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001-es BibID:BIBFORM036656
Első szerző:Garcia, Ada L.
Cím:Retinoid- and carotenoid-enriched diets influence the ontogenesis of the immune system in mice / Garcia Ada L., Ruhl Ralph, Herz Udo, Koebnick Corinna, Schweigert Florian J., Worm Margitta
Dátum:2003
ISSN:0019-2805
Megjegyzések:Vitamin A (VA) has been identified as an important factor for the development of the immune system, especially during ontogenesis. It has been shown that antibody secretion and proliferation of lymphocyte populations depend on retinoids. In the present study we investigated the influence of a base VA diet and diets enriched with VA, β-carotene and lycopene, on the ontogenesis of the immune system in mice. We examined the absolute and relative concentrations of splenic B lymphocytes (CD45R/B220), T lymphocytes (CD3+) and their subpopulations (CD4+ and CD8+), and measured serum immunoglobulin G (IgG) concentrations in the offspring of supplemented dams at different ages (1, 3, 5, 7, 14, 21 and 65 days). The experimental diets resulted in higher numbers of T and B lymphocytes after VA and carotenoid enrichment, when compared, at various time-points, with the base diet. Higher values of total serum IgG were found in the β-carotene-enriched diet group on day 7. On days 7 and 14, the enriched diets induced significant alterations in the percentages and total numbers of splenic lymphocytes in comparison to the base diet. Our results confirm that supplementation with VA and carotenoids affect the immune-cell function during ontogenesis and suggest a possible role of these nutritional factors on the development of the immune system.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Immunology. - 110 : 2 (2003), p. 180-187. -
További szerzők:Rühl, Ralph (1969-) (vegyész) Herz, Udo Koebnick, Corinna Schweigert, Florian J. Worm, Margitta
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2.

001-es BibID:BIBFORM036655
Első szerző:Rühl, Ralph (vegyész)
Cím:Inhibition of IgE-Production by Peroxisome Proliferator-Activated Receptor Ligands / Ruhl Ralph, Dahten Anja, Schweigert Florian J., Herz Udo, Worm Margitta
Dátum:2003
ISSN:0022-202X
Megjegyzések:In this study we analyzed the effect of peroxisome proliferator-activated receptor-alpha and -gamma ligands on immunoglobulin synthesis and cytokine production in non-allergic and atopic dermatitis donors in vitro, but also in vivo ovalbumin-sensitized mice. A significant inhibition in CD40+ interleukin-4-mediated, but also basal IgE synthesis from peripheral blood mononuclear cells of atopic dermatitis donors was observed in the presence of the peroxisome proliferator-activated receptor-alpha ligand (up to 47+/-12%) and peroxisome proliferator-activated receptor-gamma ligand (69+/-5%). By contrast, the production of other isotypes such as IgA, IgG, and IgM was only modest inhibited. Analysis of cytokine production from the peripheral blood mononuclear cells shows inhibition of several cytokines by both peroxisome proliferator-activated receptor ligands. The most inhibitory effect on cytokine production was observed by the peroxisome proliferator-activated receptor-gamma ligand in peripheral blood mononuclear cells from atopic dermatitis donors with high IgE baseline production. Coculture experiments show that the decrease of IgE production by ciglitazone was monocyte dependent (up to 63+/-7%). Finally, in vivo experiments from ovalbumin-sensitized mice confirmed the in vitro findings showing that the interleukin-4-mediated immune response was inhibited in ciglitazone-treated mice.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Investigative Dermatology. - 121 : 4 (2003), p. 757-764. -
További szerzők:Dahten, Anja Schweigert, Florian J. Herz, Udo Worm, Margitta
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM001537
Első szerző:Rühl, Ralph (vegyész)
Cím:Role of vitamin A elimination or supplementation diets during postnatal development on the allergic sensitisation in mice / Rühl, R., Hänel, A., Garcia, A. L., Dahten, A., Herz, U., Schweigert, F. J., Worm, M.
Dátum:2007
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Molecular nutrition and food research. - 51 : 9 (2007), p. 1173-1187. -
További szerzők:Garcia, Ada L. Hänel, Andrej Dahten, Anja Herz, Udo Worm, Margitta Schweigert, Florian J.
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