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001-es BibID:BIBFORM078829
035-os BibID:(WOS)000423196400001 (PMID)29359995 (PMCID)PMC5987990
Első szerző:Smith, David
Cím:Classification and reporting of severity experienced by animals used in scientific procedures: FELASA/ECLAM/ESLAV Working Group report / David Smith, David Anderson, Anne-Dominique Degryse, Carla Bol, Ana Criado, Alessia Ferrara, Nuno Henrique Franco, István Gyertyán, Jose M. Orellana, Grete Ostergaard, Orsolya Varga, Hanna-Marja Voipio
Dátum:2018
ISSN:0023-6772
Megjegyzések:Directive 2010/63/EU introduced requirements for the classification of the severity of procedures to be applied during the project authorisation process to use animals in scientific procedures and also to report actual severity experienced by each animal used in such procedures. These requirements offer opportunities during the design, conduct and reporting of procedures to consider the adverse effects of procedures and how these can be reduced to minimize the welfare consequences for the animals. Better recording and reporting of adverse effects should also help in highlighting priorities for refinement of future similar procedures and benchmarking good practice. Reporting of actual severity should help inform the public of the relative severity of different areas of scientific research and, over time, may show trends regarding refinement. Consistency of assignment of severity categories across Member States is a key requirement, particularly if re-use is considered, or the safeguard clause is to be invoked. The examples of severity classification given in Annex VIII are limited in number, and have little descriptive power to aid assignment. Additionally, the examples given often relate to the procedure and do not attempt to assess the outcome, such as adverse effects that may occur. The aim of this report is to deliver guidance on the assignment of severity, both prospectively and at the end of a procedure. A number of animal models, in current use, have been used to illustrate the severity assessment process from inception of the project, through monitoring during the course of the procedure to the final assessment of actual severity at the end of the procedure (Appendix 1).
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
severity
humane end-point
refinement
ethics & welfare
Megjelenés:Laboratory Animals. - 52 : suppl 1 (2018), p. 5-57. -
További szerzők:Anderson, David Degryse, Anne-Dominique Bol, Carla Criado, Ana Ferrara, Alessia Franco, Nuno Henrique Gyertyán István Orellana, Jose M. Ostergaard, Grete Varga Orsolya (1977-) (orvos, jogász) Voipio, Hanna-Marja
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001-es BibID:BIBFORM047621
035-os BibID:PMID:20602541 WOS:000279734200017
Első szerző:Varga Orsolya (orvos, jogász)
Cím:Validating animal models for preclinical research : a scientific and ethical discussion / Orsolya E. Varga, Axel K. Hansen, Peter Sandøe, I. Anna S. Olsson
Dátum:2010
Megjegyzések:The use of animals to model humans in biomedical research relies on the notion that basic processes are sufficiently similar across species to allow extrapolation. Animal model validity is discussed in terms of the similarity between the model and the human condition it is intended to model, but no formal validation of models is applied. There is a stark contrast here with the use of non-animal alternatives in toxicology and safety studies, for which an extensive validation is required. We discuss both the potential and the limitations of validating preclinical animal models for proof-of-concept studies, by using an approach similar to that applied to alternative non-animal methods in toxicology and safety testing. A major challenge in devising a validation system for animal models is the lack of a clear gold standard with which to compare results. While a complete adoption of the validation approach for alternative methods is probably inappropriate for research animal models, key features, such as making data available for external validation and defining a strategy to run experiments in a way that permits meaningful retrospective analysis, remain highly relevant.
Tárgyszavak:Orvostudományok Elméleti orvostudományok szerkesztőségi anyag
Megjelenés:Alternatives to Laboratory Animals. - 38 : 3 (2010), p. 245-248. -
További szerzők:Hansen, Axel Kornerup Sandøe, Peter Olsson, I. Anna
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