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001-es BibID:	BIBFORM037151
Első szerző:	Oláh Zsolt (belgyógyász)
Cím:	Rapid-onset heparin-induced thrombocytopenia without previous heparin exposure / Olah Zsolt, Kerenyi Adrienne, Kappelmayer Janos, Schlammadinger Agota, Razso Katalin, Boda Zoltan
Dátum:	2012
ISSN:	0953-7104
Megjegyzések:	Heparin-induced thrombocytopenia (HIT) is one of the most common immune-mediated drug reactions. Immunoglobulin G-type antibodies against platelet factor 4(PF4)/heparin complexes are known to play a key role in the pathogenesis of HIT. Rapid-onset HIT is caused by the presence of circulating HIT antibodies at the time of heparin readministration. These antibodies are generally resulted from a recent immunizing exposure to heparin. Here we report a case of rapid-onset HIT developed after a septicemia without previous heparin exposure. The diagnosis of HIT as well as the presence of platelet activating and heparin-dependent antibodies was confirmed by ELISA and flow cytometric functional assays. Our case report reinforces that rapid-onset HIT cannot be excluded only based on the absence of previous heparin exposure. In addition, it may support the new theory of pre-immunization by PF4-coated bacteria in the pathomechanism of HIT. We also call the attention that venous limb gangrene can be rarely associated with HIT and thrombosis even in the absence of coumarin therapy. Furthermore, transient presence of anti-phospholipid antibodies can cause a differential diagnostic problem in the cases of HIT.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Platelets. - 23 : 6 (2012), p. 495-498. -
További szerzők:	Kerényi Adrienne (1970-) (laboratóriumi szakorvos) Kappelmayer János (1960-) (laboratóriumi szakorvos) Schlammadinger Ágota (1971-) (belgyógyász, haematológus) Molnárné Rázsó Katalin (1966-) (belgyógyász, haematológus, klinikai onkológus) Boda Zoltán (1947-) (belgyógyász, haematologus, klinikai onkológus)
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001-es BibID:	BIBFORM034352
Első szerző:	Rejtő László (belgyógyász, haematológus)
Cím:	Use of a platelet filter test in patients with thrombocytosis / László Rejtő, Ágota Schlammadinger, Pál László, Attila Kiss, Béla Telek, Zoltán Boda
Dátum:	2000
ISSN:	0953-7104
Megjegyzések:	In the differential diagnosis of primary and secondary thrombocytosis platelet function tests may play an important role. We examined the applicability of a platelet filter test (shear-dependent platelet aggregation) as a tool, to differentiate primary thrombocytosis (cases with myeloproliferative disorders) from secondary (reactive) thrombocytosis. The test was carried out in 53 patients suffering from myeloproliferative disorders associated with primary thrombocytosis and in 21 patients with other diseases complicated by secondary thrombocytosis. Using citrate as anticoagulant, the sensitivity of the O'Brien's test proved to be 77.1%, and its specificity 94.4%. Using heparin as anticoagulant the sensitivity and specificity of the test were found to be also reliably high. Based on these studies we suggest the use of the O'Brien's filterometer as a screening test in the differential diagnosis in patients with elevated platelet count. In the case of normal results, the causes of reactive thrombocytosis should be clarified first, while with abnormal results, haematological examination of the patients should be performed.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Platelets. - 11 : 1 (2000), p. 38-42. -
További szerzők:	Schlammadinger Ágota (1971-) (belgyógyász, haematológus) László Pál (belgyógyász) Kiss Attila (1942-) (belgyógyász, haematológus) Telek Béla (1948-) (belgyógyász, haematológus) Boda Zoltán (1947-) (belgyógyász, haematologus, klinikai onkológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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