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001-es BibID:	BIBFORM035082
Első szerző:	Cauwenberghs, Nancy
Cím:	Fc-receptor Dependent Platelet Aggregation Induced by Monoclonal Antibodies against Platelet Glycoprotein Ib or von Willebrand Factor / Nancy Cauwenberghs, Agotha Schlammadinger, Stephan Vauterin, Susan Cooper, Gretel Descheemaeker, István Tornai, Hans Deckmyn
Dátum:	2001
ISSN:	0340-6245
Megjegyzések:	In this paper we describe two pathways leading to platelet activation by crosslinking glycoprotein (GP) Ibalpha to the platelet Fc-receptor (FcgammaRII). First the monoclonal antibody (MoAb) 9C8, raised against human platelet GPIbalpha, dose-dependently induced platelet aggregation of citrate-anticoagulated platelet-rich plasma, an effect that can be inhibited by several activation inhibitors. The FcgammaRII-inhibitory MoAb IV.3 was able to prevent the aggregatory effects of MoAb 9C8, indicating that crosslinking of the antigen GPIbalpha to the FcgammaII-receptor is necessary for the activating effect. Secondly we observed a synergistic activating effect of two anti-von Willebrand factor (vWF) MoAbs IC1E7 and B724, both known to enhance vWF binding to GPIbalpha in the presence of shear or ristocetin. When these antibodies are added together to PRP, platelet aggregation is induced without further need for an additional modulator. This effect can be blocked by either MoAb IV.3 or an inhibitory anti-GPIb MoAb, indicating that again the platelet activation results from signaling through FcgammaRII crosslinked to vWF bound to GPIbalpha. In addition, both the anti-GPIb MoAb 9C8, or the two anti-vWF MoAbs 1C1E7 and B724 induce genuine platelet activation, as evidenced by the secretion of ATP and protein tyrosine phosphorylation. These findings with both anti-GPIb and anti-vWF MoAbs add further proof to recent reports demonstrating an interaction between the platelet receptors GPIb and FcgammaRII, suggesting a role for the FcgammaII-receptor in GPIb-related signaling.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Monoclonal antibody von Willebrand factor glycoprotein Ib FeyII-receptor külföldön készült közlemény platelet activation
Megjelenés:	Thrombosis and Haemostasis. - 85 : 4 (2001), p. 679-685. -
További szerzők:	Schlammadinger Ágota (1971-) (belgyógyász, haematológus) Vauterin, Stephan Cooper, Susan Descheemaeker, Gretel Tornai István (1954-) (belgyógyász, gasztroenterológus) Deckmyn, Hans
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM007183
Első szerző:	Ilonczai Péter (orvos, belgyógyász, haematológus szakorvos)
Cím:	Temporarily successful eradication therapy in acquired haemophilia with high inhibitor titer : a case report with a new protocol / Péter Ilonczai, Ágota Schlammadinger, Zsolt Oláh, Katalin Rázsó, Zsuzsanna Bereczky, Zoltán Boda
Dátum:	2008
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Thombosis and Haemostasis. - 100 : 1 (2008), p. 149-150. -
További szerzők:	Schlammadinger Ágota (1971-) (belgyógyász, haematológus) Oláh Zsolt (1974-) (belgyógyász) Molnárné Rázsó Katalin (1966-) (belgyógyász, haematológus, klinikai onkológus) Bereczky Zsuzsanna (1974-) (orvosi laboratóriumi diagnosztika szakorvos) Boda Zoltán (1947-) (belgyógyász, haematologus, klinikai onkológus)
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001-es BibID:	BIBFORM034354
Első szerző:	Schlammadinger Ágota (belgyógyász, haematológus)
Cím:	Comparison of the O'Brien filter test and the PFA-100 platelet analyzer in the laboratory diagnosis of von Willebrand's disease / Agota Schlammadinger, Adrienne Kerenyi, Laszlo Muszbek, Zoltan Boda
Dátum:	2000
ISSN:	0340-6245
Megjegyzések:	Von Willebrand's disease (vWD) is the most common congenital haemorrhagic diathesis, characterized by the quantitative or qualitative disorder of von Willebrand factor (vWF). A number of methods have been used for the diagnosis of the disease, and the bleeding time determination is widely accepted as a screening test in spite of its low sensitivity. Our aim was to evaluate and compare the performance of two high shear systems (the O'Brien filter test and the PFA-100 device) in the screening and diagnosis of vWD. Thirty patients (n=13 type 1 with mild symptoms, n = 9 type 1 with severe symptoms, n = 2 type 2A, n = 3 type 2B and n = 3 type 3 vWD) and twenty controls were investigated. In mild vWD the platelet retention in the second phase of the filter test with citrated blood showed the highest sensitivity (91.6%). The sensitivity of the PFA-100 method with collagen-epinephrine cartridges in this group was 76.9%, while the bleeding time was prolonged only in 15.4% of the cases. In severe type 1, in type 2A and type 3 all functional tests reflected the bleeding tendency of the patients. In type 2B disease the bleeding time was prolonged only when the patient was thrombocytopenic, but both high shear systems revealed the disease independently of the presence of thrombocytopenia. The overall sensitivity of the bleeding time determination was 50% compared to the 80-90% sensitivity of the O'Brien filter test and the PFA-100 system. The sensitivity values of the filter test and the PFA-100 device with collagen-epinephrine cartridges were in the same range, but the collagen-ADP cartridges showed a lower (65.5%) sensitivity, though the results were specific and had high positive predictive value. We conclude that both high shear systems are suitable for the screening of vWD, and that they are superior to the traditional bleeding time determination in case of mild disease or type 2B vWD.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban von Willebrand' disease high shear induced platelet activation O'Brien filter test PFA-100 system
Megjelenés:	Thrombosis And Haemostasis. - 84 : 1 (2000), p. 88-92. -
További szerzők:	Kerényi Adrienne (1970-) (laboratóriumi szakorvos) Muszbek László (1942-) (haematológus, kutató orvos) Boda Zoltán (1947-) (belgyógyász, haematologus, klinikai onkológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM002137
Első szerző:	Szántó Tímea
Cím:	Type 2B von Willebrand disease in seven individuals from three different families : phenotypic and genotypic characterization / Szanto T., Schlammadinger A., Salles I., Pareyn I., Vauterin S., Harsfalvi J., Vanden Bulcke A. M., Deckmyn H., Vanhoorelbeke K.
Dátum:	2007
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Thrombosis Haemostasis. - 98 : 1 (2007), p. 251-254. -
További szerzők:	Schlammadinger Ágota (1971-) (belgyógyász, haematológus) Salles, Isabelle Pareyn, Inge Vauterin, Stephan Vanden Bulcke, Anne-Marie Deckmyn, Hans Vanhoorelbeke, Karen Hársfalvi Jolán (1949-) (klinikai biokémikus)
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