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001-es BibID:	BIBFORM029697
Első szerző:	Blasberg, Ronald
Cím:	Local blood flow in Walker 256 metastatic brain tumors / Blasberg R. G., Shapiro W. R., Molnar P., Patlak C. S., Fenstermacher J. D.
Dátum:	1984
Megjegyzések:	Local blood flow (F) in metastatic Walker 256 (WL-256) brain tumors produced by the intracarotid artery injection of WL-256 tumor cells in rats was measured using 14C-iodoantipyrine and quantitative autoradiography. Blood flow was variable in the tumors; the overall range was 2 to 222 ml hg-1 min-1 and the maximum range in an individual tumor extended over 150 ml hg-1 min-1. Small tumors had mean blood flows similar to surrounding brain. Medium to large tumors had significantly lower flows; the lowest values were usually measured in necrotic or cystic regions, although low values (less than 20 ml hg-1) were also measured in some viable-appearing tumor regions. Blood flow was significantly reduced in brain adjacent to medium and large but not small tumors. A global depression of brain and tumor blood flow was measured in two animals with hydrocephalus and the largest tumor burden. The blood flow patterns of the WL-256 metastatic tumor model are not uniquely different from other brain tumor models although some individual differences exist.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Neuro-Oncology. - 2 : 3 (1984), p. 195-204. -
További szerzők:	Shapiro, William R. Molnár Péter Pál (1951-) (pathológus) Patlak, Clifford S. Fenstermacher, Joseph D.
Internet cím:	DOI
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001-es BibID:	BIBFORM029698
Első szerző:	Blasberg, Ronald
Cím:	Local blood-to-tissue transport in Walker 256 metastatic brain tumors / Blasberg R. G., Shapiro W. R., Molnar P., Patlak C. S., Fenstermacher J. D.
Dátum:	1984
Megjegyzések:	Local blood-to-tissue transfer constants (K) in metastatic Walker 256 (WL-256) brain tumors produced by the intracarotid artery injection of WL-256 tumor cells in rats were measured using 14C-alpha-aminoisobutyric acid and quantitative autoradiography. Small compact and diffuse infiltrative intraparenchymal tumors had values of K similar to that of contralateral nontumorous brain tissue. Medium and large tumors, meningeal metastases and intraventricular tumors had higher K values (5 to 30 fold) than contralateral nontumorous brain tissue indicating that intraparenchymal tumor size and location in meningeal and choroidal tissue influence the permeability of tumor capillaries. The local intratumor values of K varied considerably in these tumors and this variability of K correlated to only a few specific histopathologic features of the tumors. The value of K abruptly decreased at the tumor-brain interface when this interface was sharply defined, indicating that the metastatic tumors have only a small effect on the permeability of adjacent brain capillaries. Low blood-to-tumor transport of water soluble drugs will significantly affect drug concentrations in the tumor and the tumor-drug exposure.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Neuro-Oncology. - 2 : 3 (1984), p. 205-218. -
További szerzők:	Shapiro, William R. Molnár Péter Pál (1951-) (pathológus) Patlak, Clifford S. Fenstermacher, Joseph D.
Internet cím:	DOI
Borító:
Saját polcon: