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001-es BibID:	BIBFORM035082
Első szerző:	Cauwenberghs, Nancy
Cím:	Fc-receptor Dependent Platelet Aggregation Induced by Monoclonal Antibodies against Platelet Glycoprotein Ib or von Willebrand Factor / Nancy Cauwenberghs, Agotha Schlammadinger, Stephan Vauterin, Susan Cooper, Gretel Descheemaeker, István Tornai, Hans Deckmyn
Dátum:	2001
ISSN:	0340-6245
Megjegyzések:	In this paper we describe two pathways leading to platelet activation by crosslinking glycoprotein (GP) Ibalpha to the platelet Fc-receptor (FcgammaRII). First the monoclonal antibody (MoAb) 9C8, raised against human platelet GPIbalpha, dose-dependently induced platelet aggregation of citrate-anticoagulated platelet-rich plasma, an effect that can be inhibited by several activation inhibitors. The FcgammaRII-inhibitory MoAb IV.3 was able to prevent the aggregatory effects of MoAb 9C8, indicating that crosslinking of the antigen GPIbalpha to the FcgammaII-receptor is necessary for the activating effect. Secondly we observed a synergistic activating effect of two anti-von Willebrand factor (vWF) MoAbs IC1E7 and B724, both known to enhance vWF binding to GPIbalpha in the presence of shear or ristocetin. When these antibodies are added together to PRP, platelet aggregation is induced without further need for an additional modulator. This effect can be blocked by either MoAb IV.3 or an inhibitory anti-GPIb MoAb, indicating that again the platelet activation results from signaling through FcgammaRII crosslinked to vWF bound to GPIbalpha. In addition, both the anti-GPIb MoAb 9C8, or the two anti-vWF MoAbs 1C1E7 and B724 induce genuine platelet activation, as evidenced by the secretion of ATP and protein tyrosine phosphorylation. These findings with both anti-GPIb and anti-vWF MoAbs add further proof to recent reports demonstrating an interaction between the platelet receptors GPIb and FcgammaRII, suggesting a role for the FcgammaII-receptor in GPIb-related signaling.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Monoclonal antibody von Willebrand factor glycoprotein Ib FeyII-receptor külföldön készült közlemény platelet activation
Megjelenés:	Thrombosis and Haemostasis. - 85 : 4 (2001), p. 679-685. -
További szerzők:	Schlammadinger Ágota (1971-) (belgyógyász, haematológus) Vauterin, Stephan Cooper, Susan Descheemaeker, Gretel Tornai István (1954-) (belgyógyász, gasztroenterológus) Deckmyn, Hans
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001-es BibID:	BIBFORM035072
Első szerző:	Tornai István (belgyógyász, gasztroenterológus)
Cím:	Acquired Bernard-Soulier syndrome : a case with necrotizing vasculitis and thrombosis / Istvan Tornai, Zoltan Boda, Agota Schlammadinger, Attila Juhasz, Nancy Cauwenberghs, Hans Deckmyn, Jolan Harsfalvi
Dátum:	1999
Megjegyzések:	We describe a patient with positive antinuclear antibodies, polyclonal gammopathy and high level of circulating immunocomplexes, resulting in vascular purpura. In addition, the patient had a slightly prolonged bleeding time and an isolated defect of ristocetin-induced platelet aggregation (RIPA) in platelet-rich plasma (PRP). The patient's plasma also inhibited RIPA in normal PRP and in normal platelet suspension. The activity and multimeric structure of plasmatic von Willebrand factor showed no alteration. We could demonstrate an autoantibody against platelet membrane glycoprotein (GP) Ib, using an ELISA-type assay. These data suggest an acquired Bernard-Soulier syndrome. We suggest that the patient had an immunocomplex-mediated leukocytoclastic vasculitis accompanied by production of antinuclear autoantibodies as well as the presence of an autoantibody against GPIb. The titer of the anti-GPIb antibody, however, was too low to induce significant platelet-type bleeding tendency, only laboratory alterations were found. Moreover, in a later stage of her disease, she developed a severe necrotizing vasculitis which was followed by a deep venous thrombosis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Haemostasis. - 29 : 4 (1999), p. 229-236. -
További szerzők:	Boda Zoltán (1947-) (belgyógyász, haematologus, klinikai onkológus) Schlammadinger Ágota (1971-) (belgyógyász, haematológus) Juhász Attila (1970-) (szakorvos, klinikai mikrobiológus) Cauwenberghs, Nancy Deckmyn, Hans Hársfalvi Jolán (1949-) (klinikai biokémikus)
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