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1.

001-es BibID:BIBFORM087410
Első szerző:Gatselis, Nikolaos K.
Cím:Golgi protein-73 : a biomarker for assessing cirrhosis and prognosis of liver disease patients / Nikolaos K. Gatselis, Tamás Tornai, Zakera Shums, Kalliopi Zachou, Asterios Saitis, Stella Gabeta, Roger Albesa, Gary L. Norman, Mária Papp, George N. Dalekos
Dátum:2020
ISSN:1007-9327
Megjegyzések:Abstract BACKGROUND Reliable biomarkers of cirrhosis, hepatocellular carcinoma (HCC), or progression of chronic liver diseases are missing. In this context, Golgi protein-73 (GP73) also called Golgi phosphoprotein-2, was originally defined as a resident Golgi type II transmembrane protein expressed in epithelial cells. As a result, GP73 expression was found primarily in biliary epithelial cells, with only slight detection in hepatocytes. However, in patients with acute or chronic liver diseases and especially in HCC, the expression of GP73 is significantly up-regulated in hepatocytes. So far, few studies have assessed GP73 as a diagnostic or prognostic marker of liver fibrosis and disease progression. AIM To assess serum GP73 efficacy as a diagnostic marker of cirrhosis and/or HCC or as predictor of liver disease progression. METHODS GP73 serum levels were retrospectively determined by a novel GP73 ELISA (QUANTA Lite? GP73, Inova Diagnostics, Inc., Research Use Only) in a large cohort of 632 consecutive patients with chronic viral and non-viral liver diseases collected from two tertiary Academic centers in Larissa, Greece (n=366) and Debrecen, Hungary (n=266). Aspartate aminotransferase (AST)/Platelets (PLT) ratio index (APRI) was also calculated at the relevant time points in all patients. Two hundred and three patients had chronic hepatitis B, 183 chronic hepatitis C, 198 alcoholic liver disease, 28 autoimmune cholestatic liver diseases, 15 autoimmune hepatitis, and 5 with other liver-related disorders. The duration of follow-up was 50 (57) mo [median (interquartile range)]. The development of cirrhosis, liver decompensation and/or HCC during follow-up were assessed according to internationally accepted guidelines. In particular, the surveillance for the development of HCC was performed regularly with ultrasound imaging and alpha-fetoprotein (AFP) determination every 6 mo in cirrhotic and every 12 mo in non-cirrhotic patients. RESULTS Increased serum levels of GP73 (> 20 units) were detected at initial evaluation in 277 out of 632 patients (43.8%). GP73-seropositivity correlated at baseline with the presence of cirrhosis (96.4% vs 51.5%, P < 0.001), decompensation of cirrhosis (60.3% vs 35.5%, P < 0.001), presence of HCC (18.4% vs 7.9%, P < 0.001) and advanced HCC stage (52.9% vs 14.8%, P = 0.002). GP73 had higher diagnostic accuracy for the presence of cirrhosis compared to APRI score [Area under the curve (AUC) (95%CI): 0.909 (0.885-0.934) vs 0.849 (0.813-0.886), P = 0.003]. Combination of GP73 with APRI improved further the accuracy (AUC: 0.925) compared to GP73 (AUC: 0.909, P = 0.005) or APRI alone (AUC: 0.849, P < 0.001). GP73 levels were significantly higher in HCC patients compared to non-HCC [22.5 (29.2) vs 16 (20.3) units, P < 0.001) and positively associated with BCLC stage [stage 0: 13.9 (10.8); stage A: 17.1 (16.8); stage B: 19.6 (22.3); stage C: 32.2 (30.8); stage D: 45.3 (86.6) units, P < 0.001] and tumor dimensions [very early: 13.9 (10.8); intermediate: 19.6 (18.4); advanced: 29.1 (33.6) units, P = 0.004]. However, the discriminative ability for HCC diagnosis was relatively low [AUC (95%CI): 0.623 (0.570-0.675)]. Kaplan-Meier analysis showed that the detection of GP73 in patients with compensated cirrhosis at baseline, was prognostic of higher rates of decompensation (P = 0.036), HCC development (P = 0.08), and liver-related deaths (P < 0.001) during follow-up. CONCLUSION GP73 alone appears efficient for detecting cirrhosis and superior to APRI determination. In combination with APRI, its diagnostic performance can be further improved. Most importantly, the simple GP73 measurement proved promising for predicting a worse outcome of patients with both viral and non-viral chronic liver diseases.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:World Journal of Gastroenterology. - 26 : 34 (2020), p. 5130-5145. -
További szerzők:Tornai Tamás István (1984-) (belgyógyász) Shums, Zakera Zachou, Kalliopi Saitis, Asterios Gabeta, Stella Albesa, Roger Norman, Gary L. Papp Mária (1975-) (belgyógyász, gasztroenterológus) Dalekos, George N.
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2.

001-es BibID:BIBFORM072903
035-os BibID:(cikkazonosító)e0194166 (WOS)000428603100051 (Scopus)85044720189
Első szerző:Kovács György (belgyógyász, gasztroenterológus)
Cím:Significance of serological markers in the disease course of ulcerative colitis in a prospective clinical cohort of patients / Gyorgy Kovacs, Nora Sipeki, Boglarka Suga, Tamas Tornai, Kai Fechner, Gary L. Norman, Zakera Shums, Peter Antal-Szalmas, Maria Papp
Dátum:2018
ISSN:1932-6203
Megjegyzések:Background & aimsTo determine the prognostic potential of classic and novel serologic antibodies regarding unfavorable disease course in a prospective ulcerative colitis (UC) patient cohort, since few and conflicting data are available in the literature regarding this matter.Methods187 consecutive patients were studied prospectively (median follow-up: 135 months) from a single referral IBD center in Hungary. Sera were tested for different IgA/IgG type autoantibodies (anti-neutrophil cytoplasmic [ANCA], anti-DNA-bound-lactoferrin [anti-LFS], anti-goblet cell [anti-GAB] and anti-pancreatic [PAB: anti-CUZD1 and anti-GP2)]) by indirect immunofluorescence technique and for anti-microbial (anti-Saccharomyces cerevisiae [ASCA] IgG/IgA and anti-OMP Plus? IgA) antibodies by enzyme-linked immunosorbent assays.ResultsA total of 73.6%, 62.4% and 11.2% of UC patients were positive for IgA/IgG type of atypical perinuclear-ANCA, anti-LFS and anti-GAB, respectively. Occurrences of PABs were 9.6%, while ASCA IgA/IgG and anti-OMP IgA were 17.6% and 19.8%, respectively. Antibody status was stable over time. IgA type PABs were more prevalent in patients with primary sclerosing cholangitis (37.5% vs. 4.7% for anti-CUZD1 and 12.5% vs. 0% for anti-GP2, p<0.001 for both). IgA type ASCA and anti-CUZD1 antibodies were associated with higher risk of requirement for long-term immunosuppressant therapy in Kaplan-Meier analysis (pLogRank <0.01 for both). However, in multivariate Cox-regression analysis only ASCA IgA (HR: 2.74, 95%CI: 1.46?5.14, p<0.01) remained independent predictor. UC-related hospitalization due to disease activity was only associated with multiple antibody positivity (for 3 or more; HR 2.03 [95% CI: 1.16?3.56]; p = 0.013). None of the individual antibodies or their combination was associated with the risk of development of extensive disease or colectomy.ConclusionEven with low prevalence rates, present study gives further evidence to the role of certain antibodies as markers for distinct phenotype and disease outcome in UC. Considering the result of the multivariate analysis the novel antibodies investigated do not seem to be associated with poor clinical outcome in UC, only a classic antibody, IgA subtype ASCA remained an independent predictor of long-term immunosuppressive therapy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Plos One. - 13 : 3 (2018), p. 1-18. -
További szerzők:Sipeki Nóra (1987-) (általános orvos) Suga Boglárka Tornai Tamás István (1984-) (belgyógyász) Fechner, Kai Norman, Gary L. Shums, Zakera Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Pályázati támogatás:OTKA-115818
OTKA
RH/885/2013
Egyéb
BO/00426/11
Egyéb
IOIBD Research Grant (2012-2015)
Egyéb
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3.

001-es BibID:BIBFORM059587
Első szerző:Lakatos Péter (Semmelweis Egyetem)
Cím:Risk matrix for prediction of disease progression in a referral cohort of patients with Crohn's disease / Peter L. Lakatos, Nora Sipeki, Gyorgy Kovacs, Eszter Palyu, Gary L. Norman, Zakera Shums, Petra A. Golovics, Barbara D. Lovasz, Peter Antal-Szalmas, Maria Papp
Dátum:2015
Megjegyzések:BACKGROUND: Early identification of patients with Crohn's disease (CD) at riskfor subsequent complications is essential for adapting treatment strategy. Weaimed to develop a prediction model including clinical and serologic markers for assessing the probability of developing advanced disease in a prospectivereferral CD cohort.PATIENT AND METHODS: 271 consecutive CD patients (42.4% males, median follow-up: 108 months) were included and followed-up prospectively. Anti-Saccharomycescerevisiae antibodies (ASCA IgA/IgG) antibodies were determined by enzyme-linked immunosorbent assay (ELISA). The final analysis was limited to patients withinflammatory disease behaviour at diagnosis. The final definition for advanceddisease outcome was having intestinal resection or disease behaviour progression.RESULTS: ASCA (IgA and/or IgG) status, disease location, and need for earlyazathioprine (AZA) were included in a 3-, 5- and 7-year prediction matrix. Theprobabilities of advanced disease after 5-years varied from 6.2% to 55% dependingon the combination of predictors. Similar findings were obtained in Kaplan-Meier analysis, the combination of ASCA, location and early use for AZA was associated with the probability to develop advanced disease (pLogRank<0.001).CONCLUSION: Our prediction models identified substantial differences in theprobability of developing advanced disease in the early disease course of CD.Markers identified in this referral cohort were different from those previouslypublished in a population-based cohort suggesting that different predictionmodels should be used in referral setting.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
ASCA; Crohn's disease; azathioprine; disease progression; referral cohort; serologic antibodies
Megjelenés:Journal of Crohn's & colitis. - 9 : 10 (2015), p. 891-898. -
További szerzők:Sipeki Nóra (1987-) (általános orvos) Kovács György (1982-) (belgyógyász, gasztroenterológus) Pályu Eszter (1983-) Norman, Gary L. Shums, Zakera Golovics Petra Anna Lovász Barbara Dorottya Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
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4.

001-es BibID:BIBFORM058617
Első szerző:Papp Mária (belgyógyász, gasztroenterológus)
Cím:Rediscovery of the anti-pancreatic antibodies and evaluation of their prognostic value in a prospective clinical cohort of Crohn's patients : the importance of specific target antigens (GP2 and CUZD1) / Maria Papp, Nora Sipeki, Tamas Tornai, Istvan Altorjay, Gary L. Norman, Zakera Shums, Dirk Roggenbuck, Kai Fechner, Winfried Stöcker, Peter Antal-Szalmas, Gabor Veres, Peter Laszlo Lakatos
Dátum:2015
ISSN:1873-9946
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
serologic antibodies
anti-pancreatic antibodies
glycoprotein CUZD1
glycoprotein 2
immunoglobulin A
Crohn's disease
ulcerative colitis
disease progression
Megjelenés:Journal of Crohns & Colitis. - 9 : 8 (2015), p. 659-668. -
További szerzők:Sipeki Nóra (1987-) (általános orvos) Tornai Tamás István (1984-) (belgyógyász) Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) Norman, Gary L. Shums, Zakera Roggenbuck, Dirk Fechner, Kai Stocker, Winfried Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Veres Gábor (orvos) Lakatos Péter (Semmelweis Egyetem)
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5.

001-es BibID:BIBFORM013687
Első szerző:Papp Mária (belgyógyász, gasztroenterológus)
Cím:Presence of Anti-Microbial Antibodies in Liver Cirrhosis : a Tell-Tale Sign of Compromised Immunity? / Papp Maria, Norman Gary L., Vitalis Zsuzsanna, Tornai Istvan, Altorjay Istvan, Földi Ildikó, Udvardy Miklos, Shums Zakera, Dinya Tamas, Orosz Peter, Lombay Bela, Par Gabriella, Par Alajos, Veres Gabor, Csak Timea, Osztovits Janos, Szalay Ferenc, Lakatos Peter Laszlo
Dátum:2010
ISSN:0163-2116
Megjegyzések:Bacterial translocation plays important role in the complications of liver cirrhosis. Antibody formation against various microbial antigens is common in Crohn's disease and considered to be caused by sustained exposure to gut microflora constituents. We hypothesized that anti-microbial antibodies are present in patients with liver cirrhosis and may be associated with the development of bacterial infections. Methodology/Principal Findings: Sera of 676 patients with various chronic liver diseases (autoimmune diseases:266, viral hepatitis C:124, and liver cirrhosis of different etiology:286) and 100 controls were assayed for antibodies to Saccharomyces cerevisiae(ASCA) and to antigens derived from two intestinal bacterial isolates (one gram positive, one gram negative, neither is Escherichia coli). In patients with liver cirrhosis, we also prospectively recorded the development of severe episodes of bacterial infection. ASCA and anti-OMP PlusTM antibodies were present in 38.5% and 62.6% of patients with cirrhosis and in 16% and 20% of controls, respectively (p,0.001). Occurrence of these antibodies was more frequent in cases of advanced cirrhosis (according to Child-Pugh and MELD score; p,0.001) or in the presence of ascites (p,0.001). During the median follow-up of 425 days, 81 patients (28.3%) presented with severe bacterial infections. Anti-microbial antibody titers (p = 0.003), as well as multiple seroreactivity (p = 0.036), was associated with infectious events. In logistic regression analysis, the presence of ascites (OR:1.62, 95%CI:1.16?2.25), co-morbidities (OR:2.22, 95%CI:1.27?3.86), and ASCA positivity (OR:1.59, 95%CI:1.07?2.36) were independent risk factors for severe infections. A shorter time period until the first infection was associated with the presence of ASCA (p = 0.03) and multiple seropositivity (p = 0.037) by Kaplan-Meier analysis, and with Child-Pugh stage (p = 0.018, OR:1.85) and co-morbidities (p,0.001, OR:2.02) by Cox-regression analysis. Conclusions/Significance: The present study suggests that systemic reactivity to microbial components reflects compromised mucosal immunity in patients with liver cirrhosis, further supporting the possible role of bacterial translocation in the formation of anti-microbial antibodies.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Haptoglobin polymorphism
Crohn's disease
Disease behavior
Th1/Th2 orientation
Primary sclerosing cholangitis
egyetemen (Magyarországon) készült közlemény
Megjelenés:PloS One. - 5 : 9 (2010), p. e12957-1-e12957-9. -
További szerzők:Norman, Gary L. Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) Földi Ildikó (1981-) (orvos) Udvardy Miklós (1947-) (belgyógyász, haematológus) Shums, Zakera Dinya Tamás (1974-) (sebész szakorvos, onkológus szakorvos) Orosz Péter (Miskolc) Lombay Béla Jr. Pár Gabriella Pár Alajos Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus) Csak Timea Osztovits János Szalay Ferenc (belgyógyász) Lakatos Péter (Semmelweis Egyetem)
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6.

001-es BibID:BIBFORM002139
Első szerző:Papp Mária (belgyógyász, gasztroenterológus)
Cím:Seroreactivity to microbial components in Crohn's disease is associated with ileal involvement, noninflammatory disease behavior and NOD2/CARD15 genotype, but not with risk for surgery in a Hungarian cohort of IBD patients / Papp M., Altorjay I., Norman G. L., Shums Z., Palatka K., Vitalis Z., Foldi I., Lakos G., Tumpek J., Udvardy M. L., Harsfalvi J., Fischer S., Lakatos L., Kovacs A., Bene L., Molnar T., Tulassay Z., Miheller P., Veres G., Papp J., Lakatos P. L.
Dátum:2007
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Inflammatory Bowel Disease 13 : 8 (2007), p. 984-992. -
További szerzők:Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) Norman, Gary L. Shums, Zakera Palatka Károly (1961-) (belgyógyász, gasztroenterológus) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Földi Ildikó (1981-) (orvos) Lakos Gabriella (1963-) (laboratóriumi szakorvos, transzfúziológus, immunológus) Tumpek Judit (1944-) (orvosi laboratóriumi szakorvos) Udvardy Miklós László (1977-) (orvos, tudományos segédmunkatárs) Hársfalvi Jolán (1949-) (klinikai biokémikus) Fischer Simon Lakatos László (orvos Budapest) Kovács Ágota Bene László (Budapest) Molnár Tamás (orvos) Tulassay Zsolt (1944-) (belgyógyász, gasztroenterológus) Miheller Pál Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus) Papp János (orvos Veszprém) Lakatos Péter (Semmelweis Egyetem)
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7.

001-es BibID:BIBFORM056692
Első szerző:Pavlidis, Polychronis
Cím:Diagnostic and clinical significance of Crohn's disease-specific anti-MZGP2 pancreatic antibodies by a novel ELISA / Polychronis Pavlidis, Zakera Shums, Andreas L. Koutsoumpas, Jay Milo, Maria Papp, Takeji Uemurea, Peter Lakatos, Daniel S. Smyk, Dimitrios P. Bogdanos, Alastair Forbes, Gary L. Norman
Dátum:2015
ISSN:0009-8981
Megjegyzések:BACKGROUND:We developed a new IgA and IgG anti-MZGP2 antibody ELISAs based on recombinant isoform-4 of human zymogen granule protein-2 (GP2), which is the major autoantigen of Crohn's disease (CrD)-specific pancreatic autoantibodies and assessed their clinical relevance in the largest inflammatory bowel disease (IBD) cohort tested to date.METHODS:832 sera were studied, including 617 consecutive IBD patients from 323 CrD and 294 ulcerative colitis (UC) follow-up in a tertiary centre, and 112 pathological and 103 normal controls.RESULTS:Sensitivity of IgA anti-MZGP2 for CrD in the IBD population was 15% and specificity was 98% (95, 99), while the sensitivity and specificity of IgG anti-MZGP2 were 27% and 97%. IgA and IgG anti-MZGP2 combined testing led to a sensitivity of 31% and a specificity of 96%. Positivity for either ASCA (IgA or IgG) or anti-MZGP2 (IgA or IgG) showed a sensitivity of 75% (70, 80) and a specificity of 84% (79, 89). IgA anti-MZGP2 antibodies were more prevalent in CrD patients with early disease onset (p=0.011). Also, anti-MZGP2 positive patients more frequently had extensive disease with ileal involvement. Patients with longer disease duration were more likely to have IgG anti-MZGP2 antibodies.CONCLUSIONS:Our novel ELISA confirms the high specificity of anti-MZGP2 antibodies for CrD and their association with disease severity phenotypes.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Autoantibody
Bowel disease
Marker
Sensitivity
Specificity
Megjelenés:Clinica Chimica Acta. - 441 (2015), p. 176-181. -
További szerzők:Shums, Zakera Koutsoumpas, Andreas L. Milo, Jay Papp Mária (1975-) (belgyógyász, gasztroenterológus) Uemurea, Takeji Lakatos Péter Smyk, Daniel S. Bogdanos, Dimitrios P. Forbes, Alastair Norman, Gary L.
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8.

001-es BibID:BIBFORM090167
035-os BibID:(WoS)000518803401187
Első szerző:Sipeki Nóra (általános orvos)
Cím:Gut barrier failure biomarkers in IBD : is there anything new beyond "The Wall"? / N. Sipeki, P. Kovats, B. Balogh, Z. Shums, G. L. Norman, P. Antal-Szalmas, M. Papp
Dátum:2020
ISSN:1873-9946
Megjegyzések:Background: Several defects in the many specialised components of mucosal barrier have been reported in inflammatory bowel disease (IBD). These alterations may represent a primary dysfunction in Crohn's disease(CD), but they may also perpetuate chronic mucosal inflammation in ulcerative colitis(UC). Changes in intestinal permeability can predict IBD course. Methods: We aim to determine the predictive potential of a panel of serological markers that reflect either mechanical or immunological gut barrier dysfunction regarding determination of disease phenotype, therapeutic strategy and long-term disease course in a prospective referral adult IBD patient cohort. Sera of 266 CD (m/f:112/154, median age:25 years, B1:80.1%, P1:18.0%) and 187 UC (m/f:86/101, median age:33 years, extensive colitis:28.3%) patients were assayed for intestinal fatty acidbinding protein(I-FABP) and various immunoglobulin A (IgA) molecules, anti-F-actin[AAA IgA/IgG] and anti-gliadin[AGA IgA/ IgG]) by enzyme-linked immunosorbent assay (ELISA) along with 155 healthy controls (HCONT). Clinical data were available on unfavourable disease outcome as well as disease activity and medical treatment during the prospective follow-up (median: 143 and 135 mths for CD and UC respectively). Results: In UC, median I-FABP level was significantly lower than in HCONT(177.2 vs. 244.3 pg/ml; p < 0.05). sIgA level was higher in both CD and UC compared with HCONT(51.2 and 46.0 vs. 29.2 ?g/ml; p < 0.0001). AAA positivity with IgA type predominance was significantly higher in CD(40.2vs UC:15.7; HCONT:6.2%). AGA was also more prevalent in CD(16.5vs UC:6.7; HCONT:7.2%). There was an association between the presence of IgA type AAA or AGA and antimicrobial antibodies. ACA IgA was also more prevalent in case of AAA IgA positivity(52.9 vs. 32.7%, p = 0.009). PS/PT IgA positivity was higher in AGA IgA positive patients (33.3 vs. 7.6%, p = 0.001). Complicated disease behaviour at sample procurement was associated with the presence of AAA and AGA IgA positivity. In Kaplan?Meier analysis concomitant presence of IgA and IgG type AAA was associated with a shorter time to resective surgery (HR[95% CI]: 2.03[1.06?3.90]) along with a higher risk of a second surgery needed (HR[95% CI]: 2.82[1.14?6.98]). Sensitivity analysis showed that the later remained significant in B1 patients (p = 0.002) and also remained independent predictor in multivariate Cox-regression analysis comprising relevant clinical factors(HR[95% CI]: 2.88[1.07?7.78], p = 0.037). Conclusion: The presence of AAA and AGA reflects the ongoing mucosal damage in IBD rather than has a value in predicting the disease course.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Journal of Crohns & Colitis. - 14 : Suppl1 (2020), p. S296. -
További szerzők:Kováts Patrícia (1995-) Balogh Boglárka (1993-) (belgyógyász) Shums, Zakera Norman, Gary L. Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
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9.

001-es BibID:BIBFORM058618
Első szerző:Sipeki Nóra (általános orvos)
Cím:Prevalence, significance and predictive value of antiphospholipid antibodies in Crohn's disease / Nora Sipeki, Laszlo Davida, Eszter Palyu, Istvan Altorjay, Jolan Harsfalvi, Peter Antal Szalmas, Zoltan Szabo, Gabor Veres, Zakera Shums, Gary L. Norman, Peter L. Lakatos, Maria Papp
Dátum:2015
ISSN:1007-9327
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Crohn's disease
Ulcerative colitis
Disease progression
Antiphospholipid antibodies
Anti-[béta]2- Glycoprotein-I antibodies
Anti-phosphatidylserine/ prothrombin
Anti-cardiolipin antibodies
Thrombosis
Megjelenés:World Journal of Gastroenterology. - 21 : 22 (2015), p. 6952-6964. -
További szerzők:Dávida László (belgyógyász) Pályu Eszter (1983-) Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) Hársfalvi Jolán (1949-) (klinikai biokémikus) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Szabó Zoltán (1973-) (belgyógyász, kardiológus) Veres Gábor (orvos) Shums, Zakera Norman, Gary L. Lakatos Péter (Semmelweis Egyetem) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
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10.

001-es BibID:BIBFORM069781
Első szerző:Tornai Tamás István (belgyógyász)
Cím:Gut barrier failure biomarkers are associated with poor disease outcome in patients with primary sclerosing cholangitis / Tamas Tornai, Eszter Palyu, Zsuzsanna Vitalis, Istvan Tornai, David Tornai, Peter Antal-Szalmas, Gary L. Norman, Zakera Shums, Gabor Veres, Antal Dezsofi, Gabriella Par, Alajos Par, Peter Orosz, Ferenc Szalay, Peter L. Lakatos, Maria Papp
Dátum:2017
ISSN:1007-9327
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:World Journal of Gastroenterology. - 23 : 29 (2017), p. 5412-5421. -
További szerzők:Pályu Eszter (1983-) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Norman, Gary L. Shums, Zakera Veres Gábor (orvos) Dezsőfi Antal Pár Gabriella Pár Alajos Orosz Péter (Miskolc) Szalay Ferenc (belgyógyász) Lakatos Péter (Semmelweis Egyetem) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Pályázati támogatás:OTKA-115818
OTKA
MTA-Bolyai János Kutatási Ösztöndíj
Egyéb
ÚNKP-16-3
Egyéb
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:
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