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1.

001-es BibID:BIBFORM029712
Első szerző:Blasberg, Ronald
Cím:Concurrent measurements of blood flow and transcapillary transport in avian sarcoma virus-induced experimental brain tumors : implications for chemotherapy / Blasberg R., Molnar P., Groothuis D., Patlak C., Owens E., Fenstermacher J.
Dátum:1984
ISSN:0022-3565
Megjegyzések:A blood-to-tissue transfer constant, K, and tissue blood flow, F, were measured concurrently in seven rats with a total of 19 separate brain tumors induced by intracerebral inoculation of avian sarcoma virus. Regional and local measurements of K and F were obtained using double-label quantitative autoradiography with alpha-[14C]aminoisobutyric acid and [131I]iodoantipyrine, computerized microdensitometry and image analysis. Apparent tissue extraction fractions and capillary permeability-surface area products were calculated for different tumor regions, brain adjacent to tumor and tumor-free brain. The following observations were made: five histological categories of the tumors were found; significant local and regional variations of both K and F were typical in each group, resulting in marked regional variability of permeability-surface area products but more uniform values of apparent extraction fraction; the values of F, K, permeability-surface area products and apparent extraction fraction correlated poorly with morphological features of the tumors (necrosis, cellularity, cytology, location and size); the extraction fraction of alpha-aminoisobutyric acid was usually highest in tumor centers and then decreased in a gradient from tumor periphery through adjacent brain; and regardless of classification or histological features, capillary permeability and surface area, and not tissue perfusion or blood flow, seem to determine the blood-to-tissue transport processes (delivery of bloodborne materials) in most regions of these experimental brain tumors. An operational pharmacokinetic model of drug concentration in tumor tissue is developed and the results of our analysis indicate that increases in capillary permeability such as measured in these studies would not be sufficient to deliver adequate amounts of water-soluble drugs with short plasma half-lives to tumor tissue.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Pharmacology And Experimental Therapeutics. - 231 : 3 (1984), p. 724-735. -
További szerzők:Molnár Péter Pál (1951-) (pathológus) Groothuis, Dennis Patlak, Clifford S. Owens, E. Fenstermacher, Joseph D.
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2.

001-es BibID:BIBFORM029697
Első szerző:Blasberg, Ronald
Cím:Local blood flow in Walker 256 metastatic brain tumors / Blasberg R. G., Shapiro W. R., Molnar P., Patlak C. S., Fenstermacher J. D.
Dátum:1984
Megjegyzések:Local blood flow (F) in metastatic Walker 256 (WL-256) brain tumors produced by the intracarotid artery injection of WL-256 tumor cells in rats was measured using 14C-iodoantipyrine and quantitative autoradiography. Blood flow was variable in the tumors; the overall range was 2 to 222 ml hg-1 min-1 and the maximum range in an individual tumor extended over 150 ml hg-1 min-1. Small tumors had mean blood flows similar to surrounding brain. Medium to large tumors had significantly lower flows; the lowest values were usually measured in necrotic or cystic regions, although low values (less than 20 ml hg-1) were also measured in some viable-appearing tumor regions. Blood flow was significantly reduced in brain adjacent to medium and large but not small tumors. A global depression of brain and tumor blood flow was measured in two animals with hydrocephalus and the largest tumor burden. The blood flow patterns of the WL-256 metastatic tumor model are not uniquely different from other brain tumor models although some individual differences exist.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neuro-Oncology. - 2 : 3 (1984), p. 195-204. -
További szerzők:Shapiro, William R. Molnár Péter Pál (1951-) (pathológus) Patlak, Clifford S. Fenstermacher, Joseph D.
Internet cím:DOI
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3.

001-es BibID:BIBFORM029698
Első szerző:Blasberg, Ronald
Cím:Local blood-to-tissue transport in Walker 256 metastatic brain tumors / Blasberg R. G., Shapiro W. R., Molnar P., Patlak C. S., Fenstermacher J. D.
Dátum:1984
Megjegyzések:Local blood-to-tissue transfer constants (K) in metastatic Walker 256 (WL-256) brain tumors produced by the intracarotid artery injection of WL-256 tumor cells in rats were measured using 14C-alpha-aminoisobutyric acid and quantitative autoradiography. Small compact and diffuse infiltrative intraparenchymal tumors had values of K similar to that of contralateral nontumorous brain tissue. Medium and large tumors, meningeal metastases and intraventricular tumors had higher K values (5 to 30 fold) than contralateral nontumorous brain tissue indicating that intraparenchymal tumor size and location in meningeal and choroidal tissue influence the permeability of tumor capillaries. The local intratumor values of K varied considerably in these tumors and this variability of K correlated to only a few specific histopathologic features of the tumors. The value of K abruptly decreased at the tumor-brain interface when this interface was sharply defined, indicating that the metastatic tumors have only a small effect on the permeability of adjacent brain capillaries. Low blood-to-tumor transport of water soluble drugs will significantly affect drug concentrations in the tumor and the tumor-drug exposure.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Neuro-Oncology. - 2 : 3 (1984), p. 205-218. -
További szerzők:Shapiro, William R. Molnár Péter Pál (1951-) (pathológus) Patlak, Clifford S. Fenstermacher, Joseph D.
Internet cím:DOI
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4.

001-es BibID:BIBFORM029689
Első szerző:Horowitz, Marc
Cím:Increased blood-brain transfer in a rabbit model of acute liver failure / Horowitz M. E., Schafer D. F., Molnar P., Jones E. A., Blasberg R. G., Patlak C. S., Waggoner J., Fenstermacher J. D.
Dátum:1983
ISSN:0944-1174
Megjegyzések:The blood-to-brain transfer of [14C]alpha-aminoisobutyric acid was investigated by quantitative autoradiography in normal rabbits and rabbits with acute liver failure induced by the selective hepatotoxin galactosamine. The blood-to-brain transfer of alpha-aminoisobutyric acid was similar in control animals and animals 2 and 7 h after galactosamine injections, but was increased five- to tenfold in certain gray-matter areas of the brain in animals 11 and 18 h after galactosamine treatment. No detectable differences in white-matter uptake of [14C]alpha-aminoisobutyric acid were found between the control and treated groups. The increase in alpha-aminoisobutyric acid transfer within the gray-matter areas suggested that a general or nonspecific increase in brain capillary permeability occurred in these areas. No clinical signs of early hepatic encephalopathy were observed in the treated rabbits, except for 1 animal from the 18-h postgalactosamine group. Thus, enhanced blood-brain transfer of alpha-aminoisobutyric acid preceded the development of overt hepatic encephalopathy. The distribution of radioactivity after the intravenous administration of [14C]galactosamine showed that virtually none of the hepatotoxin localized in the brain, suggesting that the drug itself does not have a direct effect upon the blood-brain barrier or the brain. The increased uptake of alpha-aminoisobutyric acid at 11 and 18 h implies that the transfer of other solutes would also be enhanced, that central nervous system homeostasis would be compromised, and that the resulting changes in brain fluid composition could contribute to or cause hepatic encephalopathy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Gastroenterology 84 : 5 Pt1 (1983), p. 1003-1011. -
További szerzők:Schafer, D. F. Molnár Péter Pál (1951-) (pathológus) Jones, E. Blasberg, Ronald Patlak, Clifford S. Waggoner, J. Fenstermacher, Joseph D.
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5.

001-es BibID:BIBFORM029819
Első szerző:Molnár Péter Pál (pathológus)
Cím:[Macroscopic quantitative autoradiography (QAR) : II. Studies on transport and metabolism] / Molnar P., Groothuis D. R., Blasberg R. G., Patlak C., Fenstermacher J. D.
Dátum:1986
ISSN:0019-1442
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
Megjelenés:Ideggyógyászati Szemle. - 39 (1986), p. 379-388. -
További szerzők:Groothuis, Dennis Blasberg, Ronald Patlak, Clifford S. Fenstermacher, Joseph D.
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6.

001-es BibID:BIBFORM029818
Első szerző:Molnár Péter Pál (pathológus)
Cím:[Macroscopic quantitative autoradiography (QAR) : I. Historical survey, theoretical basis, and measurements of blood flow] / Molnar P., Groothuis D. R., Blasberg R. G., Patlak C., Fenstermacher J. D.
Dátum:1986
ISSN:0019-1442
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
Megjelenés:Ideggyógyászati Szemle. - 39 (1986), p. 379-388. -
További szerzők:Groothuis, Dennis Blasberg, Ronald Patlak, Clifford S. Fenstermacher, Joseph D.
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