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001-es BibID:	BIBFORM031277
Első szerző:	Aydemir, Gamze (biotechnológus)
Cím:	Lycopene induces retinoic acid receptor transcriptional activation in mice / Gamze Aydemir, Harald Carlsen, Rune Blomhoff, Ralph Rühl
Dátum:	2012
ISSN:	1613-4125
Megjegyzések:	Lycopene is a lipophilic carotenoid and provides the red color to tomatoes and tomato product. Various studies indicated that lycopene and tomatoes / tomato products are able to positively influence various diseases associated with a chronic inflammation. The mechanism of action of lycopene to elicit these effects is partly unknown. A possible mechanism is that biological metabolites of lycopene may activate nuclear hormone receptors in mammalian cells. The aim of this study was to investigate the potential of orally administered lycopene and all-trans retinoic acid (ATRA) for the induction of the retinoic acid receptor (RAR) in a transgenic retinoic acid response-element (RARE)-reporter mouse system. Methods and Results:Orally administered lycopene (100 mg/kg bw in beadlets, n=6) and all-trans retinoic acid (ATRA) as an endogenous retinoic acid receptor (RAR)-ligand (50 mg/kg bw, n=6) for the induction of the retinoic acid receptor in male mice using a transgenic retinoic acid response-element (RARE)-reporter mouse system. Lycopene-treatments induced RARE-mediated cell signaling indicated by quantified bio-imaging, increased luciferase activity and up-regulated the retinoid target genes in selected organs of the mice. Conclusion:We conclude that lycopene can induce RAR-transcriptional activation in mice and lycopene might be a precursor of still non identified biologically active metabolites.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban lycopene retinoid signalling külföldön készült közlemény
Megjelenés:	Molecular Nutrition and Food Research. - 56 : 5 (2012), p. 702-712. -
További szerzők:	Carlsen, Harald Blomhoff, Rune Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:	TÁMOP 4.2.1./B-09/1/KONV-2010-007 TÁMOP
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM031278
Első szerző:	Gouranton, E.
Cím:	Apo-10'-lycopenoic acid impacts adipose tissue biology via the retinoic acid receptors / E. Gouranton, G. Aydemir, E. Reynaud, J. Marcotorchino, C. Malezet, C. Caris-Veyrat, R. Blomhoff, J.F. Landrier, R. Rühl
Dátum:	2011
ISSN:	1388-1981
Megjegyzések:	Apo-10'-lycopenoic acid (apo-10-lycac), a metabolite of lycopene, has been shown to possess potent biological activities, notably via the retinoic acid receptors (RAR). In the current study, its impact on adipose tissue and adipocytes was studied. In microarray experiments, the set of genes regulated by apo-10-lycac treatments was compared to the set of genes regulated by all-trans retinoic acid (ATRA), the natural ligand of RAR, in adipocytes. Approximately 27.5% of the genes regulated by apo-10-lycac treatments were also regulated by ATRA, suggesting a common ability in terms of gene expression modulation, possibly via RAR transactivation. The physiological impact of apo-10-lycac on adipose tissue biology was evaluated. If it had no effect on adipogenesis in the 3T3-L1 cell model, this metabolite may have a preventative effect against inflammation, by preventing the increase in the inflammatory markers, interleukin 6 and interleukin 1β in various dedicated models. The ability of apo-10-lycac to transactivate the RAR and to modulate the transcription of RAR target gene was brought in vivo in adipose tissue. While apo-10-lycac was not detected in adipose tissue, a metabolite with a molecular weight with 2Da larger mass was detected, suggesting that a dihydro-apo-10'-lycopenoic acid, may be present in adipose tissue and that this compound could active or may lead to further active RAR-activating apo-10-lycac metabolites. Since apo-10-lycac treatments induce anti-inflammatory effects in adipose tissue but do not inhibit adipogenesis, we propose that apo-10-lycac treatments and its potential active metabolites in WAT may be considered for prevention strategies relevant for obesity-associated pathologies.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Apo-10'-lycopenoic acid Molekuláris Medicina egyetemen (Magyarországon) készült közlemény
Megjelenés:	Biochimica et Biophysica Acta (BBA). Molecular and Cell Biology of Lipids. - 1811 : 12 (2011), p. 1105-1114. -
További szerzők:	Aydemir, Gamze (1977-) (biotechnológus) Reynaud, Eric Marcotorchino, J. Malezet, C. Caris-Veyrat, Catherine Blomhoff, Rune Landrier, J. F. Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:	TAMOP 4.2.1./B-09/1/KONV-2010-007 TAMOP
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM042253
Első szerző:	Mihály Johanna (biológus, vegyész)
Cím:	Reduced retinoid signaling in the skin after systemic retinoid-X receptor ligand treatment in mice with potential relevance for skin disorders / Johanna Mihály, Janine Gericke, Gamze Aydemir, Kathrin Weiss, Harald Carlsen, Rune Blomhoff, Javier Garcia, Ralph Rühl
Dátum:	2012
ISSN:	1018-8665
Megjegyzések:	Retinoid-X receptor (RXR)- and retinoic acid receptor (RAR)-mediated signaling is induced by retinoic acids (RA), which are involved in the regulation of skin permeability, differentiation and immune response. Dysregulation of retinoid signaling is present in various skin disorders. Topically and systemically administered synthetic RAR or RXR agonists might influence retinoid-mediated signaling in the skin of RARE reporter animals and gene expression analysis for retinoid, skin homeostasis and skin inflammation marker genes and local retinoid concentrations. Mice were treated orally and topically with synthetic ligands and bioimaging, QRT-PCR and retinoid analysis were performed. Topical application of the synthetic RAR ligand AM580 significantly enhanced retinoid signaling in skin while topical application of the RXR ligand LG268 did not influence retinoic acid receptor response elements (RARE)-mediated signaling. Systemic treatments with LG268 decreased the expression of genes involved in skin homeostasis, RA synthesis and skin RA concentrations, while it increased various markers for skin inflammation and RA degradation, which corresponds to decreased skin RARE signaling. We conclude from these observations that increased systemic concentrations of an RXR -ligand may be one reason for reduced retinoid signaling, -reduced all-trans RA levels in the skin, reduced epidermal homeostasis and increased skin inflammation marker expression with potential relevance for various skin disorders, like atopic dermatitis.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Molekuláris Medicina
Megjelenés:	Dermatology. - 225 : 4 (2012), p. 304-311. -
További szerzők:	Gericke, Janine (1982-) (táplálkozástudományi szakember) Aydemir, Gamze (1977-) (biotechnológus) Weiss, Kathrin (1978-) Carlsen, Harald Blomhoff, Rune Garcia, Javier Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:	TÁMOP-4.2.1./B-09/1/KONV-2010-007 TÁMOP Magreceptorok szerepe a sejtdifferenciacioban es metabolikus folyamatokban TÁMOP-4.2.2.A-11/1/KONV-2012-0023 TÁMOP COST projects ♭Mast Cells and Basophils ? Targets for innovative therapies' and ♭SkinBAD'. Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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