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1.

001-es BibID:BIBFORM055551
Első szerző:Blasberg, Ronald
Cím:A review of hyperosmotic blood-brain barrier disruption in seven experimental brain tumor models / Ronald G. Blasberg, Dennis Groothuis, Peter Molnár
Dátum:1990
ISBN:0-444-81120-6
Tárgyszavak:Orvostudományok Klinikai orvostudományok könyvfejezet
Megjelenés:Pathophysiology of the blood-brain barrier : long term consequences of barrier dysfunction for the brain / eds. Barbro B. Johansson, Christer Owman, Hakan Widner. - p. 197-220. -
További szerzők:Groothuis, Dennis Molnár Péter Pál (1951-) (pathológus)
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2.

001-es BibID:BIBFORM029757
Első szerző:Blasberg, Ronald
Cím:Drug delivery to brain tumors : physiological and pharmacokinetic aspects of chemotherapy / Blasberg R. G., Groothuis D. R., Wright D. C., Molnár P.
Dátum:1986
Tárgyszavak:Orvostudományok Klinikai orvostudományok könyvfejezet
Megjelenés:Biology of Brain Tumor / eds. Walker, M. D., Thomas D. G. T. - p. 211-220
További szerzők:Groothuis, Dennis Wright, D. C. Molnár Péter Pál (1951-) (pathológus)
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3.

001-es BibID:BIBFORM029712
Első szerző:Blasberg, Ronald
Cím:Concurrent measurements of blood flow and transcapillary transport in avian sarcoma virus-induced experimental brain tumors : implications for chemotherapy / Blasberg R., Molnar P., Groothuis D., Patlak C., Owens E., Fenstermacher J.
Dátum:1984
ISSN:0022-3565
Megjegyzések:A blood-to-tissue transfer constant, K, and tissue blood flow, F, were measured concurrently in seven rats with a total of 19 separate brain tumors induced by intracerebral inoculation of avian sarcoma virus. Regional and local measurements of K and F were obtained using double-label quantitative autoradiography with alpha-[14C]aminoisobutyric acid and [131I]iodoantipyrine, computerized microdensitometry and image analysis. Apparent tissue extraction fractions and capillary permeability-surface area products were calculated for different tumor regions, brain adjacent to tumor and tumor-free brain. The following observations were made: five histological categories of the tumors were found; significant local and regional variations of both K and F were typical in each group, resulting in marked regional variability of permeability-surface area products but more uniform values of apparent extraction fraction; the values of F, K, permeability-surface area products and apparent extraction fraction correlated poorly with morphological features of the tumors (necrosis, cellularity, cytology, location and size); the extraction fraction of alpha-aminoisobutyric acid was usually highest in tumor centers and then decreased in a gradient from tumor periphery through adjacent brain; and regardless of classification or histological features, capillary permeability and surface area, and not tissue perfusion or blood flow, seem to determine the blood-to-tissue transport processes (delivery of bloodborne materials) in most regions of these experimental brain tumors. An operational pharmacokinetic model of drug concentration in tumor tissue is developed and the results of our analysis indicate that increases in capillary permeability such as measured in these studies would not be sufficient to deliver adequate amounts of water-soluble drugs with short plasma half-lives to tumor tissue.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Pharmacology And Experimental Therapeutics. - 231 : 3 (1984), p. 724-735. -
További szerzők:Molnár Péter Pál (1951-) (pathológus) Groothuis, Dennis Patlak, Clifford S. Owens, E. Fenstermacher, Joseph D.
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4.

001-es BibID:BIBFORM029711
Első szerző:Blasberg, Ronald
Cím:Application of quantitative autoradiographic measurements in experimental brain tumor models / Blasberg R. G., Groothuis D. R., Molnar P.
Dátum:1981
ISSN:0271-8235
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Seminars In Neurology. - 1 : 3 (1981), p. 203-221. -
További szerzők:Groothuis, Dennis Molnár Péter Pál (1951-) (pathológus)
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5.

001-es BibID:BIBFORM029710
Első szerző:Blasberg, Ronald
Cím:Regional blood flow in ethylnitrosourea-induced brain tumors / Blasberg Ronald G., Kobayashi Tomowo, Horowitz Marc, Rice J. M., Groothuis Dennis, Molnar Peter, Fenstermacher Joseph D.
Dátum:1983
ISSN:0364-5134
Megjegyzések:Regional blood flow was measured in experimental brain tumors using iodoantipyrine labeled with carbon 14 and quantitative autoradiography. A total of fifteen oligodendrogliomas, sixteen mixed gliomas, one astrocytoma, one ependymoma, and three malignant schwannomas were studied in 9 rats. The mean tumor blood flows for all glioma classifications were similar, averaging 45 +/- 3 (standard error of the mean) ml . hg-1 . min-1. Flow was fairly uniform within individual oligodendrogliomas and there was no apparent correlation between blood flow and tumor size or location. The mixed gliomas were larger than the oligodendrogliomas and had a wider range of blood flow. Small focal areas of necrosis were observed in 7 mixed gliomas, and low flows were usually measured in these regions; these flows were not always the lowest regional values measured within the mixed gliomas or total group of tumors, however. Small tumor regions with increased vascularity, frequently with endothelial cell proliferation, were observed in oligodendrogliomas and to a greater extent in mixed gliomas; these regions were correlated with small elevations in blood flow (10 to 15 ml . hg-1 . min-1) in comparison with surrounding tumor tissue. Brain adjacent to tumor usually had higher blood flows than that in tumor periphery. Hemispheric differences in blood flow related to the site of primary tumor growth were not observed.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Annals Of Neurology. - 14 : 2 (1983), p. 189-201. -
További szerzők:Kobayashi, Tomowo Horowitz, Marc Rice, Jerry M. Groothuis, Dennis Molnár Péter Pál (1951-) (pathológus) Fenstermacher, Joseph D.
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6.

001-es BibID:BIBFORM029709
Első szerző:Blasberg, Ronald
Cím:Regional blood-to-tissue transport in ethylnitrosourea-induced brain tumors / Blasberg R. G., Kobayashi T., Horowitz M., Rice J. M., Groothuis D., Molnar P., Fenstermacher J. D.
Dátum:1983
ISSN:0364-5134
Megjegyzések:Regional blood-to-tissue transport, expressed as a unidirectional transfer rate constant (K), was measured in experimental brain tumors using alpha-aminoisobutyric acid (AIB) labeled with carbon 14 and quantitative autoradiography. A total of sixteen oligodendrogliomas, four mixed gliomas, three astrocytomas, two diffuse gliomatosis, one anaplastic astrocytoma, one ependymoma and four malignant schwannomas were studied in 9 rats. The mean Ks for all glioma classifications were similar, averaging 2.6 +/- 0.4 (standard error of the mean) ml . kg-1 . min-1, and were only slightly higher than those for nontumorous parietal cortex (2.1 ml . kg-1 . min-1), corpus callosum (0.9 ml . kg-1 . min-1), and a comparable region of brain tissue in the contralateral hemisphere (1.3 ml . kg-1 . min-1). Values of K varied minimally in the intracerebral gliomas and were marginally correlated with tumor cell morphology in only two tumors. In some (but not all) of the larger gliomas, increased vascularity, with or without endothelial proliferation, was associated with a 3- to 15-fold increase in K. Regional K values in malignant schwannomas were highly variable (4 to 207 ml . kg-1 . min-1) and generally were not correlated with specific histological features of the tumor, except in some regions with increased vascularity. Estimates of the average fractional extraction of AIB by the intracranial gliomas and malignant schwannomas were 0.01 and 0.2, respectively; average fractional extractions for nontumorous brain were approximately 0.003.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Annals Of Neurology. - 14 : 2 (1983), p. 202-215. -
További szerzők:Kobayashi, Tomowo Horowitz, Marc Rice, Jerry M. Groothuis, Dennis Molnár Péter Pál (1951-) (pathológus) Fenstermacher, Joseph D.
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7.

001-es BibID:BIBFORM029708
Első szerző:Blasberg, Ronald
Cím:Regional blood flow in RT-9 brain tumors / Blasberg R. G., Molnar P., Horowitz M., Kornblith P., Pleasants R., Fenstermacher J.
Dátum:1983
Megjegyzések:Regional blood flow (BF) was measured in RT-9 experimental brain tumors using carbon-14 labeled iodoantipyrine, the Kety tissue-exchange equations, and quantitative autoradiographic techniques. Blood flow was variable within tumor tissue, and the range of BF increased with increasing tumor size; the overall range was 6 to 138 ml/100 gm/min and the maximum range within an individual tumor was 55 ml/100 gm/min. In all but one case, mean tumor BF was less than that in the same anatomic region of the contralateral hemisphere (CBA). The magnitude of BF within individual tumor foci generally could be related to tumor size, location (intraparenchymal versus extraparenchymal), and the presence of necrosis or cysts; it was lower in the geometric centers than in the periphery of medium-sized and large tumors. Brain adjacent to tumor had higher BF's than the tumor periphery; generally, the BF in the brain adjacent to the tumor was less than that in the CBA. A global depression of BF was observed within tumor-free cortex and corpus callosum of the hemisphere ipsilateral to tumor implantation and primary growth, suggesting a hemispheric reduction in metabolic and functional activity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neurosurgery. - 58 : 6 (1983), p. 863-873. -
További szerzők:Molnár Péter Pál (1951-) (pathológus) Horowitz, Marc Kornblith, Paul Pleasants, Roger Fenstermacher, Joseph D.
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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8.

001-es BibID:BIBFORM029697
Első szerző:Blasberg, Ronald
Cím:Local blood flow in Walker 256 metastatic brain tumors / Blasberg R. G., Shapiro W. R., Molnar P., Patlak C. S., Fenstermacher J. D.
Dátum:1984
Megjegyzések:Local blood flow (F) in metastatic Walker 256 (WL-256) brain tumors produced by the intracarotid artery injection of WL-256 tumor cells in rats was measured using 14C-iodoantipyrine and quantitative autoradiography. Blood flow was variable in the tumors; the overall range was 2 to 222 ml hg-1 min-1 and the maximum range in an individual tumor extended over 150 ml hg-1 min-1. Small tumors had mean blood flows similar to surrounding brain. Medium to large tumors had significantly lower flows; the lowest values were usually measured in necrotic or cystic regions, although low values (less than 20 ml hg-1) were also measured in some viable-appearing tumor regions. Blood flow was significantly reduced in brain adjacent to medium and large but not small tumors. A global depression of brain and tumor blood flow was measured in two animals with hydrocephalus and the largest tumor burden. The blood flow patterns of the WL-256 metastatic tumor model are not uniquely different from other brain tumor models although some individual differences exist.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neuro-Oncology. - 2 : 3 (1984), p. 195-204. -
További szerzők:Shapiro, William R. Molnár Péter Pál (1951-) (pathológus) Patlak, Clifford S. Fenstermacher, Joseph D.
Internet cím:DOI
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9.

001-es BibID:BIBFORM029698
Első szerző:Blasberg, Ronald
Cím:Local blood-to-tissue transport in Walker 256 metastatic brain tumors / Blasberg R. G., Shapiro W. R., Molnar P., Patlak C. S., Fenstermacher J. D.
Dátum:1984
Megjegyzések:Local blood-to-tissue transfer constants (K) in metastatic Walker 256 (WL-256) brain tumors produced by the intracarotid artery injection of WL-256 tumor cells in rats were measured using 14C-alpha-aminoisobutyric acid and quantitative autoradiography. Small compact and diffuse infiltrative intraparenchymal tumors had values of K similar to that of contralateral nontumorous brain tissue. Medium and large tumors, meningeal metastases and intraventricular tumors had higher K values (5 to 30 fold) than contralateral nontumorous brain tissue indicating that intraparenchymal tumor size and location in meningeal and choroidal tissue influence the permeability of tumor capillaries. The local intratumor values of K varied considerably in these tumors and this variability of K correlated to only a few specific histopathologic features of the tumors. The value of K abruptly decreased at the tumor-brain interface when this interface was sharply defined, indicating that the metastatic tumors have only a small effect on the permeability of adjacent brain capillaries. Low blood-to-tumor transport of water soluble drugs will significantly affect drug concentrations in the tumor and the tumor-drug exposure.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neuro-Oncology. - 2 : 3 (1984), p. 205-218. -
További szerzők:Shapiro, William R. Molnár Péter Pál (1951-) (pathológus) Patlak, Clifford S. Fenstermacher, Joseph D.
Internet cím:DOI
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10.

001-es BibID:BIBFORM029685
Első szerző:Groothuis, Dennis
Cím:Regional blood flow in avian sarcoma virus (ASV)-induced brain tumors / Groothuis D., Blasberg R. G., Molnár P., Bigner D., Fenstermacher J. D.
Dátum:1983
ISSN:0340-5354
Megjegyzések:Regional blood flow (F) was measured in avian sarcoma virus (ASV)-induced brain tumors in rats. Blood flow was variable in individual as well as different tumors; tumor F did not correlate with histologic classification, tumor size, central versus peripheral tumor regions, intraparenchymal location, cell density, or specific cytologic characteristics. Low values of F did correlate with tumor necrosis and hydrocephalus; high values of F correlated with tumorous invasion or association with choroid plexus. Mean tumor F was not significantly different from that of the same anatomic, tumor-free brain region of the contralateral hemisphere, but F in brain tissue adjacent to the tumor was depressed significantly. Depression of F was observed in tumor-free cortex and corpus callosum, especially in the hemisphere ipsilateral to the main tumor mass and in those animals with hydrocephalus.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Neurology. - 33 : 6 (1983), p. 686-696. -
További szerzők:Blasberg, Ronald Molnár Péter Pál (1951-) (pathológus) Bigner, Darell Fenstermacher, Joseph D.
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11.

001-es BibID:BIBFORM029699
Első szerző:Groothuis, Dennis
Cím:Regional blood flow and blood-to-tissue transport in five brain tumor models. Implications for chemotherapy / Groothuis D. R., Molnar P., Blasberg R. G.
Dátum:1984
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Progress in Experimental Tumor Research. - 27 (1984), p. 132-153. -
További szerzők:Molnár Péter Pál (1951-) (pathológus) Blasberg, Ronald
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12.

001-es BibID:BIBFORM029689
Első szerző:Horowitz, Marc
Cím:Increased blood-brain transfer in a rabbit model of acute liver failure / Horowitz M. E., Schafer D. F., Molnar P., Jones E. A., Blasberg R. G., Patlak C. S., Waggoner J., Fenstermacher J. D.
Dátum:1983
ISSN:0944-1174
Megjegyzések:The blood-to-brain transfer of [14C]alpha-aminoisobutyric acid was investigated by quantitative autoradiography in normal rabbits and rabbits with acute liver failure induced by the selective hepatotoxin galactosamine. The blood-to-brain transfer of alpha-aminoisobutyric acid was similar in control animals and animals 2 and 7 h after galactosamine injections, but was increased five- to tenfold in certain gray-matter areas of the brain in animals 11 and 18 h after galactosamine treatment. No detectable differences in white-matter uptake of [14C]alpha-aminoisobutyric acid were found between the control and treated groups. The increase in alpha-aminoisobutyric acid transfer within the gray-matter areas suggested that a general or nonspecific increase in brain capillary permeability occurred in these areas. No clinical signs of early hepatic encephalopathy were observed in the treated rabbits, except for 1 animal from the 18-h postgalactosamine group. Thus, enhanced blood-brain transfer of alpha-aminoisobutyric acid preceded the development of overt hepatic encephalopathy. The distribution of radioactivity after the intravenous administration of [14C]galactosamine showed that virtually none of the hepatotoxin localized in the brain, suggesting that the drug itself does not have a direct effect upon the blood-brain barrier or the brain. The increased uptake of alpha-aminoisobutyric acid at 11 and 18 h implies that the transfer of other solutes would also be enhanced, that central nervous system homeostasis would be compromised, and that the resulting changes in brain fluid composition could contribute to or cause hepatic encephalopathy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Gastroenterology 84 : 5 Pt1 (1983), p. 1003-1011. -
További szerzők:Schafer, D. F. Molnár Péter Pál (1951-) (pathológus) Jones, E. Blasberg, Ronald Patlak, Clifford S. Waggoner, J. Fenstermacher, Joseph D.
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