ROL and ATRA concentrations were measured after each 2-wk study period. RESULTS AND CONCLUSION: This study shows that consumption of carrot juice containing high concentrations of the pro-vitamin A carotenoid beta-carotene results in slightly, non-significantly increased plasma ROL concentrations and strong, significantly increased (almost double, from 1.2 +/- 0.3 to 2.0 +/- 0.31 ng/mL) plasma concentrations of ATRA, whereas consumption of tomato juice and spinach powder results in no significant alteration in concentrations of plasma ROL and ATRA.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Nutrition. - 24 : 11-12 (2008), p. 1224-1226. -
További szerzők:Bub, Achim Watzl, Bernhard
Internet cím:elektronikus változat
DOI
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12.

001-es BibID:BIBFORM001538
Első szerző:Rühl, Ralph (vegyész)
Cím:Effect of dietary retinoids and carotenoids on immune development / Rühl, R.
Dátum:2007
Megjegyzések:Carotenoids and retinoids are groups of nutritionally-relevant compounds present in many foods of plant origin (carotenoids) and animal origin (mainly retinoids). Their levels in human subjects vary depending on the diversity and amount of the individual's nutrient intake. Some carotenoids and retinoids have been investigated for their effects on the immune system both in vitro and in vivo. It has been shown that retinoids have the potential to mediate or induce proliferative and differentiating effects on several immune-competent cells, and various carotenoids are known to be inducers of immune function. The immune-modulating effects of retinoids have been well documented, while the effects of carotenoids on the immune system have not been investigated as extensively, because little is known about their molecular mechanism of action. The present review will mainly focus on the molecular mechanism of action of retinoids and particularly carotenoids, their nutritional origin and intake, their transfer from the maternal diet to the child and their effects or potential effects on the developing immune system.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Proceedings of the Nutrition Society. - 66 : 3 (2007), p. 458-469. -
Internet cím:elektronikus változat
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