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001-es BibID:	BIBFORM023862
Első szerző:	Csongrádi Éva (szakorvos)
Cím:	Increased levels of platelet activation markers are positively associated with carotid wall thickness and other atherosclerotic risk factors in obese patients / Csongrádi Éva, Nagy Béla Jr., Fülöp Tamás, Varga Zsuzsa, Karányi Zsolt, Magyar Mária T., Oláh László, Papp Mária, Facskó Andrea, Kappelmayer János, Paragh György, Káplár Miklós
Dátum:	2011
ISSN:	0340-6245
Megjegyzések:	The role of platelets in the development of atherosclerosis and obesity-related prothrombotic state is still under investigation. In this cross-sectional cohort study, we measured the levels of different platelet activation markers and evaluated their relationship with carotid intima-media thickness (IMT) along with other atherosclerotic risk factors in obese patients with or without atherosclerotic co-morbidities. We enrolled 154 obese patients, including 98 with either hypertension, type 2 diabetes mellitus or dyslipidaemia, 56 without these co-morbidities and 62 age- and sex-matched healthy controls. Platelet P-selectin expression and the number of platelet-derived microparticles (PMPs) were measured by flow cytometry; soluble P-selectin levels were analysed by ELISA and Thr715Pro P-selectin polymorphism was determined by PCR-RFLP. Carotid IMT was examined by ultrasonography. The levels of platelet activation parameters were significantly elevated in all obese subjects with increased carotid IMT compared to healthy controls. There was no effect of Thr715Pro genotype on soluble P-selectin levels in obese individuals contrary to normal subjects. Significant and positive association was revealed between carotid IMT and platelet P-selectin (p<0.0001), soluble P-selectin (p=0.039) and PMP (p=0.0001) levels. After adjusting for multiple variables, independent association was found between soluble P-selectin and fibrinogen (p=0.007), PMP levels and body mass index (p<0.0001) as well as platelet P-selectin and carotid IMT (p=0.012) plus plasminogen activator inhibitor-1 (p=0.009). In conclusion, P-selectin and PMP levels showed positive associations with abnormal carotid IMT and other risk factors in obesity suggesting a critical role of enhanced platelet reactivity in atherosclerotic wall alteration.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Thrombosis And Haemostasis 106 : 4 (2011), p. 683-692. -
További szerzők:	Nagy Béla Jr. (1980-) (labordiagnosztikai szakorvos) Fülöp Tamás (1928-) (népegészségügyi szakember, egészségfejlesztő) Varga Zsuzsa (1951-) (biokémikus, nephrológus) Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Magyar Mária Tünde (1970-) (neurológus) Oláh László (1967-) (neurológus) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Facskó Andrea (1953-) (szemész) Kappelmayer János (1960-) (laboratóriumi szakorvos) Paragh György (1953-) (belgyógyász) Káplár Miklós (1965-) (belgyógyász, diabetológus)
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001-es BibID:	BIBFORM063221
Első szerző:	Tornai Tamás István (belgyógyász)
Cím:	Macrophage activation marker, soluble CD163 is an independent predictor of short-term mortality in patients with cirrhosis and bacterial infection / Tornai Tamas, Vitalis Zsuzsanna, Sipeki Nora, Dinya Tamas, Tornai David, Antal-Szalmas Peter, Karanyi Zsolt, Tornai Istvan, Papp Maria
Dátum:	2016
ISSN:	1478-3223
Megjegyzések:	BACKGROUND&AIMS: Innate immune system dysfunction is common in advanced cirrhosis, with a central role of the monocyte/macrophage system. Monocytes and macrophages express the scavenger receptor CD163 which is regulated by inflammatory mediators. Cleavage of the receptor leads to formation of soluble (s)CD163, that represents anti-inflammatory response. We aimed to study the clinical importance of sCD163 in cirrhosis.METHODS:Sera of 378 patients were assayed for sCD163 by ELISA (193 outpatients and 185 patients with acute decompensation[AD]). A 5-year follow-up observational study was conducted to assess the possible association between sCD163 level and poor disease outcomes.RESULTS: sCD163 level was associated with disease severity, but not with the presence of varices or prior variceal bleeding. In outpatients, sCD163 level did not predict the development of disease-specific complications or the long-term mortality. In patients with AD episode, sCD163 level was significantly higher compared to outpatients but only in the presence of bacterial infection[INF] (AD-INF:4586, AD-NON-INF:3792 and outpatients: 3538ng/mL, p<0.015 and p=0.001, respectively). sCD163 level gradually increased according to severity of infection. During bacterial infections, high sCD163 level(>7000ng/mL) was associated with increased mortality rate (42% vs. 17%, p<0.001) and was identified as an independent predictor of 28-day mortality (HR:2.96, 95%CI:1.27-6.95) in multivariate Cox-regression model comprising etiology, co-morbidity, MELD score and leukocyte count as covariates.CONCLUSIONS:High sCD163 level is useful to identify patients with high-risk of death during an AD episode complicated by bacterial infection. This finding serves as an additional hint towards the significance of anti-inflammatory response during bacterial infection. This article is protected by copyright. All rights reserved.This article is protected by copyright. All rights reserved.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban sCD163 cirrhosis anti-inflammatory response
Megjelenés:	Liver International 36 : 11 (2016), p. 1628-1638. -
További szerzők:	Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Sipeki Nóra (1987-) (általános orvos) Dinya Tamás (1974-) (sebész szakorvos, onkológus szakorvos) Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Karányi Zsolt (1961-) (biostatisztikus, bioinformatikus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
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