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001-es BibID:	BIBFORM076050
035-os BibID:	(WoS)000447820100006 (Scopus)85048764575
Első szerző:	Hao, Wenjing
Cím:	Effects of the stimuli-dependent enrichment of 8-oxoguanine DNA glycosylase1 on chromatinized DNA / Hao Wenjing, Qi Tianyang, Pan Lang, Wang Ruoxi, Zhu Bing, Aguilera-Aguirre Leopoldo, Radak Zsolt, Hazra Tapas K., Vlahopoulos Spiros A., Bacsi Attila, Brasier Allan R., Ba Xueqing, Boldogh Istvan
Dátum:	2018
ISSN:	2213-2317
Megjegyzések:	8-Oxoguanine DNA glycosylase 1 (OGG1) initiates the base excision repair pathway by removing one of the most abundant DNA lesions, 8-oxo-7,8-dihydroguanine (8-oxoG). Recent data showed that 8-oxoG not only is a promutagenic genomic base lesion, but also functions as an epigenetic mark and that consequently OGG1 acquire distinct roles in modulation of gene expression. In support, lack of functional OGG1 in Ogg1(-/-) mice led to an altered expression of genes including those responsible for the aberrant innate and adaptive immune responses and susceptibility to metabolic disorders. Therefore, the present study examined stimulus-driven OGG1-DNA interactions at whole genome level using chromatin immunoprecipitation (ChIP)-coupled sequencing, and the roles of OGG1 enriched on the genome were validated by molecular and system-level approaches. Results showed that signaling levels of cellular ROS generated by TNF alpha, induced enrichment of OGG1 at specific sites of chromatinized DNA, primarily in the regulatory regions of genes. OGG1-ChIP-ed genes are associated with important cellular and biological processes and OGG1 enrichment was limited to a time scale required for immediate cellular responses. Prevention of OGG1-DNA interactions by siRNA depletion led to modulation of NF-kappa B's DNA occupancy and differential expression of genes. Taken together these data show TNF alpha-ROS-driven enrichment of OGG1 at gene regulatory regions in the chromatinized DNA, which is a prerequisite to modulation of gene expression for prompt cellular responses to oxidant stress.
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Redox Biology. - 18 (2018), p. 43-53. -
További szerzők:	Qi, Tianyang Pan, Lang Wang, Ruoxi Zhu, Bing Aguilera-Aguirre, Leopoldo Radák Zsolt Hazra, Tapas K. Vlahopoulos, Spiros A. Bácsi Attila (1967-) (immunológus) Brasier, Allan R. Ba, Xueqing Boldogh István
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