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001-es BibID:	BIBFORM107320
035-os BibID:	(WOS)000746032300036 (Scopus)85123453070 (cikkazonosító)e00921-21
Első szerző:	Kaszab Eszter (biológus)
Cím:	Draft Genome Sequences of Lacticaseibacillus rhamnosus cek-R1, Lacticaseibacillus paracasei cek-R2, and Lentilactobacillus otakiensis cek-R3, Isolated from a Beetroot Product / Eszter Kaszab, Levente Laczkó, Krisztina Bali, Eszter Fidrus, Krisztián Bányai, Gábor Kardos
Dátum:	2022
ISSN:	2576-098X
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Microbiology Resource Announcements. - 11 : 1 (2022), p. e00921-21. -
További szerzők:	Laczkó Levente (1992-) (biológus) Bali Krisztina Fidrus Eszter (1992-) (biotechnológus) Bányai Krisztián Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus)
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001-es BibID:	BIBFORM117396
035-os BibID:	(cikkazonosító)1728 (WoS)001132459800001 (Scopus)85180500655
Első szerző:	Kerek Ádám
Cím:	In Vitro Microevolution and Co-Selection Assessment of Florfenicol Impact on Escherichia coli Resistance Development / Ádám Kerek, Bence Török, Levente Laczkó, Gábor Kardos, Krisztián Bányai, Zoltán Somogyi, Eszter Kaszab, Krisztina Bali, Ákos Jerzsele
Dátum:	2023
ISSN:	2079-6382
Megjegyzések:	The issue of antimicrobial resistance is becoming an increasingly serious challenge in both human and veterinary medicine. Prudent antimicrobial use in veterinary medicine is warranted and supported by international guidelines, with the Antimicrobial Advice Ad Hoc Expert Group (AMEG) placing particular emphasis on the critically important group B antimicrobials. These antimicrobials are commonly employed, especially in the poultry and swine industry. The impact of florfenicol, a veterinary antibiotic, was studied on the resistance development of Escherichia coli. The aim of the study was to investigate the effect of the use of florfenicol on the development of phenotypic and genomic resistances, not only to the drug itself but also to other drugs. The minimum inhibitory concentrations (MICs) of the antibiotics were investigated at 1x, 10x, 100x and 1000x concentrations using the adapted Microbial Evolution and Growth Arena (MEGA-plate) method. The results demonstrate that florfenicol can select for resistance to fluoroquinolone antibiotics (167x MIC value increase) and cephalosporins (67x MIC value increase). A total of 44 antimicrobial resistance genes were identified, the majority of which were consistent across the samples. Chromosomal point mutations, including alterations in resistance-associated and regulatory genes (acrB, acrR, emrR and robA), are thought to trigger multiple drug efflux pump activations, leading to phenotypically increased resistance. The study underscores the impact of florfenicol and its role in the development of antimicrobial resistance, particularly concerning fluoroquinolone antibiotics and cephalosporins. This study is the first to report florfenicol's dose-dependent enhancement of other antibiotics' MICs, linked to mutations in SOS-box genes (mdtABC-tolC, emrAB-tolC and acrAB-tolC) and increased multidrug efflux pump genes. Mutations in the regulatory genes acrR, emrR and rpbA support the possibility of increased gene expression. The results are crucial for understanding antimicrobial resistance and its development, highlighting the promising potential of in vitro evolutionary and coselection studies for future research.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Antibiotics-Basel. - 12 : 12 (2023), p. 1-18. -
További szerzők:	Török Bence Laczkó Levente (1992-) (biológus) Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus) Bányai Krisztián Somogyi Zoltán Kaszab Eszter (1989-) (biológus) Bali Krisztina Jerzsele Ákos
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001-es BibID:	BIBFORM116026
035-os BibID:	(Scopus)85175859931
Első szerző:	Nagy József Bálint (molekuláris biológus)
Cím:	Carbapenem-resistant Escherichia coli in Black-headed gulls, the Danube, and human clinical samples : a One Health comparison of contemporary isolates / József Bálint Nagy, Balázs Koleszár, Bernadett Khayer, Eszter Róka, Levente Laczkó, Erika Ungvári, Eszter Kaszab, Krisztina Bali, Krisztián Bányai, Márta Vargha, Ádám Lovas-Kiss, Ákos Tóth, Gábor Kardos
Dátum:	2023
ISSN:	2213-7165
Megjegyzések:	Objectives: Our aim was to characterize and compare contemporary carbapenem-resistant Enterobacterales (CRE) isolates from gulls, the River Danube, and humans in Hungary, Budapest. Methods: Multiresistant Enterobacterales were sought for in 227 gull faecal and 24 Danube water samples from 2019 to 2020. Eosin-methylene blue agar containing 2 mg/L cefotaxime and Colilert-test containing 10 mg/L cefotaxime were used for gull and water samples, respectively. Isolates were characterized by polymerase chain reactions (PCRs); acquired carbapenemase producers were further analysed by whole-genome sequencing, together with 21 Hungarian human CR Escherichia coli (CREc) isolates. Results: Gull and water samples exhibited a CRE prevalence of 7.4% (9/122) and 6.7% (7/105), none and 5/12 water samples yielded CRE from 2019 and 2020, respectively; CRE were found only in samples taken downstream of Budapest. The dominant species was Escherichia coli and the most prevalent carbapenemase was blaNDM-1. High-risk CREc clones were found both in gulls (ST224, ST372, ST744) and the Danube (ST10, ST354, ST410); the closest associations were between ST410 from humans and the Danube, among ST1437 among gulls, and between ST1437 in gulls and the Danube (46, 0, and 22?24 allelic distances, respectively). Direct links between human and gull isolates were not demonstrated. Conclusion: The study demonstrates potential epidemiological links among humans, a river crossing a city, and urbanised birds, suggesting a local transmission network. Water bodies receiving influent wastewater, together with animals using such habitats, may serve as a local reservoir system for CRE, highlighting the importance of One Health in CRE transmission, even in a country with a low CRE prevalence in humans.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Antibiotic resistance blaNDM-1 carbapenemase Human-animal interaction ST410 Urbanised birds
Megjelenés:	Journal of Global Antimicrobial Resistance. - 35 (2023), p. 257-261. -
További szerzők:	Koleszár Balázs Khayer Bernadett Róka Eszter (1989-) (gyógyszerész, gyógyszertechnológus) Laczkó Levente (1992-) (biológus) Ungvári Erika Kaszab Eszter (1989-) (biológus) Bali Krisztina Bányai Krisztián Vargha Márta Lovas-Kiss Ádám (1991-) (biológus, botanikus) Tóth Ákos Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus)
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