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001-es BibID:BIBFORM035225
035-os BibID:(Scopus)84859963822 (WOS)000304850100018
Első szerző:Bányai Krisztián
Cím:Systematic review of regional and temporal trends in global rotavirus strain diversity in the pre rotavirus vaccine era: Insights for understanding the impact of rotavirus vaccination programs / Krisztián Bányai, Brigitta László, Jazmin Duque, A. Duncan Steele, E. Anthony S. Nelson, Jon R. Gentsch, Umesh D. Parashar
Dátum:2012
ISSN:0264-410X
Megjegyzések:Recently, two rotavirus vaccines have been recommended for routine immunization of infants worldwide. These vaccines proved efficacious during clinical trials and field use in both developing and developed countries, and appear to provide good protection against a range of rotavirus genotypes, including some that are not included in the vaccines. However, since conclusive data that the vaccines will protect against a wide variety of rotavirus strains are still lacking and since vaccines may exert some selection pressure, a detailed picture of global strain prevalence from the pre-rotavirus vaccine era is important to evaluate any potential changes in circulating strains observed after widespread introduction of rotavirus vaccines. Thus, we systematically reviewed rotavirus genotyping studies spanning a 12-year period from 1996 to 2007. In total, ?110,000 strains were genotyped from 100 reporting countries. Five genotypes (G1?G4, and G9) accounted for 88% of all strains, although extensive geographic and temporal differences were observed. For example, the prevalence of G1 strains declined from 2000 onward, while G3 strains re-emerged, and G9 and G12 strains emerged during the same period. When crude strain prevalence data were weighted by region based on the region's contribution to global rotavirus mortality, the importance of genotypes G1 and G9 strains that were more prevalent in regions with low mortality was reduced and conversely the importance of G8 strains that were more prevalent in African settings with greater contribution to global rotavirus mortality was increased. This study provides the most comprehensive, up-to-date information on rotavirus strain surveillance in the pre-rotavirus vaccine era and will provide useful background to examine the impact of rotavirus vaccine introduction on future strain prevalence.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
külföldön készült közlemény
Megjelenés:Vaccine. - 30 : Suppl. 1 (2012), p. 122-130. -
További szerzők:László Brigitta (1983-) (molekuláris biológus, mikrobiológus) Duque, Jazmin Steele, Amber Duncan Nelson, E. Anthony S. Gentsch, Jon R. Parashar, Umesh D.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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2.

001-es BibID:BIBFORM057820
Első szerző:Dóró Renáta
Cím:Review of global rotavirus strain prevalence data from six years post vaccine licensure surveillance : is there evidence of strain selection from vaccine pressure? / Renáta Dóró, Brigitta László, Vito Martella, Eyal Leshem, Jon Gentsch, Umesh Parashar, Krisztián Bányai
Dátum:2014
Megjegyzések:Comprehensive reviews of pre licensure rotavirus strain prevalence data indicatedthe global importance of six rotavirus genotypes, G1P[8], G2P[4], G3P[8], G4P[8],G9P[8] and G12P[8]. Since 2006, two vaccines, the monovalent Rotarix (RV1) andthe pentavalent RotaTeq (RV5) have been available in over 100 countriesworldwide. Of these, 60 countries have already introduced either RV1 or RV5 intheir national immunization programs. Post licensure vaccine effectiveness isclosely monitored worldwide. This review aimed at describing the global changesin rotavirus strain prevalence over time. The genotype distribution of the nearly47,000 strains that were characterized during 2007-2012 showed similar picture tothat seen in the preceding period. An intriguing finding was the transientpredominance of heterotypic strains, mainly in countries using RV1. Unusual andnovel antigen combinations continue to emerge, including some causing localoutbreaks, even in vaccinated populations. In addition, vaccine strains have beenfound in both vaccinated infants and their contacts and there is evidence forgenetic interaction between vaccine and wild-type strains. In conclusion, thepost-vaccine introduction strain prevalence data do not show any consistentpattern indicative of selection pressure resulting from vaccine use, although theincreased detection rate of heterotypic G2P[4] strains in some countriesfollowing RV1 vaccination is unusual and this issue requires further monitoring.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Genotype
RotaTeq
Rotarix
Rotavirus
Surveillance
Megjelenés:Infection Genetics and Evolution. - 28 (2014), p. 446-461. -
További szerzők:László Brigitta (1983-) (molekuláris biológus, mikrobiológus) Martella, Vito Leshem, Eyal Gentsch, Jon R. Parashar, Umesh D. Bányai Krisztián
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
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