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001-es BibID:	BIBFORM077046
035-os BibID:	(WoS)000485146200010 (Scopus)85070584761
Első szerző:	Deutschmann, Claudia
Cím:	Identification of Chitinase-3-like protein 1 as a novel neutrophil antigenic target in Crohn's disease / Deutschmann Claudia, Sowa Mandy, Murugaiyan Jayaseelan, Roesler Uwe, Röber Nadja, Conrad Karsten, Laass Martin, Bogdanos Dimitrios, Sipeki Nora, Papp Maria, Rödiger Stefan, Roggenbuck Dirk, Schierack Peter
Dátum:	2019
ISSN:	1873-9946
Megjegyzések:	Background and Aims: There is an increasing incidence of inflammatory bowel disease [IBD]. Autoimmune responses are involved in the pathophysiology of IBD, but their underlying pathways and target antigens have not yet been fully elucidated. Methods: Autoantigenic targets in IBD were identified after separation of whole cell proteins isolated from neutrophils using two-dimensional electrophoresis and matrix assisted laser desorption ionization - time of flight mass spectrometry-based protein identification of the spots that displayed Western blotting signals with anti-neutrophil cytoplasmic antibody-positive sera. The prevalence of IgG, IgA and secretory IgA [sIgA] to chitinase 3-like protein 1 [CHI3L1] was analysed by enzyme-linked immunosorbent assays using recombinant CHI3L1 in 110 patients with Crohn's disease [CD], 95 with ulcerative colitis [UC], 126 with coeliac disease [CeD] and 86 healthy controls [HCs]. Results: The 18-glycosylhydrolase family member CHI3L1 was identified as a neutrophil autoantigenic target. CD patients displayed significantly higher levels of IgG to CHI3L1 than patients with UC and CeD (p < 0.0001, respectively). IgA and sIgA to CHI3L1 was significantly higher in CD than in UC, CeD and HCs [p < 0.0001, respectively]. IgA and sIgA to CHI3L1 demonstrated the highest prevalence in CD [25.5%, 28/110; and 41.8%%, 46/110] compared to HCs [2.3%, 2/86; and 4.7%%, 4/86; p < 0.0001, respectively] and are associated with a more complicated progression of CD. Conclusion: CHI3L1 is a novel neutrophil autoantigenic target in CD. IgA and sIgA to CHI3L1 may serve as novel markers for CD and may facilitate the serological diagnosis of IBD.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk inflammatory bowel disease chitinase-3 like protein 1 autoantibody Crohn's disease enzyme-linked immunosorbent assay
Megjelenés:	Journal of Crohns & Colitis. - 13 : 7 (2019), p. 894-904. -
További szerzők:	Sowa, Mandy Murugaiyan, Jayaseelan Roesler, Uwe Röber, Nadja Conrad, Karsten Laass, Martin Bogdanos, Dimitrios P. Sipeki Nóra (1987-) (általános orvos) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Rödiger, Stefan Roggenbuck, Dirk Schierack, Peter
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM056692
Első szerző:	Pavlidis, Polychronis
Cím:	Diagnostic and clinical significance of Crohn's disease-specific anti-MZGP2 pancreatic antibodies by a novel ELISA / Polychronis Pavlidis, Zakera Shums, Andreas L. Koutsoumpas, Jay Milo, Maria Papp, Takeji Uemurea, Peter Lakatos, Daniel S. Smyk, Dimitrios P. Bogdanos, Alastair Forbes, Gary L. Norman
Dátum:	2015
ISSN:	0009-8981
Megjegyzések:	BACKGROUND:We developed a new IgA and IgG anti-MZGP2 antibody ELISAs based on recombinant isoform-4 of human zymogen granule protein-2 (GP2), which is the major autoantigen of Crohn's disease (CrD)-specific pancreatic autoantibodies and assessed their clinical relevance in the largest inflammatory bowel disease (IBD) cohort tested to date.METHODS:832 sera were studied, including 617 consecutive IBD patients from 323 CrD and 294 ulcerative colitis (UC) follow-up in a tertiary centre, and 112 pathological and 103 normal controls.RESULTS:Sensitivity of IgA anti-MZGP2 for CrD in the IBD population was 15% and specificity was 98% (95, 99), while the sensitivity and specificity of IgG anti-MZGP2 were 27% and 97%. IgA and IgG anti-MZGP2 combined testing led to a sensitivity of 31% and a specificity of 96%. Positivity for either ASCA (IgA or IgG) or anti-MZGP2 (IgA or IgG) showed a sensitivity of 75% (70, 80) and a specificity of 84% (79, 89). IgA anti-MZGP2 antibodies were more prevalent in CrD patients with early disease onset (p=0.011). Also, anti-MZGP2 positive patients more frequently had extensive disease with ileal involvement. Patients with longer disease duration were more likely to have IgG anti-MZGP2 antibodies.CONCLUSIONS:Our novel ELISA confirms the high specificity of anti-MZGP2 antibodies for CrD and their association with disease severity phenotypes.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Autoantibody Bowel disease Marker Sensitivity Specificity
Megjelenés:	Clinica Chimica Acta. - 441 (2015), p. 176-181. -
További szerzők:	Shums, Zakera Koutsoumpas, Andreas L. Milo, Jay Papp Mária (1975-) (belgyógyász, gasztroenterológus) Uemurea, Takeji Lakatos Péter Smyk, Daniel S. Bogdanos, Dimitrios P. Forbes, Alastair Norman, Gary L.
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001-es BibID:	BIBFORM111389
035-os BibID:	(cikkazonosító)103356 (WoS)001001261100001 (Scopus)85159090024
Első szerző:	Sciascia, Savino
Cím:	Autoantibodies testing in autoimmunity : Diagnostic, prognostic and classification value / Savino Sciascia, Nicola Bizzaro, Luigi Meroni Pier, Dimitrios Bogdanos, Borghi M. O., Xavier Bossuyt, Grossi C., Tornai Dávid, Papp Maria, Shoenfeld Yehuda, Ielo Daniele, Fritzler Marvin J.
Dátum:	2023
ISSN:	1568-9972
Megjegyzések:	Diagnosis of autoimmune diseases is in most cases challenging for clinicians as there is not a single specific laboratory or histological marker to diagnose or exclude the presence of the conditions. This review focused on the current knowledge of the role of autoantibodies' testing in various diseases, such as systemic lupus erythematosus, rheumatoid arthritis, antiphospholipid syndrome, undifferentiated connective tissues disease, primary biliary cirrhosis and primary sclerosing cholangitis. Similarly, the prognostic and diagnostic values of autoantibodies testing in patients with interstitial lung disease have been reviewed. In-depth research on the molecular action of these autoantibodies on immune regulation and diseases pathogenesis has been explored beyond their correlation with disease phenotypes, highlighting the impact of autoantibodies targeting on disease outcomes and etiopathogenesis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Rheumatoid arthritis Antiphospholipid syndrome Connective tissues disease Primary biliary cirrhosis Sclerosing cholangitis Interstitial lung disease
Megjelenés:	Autoimmunity Reviews. - 22 : 7 (2023), p. 1-9. -
További szerzők:	Bizzaro, Nicola Meroni, Pier Luigi Bogdanos, Dimitrios P. Borghi, M. O. Bossuyt, Xavier Grossi, C. Tornai Dávid (1989-) (hepatológia, biomarker kutatás) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Shoenfeld, Yehuda Ielo, Daniele Fritzler, Marvin J.
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001-es BibID:	BIBFORM074575
035-os BibID:	(cikkazonosító)1959 (WoS)000442936400001 (Scopus)85068120394
Első szerző:	Sowa, Mandy
Cím:	Mucosal autoimmunity to cell-bound GP2 isoforms is a sensitive marker in PSC and associated with the clinical phenotype / Mandy Sowa, Rafał Kolenda, Daniel Baumgart, Johann Pratschke, Maria Papp, Tamas Tornai, Jaroslaw Suchanski, Dimitrios Bogdanos, Maria Mytilinaiou, Jutta Hammermann, Martin Laass, Karsten Conrad, Christoph Schramm, Andre Franke, Dirk Roggenbuck, Peter Schierack
Dátum:	2018
ISSN:	1664-3224
Megjegyzések:	Introduction: Zymogen granule glycoprotein 2 (GP2) was demonstrated as first autoimmune mucosal target in primary sclerosing cholangitis (PSC) associated with disease severity. Autoantibodies to four GP2 isoforms (aGP21-4) were found in patients with inflammatory bowel diseases but reactivity against specific GP2 epitopes has not been investigated in PSC yet. Hence, the prevalence of aGP21-4 and their association with the PSC phenotype for risk prediction were examined.Methods: GP2 isoforms were stably expressed as glycosylphosphatidylinositol- anchored molecules in the membrane of HEp-2-cells and used as autoantigenic targets in indirect immunofluorescence assay (IFA). aGP21-4 IgA and IgG were detected by IFA in 212 PSC patients of four European university hospitals and 145 controls comprising 95 patients with cystic fibrosis and 50 healthy subjects.Results: Combined aGP21 and aGP24 IgA testing with a sensitivity of 66.0% and a specificity of 97.9% resulted in the best diagnostic performance (Youden index: 0.64) regarding all aGP2 and combinations thereof. aGP24 IgA positivity is significantly associated with the presence of cirrhosis in PSC (p=0.0056). Logistic regression revealed the occurrence of aGP21 IgA (odds ratio [OR] 1.38, 95% confidence interval [CI]: 1.03-1.86) and aGP24 IgA (OR 1.52, 95%CI: 1.07-2.15) along with male gender (OR 0.51, 95%CI: 0.27-0.97) and older age (OR 1.03 95%CI: 1.01-1.05) as significant risks for the concomitant presence of cirrhosis in PSC.Conclusions: Combined aGP21 and aGP24 IgA analysis is preferred to single aGP2 isoform analysis for sensitive PSC autoantibody testing. Positivity for aGP21 and aGP24 IgA is associated with cirrhosis in PSC and could be used for risk stratification.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk zymogen granule glycoprotein 2 primary sclerosing cholangitis cirrhosis cholangiocarcinoma immunoglobulin A
Megjelenés:	Frontiers in Immunology. - 9 (2018), p. 1-10. -
További szerzők:	Kolenda, Rafał Baumgart, Daniel Pratschke, Johann Papp Mária (1975-) (belgyógyász, gasztroenterológus) Tornai Tamás István (1984-) (belgyógyász) Suchanski, Jaroslaw Bogdanos, Dimitrios P. Mytilinaiou, Maria Hammermann, Jutta Laass, Martin Conrad, Karsten Schramm, Christoph Franke, Andre Roggenbuck, Dirk Schierack, Peter
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