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1.

001-es BibID:BIBFORM031960
Első szerző:Fehér Enikő (molekuláris biológus, mikrobiológus)
Cím:Comparison of diversity of torque teno virus 1 in different mucosal tissues and disorders / Fehér Enikő, Kardos Gábor, Gáll Tamás, Kis Andrea, Gergely Lajos, Szarka Krisztina
Dátum:2011
ISSN:1217-8950
Megjegyzések:Diversity of TTV1 was assessed in the head and neck region in patients with potentially malignant (oral lichen planus, oral leukoplakia) and malignant lesions (oral and laryngeal squamous cell cancers) and was compared to that found in the uterine cervix (cervical atypia and cervical cancer) by directly sequencing the NG061-063 segment of ORF1. These sequences were classified by the formerly used genogroupgenotype system as well as by the newly accepted species classification by aligning with the corresponding region of the type sequences of the 29 TTV species. All sequences obtained during the study clustered together with the TTV1 type sequence; to express diversity within TTV1, genotypes and subtypes of the former classification were used.The commonest subtypes were 2c followed by 2b, 1a and 1b. Subtypes 2b and 2c were evenly distributed among cervical samples; subtype 1a was more frequent in patients with cervical atypia or cancer. Subtypes 2c was more frequent than 2b in head and neck lesions. In conclusion, genotype and even subtype distribution may be important in association with diseases, therefore using this classification for characterization of intraspecies diversity of TTV1 is proposed.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
Megjelenés:Acta Microbiologica et Immunologica Hungarica 58 : 4 (2011), p. 319-337. -
További szerzők:Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus) Gáll Tamás (1982-) (molekuláris biológus, mikrobiológus) Kis Andrea (1981-) (molekuláris biológus, mikrobiológus) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus)
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2.

001-es BibID:BIBFORM047703
035-os BibID:PMID:23649705
Első szerző:Gáll Tamás (molekuláris biológus, mikrobiológus)
Cím:Genomic differences in the background of different severity in juvenile-onset respiratory papillomatoses associated with human papillomavirus type 11 / Tamás Gáll, Andrea Kis, Tímea Zsófia Tatár, Gábor Kardos, Lajos Gergely, Krisztina Szarka
Dátum:2013
ISSN:0300-8584
Megjegyzések:This study aimed to compare complete genome sequences of human papillomavirus (HPV) type 11 from two solitary papillomas (considered minimally aggressive), two moderately (six and nine episodes) and two highly aggressive (30 and 33 episodes) juvenile-onset respiratory papillomatoses. Genomic regions were sequenced using the Sanger method; sequences were compared to available GenBank genomes. Activity of the long control region (LCR) was assessed in HEp-2 cell line using luciferase assays and compared to that of the reference (GenBank Accession Number M14119). Site-directed mutagenesis was performed to confirm the association of polymorphisms with differences in LCR activity. Eleven alterations resulted in amino acid changes in different open reading frames. A72E in E1 and Q86K in E2 proteins were exclusively present in a moderately aggressive disease, L1 alterations A476V and S486F were unique to a severe papillomatosis. HPV11s in both solitary papillomas had identical LCRs containing a T7546C polymorphism, which strongly attenuated LCR activity, as confirmed by site-directed mutagenesis. This strong attenuator polymorphism was also present in the other four genomes showing significantly higher activities, but in these other alterations with demonstrable but statistically not significant attenuating (A7413C, 7509 T deletion) or enhancing (C7479T, T7904A) effect on transactivating potential (as demonstrated by site-directed mutagenesis) were also detected. LCR activities corresponded well to severity, excepting the highly aggressive papillomatosis with the L1 alterations. Presence of intratypic variants cannot explain differences in severity of respiratory papillomatoses associated with HPV11; virulence seems to be determined by the interaction of multiple genetic differences.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Medical Microbiology and Immunology. - 202 : 5 (2013), p. 353-363. -
További szerzők:Kis Andrea (1981-) (molekuláris biológus, mikrobiológus) Tatár Tímea Zsófia Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus)
Pályázati támogatás:OTKA 73145
OTKA
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3.

001-es BibID:BIBFORM001623
Első szerző:Sóczó Georgina
Cím:Correlation of posaconazole minimum fungicidal concentration and time-kill test against nine Candida species / G. Sóczó, G. Kardos, P. M. McNicholas, E. Balogh, L. Gergely, I. Varga, B. Kelentey, L. Majoros
Dátum:2007
Megjegyzések:OBJECTIVES: We evaluated the in vitro activity of posaconazole against nine Candida species using minimum fungicidal concentration (MFC) measurements and time-kill methods. METHODS: MFCs of posaconazole were determined for 209 clinical isolates (32 Candida albicans, 30 Candida glabrata, 21 Candida tropicalis, 29 Candida krusei, 28 Candida parapsilosis sensu stricto, 50 Candida inconspicua, 13 Candida kefyr, 3 Candida lusitaniae and 3 Candida guilliermondii) and 7 ATCC Candida strains. The following strains were tested in time-kill studies: 3 strains each of C. glabrata, C. kefyr, C. guilliermondii and C. lusitaniae; 2 C. tropicalis; 4 C. albicans; 4 C. inconspicua; 9 C. krusei; 12 C. parapsilosis; and 7 ATCC strains. RESULTS: Posaconazole was fungicidal in both MFC and time-kill experiments (at 2 mg/L within 48 h in time-kill assays) against each C. krusei, C. inconspicua and C. lusitaniae strain and was fungistatic against each C. albicans, C. glabrata, C. tropicalis and C. guilliermondii strain. For the C. parapsilosis strains, posaconazole MFCs were <or=2 mg/L for 20 of the 28 isolates tested; however, in the time-kill tests, even at drug concentrations of 32-64 x MIC, posaconazole was fungistatic against all C. parapsilosis strains tested. CONCLUSIONS: MFC values were good predictors of the fungistatic or fungicidal activity of posaconazole, as determined by time-kill curves, for all tested species except C. parapsilosis. Our results highlight the fungicidal action of posaconazole against a number of clinically relevant Candida species.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
posaconazole
Candida
Megjelenés:The Journal of Antimicrobial Chemotherapy 60 : 5 (2007), p. 1004-1009. -
További szerzők:Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus) McNicholas, Paul M. Balogh Éva Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Varga István (1974-) (fogszakorvos) Kelentey Barna (1959-) (fogszakorvos) Majoros László (1966-) (szakorvos, klinikai mikrobiológus)
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4.

001-es BibID:BIBFORM001622
Első szerző:Sóczó Georgina
Cím:Posaconazole susceptibility testing against Candida species : comparison of broth microdilution and E-test methods / Sóczó G., Kardos G., McNicholas P. M., Falusi E., Gergely L., Majoros L.
Dátum:2007
Megjegyzések:Posaconazole (POS) is a newer triazole with activity against yeasts and moulds. POS and fluconazole were tested in vitro against 32 Candida albicans, 30 C. glabrata, 21 C. tropicalis, 29 C. krusei, 28 C. parapsilosis, 50 C. inconspicua, 13 C. kefyr and 5 C. famata isolates using CLSI broth microdilution method (BMD). We compared E-test and a modified BMD using polyethylene-glycol (PEG) as solvent to the CLSI method. BMDs and E-test were performed according to CLSI and the manufacturer's instructions respectively. Geometric means of POS MICs using BMD were 0.71, 0.22 and 0.21 microg ml(-1) against C. glabrata, C. krusei and C. inconspicua, respectively, and remained below 0.1 microg ml(-1) against all other species tested. One of two C. albicans and two of three C. glabrata isolates resistant to fluconazole showed MICs above 8 microg ml(-1) to POS. The impact of using PEG instead of DMSO had only a minor effect (agreements above 95% with the exception of C. parapsilosis). E-tests read after 24 h showed good agreement with the BMD. POS exhibited excellent in vitro activity against Hungarian Candida strains. E-test showed good correlation with the CLSI method, but to facilitate the comparability of results we believe that DMSO should be used as solvent in the BMD.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Candida
posaconazole
Megjelenés:Mycoses. - 50 : 3 (2007), p. 178-182. -
További szerzők:Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus) McNicholas, Paul M. Falusi Erzsébet Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Majoros László (1966-) (szakorvos, klinikai mikrobiológus)
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elektronikus változat
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5.

001-es BibID:BIBFORM040793
Első szerző:Szládek Györgyi
Cím:High co-prevalence of genogroup 1 TT virus and human papillomavirus is associated with poor clinical outcome of laryngeal carcinoma / Szladek G., Juhasz A., Kardos G., Szoke K., Major T., Sziklai I., Tar I., Marton I., Konya J., Gergely L., Szarka K.
Dátum:2005
ISSN:0021-9746
Megjegyzések:BACKGROUND: The aetiology and factors leading to the progression of laryngeal cancer are still unclear. Although human papillomavirus (HPV) has been suggested to play a role, reports concerning the effect of HPV infection on tumour development are controversial. Recently, transfusion transmitted virus (TTV) was suggested to play a role in certain infections as a causative or coinfecting agent. AIMS: To investigate whether the development and progression of laryngeal squamous cell carcinoma is associated with coinfection with TTV and HPV. METHODS: The prevalence of TTV and HPV was investigated using the polymerase chain reaction in tissue samples from 40 healthy individuals, 10 patients with recurrent papillomatosis, five patients with papillomatosis with malignant transformation, and 25 patients with laryngeal carcinoma. The obtained prevalence data were compared and analysed statistically. RESULTS: In the 11 patients with carcinoma who had metastasis or relapse there was a high rate of coinfection with genogroup 1 TTV and HPV (eight of 11), whereas in the 14 without tumour progression no coinfection was found. Coinfection was associated with significantly lower tumour free survival in patients with carcinoma (p < 0.001). Furthermore, four of five patients who had papillomatosis with malignant transformation were coinfected with genogroup 1 TTV and HPV. CONCLUSIONS: Although the nature of cooperation between HPV and TTV needs to be investigated further, coinfection with genogroup 1 TTV and HPV appears to be associated with poor clinical outcome in laryngeal cancer.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Clinical Pathology. - 58 : 4 (2005), p. 402-405. -
További szerzők:Juhász Attila (1970-) (szakorvos, klinikai mikrobiológus) Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus) Szőke Krisztina Major Tamás (1973-) (fül-orr-gégész) Sziklai István (1954-) (fül-orr-gégész) Tar Ildikó (1967-) (fogszakorvos) Márton Ildikó (1954-) (fogszakorvos) Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus)
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