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001-es BibID:	BIBFORM065683
Első szerző:	Aydemir, Gamze (biotechnológus)
Cím:	Lycopene supplementation restores vitamin A deficiency in mice and possesses thereby partial pro-vitamin A activity transmitted via RAR-signaling / Gamze Aydemir, Yasamin Kasiri, Emöke-Márta Bartók, Eszter Birta, Kati Fröhlich, Volker Böhm, Johanna Mihaly, Ralph Rühl
Dátum:	2016
ISSN:	1613-4125
Megjegyzések:	SCOPE:The aim of this study was to compare if lycopene also possesses pro-vitamin A (VA) activity comparable to known VA derivatives.MATERIALS AND METHODS:We used a transgenic retinoic acid response element reporter mouse model (n = 8, per group) for this study, and after the initial wash out of VA using a vitamin A deficient diet (VAD) for 18 weeks, the animals were supplemented further with (a) VAD-fed mice, (b) VAD-fed mice plus retinol (20 mg/kg bw), (c) VAD-fed mice plus ?-carotene (40 mg/kg bw), and (d) VAD-fed mice plus lycopene (40 mg/kg bw). Using ex vivo scanning and gene expression analysis of retinoid target and VA marker gene analysis in various organs of these supplemented mice (b, c, d), we found increased luciferase activity and normalized marker and target gene analysis compared to group a.CONCLUSIONS:Lycopene can restore VA deficiency and compensate VA for retinoic acid receptor (RAR)-mediated signaling as the major function of VA in the mammalian organism. Lycopene administration can initiate upregulation of RAR-mediated signaling in various organs in VAD-fed animals via potential novel bioactive lycopene metabolites. This indicates that lycopene possesses partial pro-VA activity in mice transmitted via RAR-mediated signaling.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Carotenoid Retinoic acid receptor Retinol Tomato
Megjelenés:	Molecular Nutrition & Food Research 60 : 11 (2016), p. 2413-2420. -
További szerzők:	Kasiri, Yasamin Bartók Emőke Márta Birta Eszter Fröhlich Kati Böhm, Volker Mihály Johanna (1982-) (biológus, vegyész) Rühl, Ralph (1969-) (vegyész)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM052719
Első szerző:	Aydemir, Gamze (biotechnológus)
Cím:	Lycopene-derived bioactive retinoic acid receptors/retinoid-X receptors-activating metabolites may be relevant for lycopene's anti-cancer potential / Gamze Aydemir, Yasamin Kasiri, Eszter Birta, Gabriella Béke, Ada L. Garcia, Emőke-Márta Bartók, Ralph Rühl
Dátum:	2013
ISSN:	1613-4125
Megjegyzések:	Dietary consumption of tomato products and especially the red tomato pigment lycopene has been associated with lower risk of cancer. New evidence is emerging toward metabolic pathways mediating the anti-cancer activities of lycopene. In this review, we explore associations between tomatoes and lycopene intake and cancer and relate this to the metabolic activation pathways of lycopene via carotene oxygenases and further carotenoid/retinoid-metabolizing enzymes to apo-lycopenoids. Several of these apo-lycopenoids have already been identified but up to date no direct connection between lycopene metabolism and apo-lycopenoids mediated receptor activation pathways has been established. Retinoic acid receptors/retinoid-X receptors activation pathways in particular, may be mediated via lycopene metabolites that are related to retinoic acids. Various studies have shown an association between lower concentration of insulin-like growth factor-1 upon lycopene treatment, cancer incidences, and retinoid-mediated signaling. In this review, we interrelate tomato/lycopene ingestion and cancer incidence, with metabolic activation of lycopene and retinoid-mediated signaling. The aim is to discuss a potential mechanism to explain lycopene related anti-cancer activities by modulation of insulin-like growth factor-1 concentrations via lycopene metabolite activation of retinoid-mediated signaling.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Molekuláris Medicina
Megjelenés:	Molecular Nutrition & Food Research. - 57 : 5 (2013), p. 739-747. -
További szerzők:	Kasiri, Yasamin Birta Eszter Béke Gabriella (1987-) (molekuláris biológus) Garcia, Ada L. Bartók Emőke Márta Rühl, Ralph (1969-) (vegyész)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0023 TÁMOP TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Az apoptózis molekuláris mechanizmusa
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