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001-es BibID:	BIBFORM036661
Első szerző:	Rühl, Ralph (vegyész)
Cím:	Synthesis, high-performance liquid chromatography-nuclear magnetic resonance characterization and pharmacokinetics in mice of CD271 glucuronide / Rühl Ralph, Thiel Renate, Lacker Tanja Silke, Strohschein Sabine, Albert Klaus, Nau Heinz
Dátum:	2001
ISSN:	0378-4347
Megjegyzések:	Retinoic acid-glucuronides are known as retinoids with activity in acne therapy, limited placental transfer and reduced retinoid adverse effects. We synthesized the glucuronide of a novel retinoid, CD271 (adapalene), used for the treatment of moderate acne. The synthesis product ("CD271 glucuronide", CD271G) was purified by preparative HPLC. It undergoes in aqueous solution, like other glucuronides, rapid acyl-migration of the bound aglycone leading to position isomers. Thus characterization of purified CD271G could be only achieved by HPLC-NMR coupling. A subfraction ("CD271GB") consisting essentially of 2'- and 3'-CD271G was used for pharmacokinetic studies. After a single subcutaneous injection at a dosage of 30 mg/kg the substance showed considerable uptake and metabolism to CD271 indicating that CD271GB could serve as a prodrug for CD271.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Chromatography B: Biomedical Sciences and Applications. - 757 : 1 (2001), p. 101-109. -
További szerzők:	Thiel, Renate Lacker, Tanja Silke Strohschein, Sabine Albert, Klaus Nau, Heinz
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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