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001-es BibID:	BIBFORM031277
Első szerző:	Aydemir, Gamze (biotechnológus)
Cím:	Lycopene induces retinoic acid receptor transcriptional activation in mice / Gamze Aydemir, Harald Carlsen, Rune Blomhoff, Ralph Rühl
Dátum:	2012
ISSN:	1613-4125
Megjegyzések:	Lycopene is a lipophilic carotenoid and provides the red color to tomatoes and tomato product. Various studies indicated that lycopene and tomatoes / tomato products are able to positively influence various diseases associated with a chronic inflammation. The mechanism of action of lycopene to elicit these effects is partly unknown. A possible mechanism is that biological metabolites of lycopene may activate nuclear hormone receptors in mammalian cells. The aim of this study was to investigate the potential of orally administered lycopene and all-trans retinoic acid (ATRA) for the induction of the retinoic acid receptor (RAR) in a transgenic retinoic acid response-element (RARE)-reporter mouse system. Methods and Results:Orally administered lycopene (100 mg/kg bw in beadlets, n=6) and all-trans retinoic acid (ATRA) as an endogenous retinoic acid receptor (RAR)-ligand (50 mg/kg bw, n=6) for the induction of the retinoic acid receptor in male mice using a transgenic retinoic acid response-element (RARE)-reporter mouse system. Lycopene-treatments induced RARE-mediated cell signaling indicated by quantified bio-imaging, increased luciferase activity and up-regulated the retinoid target genes in selected organs of the mice. Conclusion:We conclude that lycopene can induce RAR-transcriptional activation in mice and lycopene might be a precursor of still non identified biologically active metabolites.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban lycopene retinoid signalling külföldön készült közlemény
Megjelenés:	Molecular Nutrition and Food Research. - 56 : 5 (2012), p. 702-712. -
További szerzők:	Carlsen, Harald Blomhoff, Rune Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:	TÁMOP 4.2.1./B-09/1/KONV-2010-007 TÁMOP
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM042253
Első szerző:	Mihály Johanna (biológus, vegyész)
Cím:	Reduced retinoid signaling in the skin after systemic retinoid-X receptor ligand treatment in mice with potential relevance for skin disorders / Johanna Mihály, Janine Gericke, Gamze Aydemir, Kathrin Weiss, Harald Carlsen, Rune Blomhoff, Javier Garcia, Ralph Rühl
Dátum:	2012
ISSN:	1018-8665
Megjegyzések:	Retinoid-X receptor (RXR)- and retinoic acid receptor (RAR)-mediated signaling is induced by retinoic acids (RA), which are involved in the regulation of skin permeability, differentiation and immune response. Dysregulation of retinoid signaling is present in various skin disorders. Topically and systemically administered synthetic RAR or RXR agonists might influence retinoid-mediated signaling in the skin of RARE reporter animals and gene expression analysis for retinoid, skin homeostasis and skin inflammation marker genes and local retinoid concentrations. Mice were treated orally and topically with synthetic ligands and bioimaging, QRT-PCR and retinoid analysis were performed. Topical application of the synthetic RAR ligand AM580 significantly enhanced retinoid signaling in skin while topical application of the RXR ligand LG268 did not influence retinoic acid receptor response elements (RARE)-mediated signaling. Systemic treatments with LG268 decreased the expression of genes involved in skin homeostasis, RA synthesis and skin RA concentrations, while it increased various markers for skin inflammation and RA degradation, which corresponds to decreased skin RARE signaling. We conclude from these observations that increased systemic concentrations of an RXR -ligand may be one reason for reduced retinoid signaling, -reduced all-trans RA levels in the skin, reduced epidermal homeostasis and increased skin inflammation marker expression with potential relevance for various skin disorders, like atopic dermatitis.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Molekuláris Medicina
Megjelenés:	Dermatology. - 225 : 4 (2012), p. 304-311. -
További szerzők:	Gericke, Janine (1982-) (táplálkozástudományi szakember) Aydemir, Gamze (1977-) (biotechnológus) Weiss, Kathrin (1978-) Carlsen, Harald Blomhoff, Rune Garcia, Javier Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:	TÁMOP-4.2.1./B-09/1/KONV-2010-007 TÁMOP Magreceptorok szerepe a sejtdifferenciacioban es metabolikus folyamatokban TÁMOP-4.2.2.A-11/1/KONV-2012-0023 TÁMOP COST projects ♭Mast Cells and Basophils ? Targets for innovative therapies' and ♭SkinBAD'. Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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