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001-es BibID:BIBFORM091566
035-os BibID:(cikkazonosító)155
Első szerző:Franco, Nuno Henrique
Cím:Assessing Scientific Soundness and Translational Value of Animal Studies on DPP4 Inhibitors for Treating Type 2 Diabetes Mellitus / Nuno Henrique Franco, Sonia Miranda Batista, Nóra Kovács, Attila Csaba Nagy, Thiên, Bùi Quôc, Flávio Reis, Orsolya Varga
Dátum:2021
ISSN:2079-7737
Megjegyzések:Although there is a wide range of animal models of type 2 diabetes mellitus (T2DM) used in re-search; we have limited evidence on their translation value. This paper provides a) a comparison of preclinical animal and clinical results on the effect of five dipeptidyl peptidase-4 (DPP4) in-hibitors by comparing the pharmaceutical caused glucose changes, and b) an evaluation of methodological and reporting standards in T2DM preclinical animal studies. DPP4 inhibitors play an important role in the clinical management of T2DM: if metformin alone is not sufficient enough to control the blood sugar levels, DPP4 inhibitors are often used as second-line therapy; additionally, DPP-4 inhibitors are also used in triple therapies with metformin and sodi-um-glucose co-transporter-2 (SGLT-2) inhibitors or with metformin and insulin. In our analysis of 124 preclinical studies and 47 clinical trials, (1) we found no evidence of species differences in glucose change response to DPP4 inhibitors, which may suggest that, for this drug class, studies in mice and rats may be equally predictive of how well a drug will work in humans; and (2) there is good reporting of group size, sex, age, euthanasia method and self-reported compliance with animal welfare regulations in animal studies but poor reporting of justification of group size, along with a strong bias towards the use of male animals and young animals. Instead of the common non-transparent model selection, we call for a reflective and evidenced-based assess-ment of predictive validity of the animal models currently available.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Biology. - 10 : 2 (2021), p. 1-18. -
További szerzők:Batista, Sonia Miranda Kovács Nóra (1989-) (népegészségügyi szakember) Nagy Attila Csaba (1981-) (megelőző orvostan és népegészségtan szakorvos, epidemiológus) Thiên, Bùi Quôc Reis, Flávio Varga Orsolya (1977-) (orvos, jogász)
Internet cím:DOI
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2.

001-es BibID:BIBFORM095943
035-os BibID:(cikkazonosító)e0232378 (WOS)000537475000009 (Scopus)85084570757
Első szerző:Horváth Tamara
Cím:Hydroxyapatite-coated implants provide better fixation in total knee arthroplasty. A meta-analysis of randomized controlled trials / Horváth Tamara, Hanák Lilla, Hegyi Péter Jr., Butt Edina, Solymár Margit, Szűcs Ákos, Varga Orsolya, Thien Bui Quoc, Szakács Zsolt, Csonka Endre, Hartmann Petra
Dátum:2020
ISSN:1932-6203
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Plos One. - 15 : 5 (2020), p. 1-13. -
További szerzők:Hanák Lilla Hegyi Péter Jr. (belgyógyász) Butt Edina Solymár Margit Szűcs Ákos (sebész) Varga Orsolya (1977-) (orvos, jogász) Thiên, Bùi Quôc Szakács Zsolt Csonka Endre Hartmann Petra
Pályázati támogatás:K-120232
NKFIH
GINOP-2.3.2-15-2016-00015
GINOP
EFOP-3.6.2-16-2017-0006
EFOP
GINOP2.3.2-15-2016-00048
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM101723
035-os BibID:(cikkazonosító)846730 (WoS)000805912200001 (Scopus)85130050134
Első szerző:Septia Irawan, Anggi
Cím:Analysis of Content, Social Networks, and Sentiment of Front-of-Pack Nutrition Labeling in the European Union on Twitter / Septia Irawan Anggi, Shahin Balqees, Wangeshi Njuguna Diana, Nellamkuzhi Noel Johny, Thien Bui Quoc, Mahrouseh Nour, Varga Orsolya
Dátum:2022
ISSN:2296-861X
Megjegyzések:n recent years, concerted political efforts have been made at the national and European Union (EU) level to promote the consumption of healthy foods. The European Commission (EC) expressed the need for a harmonized and mandatory front-of-pack nutrition labeling (FOPL) system at the EU level. The EC will adopt the proposal by the end of 2022. Our research work aims to understand the public discourse on FOPL in the EU via Twitter, by analyzing tweet content, sentiment, and mapping network characteristics. Tweet search and data collection were performed using the Twitter application programming interface (API), with no time or language restrictions. The content was coded with the QRS Nvivo software package and analyzed thematically. Automatic sentiment analysis was performed with QSR Nvivo, and network analysis was performed with Gephi 0.9.2. A total of 4,073 tweets were posted, mostly from the UK, Spain, and France. Themes that have emerged from the discussion on Twitter include the types of food labeling, food industry, healthy vs. unhealthy foods in the context of food labeling, EU regulation, political conflicts, and science and education. Nutri-Score dominated the discussion on Twitter. General topics were perceived negatively by Twitter users with more positive sentiments toward the food industry, while negative sentiments were observed toward the discourse of political conflicts. The network analysis showed that a centralized communication was hardly existed between countries. Our results reveal that the discussion of FOPL on Twitter is limited to a very limited group of people, and it seems necessary to inform a wide range of consumers about existing and upcoming FOPL schemes. Educational programs should empower consumers to understand what a healthy diet is and how it relates to FOPL, regardless of the existing labeling system.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
front-of-pack nutrition labeling
European Union
public understanding
European Commission (EC)
obesity
Megjelenés:Frontiers in Nutrition. - 9 (2022), p. 1-14. -
További szerzők:Shahin, Balqees Wangeshi Njuguna, Diana Nellamkuzhi, Noel Johny Thiên, Bùi Quôc Mahrouseh, Nour(1993-) (Phd hallgató) Varga Orsolya (1977-) (orvos, jogász)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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