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001-es BibID:	BIBFORM077848
035-os BibID:	(PMID)30101988 (Scopus)85052790800 (WOS)000450406900003
Első szerző:	Guttman András (vegyészmérnök)
Cím:	Authors' Reply to the Commentary in the journal of Electrophoresis regarding "The effect of simulated space radiation on the N-glycosylation of human immunoglobulin G1" by J.J. Bevelacqua and S.M.J. Mortazavi / Andras Guttman, Szabolcs Szilasi, Boglarka Donczo, Mate Szarka
Dátum:	2018
ISSN:	0173-0835 1522-2683
Megjegyzések:	By reading the commentary of Bevelacqua and Mortazavi regarding our recently published paper titled as "The effect of simulated space radiation on the N?glycosylation of human immunoglobulin G1"[1], we are afraid that some of the important messaging aspects of our paper might not have been articulated adequately to be fully understandable for a wider audience, i.e., not separation scientists. First, we should clarify that complete space radiation description was not the goal of this paper. In this short communication we only intended to show the effect of simulated space radiation on the conserved N?glycosylation of IgG1 molecules with the goal to understand if they could be utilized as disease biomarkers during longer space missions, similar to that as they are currently used here on Earth, e.g. for autoimmune disease or aging markers. Therefore, no discussion was given about any biological effects either as our study only investigated the qualitative effects of proton irradiation on the N?linked carbohydrate decomposition of IgG type 1 molecules with the intent of suggesting them to be used as biomarkers during deep space travel. Radioadaptation was never an issue in our study for the reasons mentioned above.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok szerkesztői levél folyóiratcikk Glycans IgG Space
Megjelenés:	Electrophoresis. - 39 : 22 (2018), p. 2851-2853. -
További szerzők:	Szilasi Szabolcs Döncző Boglárka (1987-) (biológiatanár-földrajztanár) Szarka Máté (1990-)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM069064
035-os BibID:	(Scopus)84957842874 (WOS)000369959400017
Első szerző:	Rajta István (fizikus)
Cím:	Tilted pillar array fabrication by the combination of proton beam writing and soft lithography for microfluidic cell capture: Part 1 Design and feasibility / Istvan Rajta, Robert Huszánk, Atilla T. T. Szabó, Gyula U. L. Nagy, Szabolcs Szilasi, Peter Fürjes, Eszter Holczer, Zoltan Fekete, Gabor Járvás, Marton Szigeti, Laszlo Hajba, Judit Bodnár, Andras Guttman
Dátum:	2016
ISSN:	0173-0835
Megjegyzések:	Design, fabrication, integration, and feasibility test results of a novel microfluidic cell capture device is presented, exploiting the advantages of proton beam writing to make lithographic irradiations under multiple target tilting angles and UV lithography to easily reproduce large area structures. A cell capture device is demonstrated with a unique doubly tilted micropillar array design for cell manipulation in microfluidic applications. Tilting the pillars increased their functional surface, therefore, enhanced fluidic interaction when special bioaffinity coating was used, and improved fluid dynamic behavior regarding cell culture injection. The proposed microstructures were capable to support adequate distribution of body fluids, such as blood, spinal fluid, etc., between the inlet and outlet of the microfluidic sample reservoirs, offering advanced cell capture capability on the functionalized surfaces. The hydrodynamic characteristics of the microfluidic systems were tested with yeast cells (similar size as red blood cells) for efficient capture.
Tárgyszavak:	Természettudományok Fizikai tudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Cell capture Proton beam writing Soft lithography
Megjelenés:	Electrophoresis. - 37 : 3 (2016), p. 498-503. -
További szerzők:	Huszánk Róbert (vegyész kutató) Szabó Atilla T. T. Nagy Gyula (1986-) (környezetkutató fizikus) Szilasi Szabolcs Fürjes Péter Holczer Eszter Fekete Zoltán Járvás Gábor (1982-) (vegyészmérnök) Szigeti Márton (1986-) (környezetmérnök) Hajba László Bodnár Judit Guttman András (1954-) (vegyészmérnök)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM077851
035-os BibID:	(Scopus)85056587326 (WOS)000450406900006
Első szerző:	Szarka Máté
Cím:	The effect of simulated space radiation on the N-glycosylation of human immunoglobulin G1 / Mate Szarka, Szabolcs Szilasi, Boglarka Donczo, Daniel Sarkozy, Istvan Rajta, Andras Guttman
Dátum:	2018
ISSN:	0173-0835 1522-2683
Megjegyzések:	On a roundtrip to Mars, astronauts are expectedly exposed to an approximate amountof radiation that exceeds the lifetime limits on Earth. This elevated radiation dose ismainly due to Galactic Cosmic Rays and Solar Particle Events. Specific patterns of theN-glycosylation of human Igs have already been associated with various ailments such asautoimmune diseases, malignant transformation, chronic inflammation, and ageing. Thefocus of our work was to investigate the effect of low-energy proton irradiation on the IgGN-glycosylation profile with the goal if disease associated changes could be detected duringspace travel and not altered by space radiation. Two ionization sources were used duringthe experiments, a Van de Graaff generator for the irradiation of solidified hIgG samples invacuum, and a Tandetron accelerator to irradiate hIgG samples in aqueous solution form.Structural carbohydrate analysis was accomplished by CE with laser induced fluorescentdetection to determine the effects of simulated space radiation onN-glycosylation of hIgG1samples. Our results revealed that even several thousand times higher radiation doses thatof astronauts can suffer during long duration missions beyond the shielding environmentof Low Earth Orbit, no changes were observed in hIgG1N-glycosylation. Consequently,changes inN-linked carbohydrate profile of IgG1 can be used as molecular diagnostic toolsin space.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Electrophoresis. - 39 : 22 (2018), p. 2872-2876. -
További szerzők:	Szilasi Szabolcs Döncző Boglárka (1987-) (biológiatanár-földrajztanár) Sárközy Dániel (1993-) (PhD hallgató) Rajta István (1970-) (fizikus) Guttman András (1954-) (vegyészmérnök)
Pályázati támogatás:	NKFIH K 116263 NKFIH NKFIH NN127062 NKFIH BIONANO GINOP-2.3.2-15-2016-00017 GINOP
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