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001-es BibID:	BIBFORM055442
Első szerző:	Molnár Péter Pál (pathológus)
Cím:	Malignant infantile granular cell tumor. The youngest patient so far reported with successful treatment / P. Molnar, F. Kiss, I. Szegedi, E. Berenyi, B. W. Scheithauer
Dátum:	2011
ISSN:	0305-1846
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:	Neuropathology and Applied Neurobiology. - 37 (2011), p. 39-40. -
További szerzők:	Kiss F. Szegedi István (1969-) (hematológus, onkológus, nefrológus) Berényi E. Scheithauer, Bernd W.
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001-es BibID:	BIBFORM055456
Első szerző:	Molnár Péter Pál (pathológus)
Cím:	Functional and ultrastructural features of the blood-tumor barrier in experimental and human brain tumors / P. P. Molnar, B. P. O'Neill, B. W. Scheithauer, D.Groothuis
Dátum:	1996
ISSN:	1522-8517
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:	Neuro-Oncology. - 30 (1996), p. 119. -
További szerzők:	O'Neill, Brian P. Scheithauer, Bernd W. Groothuis, Dennis
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001-es BibID:	BIBFORM029721
Első szerző:	Molnár Péter Pál (pathológus)
Cím:	The blood-brain barrier in primary CNS lymphomas : ultrastructural evidence of endothelial cell death / Molnár P. P., O'Neill B. P., Scheithauer B. W., Groothuis D. R.
Dátum:	1999
ISSN:	1522-8517
Megjegyzések:	The vasculature of 24 primary CNS B-cell lymphomas that were not related to acquired immunodeficiency syndrome was systematically studied by electron microscopy. Seven low-grade astrocytic tumors were included for comparison. Classical electron microscopy features of apoptosis were found in lymphoma cells of 21 of 22 subjects. Capillaries of gliomas and lymphomas showed changes reported previously: variability of endothelial cell (EC)-thickness and number, basal lamina thickness and duplication, and fenestrations. Primary CNS B-cell lymphoma ECs showed two distinctive populations of electron-dense and electron-lucent cells. The electron-dense ECs occurred in 38% of all capillaries, with changes consisting of chromatin condensation in bizarre and contracted nuclei, cytoplasmic shrinkage with markedly increased electron density, and dilatation of the endoplasmic reticulum. We interpreted these changes as indicative of apoptosis. Cell death eventually resulted in complete disintegration of the endothelium with frank discontinuities of the EC component of the blood-tumor barrier in capillaries and postcapillary venules. Another population of ECs had increased cell volume, conspicuous cytoplasmic electron lucency, dispersed organelles, scattered vesicles, and apical stress fibers. We interpreted these changes as indicative of cellular regeneration. Individual apoptotic ECs often lay next to normal or regenerating ECs. Neither type of EC change was observed in gliomas, which also lacked perivascular neoplastic lymphocytic cuffing. We believe that these populations of ECs, which have not been described in other disorders affecting the blood-brain barrier, may be induced by cytokines released from necrotic and/or apoptotic tumor lymphocytes and may explain the unusual imaging characteristics of primary CNS B-cell lymphomas treated with corticosteroids.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Neuro-Oncology. - 1 : 2 (1999), p. 89-100. -
További szerzők:	O'Neill, Brian P. Scheithauer, Bernd W. Groothuis, Dennis
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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