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1.

001-es BibID:BIBFORM029731
Első szerző:Ali, M. J.
Cím:Isolation of drug delivery from drug effect : problems of optimizing drug delivery parameters / Ali M. J., Navalitloha Y., Vavra M. W., Kang E. W., Itskovich A. C., Molnar P., Levy R. M., Groothuis D. R.
Dátum:2006
ISSN:1522-8517
Megjegyzések:A recurring question in the treatment of malignant brain tumors has been whether treatment failure is due to inadequate delivery or ineffective drugs. To isolate these issues, we tested a paradigm in which the "therapeutic" agent was a toxin about which there could be no question of efficacy, provided it was delivered in adequate amounts; we used 10% formalin. We infused 10% formalin into 5- to 8-mm subcutaneous RG-2 and D54-MG gliomas at increasing rates until we achieved 100% tumor cell kill. In RG-2 gliomas, infusions of 10 microl/h x 7 days, and 2, 4, 6, and 8 microl/min x 2 h failed to kill tumors, although growth was delayed, while infusion rates of 12 microl/min x 60 min and 48 microl/min x 15 min produced 100% tumor kill. In D54-MG tumors, infusions of 4, 8, and 24 microl/min produced 100% tumor kill. 14C-Formalin autoradiographs showed a heterogeneous distribution after infusions of 2 microl/min x 2 h, whereas infusions of 48 microl/min x 15 min showed a homogeneous distribution within the tumor, but more than 95% of tissue radioactivity was found in tissue surrounding tumor. Drug delivery remains a major issue in brain tumor treatment: Distribution inhomogeneity, rapid efflux, and consequent treatment failures are likely due to high interstitial fluid pressure. Because the infusion rates being used in the treatment of human brain tumors are low and the tumors are larger, treatment failures can be expected on the basis of inadequate drug delivery alone, regardless of the effectiveness of the drug.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neuro-Oncology. - 8 : 2 (2006), p. 109-118. -
További szerzők:Navalitloha, Y. Vavra, M. W. Kang, E. W. Itskovich, A. C. Molnár Péter Pál (1951-) (pathológus) Levy, R. M. Groothuis, Dennis
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DOI
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2.

001-es BibID:BIBFORM055454
Első szerző:Berényi E.
Cím:Diffusion tensor imaging and fibertracking in pediatric gliomas / E. Berenyi, L. Novak, L. Bognar, P. Molnar
Dátum:2008
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Neuro-Oncology. - 10 : 3 (2008), p. 428-429. -
További szerzők:Novák László (1964-) (idegsebész) Bognár László (1958-) (idegsebész, gyermekidegsebész) Molnár Péter Pál (1951-) (pathológus)
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3.

001-es BibID:BIBFORM029697
Első szerző:Blasberg, Ronald
Cím:Local blood flow in Walker 256 metastatic brain tumors / Blasberg R. G., Shapiro W. R., Molnar P., Patlak C. S., Fenstermacher J. D.
Dátum:1984
Megjegyzések:Local blood flow (F) in metastatic Walker 256 (WL-256) brain tumors produced by the intracarotid artery injection of WL-256 tumor cells in rats was measured using 14C-iodoantipyrine and quantitative autoradiography. Blood flow was variable in the tumors; the overall range was 2 to 222 ml hg-1 min-1 and the maximum range in an individual tumor extended over 150 ml hg-1 min-1. Small tumors had mean blood flows similar to surrounding brain. Medium to large tumors had significantly lower flows; the lowest values were usually measured in necrotic or cystic regions, although low values (less than 20 ml hg-1) were also measured in some viable-appearing tumor regions. Blood flow was significantly reduced in brain adjacent to medium and large but not small tumors. A global depression of brain and tumor blood flow was measured in two animals with hydrocephalus and the largest tumor burden. The blood flow patterns of the WL-256 metastatic tumor model are not uniquely different from other brain tumor models although some individual differences exist.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neuro-Oncology. - 2 : 3 (1984), p. 195-204. -
További szerzők:Shapiro, William R. Molnár Péter Pál (1951-) (pathológus) Patlak, Clifford S. Fenstermacher, Joseph D.
Internet cím:DOI
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4.

001-es BibID:BIBFORM029698
Első szerző:Blasberg, Ronald
Cím:Local blood-to-tissue transport in Walker 256 metastatic brain tumors / Blasberg R. G., Shapiro W. R., Molnar P., Patlak C. S., Fenstermacher J. D.
Dátum:1984
Megjegyzések:Local blood-to-tissue transfer constants (K) in metastatic Walker 256 (WL-256) brain tumors produced by the intracarotid artery injection of WL-256 tumor cells in rats were measured using 14C-alpha-aminoisobutyric acid and quantitative autoradiography. Small compact and diffuse infiltrative intraparenchymal tumors had values of K similar to that of contralateral nontumorous brain tissue. Medium and large tumors, meningeal metastases and intraventricular tumors had higher K values (5 to 30 fold) than contralateral nontumorous brain tissue indicating that intraparenchymal tumor size and location in meningeal and choroidal tissue influence the permeability of tumor capillaries. The local intratumor values of K varied considerably in these tumors and this variability of K correlated to only a few specific histopathologic features of the tumors. The value of K abruptly decreased at the tumor-brain interface when this interface was sharply defined, indicating that the metastatic tumors have only a small effect on the permeability of adjacent brain capillaries. Low blood-to-tumor transport of water soluble drugs will significantly affect drug concentrations in the tumor and the tumor-drug exposure.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neuro-Oncology. - 2 : 3 (1984), p. 205-218. -
További szerzők:Shapiro, William R. Molnár Péter Pál (1951-) (pathológus) Patlak, Clifford S. Fenstermacher, Joseph D.
Internet cím:DOI
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5.

001-es BibID:BIBFORM055453
Első szerző:Molnár Péter Pál (pathológus)
Cím:Multifocal, proteinaceous CNS deposits mimicking neoplasia : report of an unusual cerebral and cerebellar amyloidoma with long lasting clinical history / Peter Molnar
Dátum:2009
ISSN:1522-8517
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neuro-Oncology. - 11 : 6 (2009), p. 942-943. -
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM055455
Első szerző:Molnár Péter Pál (pathológus)
Cím:Malignant spinal epidural nerve sheath tumor (MPNST) with giant rosettes / P. P. Molnar, A. Lajgut, J. Dobai
Dátum:2006
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Neuro-Oncology. - 8 : 4 (2006), p. 339. -
További szerzők:Lajgut Attila (1962-) (idegsebész) Dobai József (1969-) (idegsebész)
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7.

001-es BibID:BIBFORM055456
Első szerző:Molnár Péter Pál (pathológus)
Cím:Functional and ultrastructural features of the blood-tumor barrier in experimental and human brain tumors / P. P. Molnar, B. P. O'Neill, B. W. Scheithauer, D.Groothuis
Dátum:1996
ISSN:1522-8517
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Neuro-Oncology. - 30 (1996), p. 119. -
További szerzők:O'Neill, Brian P. Scheithauer, Bernd W. Groothuis, Dennis
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8.

001-es BibID:BIBFORM055457
Első szerző:Molnár Péter Pál (pathológus)
Cím:Brain tumors : the relationship between permeability, vascularity and information derived from tumor images / P. P. Molnar, I. Fekete, G. G. Lapin, D. R. Groothuis
Dátum:1988
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Neuro-Oncology. - 39 (1988), p. 161. -
További szerzők:Fekete István Lapin, Gregory D. Groothuis, Dennis
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9.

001-es BibID:BIBFORM029754
Első szerző:Molnár Péter Pál (pathológus)
Cím:The effects of dexamethasone on experimental brain tumors : I. Transcapillary transport and blood flow in RG-2 rat gliomas / Molnar P., Lapin G. D., Groothuis D. R.
Dátum:1995
ISSN:0167-594X
Megjegyzések:Dexamethasone dramatically improves cerebral edema associated with malignant gliomas. Although the pathophysiology of this effect is not clearly understood, many investigators have postulated that tumor capillary permeability is reduced by dexamethasone. We studied blood-to-tissue transport and blood flow in 178 RG-2 transplanted gliomas in a control group and four groups given dexamethasone at doses of 3, 6, 9, and 12 mg/kg for four days. 14C-alpha aminoisobutyric acid (AIB) was used to study blood-to-tissue transport in 31 animals; in an additional 27 animals 14C-AIB and 131I-iodoantipyrine (IAP) were used in double label experiments to study blood-to-tissue transport and blood flow. Regional measurements of the transfer constant (K) of AIB and blood flow (F) were made with quantitative autoradiography. There were significant differences between the control and dexamethasone-treated groups with regard to weight loss and plasma glucose. However, there was no significant effect of dexamethasone on values of K or F, regardless of the tumor or brain region examined, and regardless of the dose of dexamethasone administered. Analysis of the profiles of the transfer constant of AIB in the brain around tumor showed that the K of AIB decreased within 0.5 mm of the tumor edge in direct relationship to the dexamethasone dose. These results do not support the hypothesis that dexamethasone reduces brain tumor capillary permeability, and suggest that dexamethasone may decrease tumor-associated cerebral edema by effects on bulk flow away from the tumor margin.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neuro-Oncology. - 25 : 1 (1995), p. 19-28. -
További szerzők:Lapin, Gregory D. Groothuis, Dennis
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10.

001-es BibID:BIBFORM029721
Első szerző:Molnár Péter Pál (pathológus)
Cím:The blood-brain barrier in primary CNS lymphomas : ultrastructural evidence of endothelial cell death / Molnár P. P., O'Neill B. P., Scheithauer B. W., Groothuis D. R.
Dátum:1999
ISSN:1522-8517
Megjegyzések:The vasculature of 24 primary CNS B-cell lymphomas that were not related to acquired immunodeficiency syndrome was systematically studied by electron microscopy. Seven low-grade astrocytic tumors were included for comparison. Classical electron microscopy features of apoptosis were found in lymphoma cells of 21 of 22 subjects. Capillaries of gliomas and lymphomas showed changes reported previously: variability of endothelial cell (EC)-thickness and number, basal lamina thickness and duplication, and fenestrations. Primary CNS B-cell lymphoma ECs showed two distinctive populations of electron-dense and electron-lucent cells. The electron-dense ECs occurred in 38% of all capillaries, with changes consisting of chromatin condensation in bizarre and contracted nuclei, cytoplasmic shrinkage with markedly increased electron density, and dilatation of the endoplasmic reticulum. We interpreted these changes as indicative of apoptosis. Cell death eventually resulted in complete disintegration of the endothelium with frank discontinuities of the EC component of the blood-tumor barrier in capillaries and postcapillary venules. Another population of ECs had increased cell volume, conspicuous cytoplasmic electron lucency, dispersed organelles, scattered vesicles, and apical stress fibers. We interpreted these changes as indicative of cellular regeneration. Individual apoptotic ECs often lay next to normal or regenerating ECs. Neither type of EC change was observed in gliomas, which also lacked perivascular neoplastic lymphocytic cuffing. We believe that these populations of ECs, which have not been described in other disorders affecting the blood-brain barrier, may be induced by cytokines released from necrotic and/or apoptotic tumor lymphocytes and may explain the unusual imaging characteristics of primary CNS B-cell lymphomas treated with corticosteroids.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neuro-Oncology. - 1 : 2 (1999), p. 89-100. -
További szerzők:O'Neill, Brian P. Scheithauer, Bernd W. Groothuis, Dennis
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11.

001-es BibID:BIBFORM029755
Első szerző:Warnke, Peter C.
Cím:The effects of dexamethasone on transcapillary transport in experimental brain tumors : II. Canine brain tumors / Warnke P. C., Molnar P., Lapin G. D., Kuruvilla A., Groothuis D. R.
Dátum:1995
ISSN:0167-594X
Megjegyzések:We studied the effect of dexamethasone on transcapillary transport in ten Avian Sarcoma Virus (ASV)-induced canine brain tumors, before and one week after administration of dexamethasone, 2.5 mg/kg/day. A computed tomographic (CT) method was used to measure regional values of K1 (blood-to-tissue transfer constant), k2 (tissue-to-blood efflux constant), and Vp (tissue plasma vascular space) of meglumine iothalamate (Conray-60); the values were reconstructed for each 0.8 x 0.8 x 5 mm volume element of the CT data. For all tumors considered together, there was a decrease in the whole tumor K1 value of meglumine iothalamate from 26 +/- 2.2 (SE) before dexamethasone to 24 +/- 2.9 microliters/g/min after dexamethasone. Vp decreased from 7.2 +/- 0.7 to 6.7 +/- 0.9 ml/100 g, and the size of the tumor extracellular space (Ve) decreased from 0.30 to 0.26 ml/g. These changes were not statistically significant. However, when each tumor was used as its own control, K1 significantly decreased after dexamethasone in four tumors, significantly increased in two and was unchanged in four. These results suggest that decreased blood-to-tissue transport may be one mechanism underlying resolution of tumor associated cerebral edema in some brain tumors and that the effects of dexamethasone on blood-to-tissue transport in brain tumors are variable from one tumor to the next. Decreased 'permeability' may not be the sole mechanism by which dexamethasone reduces tumor-associated cerebral edema.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Neuro-Oncology. - 25 : 1 (1995), p. 29-38. -
További szerzők:Molnár Péter Pál (1951-) (pathológus) Lapin, Gregory D. Kuruvilla, A. Groothuis, Dennis
Internet cím:DOI
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