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001-es BibID:	BIBFORM071774
035-os BibID:	(WoS)000423235202293
Első szerző:	Lampé Rudolf (szülész-nőgyógyász)
Cím:	Laparoscopic radical hysterectomy : a single institution experience / Lampé Rudolf, Póka Róbert
Dátum:	2017
ISSN:	1048-891X
Megjegyzések:	AimsLaparoscopic radical hysterectomy is a widely accepted operative treatment of early stage cervical cancer. Our aim was toanalyze retrospectively our initial results and the feasibility of this technique.MethodBetween July 2016 and April 2017 we performed laparoscopic type-C radical hysterectomy and pelvic lymphadenectomy in tenpatients with early stage (IA2-IIB) cervical cancer.ResultsThe mean operation time was 165 min (range, 135-198). During surgery, the average decrease in hemoglobin and hematocritlevels was 20.3 g/L and 0.07, respectively. The average width of parametrial resection was 3.7 cm and the mean lymph nodecount was 16.3. There was no conversion to laparotomy. One intraoperative urinary bladder injury occurred and treatedlaparoscopically at the same time. No postoperative complications higher than grade 2 occurred according to the Clavien-Dindoclassification. The mean hospital stay was 4.7 days.ConclusionAccording to our initial results, introduction of laparoscopic radical hysterectomy is a feasible approach to change practice insurgical treatment of early stage cervical cancer. It is associated with low blood loss and short hospitalization. In addition, it is asafe and effective technique for staging and treating cervical cancer. In comparison to open surgery, pathological evaluationsuggests non-inferior prognosis, but further analysis is required to assess long term outcome measures.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	International Journal of Gynecological Cancer. - 27 : S4 (2017), p. 806. -
További szerzők:	Póka Róbert (1960-) (szülész-nőgyógyász, klinikai onkológus)
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001-es BibID:	BIBFORM097366
035-os BibID:	(WoS)000773543201173
Első szerző:	Molnár Szabolcs (szülész-nőgyógyász szakorvos)
Cím:	The role of neoadjuvant chemotherapy in the treatment of iiic-iva stage epithelial ovarian cancer : a single center experience / Molnár Szabolcs, Vas Lilla Éva, Maka Eszter, Lampé Rudolf, Vida Beáta, Krasznai Zoárd
Dátum:	2021
ISSN:	1048-891X
Megjegyzések:	Introduction/Background* Ovarian cancer is the 7th most common malignancy among women and the leading cause of gynecologic cancer death. The most important prognostic factor of the disease is optimal debulking surgery (R0) with no macroscopic residual disease. Achieving optimal result is a challenging duty in advanced stage (FIGO IIIC-IV). Based on previous studies neoadjuvant chemotherapy (NAC) can help to improve the optimally debulked ratio of this popu- lation with non-inferior survival outcome. The aim of our study was to evaluate the effectiveness of NAC among pri- marily inoperable patients. The focus was not only on sur- vival outcome but on cost effectiveness (need for transfusion, hospitalization, ICU admission, medication demand, etc.). Methodology Between 2015-2018 112 debulking surgeries were performed on stage FIGO IIIC-IV ovarian cancer patients. The cases were divided into potentially operable and inoperable group based on preoperative imaging, tumor marker levels according to our institutional protocol. In spe- cial situation where operability was not obvious, diagnostic laparoscopy was done to categorize patients. The peri-, intra-, postoperative reports and survival data was collected. Result(s)* Complete tumor reduction was performed in 63 cases while in 49 cases only partial tumor reduction was achieved. Median progression-free survival did not differ sig- nificantly between patients who underwent primary or interval debulking surgery (PDS = 12 months, IDS = 11.2 months, p = 0.264). The rate of R0 resection was higher after NAC, but not significantly (37.9% vs. 54.2%, p = 0.179). There was no significant difference in survival of patients who suc- cessfully underwent complete tumor reduction, despite the fact that the "inoperable" group treated with NAC had a worse prognosis (p = 0.264). The cost-effectiveness was comparable between groups, the hospital stay and transfusion demand was favourable in neoadjuvant group. Conclusion* The rate of optimal tumor reduction can be improved not only by increasing radicality but also by apply- ing appropriate patient selection criteria. Neoadjuvant treat- ment according to the current recommendations is applicable in the inoperable group, in accordance with the protocol we use. The survival data of patients who have undergone com- plete tumor reduction after NAC was not inferior to those who went through primary debulking.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk petefészek daganat neoadjuváns kemoterápia debulking műtét progressziómentes túlélés
Megjelenés:	International Journal Of Gynecological Cancer. - 31 : Suppl. 3 (2021), p. A247. -
További szerzők:	Vas Lilla Éva Maka Eszter (1988-) (szülész-nőgyógyász rezidens) Lampé Rudolf (1983-) (szülész-nőgyógyász) Vida Beáta (1994-) (szülészet-nőgyógyászat) Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász)
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001-es BibID:	BIBFORM072789
035-os BibID:	(WoS)000423235202023
Első szerző:	Póka Róbert (szülész-nőgyógyász, klinikai onkológus)
Cím:	Negative parp immunhistochemistry as a predictor of platinum sensitivity in ovarian cancer / R. Poka, S. Molnár, L. Baráth, J. Lukács, R. Lampé, Z. Krasznai, Z. Hernádi, G. Méhes
Dátum:	2017
ISSN:	1048-891X
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	International Journal of Gynecological Cancer. - 27 : Suppl. 4. (2017), p. 524. -
További szerzők:	Molnár Szabolcs (1987-) (szülész-nőgyógyász szakorvos) Baráth Lukács Lukács János (1975-) (szülész-nőgyógyász, genetikus) Lampé Rudolf (1983-) (szülész-nőgyógyász) Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Hernádi Zoltán (1948-) (szülész-nőgyógyász, klinikai onkológus) Méhes Gábor (1966-) (patológus)
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001-es BibID:	BIBFORM069986
035-os BibID:	(WoS)000408892500019
Első szerző:	Póka Róbert (szülész-nőgyógyász, klinikai onkológus)
Cím:	Intention-to-Treat Analysis of Radical Trachelectomy for Early-Stage Cervical Cancer With Special Reference to Oncologic Failures / Póka Robert, Molnár Szabolcs, Daragó Péter, Lukács János, Lampé Rudolf, Krasznai Zoárd, Hernádi Zoltán
Dátum:	2017
ISSN:	1048-891X
Megjegyzések:	Objective: Theaimofourstudywastoevaluateclinicalandpathologicaldatainorderto draw eligibility criteria for oncologically sufficient radical trachelectomy (RT) in early-stage cervical cancer. Reviewing all cases of attempted RT performed at our unit, we focused attention on prognostic indicators of the need for additional oncologic treatment following RT. The analysis was extended by extensive literature review to include previously published cases of oncologic failures.Methods: The authors retrospectively analyzed data of patients who underwent RT at the Department of Obstetrics and Gynecology, University of Debrecen. Electronic records and case notes of RT cases were reviewed to determine the incidence of abdominal and vaginal route, distribution of clinicopathologic data, and follow-up results of individual cases. Individual procedures were categorized as oncologically insufficient if additional oncologic treatment was necessary following RT. Theoretical eligibility criteria for RT in early-stage cervical cancer were determined retrospectively by selecting prognostic features that were associated with oncologic insufficiency from clinicopathologic indicators of the complete series.Results: Twenty-four cases of RT were performed by the authors, 15 vaginal RTs with laparoscopic pelvic lymphadenectomy and 9 abdominal RTs with open pelvic lymphade- nectomy. Fifteen of 24 cases proved oncologically sufficient. Three cases required imme- diate conversion to radical hysterectomy because of positive sentinel nodes and/or positive isthmic disc on frozen section. In further 5 cases, final pathology results indicated additional oncologic treatment, that is, radical hysterectomy (n = 2), chemoradiotherapy (n = 2), or chemotherapy (n = 1). One patient among immediately converted cases and another 3 among those who required additional oncologic treatment died of their disease later. There were no other cases of recurrences over a median follow-up of 34 months (range, 12Y188 months). Factors that may predict oncologic insufficiency of RTwere stage IB1 or greater, tumor size of greater than 2 cm in 1 dimension or greater than 15 mm in 3 dimensions, G3, nonsquamous/ adeno histological type, stromal invasion of greater than 9 mm, and lymphovascular space involvement in the primary tumor.Conclusions: Most cases of oncologically insufficient RTs have significant risk features that can be identified preoperatively. There is a need for more clinicopathologic data on oncologic failure of RT cases in order to improve patient selection.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Cervical cancer Clinicopathologic predictors Fertility-sparing surgery Oncologic failure
Megjelenés:	International Journal Of Gynecological Cancer. - 27 : 7 (2017), p. 1438-1445. -
További szerzők:	Molnár Szabolcs (1987-) (szülész-nőgyógyász szakorvos) Daragó Péter Lukács János (1975-) (szülész-nőgyógyász, genetikus) Lampé Rudolf (1983-) (szülész-nőgyógyász) Krasznai Zoárd Tibor (1973-) (szülész-nőgyógyász, gyermeknőgyógyász) Hernádi Zoltán (1948-) (szülész-nőgyógyász, klinikai onkológus)
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