CCL

Összesen 21 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM071355
Első szerző:Antal-Szalmás Péter (laboratóriumi szakorvos)
Cím:Serum levels of lectin complement pathway molecules do not determine the risk of bacterial infections in patients with cirrhosis / P. Antal-Szalmás, I. Földi, D. Tornai, T. Tornai, Zs. Vitális, I. Tornai, T. Dinya, M. Papp
Dátum:2016
Megjegyzések:SE1.5Serum levels of lectin complement pathway molecules do not determine the risk of bacterial infections in patientswith cirrhosisP. Antal-Szalmás1, I. Földi2, D. Tornai1, T. Tornai2, Zs. Vitális2, I Tornai2, T. Dinya3, M. Papp21Department of Laboratory Medicine, 2Department of Internal Medicine, Division of Gastroenterology, 3Institute of Surgery, Faculty ofMedicine, University of Debrecen, Debrecen, HungaryBacterial infections are a significant cause of morbidity and mortality in cirrhosis. Lectin pathway molecules of the complement system aresynthesized in the liver and have a pivotal role in the innate host defense against infectious organisms. Mannose-binding lectin (MBL) andficolins (FCNs) act as soluble pattern recognition molecules, while mannan-binding lectin serine proteases (MASPs) are effector molecules inelimination of the pathogens. Low levels of the functional proteins increase the risk of various infectious diseases but their significance hasscarcely been investigated in cirrhosis related bacterial infections.Sera of 266 patients with cirrhosis and 160 healthy subjects were assayed for the concentrations of FCN-2, FCN-3 and MASP-2 by ELISAs.In cirrhosis, a 5-year follow-up observational study was conducted to assess a possible association between lectin levels and development ofclinically significant bacterial infections (CSI) and mortality.The FCN-2, FCN-3 and MASP-2 levels were significantly lower in cirrhosis compared to healthy controls (505 vs. 769 ng/ml, 7,301 vs.10,797 ng/ml and 212 vs. 412 ng/ml, respectively, p < 0.001 for all) and decreased according to disease severity as rated by Child-Pughstage. In Kaplan-Meier analysis time to development of CSI was associated with low level of FCN-3 ( < 4,857 ng/ml, p = 0.028) but notFCN-2 ( < 427 ng/ml, p = 0.068) or MASP-2 deficiency (p = 0.368). Combined FCN deficiency even more than individual molecules wereable to predict the development of these episodes. Patients with low level of both FCNs had a cumulative risk of an infection of 52%as compared to 31% with normal level of FCNs (p = 0.021). In multivariate Cox-regression analysis, clinical factors but not the serumlectin profile remained an independent predictor of CSI. Prior episode of CSI and in a stepwise manner, the disease severity as rated byChild-Pugh stage conferred higher risk for development of CSI (HR: 2.64, 95% CI: 1.74?3.99, p < 0.001 and 2.11, 95%CI: 1.52-2.93, p < 0.001,respectively).In the present prospective study, diseases severity and prior episode of CSI but not the serum lectin profile were major determinants ofthe risk of CSI in cirrhosis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:Clinical chemistry and laboratory medicine 54 : 10 (2016), p. 162. -
További szerzők:Földi Ildikó (1981-) (orvos) Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Tornai Tamás István (1984-) (belgyógyász) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Dinya Tamás (1974-) (sebész szakorvos, onkológus szakorvos) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM089479
Első szerző:Balogh Boglárka (belgyógyász)
Cím:Gut barrier failure : a piece in the puzzle of acute-on chronic liver failure syndrome development? / Boglarka Balogh, Zsuzsa Vitalis, Tamas Tornai, Istvan Tornai, David Tornai, Aniko Csillag, Peter Antal-Szalmas, Maria Papp
Dátum:2020
Megjegyzések:Introduction: Intestinal barrier dysfunction induced inflammation facilitates pathologic bacterial translocation (BT) which is a characteristic feature of liver cirrhosis (LC). BT plays a crucial role in the progression of LC leading to spontaneous bacterial peritonitis (SBP), bacteraemia and induction of proinflammatory responses causing various organ damages. Therefore, the serological hallmarksof gut barrier dysfunction in cirrhosis are able to predict the accelerated progression of liver disease. Methods: In a cohort of patients with decompensated cirrhosis (n=135) prospectively followed-up for 1 year and in healthy controls (HC) (n=50) the serological markers of functional/structural gut damage (intestinal-fatty acid binding protein, I-FABP), BT (Endotoxin core antibody, EndoCab IgA) and mucosal immune response (secretory IgA, Immunoglobulin free light chain (Ig FLC) kappa and lambda,) were investigated by means of ELISA. Results: Comparing the LC to HC group the serum concentration of all investigated markers weresignificantly higher in cirrhotic patients, although they did not show any association with the disease severity. Investigating the role of the serological markers in the development of ACLF we found that significance of the serum level of Ig FLC kappa in ACLF prediction is comparable to AD score based on AUC values. Furthermore, the ACLF rate was lower in patients with low serum concentration of Ig FLC kappa compared to the group with high serum concentration of this molecule. Conclusions: Ig FLC kappa can be a usable marker in the serological panel for the prediction of ACLF development in acute decompensated cirrhotic patients. Acknowledgements: EFOP 3.6.2-16-2017-00006 (LIVE LONGER).
Tárgyszavak:Orvostudományok Klinikai orvostudományok előadáskivonat
könyvrészlet
Megjelenés:Proceedings of the EFOP-3.6.2-16-2017-00006 (LIVE LONGER) project /Ed. Rakonczay Zoltán, Kiss Lóránd. - p. 62. -
További szerzők:Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai Tamás István (1984-) (belgyógyász) Tornai István (1954-) (belgyógyász, gasztroenterológus) Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Csillag Anikó (1979-) (immunológus, biológus, angol-magyar szakfordító) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Pályázati támogatás:EFOP-3.6.2-16-2017-00006
EFOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM089481
Első szerző:Csillag Anikó (immunológus, biológus, angol-magyar szakfordító)
Cím:Filamentosus-actin related molecules : are they serologic hallmark of overwhelming damage-associated molecular patterns (DAMPs) in acute decompensation? / Aniko Csillag, Zsuzsa Vitalis, Tamas Tornai, Istvan Tornai, David Tornai, Boglarka Balogh, Peter Antal-Szalmas, Maria Papp
Dátum:2020
Megjegyzések:Introduction: The actin cytoskeleton has a fundamental function in cellular motility, integrity, structure and signaling mechanisms. In acute decompensated liver cirrhosis large quantities of filamentous actin (F-actin) as a danger signal is released from damaged and necrotic hepatic cells. Recently it also has been demonstrated that the presence of IgA type anti-F-actin antibodies is associated with the disease severity, unfavorable disease outcome and intestinal damage, as well. Thus, we hypothesized that the actin-scavenging system molecules in acute decompensation are able to predict the accelerated progression of liver disease. Methods: In a cohort of patients with decompensated cirrhosis (n=135) prospectively followed-up for 1 year and in healthy controls (HC, n=50) the serum levels of gelsolin and anti-F-actin IgA were investigated by means of ELISA. Results: Serum gelsolin levels were significantly higher in patients with acute decompensated liver cirrhosis (LC-AD) compared to healthy controls (HCONT) (p<0.0001). The frequency of anti-F-actin positivity was 65.4% (n=83/127) in LC-AD group (cut off: 25 U/mL). Our results demonstrated that in LC-AD group the serum gelsolin levels did not show correlation with the different disease severity, the presence of bacterial infection or renal failure at inclusion, similarly to the presence or absence of anti-F-actin IgA positivity. However, high serum level of gelsolin (>87.7 ?g/mL) is associated with short term (30 days) mortality. Conclusions: High serum level of gelsolin is likely to predict short term mortality both in cirrhotic patients with or without acute-on-chronic liver failure at inclusion. Acknowledgements: EFOP 3.6.2-16-2017-00006 (LIVE LONGER).
ISBN:978-963-306-764-2
Tárgyszavak:Orvostudományok Klinikai orvostudományok előadáskivonat
könyvrészlet
Megjelenés:"PROCEEDINGS OF THE EFOP-3.6.2- 16-2017-00006 (LIVE LONGER) PROJECT" / Ed. Rakonczay Zoltán, Kiss Lóránd. - p. 63. -
További szerzők:Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai Tamás István (1984-) (belgyógyász) Tornai István (1954-) (belgyógyász, gasztroenterológus) Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Balogh Boglárka (1993-) (belgyógyász) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Pályázati támogatás:EFOP-3.6.2-16-2017-00006
EFOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM071451
Első szerző:Dinya Tamás (sebész szakorvos, onkológus szakorvos)
Cím:Functional polymorphisms of innate immunity receptors are not risk factors for the non-SBP type bacterial infections in cirrhosis / Dinya Tamás, Tornai Tamás, Vitális Zsuzsanna, Tornai István, Balogh Boglárka, Tornai Dávid, Antal-Szalmás Péter, Sümegi Andrea, Andrikovics Hajnalka, Bors András, Tordai Attila, Papp Mária
Dátum:2018
ISSN:1478-3223 1478-3231
Megjegyzések:Background&Aims: Pattern recognition receptors (PRRs) have a key role in the innate host defense. Functional polymorphisms of various PRRs have been established to contribute to an increased susceptibility to spontaneous bacterial peritonitis (SBP). Their role in the development of cirrhosis-associated bacterial infections (BI), beyond SBP or progressive disease course related to pathological bacterial translocation (BT) remains unknown. Methods: 349 patients with cirrhosis were genotyped for common NOD2 (R702W, G908R and L1007PfsinsC), TLR2 (-16934T>A), and TLR4 (D299G) gene variants. Incidence of BIs, decompensating events (ascites, variceal bleeding and hepatic encephalopathy) and liver-related death were assessed in a 5-year follow-up observational study. Pathological BT was assessed based on the presence of anti-microbial antibodies or lipopolysaccharide-binding protein (LBP) level. Results: In patients with ascites (n=88) only NOD2 gene variants were associated with an increased cumulative probability of SBP compared to wild-type (76.9%?19.9% vs. 30.9%?6.9%, PLogRank=0.047). Neither individual polymorphisms, nor combined PRR genetic profiles were associated with the risk of non-SBP type BI. Advanced disease stage (HR,[95%CI]: 2.11 [1.38-3.25]) and prior history of a BI episode (HR: 2.42 [1.58-3.72]) were the major clinical risk factors of a subsequent BI. The risk of a non-SBP type BI in patients with advanced disease and a prior BI was even higher (HR: 4.74 [2.68-8.39]). The frequency of anti-microbial antibodies and LBP levels did not differ between various PRR genotypes. Correspondingly, PRR genetic profile was not able to predict the long-term disease course. Conclusions: In cirrhosis, functional polymorphisms of PRRs did not improve the identification of patients with high risk of BI beyond SBP or progressive diseases course.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
pattern recognition receptors
genetic polymorphisms
cirrhosis
bacterial infection
complication
mortality
Megjelenés:Liver International. - 38 : 7 (2018), p. 1242-1252. -
További szerzők:Tornai Tamás István (1984-) (belgyógyász) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Balogh Boglárka (1993-) (belgyógyász) Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Sümegi Andrea (1969-) (biológus) Andrikovics Hajnalka Bors András Tordai Attila Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Pályázati támogatás:OTKA-115818
OTKA
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

5.

001-es BibID:BIBFORM066819
Első szerző:Földi Ildikó (orvos)
Cím:Lectin-complement pathway molecules are decreased in patients with cirrhosis and constitute the risk of bacterial infections / Ildiko Foldi, Tamas Tornai, David Tornai, Nora Sipeki, Zsuzsanna Vitalis, Istvan Tornai, Tamas Dinya, Peter Antal-Szalmas, Maria Papp
Dátum:2017
ISSN:1478-3223
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Liver International 37 : 7 (2017), p. 1023-1031. -
További szerzők:Tornai Tamás István (1984-) (belgyógyász) Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Sipeki Nóra (1987-) (általános orvos) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Dinya Tamás (1974-) (sebész szakorvos, onkológus szakorvos) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Pályázati támogatás:K115818/2015/1
OTKA
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

6.

001-es BibID:BIBFORM114632
035-os BibID:(cikkazonosító)2954 (scopus)85172226742 (wos)001073257100001
Első szerző:Janka Tamás
Cím:The Value of Neutrophil-to-Lymphocyte Ratio to Identify Bacterial Infection and Predict Short-Term Mortality in Patients with Acutely Decompensated Cirrhosis / Tamás Janka, Dávid Tornai, Mária Papp, Zsuzsanna Vitális
Dátum:2023
ISSN:2075-4418
Megjegyzések:Liver cirrhosis patients are highly susceptible to infections, affecting survival, but current param-eters for detecting infection are not reliable enough in this population. We investigated ability of white blood cell (WBC), ?WBC, neutrophil and ?neutrophil count, neutrophil-to-lymphocyte (NLR) and ?NLR ratio, CRP, and PCT to identify infection and predict short-term mortality in liver cir-rhosis patients. We recruited 233 patients with liver cirrhosis hospitalized with acute decompen-sation (AD) who had an outpatient visit within 1 month (baseline laboratory data) and followed them for 90 days. Difference between laboratory values at baseline and the AD episode was defined as delta (?) values of the parameters. Delta values did not increase the diagnostic and predictive ability of investigated parameters. CRP was found to be the best diagnostic marker for infection in patients with cirrhosis. However, NLR seems to be superior for short-term mortality prediction, better than WBC. Distinguishing inflammations of different origin is a remaining clinical challenge in acutely decompensated cirrhosis. Based on our results NLR might be more suitable for predicting short-term mortality in patients with AD than WBC count currently included in CLIF-C AD score.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Diagnostics. - 13 : 18 (2023), p. 1-14. -
További szerzők:Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

7.

001-es BibID:BIBFORM078868
035-os BibID:(PMID)31464790
Első szerző:Janka Tamás
Cím:Deleterious effect of proton pump inhibitors on the disease course of cirrhosis / Tamas Janka, Tamas Tornai, Brigitta Borbely, David Tornai, Istvan Altorjay, Maria Papp, Zsuzsanna Vitalis
Dátum:2020
Megjegyzések:OBJECTIVES: Proton pump inhibitors (PPIs) are widely prescribed to patients with liver cirrhosis. We hypothesized that long-standing PPI use is associated with spontaneous bacterial peritonitis (SBP) and accelerated development of disease-specific complications and liver-related death. METHODS: A 5-year follow-up observational cohort study assessed the impact of long-standing PPI use on the clinical course of cirrhosis in a large referral patient cohort. 350 patients with cirrhosis (males: 188, females: 162, ages: 56?6 years, alcohol: 242 [69.1%], Child-Pugh stage A/B/C: 206/108/36) were assigned to two groups: regular PPI users (n=196) and non-users (n=154). Occurrence of SBP, decompensation events (development of ascites, hepatic encephalopathy and variceal bleeding), and liver-related death were assessed. RESULTS: Regular PPI use was associated with an increased cumulative probability of SBP compared to non-users [CP: 55% vs 24.8%, HR: 4.25 (95%CI: 1.42-12.67), p=0.05], but only in patients who had no previous SBP episode (n=84). A similar association was found between regular PPI use and decompensation events. The risk of the development of a first decompensation event (ascites, HE or VB) was higher in regular PPI users compared to non-users, in patients with compensated clinical stage at enrollment (HR: 2.81, 95%CI: 1.31-6.01, p=0.008, n=146). The risk of liver-related death was also significantly increased among regular PPI users (p<0.001). In multivariate Cox-regression analysis, regular PPI use (HR: 2.81, 95%CI: 1.43-5.51, p=0.003) and MELD score (HR: 1.21, 95%CI: 1.08-1.35, p<0.001) was an independent predictor of mortality. In the present follow-up cohort study, long-term PPI use was associated with the development of SBP and a progressive disease course in patients with cirrhosis that may have been caused by enhanced pathologic BT, accelerated development of BT-dependent disease-specific complications, and liver-related death.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
proton pump inhibitors
bacterial translocation
spontaneous bacterial peritonitis
disease progression
mortality
Megjelenés:European Journal of Gastroenterology & Hepatology. - 32 : 2 (2020), p. 257-264. -
További szerzők:Tornai Tamás István (1984-) (belgyógyász) Borbély Brigitta Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00048
GINOP
EFOP-3.6.1-16-2016-00022
EFOP
EFOP-3.6.2-16-2017-00006
EFOP
BO/00232/17/5
Egyéb
ÚNKP-17-4
Egyéb
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

8.

001-es BibID:BIBFORM079252
035-os BibID:(WoS)000480384000004 (Scopus)85069723243
Első szerző:Mezei Zoltán András (orvos)
Cím:A DNA pool of FLT3-ITD positive DNA samples can be used efficiently for analytical evaluation of NGS-based FLT3-ITD quantitation : testing several different ITD sequences and rates, simultaneously / Zoltán A. Mezei, Dávid Tornai, Róza V. Földesi, László Madar, Andrea Sümegi, Mária Papp, Péter Antal-Szalmás
Dátum:2019
ISSN:0168-1656
Megjegyzések:Internal tandem duplication (ITD) in the fms-like tyrosine kinase 3 (FLT3) gene is one of the most frequent genetic alteration in acute myeloid leukemia (AML), and it is associated with worse clinical outcome. Not only the presence but also the size, localization and the rate of this variant or the presence of multiple ITDs has prognostic information. The traditional PCR based diagnostic methods cannot provide information about all of these parameters in one assay, however the application of next generation sequencing (NGS) technique can be a reliable solution for this diagnostic problem. In order to evaluate the analytical properties of an NGS-based FLT3-ITD detection assay a QC sample was prepared from DNA of AML patients containing 19 different FLT3-ITD variants identified by NGS. The higher the total read count was in a certain sample of the NGS run, the more ITD variant types could be detected. The maximal sensitivity of FLT3-ITD detection by NGS technique was as low as 0.007% FLT3-ITD/total allele rate, however, below 0.1% rate, the reproducibility of the quantitation was poor (CV>25%). DNA pools with several FLT3-ITDs can be used efficiently for analytical evaluation of NGS-based FLT3-ITD quantitation testing several different ITD sequences and rates, simultaneously.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Fms-like tyrosine kinase 3 (FLT3)
internal tandem duplication (ITD)
deep next generation sequencing (NGS)
analytical validation
Megjelenés:Journal Of Biotechnology. - 303 (2019), p. 25-29. -
További szerzők:Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Földesi Róza (1967-) (klinikai laboratóriumi kutató, PhD hallgató) Madar László (1972-) (klinikai laboratóriumi kutató) Sümegi Andrea (1969-) (biológus) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

9.

001-es BibID:BIBFORM102220
Első szerző:Papp Mária (belgyógyász, gasztroenterológus)
Cím:Presepsin as a new biomarker for old expectations in the diagnosis and prognosis of bacterial infection in cirrhosis / Maria Papp, Tamas Tornai, David Tornai, Zsuzsanna Vitalis, Istvan Tornai, Peter Antal-Szalmas
Dátum:2015
ISSN:0270-9139
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Hepatology. - 62 : S1 (2015), p. 1227A. -
További szerzők:Tornai Tamás István (1984-) (belgyógyász) Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos)
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

10.

001-es BibID:BIBFORM065752
Első szerző:Papp Mária (belgyógyász, gasztroenterológus)
Cím:Presepsin teardown : pitfalls of biomarkers in the diagnosis and prognosis of bacterial infection in cirrhosis / Maria Papp, Tamas Tornai, Zsuzsanna Vitalis, Istvan Tornai, David Tornai, Tamas Dinya, Andrea Sumegi, Peter Antal-Szalmas
Dátum:2016
Megjegyzések:AIM: Bacterial infections are frequent complications in cirrhosis with significant mortality. Early laboratory diagnosis is essential but challenging. We aimed to evaluate the diagnostic and prognostic value of presepsin in cirrhosis associated bacterial infections. METHODS: 216 patients with cirrhosis were enrolled. At admission, presence of bacterial infections and level of plasma presepsin, serum CRP and PCT were evaluated. Patients were followed for three months to assess the possible association between presepsin level and short-term mortality. RESULTS: 34.7% of patients had bacterial infection. Presepsin levels were significantly higher in patients with infection than without (median, 1002 vs. 477 pg/mL, p<0.001), increasing with the severity of infection (organ failure[OF]Yes vs. No: 2358 vs. 710 pg/mL, p<0.001). Diagnostic accuracy of presepsin for severe infections was similar to PCT and superior to CRP (AUC-ROC: 0.85, 0.85 and 0.66, respectively, p=NS for presepsin vs. PCT and p<0.01 for presepsin vs. CRP). At the optimal cut-off value of presepsin>1206 pg/mL sensitivity, specificity, PPV and NPV were as follows: 87.5%, 74.5%, 61.8% and 92.7%. The accuracy of presepsin, however, decreased in advanced stage of the disease or in the presence of renal failure, most probably because of the significantly elevated presepsin levels in non-infected patients. 28-day mortality rate was higher among patients with >1277 pg/mL compared to those with ?1277 pg/mL (46.9% vs. 11.6%, p<0.001). In a binary logistic regression analysis, however, only PCT [OR: 1.81, (95%CI: 1.09?3.01), p=0.022] but neither presepsin and nor CRP were independent risk factor for 28-day mortality after adjusting with MELD score and leukocyte count.CONCLUSION: Presepsin is a valuable new biomarker for defining severe infections in cirrhosis proving same efficacy as PCT. However, it is not a useful marker of short-term mortality.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
presepsin
cirrhosis
bacterial infection
organ failure
mortality
Megjelenés:World Journal of Gastroenterology 22 : 41 (2016), p. 1-14. -
További szerzők:Tornai Tamás István (1984-) (belgyógyász) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Dinya Tamás (1974-) (sebész szakorvos, onkológus szakorvos) Sümegi Andrea (1969-) (biológus) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:

11.

001-es BibID:BIBFORM111389
035-os BibID:(cikkazonosító)103356 (WoS)001001261100001 (Scopus)85159090024
Első szerző:Sciascia, Savino
Cím:Autoantibodies testing in autoimmunity : Diagnostic, prognostic and classification value / Savino Sciascia, Nicola Bizzaro, Luigi Meroni Pier, Dimitrios Bogdanos, Borghi M. O., Xavier Bossuyt, Grossi C., Tornai Dávid, Papp Maria, Shoenfeld Yehuda, Ielo Daniele, Fritzler Marvin J.
Dátum:2023
ISSN:1568-9972
Megjegyzések:Diagnosis of autoimmune diseases is in most cases challenging for clinicians as there is not a single specific laboratory or histological marker to diagnose or exclude the presence of the conditions. This review focused on the current knowledge of the role of autoantibodies' testing in various diseases, such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, undifferentiated connective tissues disease, primary biliary cirrhosis and primary sclerosing cholangitis. Similarly, the prognostic and diagnostic values of autoantibodies testing in patients with interstitial lung disease have been reviewed. In-depth research on the molecular action of these autoantibodies on immune regulation and diseases pathogenesis has been explored beyond their correlation with disease phenotypes, highlighting the impact of autoantibodies targeting on disease outcomes and etiopathogenesis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Rheumatoid arthritis
Antiphospholipid syndrome
Connective tissues disease
Primary biliary cirrhosis
Sclerosing cholangitis
Interstitial lung disease
Megjelenés:Autoimmunity Reviews. - 22 : 7 (2023), p. 1-9. -
További szerzők:Bizzaro, Nicola Meroni, Pier Luigi Bogdanos, Dimitrios P. Borghi, M. O. Bossuyt, Xavier Grossi, C. Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Shoenfeld, Yehuda Ielo, Daniele Fritzler, Marvin J.
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

12.

001-es BibID:BIBFORM102132
035-os BibID:(WoS)000810325500003 (Scopus)85131793956
Első szerző:Tornai Dávid (hepatológia, biomarker kutatás)
Cím:Serological biomarkers for management of primary sclerosing cholangitis / Tornai Dávid, Vén Péter László, Lakatos Péter László, Papp Mária
Dátum:2022
ISSN:1007-9327
Megjegyzések:Clinical manifestations and progression of primary sclerosing cholangitis (PSC) are heterogeneous, and its pathogenesis is poorly understood. The importance of gut-liver interactions in the pathogenesis has been clinically confirmed and highlighted in different theories. Recent advances regarding biomarkers of biliarygut crosstalk may help to identify clinically relevant PSC subgroups assisting everyday clinical work-up (e.g., diagnosis, disease stratification, or surveillance) and the exploration of potential therapeutic targets. Alkaline phosphatase produced by the biliary epithelium is consistently associated with prognosis. However, its level shows natural fluctuation limiting its use in individual patients. Inflammatory, cell activation, and tissue remodeling markers have been reported to predict clinical outcome. Elevated immunoglobulin (Ig) G4 level is associated with a shorter transplantation-free survival. IgG type atypical perinuclear anti-neutrophil cytoplasmic antibodies (P-ANCAs) are non-specific markers of various autoimmune liver diseases and may reflect an abnormal B-cell response to gut microbial antigens. IgG type atypical P-ANCA identifies PSC patients with particular clinical and genetic (for human leukocyte antigens) characteristics. The presence of IgA type anti-F-actin antibody (AAA) may predict a progressive disease course, and it is associated with enhanced mucosal immune response to various microbial antigens and enterocyte damage. IgA type anti-glycoprotein 2 (GP2) antibodies identify patients with a severe disease phenotype and poor survival due to enhanced fibrogenesis or development of cholangiocarcinoma. Elevated soluble vascular adhesion protein-1 (sVAP-1) level is associated with adverse disease outcomes in PSC. High sVAP-1 levels correlate with mucosal addressin cell adhesion molecule-1 (MAdCAM-1) expression in the liver that contributes to gut activated T-cell homing to the hepatobiliary tract. In the present paper, we review the evidence on these possible serological markers that could potentially help address the unmet clinical needs in PSC.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Primary sclerosing cholangitis
Hepatobiliary
Serological biomarker
Immunoglobulin
Inflammatory
Tissue remodeling
Megjelenés:World Journal of Gastroenterology. - 28 : 21 (2022), p. 2291-2301. -
További szerzők:Vén Péter László Lakatos Péter (Semmelweis Egyetem) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Pályázati támogatás:OTKA-138041
OTKA
EFOP-3.6.1-16-2016-00022
EFOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1 2