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001-es BibID:	BIBFORM067028
035-os BibID:	(WoS)000383605300013 (Scopus)84983087188
Első szerző:	Herédi Emese (bőrgyógyász)
Cím:	Subclinical cardiovascular disease and it's improvement after long-term TNF-[alfa] inhibitor therapy in severe psoriatic patients / Herédi E., Végh J., Pogácsás L., Gáspár K., Varga J., Kincse G., Zeher M., Szegedi A., Gaál J.
Dátum:	2016
ISSN:	0926-9959
Megjegyzések:	BACKGROUND:There are conflicting data on the occurrence of subclinical myocardial dysfunction in psoriatic patients and on the impact of long-term tumour necrosis factor-alpha (TNF-[alfa]) inhibitor therapy on cardiac function.OBJECTIVE:In this study, we explored whether there are any signs of subclinical cardiovascular disease (echocardiographic abnormalities) in severe psoriatic patients without clinically overt heart disease. As a second objective, the influence of long-term treatment with TNF-[alfa] inhibitors on the ventricular functions of psoriatic patients was also investigated.METHODS:Clinical and echocardiographic data from 44 psoriatic patients and 45 age- and sex-matched controls were processed. As a first step, the echocardiographic parameters of psoriatic patients obtained before anti-TNF-[alfa] treatment were compared with controls. As a second step, to detect the effect of long-term anti-TNF-[alfa] treatment on echocardiographic parameters, data of patients before and after therapy were analysed.RESULTS:The right ventricular Tei index was higher (P < 0.001), whereas the tricuspid annular plane systolic excursion (TAPSE) and right ventricular free wall peak systolic velocity were lower (P < 0.001 and P < 0.0001, respectively) in the psoriatic patients than in the controls. Following treatment with TNF-[alfa] inhibitors, TAPSE and right ventricular free wall peak systolic velocity significantly improved (P < 0.0001 for both parameters). The Tei index of both ventricles improved during biological therapy; however, this change did not reach statistical significance.CONCLUSION:Patients with severe psoriasis exhibit signs of subclinical cardiovascular disease compared to control, and prolonged anti-TNF-[alfa] therapy has a potentially beneficial effect on these signs.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal Of The European Academy Of Dermatology And Venereology. - 30 : 9 (2016), p. 1531-1536. -
További szerzők:	Végh Judit (1968-) (belgyógyász, kardiológus) Pogácsás Lilla Gáspár Krisztián (1974-) (bőrgyógyász) Varga József (1955-) (fizikus) Kincse Gyöngyvér (1970-) (orvos) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szegedi Andrea (1964-) (bőrgyógyász) Gaál János (1965-) (reumatológus, belgyógyász)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM067231
Első szerző:	Rencz Fanni
Cím:	Moderate to severe psoriasis patients' subjective future expectations regarding health-related quality of life and longevity / Rencz, F., Holló, P., Kárpáti, S., Péntek, M., Remenyik, É., Szegedi, A., Balogh, O., Herédi, E., Herszényi, K., Jókai, H., Brodszky, V., Gulácsi, L.
Dátum:	2015
ISSN:	0926-9959
Megjegyzések:	AbstractBACKGROUND:Unrealistic expectations regarding treatments and clinical outcomes may lead to disappointment about therapy and sub-optimal compliance; nonetheless, these expectations have not been studied in psoriasis patients yet.OBJECTIVE:To evaluate psoriasis patients' subjective future expectations regarding health-related quality of life (HRQOL) and life expectancy, and to explore clinical features associated with under- or overestimating behaviour.METHODS:A cross-sectional questionnaire survey of consecutive adult patients with moderate to severe psoriasis was conducted. HRQOL expectations were recorded by applying the EQ-5D descriptive system for 6 months ahead and for future ages of 60, 70, 80 and 90 respectively.RESULTS:In total, 167 patients (71% males) were included in the analysis with mean age of 50.4 ? 12.4 years and mean EQ-5D score of 0.71 ? 0.30. Overall 65% had chronic plaque psoriasis, 35% nail psoriasis, 35% scalp involvement, 29% psoriatic arthritis, 9% inverse psoriasis and 5% palmoplantar psoriasis respectively (combinations occurred). Participants expected 0.1 ? 0.23 mean improvement in EQ-5D within 6 months (P < 0.001) that achieves the minimum clinically important difference. Overall 37% expected improvement and 13% decline; however, 49% expected no changes in any of the five dimensions of EQ-5D within 6 months. Female gender, inverse or palmoplantar involvement and more severe psoriasis were likely associated with higher expectations. Patients at the initiation of their first biological at the time of the survey expected 0.18 ? 0.24 increase that seems to be realistic compared to the EQ-5D utility gain achieved in randomized controlled trials. Males expected by 2.7 ? 11.1 more, while females expected by 5.2 ? 9.3 less life years compared to the average statistical gender- and age-matched life expectancy (P < 0.05). Patients who expected to be alive at ages of 60, 70, 80 and 90 scored their future EQ-5D at ages of 60 to 90: 0.59 ? 0.46, 0.48 ? 0.41, 0.42 ? 0.41 and 0.22 ? 0.47 respectively.CONCLUSION:Our findings highlight the importance of exploring expectations that might help to increase patients' compliance.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of The European Academy Of Dermatology And Venereology 29 : 7 (2015), p. 1398-1405. -
További szerzők:	Holló Péter Kárpáti Sarolta Péntek Márta Remenyik Éva (1956-) (bőrgyógyász) Szegedi Andrea (1964-) (bőrgyógyász) Balogh Orsolya Herédi Emese (1979-) (bőrgyógyász) Herszényi Krisztina Jókai Hajnalka Brodszky Valentin Gulácsi László
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