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1.

001-es BibID:BIBFORM029708
Első szerző:Blasberg, Ronald
Cím:Regional blood flow in RT-9 brain tumors / Blasberg R. G., Molnar P., Horowitz M., Kornblith P., Pleasants R., Fenstermacher J.
Dátum:1983
Megjegyzések:Regional blood flow (BF) was measured in RT-9 experimental brain tumors using carbon-14 labeled iodoantipyrine, the Kety tissue-exchange equations, and quantitative autoradiographic techniques. Blood flow was variable within tumor tissue, and the range of BF increased with increasing tumor size; the overall range was 6 to 138 ml/100 gm/min and the maximum range within an individual tumor was 55 ml/100 gm/min. In all but one case, mean tumor BF was less than that in the same anatomic region of the contralateral hemisphere (CBA). The magnitude of BF within individual tumor foci generally could be related to tumor size, location (intraparenchymal versus extraparenchymal), and the presence of necrosis or cysts; it was lower in the geometric centers than in the periphery of medium-sized and large tumors. Brain adjacent to tumor had higher BF's than the tumor periphery; generally, the BF in the brain adjacent to the tumor was less than that in the CBA. A global depression of BF was observed within tumor-free cortex and corpus callosum of the hemisphere ipsilateral to tumor implantation and primary growth, suggesting a hemispheric reduction in metabolic and functional activity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neurosurgery. - 58 : 6 (1983), p. 863-873. -
További szerzők:Molnár Péter Pál (1951-) (pathológus) Horowitz, Marc Kornblith, Paul Pleasants, Roger Fenstermacher, Joseph D.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM029746
Első szerző:Groothuis, Dennis
Cím:Hyperosmotic Blood-Brain Barrier Disruption : reply / Dennis Groothuis, Gregory Lapin, Peter Warnke, Peter Molnar
Dátum:1990
ISSN:0022-3085
Tárgyszavak:Orvostudományok Klinikai orvostudományok levél
Megjelenés:Journal Of Neurosurgery. - 73 : 5 (1990), p. 806-807. -
További szerzők:Lapin, Gregory D. Warnke, Peter C. Molnár Péter Pál (1951-) (pathológus)
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3.

001-es BibID:BIBFORM029745
Első szerző:Groothuis, Dennis
Cím:Blood-brain barrier disruption in brain-tumor therapy / Dennis R. Groothuis, Peter C. Warnke, Peter Molnar, Gregory D. Lapin, Michael A. Mikhael.
Dátum:1990
Tárgyszavak:Orvostudományok Klinikai orvostudományok levél
Megjelenés:Journal of Neurosurgery. - 73 : 3 (1990), p. 476-477. -
További szerzők:Warnke, Peter C. Molnár Péter Pál (1951-) (pathológus) Lapin, Gregory D. Mikhael, Michael A.
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4.

001-es BibID:BIBFORM029733
Első szerző:Groothuis, Dennis
Cím:Effect of hyperosmotic blood-brain barrier disruption on transcapillary transport in canine brain tumors / Groothuis Dennis R., Warnke Peter C., Molnar Peter, Lapin Gregory D., Mikhael Michael A.
Dátum:1990
ISSN:0022-3085
Megjegyzések:Whether hyperosmotic blood-brain barrier (BBB) disruption is a technique that can be used to increase permeability of brain-tumor capillaries and thereby transiently increase drug delivery to the brain tumor is controversial. Nine virally induced brain tumors were studied in seven dogs, before and after hyperosmotic BBB disruption with 1.4 osmolar mannitol. Each dog was studied with computerized tomography (CT) after administration of the water-soluble tracer meglumine iothalamate. Each study lasted 30 minutes. A baseline CT scan and 35 to 40 additional CT scans were obtained to provide a time-related measurement of the amount of meglumine iothalamate in tissue (Am(t], and 30 plasma samples were collected to provide the time-related measurement of meglumine iothalamate in plasma (Cp(t]. The data were analyzed by three different methods: 1) a two-compartment model and nonlinear curve fitting were used to calculate K1 (blood-to-tissue or influx constant), k2 (tissue-to-blood or efflux constant), and Vp (plasma vascular space); 2) K1 values were calculated with a two-compartment model, assuming no efflux, at the time point for each CT scan; and 3) a "tissue advantage ratio" was calculated that expressed the ratio of tissue uptake of meglumine iothalamate at each time point, comparing values before and after BBB disruption. Regardless of which method of data analysis was used, there was a marked and significant increase in transcapillary transport of meglumine iothalamate to tumor-free brain regions, while there was only a small, transient, and insignificant increase to the brain tumors. Although there were often marked increases in delivery to cortex in the same hemisphere as the tumors, there was no significant increase to brain immediately surrounding the tumors, perhaps due to altered circulatory dynamics in this region. These data raise serious questions as to the wisdom of using this technique to increase drug delivery to brain tumors in patients and strongly support the continued study of this technique in experimental brain tumors before it is used in patients.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neurosurgery. - 72 : 3 (1990), p. 441-449. -
További szerzők:Warnke, Peter C. Molnár Péter Pál (1951-) (pathológus) Lapin, Gregory D. Mikhael, Michael A.
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5.

001-es BibID:BIBFORM029713
Első szerző:Hegedűs Katalin (ideggyógyász, neuropathológus)
Cím:Histopathological study of major intracranial arteries in premature infants related to intracranial hemorrhage / Hegedüs Katalin, Molnár Péter
Dátum:1985
ISSN:0022-3085
Megjegyzések:The incidence of various types of intracranial hemorrhage (ICH) and the microscopic appearance of the major intracranial arteries were investigated in 112 premature infants, and related to birth weight. In none of the premature newborns, regardless of the presence of ICH, did the intracranial arteries contain true elastic elements. The wall of the basilar artery was significantly thinner in all premature infants with any kind of ICH. Within each body-weight group those with ICH had intracranial arteries with fewer reticular fibers than did those without ICH. The density of the reticular fibers in the cerebral arteries of premature neonates without ICH did not seem to depend on maturity. The authors believe that the hypoplasia of the major intracranial arteries and the reticular fiber deficiency most probably involve the whole vascular system of the brain and may predispose to hemorrhage.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neurosurgery. - 62 : 3 (1985), p. 419-424. -
További szerzők:Molnár Péter Pál (1951-) (pathológus)
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6.

001-es BibID:BIBFORM029714
Első szerző:Hegedűs Katalin (ideggyógyász, neuropathológus)
Cím:Primary cerebellar glioblastoma multiforme with an unusually long survival / Hegedűs Katalin, Molnár Péter
Dátum:1983
ISSN:0022-3085
Megjegyzések:Light microscopic and electron microscopic findings of a primary cerebellar glioblastoma multiforme (GM) are presented. An infiltrating tumor of the vermis and the right cerebellar hemisphere had been partially removed from a 39-year-old woman. Postoperative irradiation to the posterior fossa enabled her to work for the next 5 1/2 years. At readmission, progressive pontocerebellar signs were observed. In spite of repeated irradiation and intrathecal chemotherapy, she died after 1 month. Autopsy revealed extensive tumorous infiltration of the right cerebellar hemisphere, pons, and medulla. Both the biopsy and autopsy specimens showed typical features of GM. Tumorous propagation resulted in extreme enlargement of the right inferior olive. Electron microscopic analysis disclosed characteristic bundles of glial filaments, cytoplasmic inclusions lying within nuclear folds, and intracytoplasmic granules of uncertain nature. The possible cause of the long survival is discussed and a comparison is made with previously reported cases.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Case report
Megjelenés:Journal Of Neurosurgery. - 58 : 4 (1983), p. 589-592. -
További szerzők:Molnár Péter Pál (1951-) (pathológus)
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7.

001-es BibID:BIBFORM029717
Első szerző:Molnár Péter Pál (pathológus)
Cím:Regional blood-to-tissue transport in RT-9 brain tumors / Molnar Peter, Blasberg Ronald G., Horowitz Marc, Smith Barry, Fenstermacher Joseph
Dátum:1983
ISSN:0022-3085
Megjegyzések:Regional blood-to-tissue transport, expressed as a unidirectional transfer rate constant (K), was measured in experimental RT-9 brain tumors using 14C-alpha-aminoisobutyric acid (AIB) and quantitative autoradiographic techniques. The magnitude of K depends on the permeability, surface area, and blood flow of the tissue capillaries. The transfer rate constant was variable within tumor tissue (range 0.001 to 0.178 ml/gm/min) and depended on tumor size, location (intraparenchymal, meningeal, or choroid plexus associated), and to a lesser extent on necrosis and cyst formation. Brain adjacent to tumor had higher K values, particularly around larger tumors (0.004 to 0.014 ml/gm/min), than corresponding brain regions in the contralateral hemisphere (0.001 to 0.002 ml/gm/min). Estimates of the fractional extraction of AIB by intraparenchymal tumors were between 0.008 and 0.4 ml/gm/min. Values of fractional extraction in this range indicate that tumor capillaries are not freely permeable to this solute. The values of K measured with AIB in this study, for the most part, approximate the permeability-surface area product of tumor and brain capillaries. The experimental data suggest that the permeability-surface area characteristics of the microvasculature in small RT-9 tumors are similar to those of the host tissue, whereas the microvasculature of larger RT-9 tumors is influenced more by intrinsic tumor factors.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neurosurgery. - 58 : 6 (1983), p. 874-884. -
További szerzők:Blasberg, Ronald Horowitz, Marc Smith, Barry Fenstermacher, Joseph D.
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8.

001-es BibID:BIBFORM055441
Első szerző:Zakaria, Zaitun
Cím:Stupp-treated glioblastoma accompanied by EBV-positive primary CNS lymphoma / Zaitun Zakaria, Eoin Fenton, Ayman Khalil, Muhammad Taufiq Sattar, Peter Molnar
Dátum:2014
ISSN:0268-8697
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal of Neurosurgery. - 28 : 2 (2014), p. 287-289. -
További szerzők:Fenton, Eoin Khalil, Ayman Sattar, Muhammad Taufiq Molnár Péter Pál (1951-) (pathológus)
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