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001-es BibID:	BIBFORM030681
Első szerző:	Papp Zoltán (kardiológus, élettanász)
Cím:	How cardiomyocytes make the heart old / Papp Z., Czuriga D., Balogh L., Balogh A., Borbély A.
Dátum:	2012
ISSN:	1389-2010
Megjegyzések:	Naturally occurring decline in cardiovascular reserve with age associates with a combination of the reduction in cardiomyocyte number and altered cardiomyocyte function. Recent investigations suggested that about half of the cardiomyocytes is the same as at birth, while the other half of the cardiomyocytes is the result of cardiomyocyte renewal in the senescent heart. In addition, the total number of cardiomyocytes is estimated to be less by one third in the old heart than the number of cardiomyocytes at birth. Thus, the reduction in cardiomyocyte number of the aging heart cannot be fully compensated by cardiomyocyte renewal. Aging of long-lived differentiated myocardial cells, as well as of cardiac progenitor stem cells may contribute to an increased rate of apoptosis, and decreased capacity of cell duplication and/or differentiation. In addition, differentiated cardiomyocytes are prone for accumulating biological by-products of cellular metabolism and of incompletely processed oxidative insults. In this context, interactions between lysosomes and mitochondria may provide a mechanistic background for the age-dependent alterations in cardiac macromolecules. This reasoning postulates a direct relationship between the number of pro-oxidative, ill-functioning mitochondria and the amount of ballast-overloaded lysosomes in long-lived cardiomyocytes. Accumulation of biological garbage and telomere shortening might be considered as hallmarks of cardiomyocyte aging with implications for depressed cardiac function and cardiomyocyte renewal. Changes in protein expression together with posttranslational modifications of myocardial proteins affect excitation-contraction coupling and explain the declining mechanical function of the cardiomyocytes. Altogether, these changes represent a significant part of the reduced cardiovascular reserve in aged individuals.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Egészség- és Környezettudomány Aging Cardiomyocyte cell death Cardiomyocyte renewal Telomere
Megjelenés:	Current Pharmaceutical Biotechnology. - 13 : 13 (2012), p. 2515-2521. -
További szerzők:	Czuriga Dániel (1982-) (kardiológus) Balogh László (1976-) (kardiológus) Balogh Ágnes (1984-) (kardiológus) Borbély Attila (1978-) (kardiológus)
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Vascularis rizikó- és stroke betegek vizsgálata
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM101808
035-os BibID:	(cikkazonosító)1132 (WoS)000803448700001 (Scopus)85130014816
Első szerző:	Sepp Róbert
Cím:	The Genetic Architecture of Hypertrophic Cardiomyopathy in Hungary : analysis of 242 Patients with a Panel of 98 Genes / Sepp Róbert, Hategan Lidia, Csányi Beáta, Borbás János, Tringer Annamária, Pálinkás Eszter Dalma, Nagy Viktória, Takács Hedvig, Latinovics Dóra, Nyolczas Noémi, Pálinkás Attila, Faludi Réka, Rábai Miklós, Szabó Gábor Tamás, Czuriga Dániel, Balogh László, Halmosi Róbert, Borbély Attila, Habon Tamás, Hegedűs Zoltán, Nagy István
Dátum:	2022
ISSN:	2075-4418
Megjegyzések:	Hypertrophic cardiomyopathy (HCM) is a primary disease of the myocardium most commonly caused by mutations in sarcomeric genes. We aimed to perform a nationwide large-scale genetic analysis of a previously unreported, representative HCM cohort in Hungary. A total of 242 consecutive HCM index patients (127 men, 44 11 years) were studied with next generation sequencing using a custom-designed gene-panel comprising 98 cardiomyopathy-related genes. A total of 90 patients (37%) carried pathogenic/likely pathogenic (P/LP) variants. The percentage of patients with P/LP variants in genes with definitive evidence for HCM association was 93%. Most of the patients with P/LP variants had mutations in MYBPC3 (55 pts, 61%) and in MYH7 (21 pts, 23%). Double P/LP variants were present in four patients (1.7%). P/LP variants in other genes could be detected in 3% of patients. Of the patients without P/LP variants, 46 patients (19%) carried a variant of unknown significance. Non-HCM P/LP variants were identified in six patients (2.5%), with two in RAF1 (p.Leu633Val, p.Ser257Leu) and one in DES (p.Arg406Trp), FHL1 (p.Glu96Ter), TTN (p.Lys23480fs), and in the mitochondrial genome (m.3243A>G). Frameshift, nonsense, and splice-variants made up 82% of all P/LP MYBPC3 variants. In all the other genes, missense mutations were the dominant form of variants. The MYBPC3 p.Gln1233Ter, the MYBPC3 p.Pro955ArgfsTer95, and the MYBPC3 p.Ser593ProfsTer11 variants were identified in 12, 7, and 13 patients, respectively. These three variants made up 36% of all patients with identified P/LP variants, raising the possibility of a possible founder effect for these mutations. Similar to other HCM opulations, the MYBPC3 and the MYH7 genes seemed to be the most frequently affected genes in Hungarian HCM patients. The high prevalence of three MYBPC3 mutations raises the possibility of a founder effect in our HCM cohort.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk hypertrophic cardiomyopathy genetic analysis genetic variant
Megjelenés:	Diagnostics. - 12 : 5 (2022), p. 1-12. -
További szerzők:	Hategan, Lidia Csányi Beáta Borbás János Tringer Annamária Pálinkás Eszter Dalma Nagy Viktória (1989-) (vegyész és kémia tanár) Takács Hedvig Latinovics Dóra Nyolczas Noémi Pálinkás Attila Faludi Réka Rábai Miklós Szabó Gábor Tamás (1982-) (kardiológus) Czuriga Dániel (1982-) (kardiológus) Balogh László (1976-) (kardiológus) Halmosi Róbert Borbély Attila (1978-) (kardiológus) Habon Tamás Hegedűs Zoltán Nagy István Péter (1964-) (vegyész, kémikus)
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