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001-es BibID:	BIBFORM047648
Első szerző:	Bácsi Attila (immunológus)
Cím:	Colostrinin-Driven Neurite Outgrowth Requires p53 Activation in PC12 Cells / Attila Bacsi, G. John Stanton, Thomas K. Hughes, Marian Kruzel, Istvan Boldogh
Dátum:	2005
ISSN:	0272-4340
Megjegyzések:	1. Colostrinin (CLN) induces maturation and differentiation of murine thymocytes,promotes proliferation of peripheral blood leukocytes, induces immunomodulatorcytokines, and ameliorates oxidative stress-mediated activation of c-Jun NH2-terminalkinases.2. Here we report that upon treatment with CLN, medullary pheochromocytoma(PC12) cells ceased to proliferate and extend neurites.3. The arrest of CLN-treated PC12 cells in the G1 phase of the cell cycle was due toan increase in the phosphorylation of p53 at serine15 (p53ser15) and expression of p21WAF1.PC12 cells treated with inhibitory oligonucleotides to p53 lacked p53ser15 and p21WAF1expression, and did not show morphological changes after CLN exposure. Transfectionwith inhibitory oligonucleotides to p21WAF1 had no effect on p53 activation; however, cellsfailed to arrest or extend neurites. An oligonucleotide inhibiting luciferase expression hadno effect on CLN-mediated p53 activation, p21WAF1 expression, growth arrest, or neuriteoutgrowth.4. We conclude that CLN induces delicate cassettes of signaling pathways common tocell proliferation and differentiation, and mediates activities that are similar to those ofhormones and neurotrophins, leading to neurite outgrowth.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban colostrinin pheochromocytoma cell neurite outgrowth p53 activation
Megjelenés:	Cellular And Molecular Neurobiology. - 25 : 7 (2005), p. 1123-1139. -
További szerzők:	Stanton, G. John Hughes, Thomas K. Kruzel, Marian L. Boldogh István
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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