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1.

001-es BibID:BIBFORM088207
Első szerző:Demcsák Alexandra
Cím:Acid suppression therapy, gastrointestinal bleeding and infection in acute pancreatitis - An international cohort study / Alexandra Demcsak, Alexandra Soos, Lilla Kincses, Ines Capunge, Georgi Minkov, Mila Kovacheva-Slavova, Radislav Nakov, Dong Wu, Wei Huang, Qing Xia, Lihui Deng, Marcus Hollenbach, Alexander Schneider, Michael Hirth, Orestis Ioannidis, Aron Vincze, Judit Bajor, Patrícia Sarlos, Laszló Czakó, Dora Illés, Ferenc Izbeki, Laszló Gajdán, Maria Papp, Jozsef Hamvas, Marta Varga, Peter Kanizsai, Ernő Bóna, Alexandra Miko, Szilard Váncsa, Márk Félix Juhász, Klementina Ocskay, Erika Darvasi, Emőke Miklós, Balint Erőss, Andrea Szentesi, Andrea Parniczky, Riccardo Casadei, Claudio Ricci, Carlo Ingaldi, Laura Mastrangelo, Elio Jovine, Vincenzo Cennamo, Marco V. Marino, Giedrius Barauskas, Povilas Ignatavicius, Mario Pelaez-Luna, Andrea Soriano Rios, Svetlana Turcan, Eugen Tcaciuc, Ewa Małecka-Panas, Hubert Zatorski, Vitor Nunes, Antonio Gomes, Tiago Cúrdia Gonçalves, Marta Freitas, Júlio Constantino, Milene Sa, Jorge Pereira, Bogdan Mateescu, Gabriel Constantinescu, Vasile Sandru, Ionut Negoi, Cezar Ciubotaru, Valentina Negoita, Stefania Bunduc, Cristian Gheorghe, Sorin Barbu, Alina Tantau, Marcel Tantau, Eugen Dumitru, Andra Iulia Suceveanu, Cristina Tocia, Adriana Gherbon, Andrey Litvin, Natalia Shirinskaya, Yliya Rabotyagova, Mihailo Bezmarevic, Péter Jenő Hegyi, Jimin Han, Juan Armando Rodriguez-Oballe, Isabel Miguel Salas, Eva Pijoan Comas, Daniel de la Iglesia Garcia, Andrea Jardi Cuadrado, Adriano Quiroga Castineira, Yu-Ting Chang, Ming-Chu Chang, Ali Kchaou, Ahmed Tlili, Sabite Kacar, Volkan Gokbulut, Deniz Duman, Haluk Tarik Kani, Engin Altintas, Serge Chooklin, Serhii Chuklin, Amir Gougol, George Papachristou, Peter Hegyi Jr.
Dátum:2020
ISSN:1424-3903
Megjegyzések:Background:Acid suppressing drugs (ASD) are generally used in acute pancreatitis (AP); however, largecohorts are not available to understand their efficiency and safety. Therefore, our aims were to evaluatethe association between the administration of ASDs, the outcome of AP, the frequency of gastrointestinal(GI) bleeding and GI infection in patients with AP.Methods:We initiated an international survey and performed retrospective data analysis on AP patientshospitalized between January 2013 and December 2018.Results:Data of 17,422 adult patients with AP were collected from 59 centers of 23 countries. We foundthat 23.3% of patients received ASDs before and 86.6% during the course of AP. ASDs were prescribed to57.6% of patients at discharge. ASD administration was associated with more severe AP and highermortality. GI bleeding was reported in 4.7% of patients, and it was associated with pancreatitis severity,mortality and ASD therapy. Stool culture test was performed in 6.3% of the patients with 28.4% positiveresults.Clostridium difficilewas the cause of GI infection in 60.5% of cases. Among the patients with GIinfections, 28.9% received ASDs, whereas 24.1% were without any acid suppression treatment. GI infec-tion was associated with more severe pancreatitis and higher mortality.Conclusions:Although ASD therapy is widely used, it is unlikely to have beneficial effects either on theoutcome of AP or on the prevention of GI bleeding during AP. Therefore, ASD therapy should be sub-stantially decreased in the therapeutic management of AP.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Acid suppressing drug
Gastrointestinal bleeding
Gastrointestinal infection
Acute pancreatitis
Proton pump inhibitor
Megjelenés:Pancreatology. - 20 : 7 (2020), p. 1323-1331. -
További szerzők:Soós Alexandra Kincses Lilla Capunge, Ines Minkov, Georgi Kovacheva-Slavova, Mila Nakov, Radislav Wu, Dong Huang, Wei Xia, Qing Deng, Lihui Hollenbach, Marcus Schneider, Alexander Hirth, Michael Ioannidis, Orestis Vincze Áron Bajor Judit Sarlós Patrícia Czakó László Illés Dóra Izbéki Ferenc Gajdán László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hamvas József Varga Márta Kanizsai Péter Bóna Ernő Mikó Alexandra Váncsa Szilárd Juhász Márk Félix Ocskay Klementina Darvasi Erika Miklós Emőke Erőss Bálint Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Casadei, Riccardo Ricci, Claudio Ingaldi, Carlo Mastrangelo, Laura Jovine, Elio Cennamo, Vincenzo Marino, Marco Vito Barauskas, Giedrius Ignatavicius, Povilas Pelaez-Luna, Mario Rios, Andrea Soriano Turcan, Svetlana Tcaciuc, Eugen Małecka-Panas, Ewa Zatorski, Hubert Nunes, Vitor Gomes, António Pedro Gonçalves, Tiago Cúrdia Freitas, Marta Constantino, Júlio Sá, Milene Pereira, Jorge Mateescu, Bogdan Constantinescu, Gabriel Sandru, Vasile Negoi, Ionut Ciubotaru, Cezar Negoita, Valentina Bunduc, Stefania Gheorghe, Cristian Barbu, Sorin Tantau, Alina Tantau, Marcel Dumitru, Eugen Suceveanu, Andra Iulia Tocia, Cristina Gherbon, Adriana Litvin, A. Andrey Shirinskaya, Natalia V. Rabotyagova, Yliya Bezmarevic, Mihailo Hegyi Péter Jenő (belgyógyász) Han, Jimin Rodriguez-Oballe, Juan Armando Salas, Isabel Miguel Comas, Eva Pijoan Garcia, Daniel de la Iglesia Cuadrado, Andrea Jardi Castiñeira, Adriano Quiroga Chang, Yu-Ting Chang, Ming-Chu Kchaou, Ali Tlili, Ahmed Kacar, Sabite Gökbulut, Volkan Duman, Deniz Kani, Haluk Tarik Altintas, Engin Chooklin, Serge Chuklin, Serhii Gougol, Amir Papachristou, Georgios I. Hegyi Péter Jr. (belgyógyász)
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2.

001-es BibID:BIBFORM105425
035-os BibID:(scopus)85139358640
Első szerző:Dohos Dóra
Cím:Inflammatory bowel disease does not alter the clinical features and the management of acute pancreatitis : A prospective, multicentre, exact-matched cohort analysis / Dora Dohos, Nelli Farkas, Alex Varadi, Balint Erőss, Andrea Parniczky, Andrea Szentesi, Peter Hegyi, Patrícia Sarlos, Hungarian Pancreatic Study Group
Dátum:2022
ISSN:1424-3903
Megjegyzések:Objective and aims: Acute pancreatitis in inflammatory bowel disease occurs mainly as an extraintestinal manifestation or a side effect of medications. We aimed to investigate the prognostic factors and severity indicators of acute pancreatitis and the treatment of patients with both diseases. Design: We performed a matched case-control registry analysis of a multicentre, prospective, interna tional acute pancreatitis registry. Patients with both diseases were matched to patients with acute pancreatitis only in a 1:3 ratio by age and gender. Subgroup analyses were also carried out based on disease type, activity, and treatment of inflammatory bowel disease. Results: No difference in prognostic factors (laboratory parameters, bedside index of severity in acute pancreatitis, imaging results) and outcomes of acute pancreatitis (length of hospitalization, severity, and local or systemic complications) were detected between groups. Significantly lower analgesic use was observed in the inflammatory bowel disease population. Antibiotic use during acute pancreatitis was significantly more common in the immunosuppressed group than in the non-immunosuppressed group (p ? 0.017). However, none of the prognostic parameters or the severity indicators showed a significant difference between any subgroup of patients with inflammatory bowel disease. Conclusion: No significant differences in the prognosis and severity of acute pancreatitis could be detected between patients with both diseases and with pancreatitis only. The need for different acute pancreatitis management is not justified in the coexistence of inflammatory bowel disease, and antibiotic overuse should be avoided. ? 2022 The Authors. Published by Elsevier B.V. on behalf of IAP and EPC. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/)
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Pancreatology. - 22 : 8 (2022), p. 1071-1078. -
További szerzők:Farkas Nelli Váradi Alex (1991-) (biológus) Erőss Bálint Párniczky Andrea (gyermekgyógyász) Szentesi Andrea Hegyi Péter Jr. (belgyógyász) Sarlós Patrícia Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hungarian Pancreatic Study Group
Pályázati támogatás:ÚNKP-21-5-PTE-1341
Egyéb
FK 132834
Egyéb
FK 138929
Egyéb
ÚNKP-21-5
Egyéb
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3.

001-es BibID:BIBFORM082673
035-os BibID:(cikkazonosító)1092 (WoS)000483784200001 (Scopus)85072948362
Első szerző:Farkas Nelli
Cím:A Multicenter, International Cohort Analysis of 1435 Cases to Support Clinical Trial Design in Acute Pancreatitis / Nelli Farkas, Lilla Hanák, Alexandra Mikó, Judit Bajor, Patrícia Sarlós, József Czimmer, Áron Vincze, Szilárd Gódi, Dániel Pécsi, Péter Varjú, Katalin Márta, Péter Jenő Hegyi, Bálint Erőss, Zsolt Szakács, Tamás Takács, László Czakó, Balázs Németh, Dóra Illés, Balázs Kui, Erika Darvasi, Ferenc Izbéki, Adrienn Halász, Veronika Dunás-Varga, László Gajdán, József Hamvas, Mária Papp, Ildikó Földi, Krisztina Eszter Fehér, Márta Varga, Klára Csefkó, Imola Török, Farkas Hunor-Pál, Artautas Mickevicius, Elena Ramirez Maldonado, Ville Sallinen, János Novák, Ali Tüzün Ince, Shamil Galeev, Barnabás Bod, János Sümegi, Petr Pencik, Attila Szepes, Andrea Szentesi, Andrea Párniczky, Péter Jr. Hegyi, Hungarian Pancreatic Study Group
Dátum:2019
ISSN:1664-042X
Megjegyzések:Background: C-reactive protein level (CRP) and white blood cell count (WBC) have been variably used in clinical trials on acute pancreatitis (AP). We assessed their potential role. Methods: First, we investigated studies which have used CRP or WBC, to describe their current role in trials on AP. Second, we extracted the data of 1435 episodes of AP from our registry. CRP and WBC on admission, within 24 h from the onset of pain and their highest values were analyzed. Descriptive statistical tools as Kruskal?Wallis, Mann? Whitney U, Levene's F tests, Receiver Operating Characteristic (ROC) curve analysis and AUC (Area Under the Curve) with 95% confidence interval (CI) were performed. Results: Our literature review showed extreme variability of CRP used as an inclusion criterion or as a primary outcome or both in past and current trials on AP. In our cohort, CRP levels on admission poorly predicted mortality and severe cases of AP; AUC: 0.669 (CI:0.569?0.770); AUC:0.681 (CI: 0.601?0.761), respectively. CRP levels measured within 24 h from the onset of pain failed to predict mortality or severity; AUC: 0.741 (CI:0.627?0.854); AUC:0.690 (CI:0.586?0.793), respectively. The highest CRP during hospitalization had equally poor predictive accuracy for mortality and severity AUC:0.656 (CI:0.544?0.768); AUC:0.705 (CI:0.640?0.769) respectively. CRP within 24 h from the onset of pain used as an inclusion criterion markedly increased the combined event rate of mortality and severe AP (13% for CRP > 25 mg/l and 28% for CRP > 200 mg/l). Conclusion: CRP within 24 h from the onset of pain as an inclusion criterion elevates event rates and reduces the number of patients required in trials on AP.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
acute pancreatitis
C-reactive protein
white blood cell
trial design
sample size calculation
Megjelenés:Frontiers in Physiology. - 10 (2019), p. 1-12. -
További szerzők:Hanák Lilla Mikó Alexandra Bajor Judit Sarlós Patrícia Czimmer József Vincze Áron Gódi Szilárd Pécsi Dániel Varjú Péter Márta Katalin Hegyi Péter Jenő (belgyógyász) Erőss Bálint Szakács Zsolt Takács Tamás (Szeged) Czakó László Németh Balázs Tamás Illés Dóra Kui Balázs Darvasi Erika Izbéki Ferenc Halász Adrienn Dunás-Varga Veronika Gajdán László Hamvas József Papp Mária (1975-) (belgyógyász, gasztroenterológus) Földi Ildikó (1981-) (orvos) Fehér Krisztina Eszter Varga Márta Csefkó Klára Török Imola Farkas Hunor Mickevicius, Artautas Maldonado, Elena Ramirez Sallinen, Ville Novák János Ince, Ali Tüzün Galeev, Shamil Bod Barnabás Sümegi János Pencik, Petr Szepes Attila (Szeged) Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Hegyi Péter Jr. (belgyógyász) Hungarian Pancreatic Study Group
Pályázati támogatás:GINOP 2.3.2-15-2016-00048
GINOP
EFOP-3.6.2-16-2017-00006
EFOP
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4.

001-es BibID:BIBFORM090166
Első szerző:Hágendorn Roland
Cím:Disturbance of consciousness deteriorates the severity of acute pancreatitis. An international multicentre cohort analyses of 1220 prospectively collected patients / R. Hagendorn, Á. Vincze, F. Izbeki, L. Gajdan, S. Godi, A. Illes, P. Sarlos, N. Farkas, B. Erős, V. Lillik, D. Illes, P. Varjú, K. Marta, I. Török, M. Papp, Z. Vitalis, B. Bod, J. Hamvas, Z. Szepes, T. Takacs, L. Czakó, A. Szentesi, A. Parniczky, P. Hegyi, A. Miko
Dátum:2020
ISSN:1424-3903
Megjegyzések:Purpose: Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient's condition, but we have no exact data on how DOC affects the outcome of AP. Materials and methods: From the Hungarian Pancreatic Study Groups' AP registry, 1220 cases contained the exact data on DOC. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC-DOC groups. Statistical analysis was performed by SPSS 24 Software Package. Results: From the 1220 patients, 47 (3.85%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. The incidence of severe AP was higher in the DOC compared to the Non-DOC group (19.15% vs. 5.29%, p<0.001). The mortality was higher in the DOC vs. Non-DOC group (14.89% vs. 1.71%, p<0.001). Length of hospitalization (LOH) was longer in the DOC vs. non-DOC group (Me:11; IQR:8-17 days vs. Me:9; IQR:6-13 days, p?0.049). Patients with ALC DOC developed more frequently moderately-severe AP vs. Non-ALC DOC (43.48% vs. 12.5%), while the incidence of severe AP was significantly higher in Non-ALC vs. ALC DOC group (33.33% vs. 4.35%) (p<0.001). LOH showed tendency to be longer in Non-ALC DOC compared to ALC DOC respectively (Me:13; IQR:7-20 days vs. Me:9.5; IQR:8-15.5 days, p?0.119). Conclusions: DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality; therefore, the DOC should be closely monitored and prevented in AP.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Pancreatology. - 20 (2020), p. S25. -
További szerzők:Vincze Áron Izbéki Ferenc Gajdán László Gódi Szilárd Illés Árpád (1959-) (belgyógyász, haematológus, onkológus) Sarlós Péter Farkas Nelli Erős Bálint Lillik Veronika Illés Dóra Varjú Péter Márta Katalin Török I. Papp Mária (1975-) (belgyógyász, gasztroenterológus) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Bod Barnabás Hamvas József Szepes Zoltán Takács T. Czakó László Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Hegyi Péter Jenő (belgyógyász) Mikó Alexandra
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5.

001-es BibID:BIBFORM085501
Első szerző:Hágendorn Roland
Cím:Development of disturbance of consciousness is associated with increased severity in acute pancreatitis / Roland Hágendorn, Áron Vincze, Ferenc Izbéki, László Gajdán, Szilárd Gódi, Anita Illés, Patrícia Sarlós, Nelli Farkas, Bálint Erőss, Veronika Lillik, Dóra Illés, Péter Varjú, Katalin Márta, Imola Török, Mária Papp, Zsuzsanna Vitális, Barnabás Bod, József Hamvas, Zoltán Szepes, Tamás Takács, László Czakó, Zsolt Márton, Andrea Szentesi, Andrea Párniczky, Péter Hegyi, Alexandra Mikó
Dátum:2020
ISSN:1424-3903
Megjegyzések:Background Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient's condition, but we have no exact data on how DOC affects the outcome of AP. Methods From the Hungarian Pancreatic Study Groups' AP registry, 1220 prospectively collected cases were analysed, which contained exact data on DOC, included patients with confusion, delirium, convulsion, and alcohol withdrawal, answering a post hoc defined research question. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC DOC groups. For statistical analysis, independent sample t-test, Mann-Whitney, Chi-squared, or Fisher exact test were used. Results From the 1220 patients, 47 (3.9%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. Analysis between the DOC and Non-DOC groups showed a higher incidence of severe AP (19.2% vs. 5.3%, p<0.001), higher mortality (14.9% vs. 1.7%, p<0.001), and a longer length of hospitalization (LOH) (Me=11; IQR: 8-17 days vs. Me=9; IQR: 6-13 days, p=0.049) respectively. Patients with ALC DOC developed more frequently moderate AP vs. Non-ALC DOC (43.5% vs. 12.5%), while the incidence of severe AP was higher in Non-ALC vs. ALC DOC group (33.3% vs. 4.4%) (p<0.001). LOH showed a tendency to be longer in Non-ALC DOC compared to ALC DOC, respectively (Me:13; IQR:7-20 days vs. Me:9.5; IQR:8-15.5 days, p=0.119). Conclusion DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
disturbance of consciousness
acute pancreatitis
alcohol
delirium
mortality
Megjelenés:Pancreatology. - 20 : 5 (2020), p. 806-812. -
További szerzők:Vincze Áron Izbéki Ferenc Gajdán László Gódi Szilárd Illés Anita Sarlós Patrícia Farkas Nelli Erőss Bálint Lillik Veronika Illés Dóra Varjú Péter Márta Katalin Török Imola Papp Mária (1975-) (belgyógyász, gasztroenterológus) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Bod Barnabás Hamvas József Szepes Zoltán Takács Tamás (Szeged) Czakó László Márton Zsolt Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Hegyi Péter Jenő (belgyógyász) Mikó Alexandra
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6.

001-es BibID:BIBFORM090160
035-os BibID:(cikkazonosító)1367 (WOS)000626774100081 (Scopus)85099483306
Első szerző:Hegyi Péter Jr. (belgyógyász)
Cím:Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis : a cross-sectional multicentre international study with experimental animal model / Péter J. Hegyi, Alexandra Soós, Emese Tóth, Attila Ébert, Viktória Venglovecz, Katalin Márta, Péter Mátrai, Alexandra Mikó, Judit Bajor, Patrícia Sarlós, Áron Vincze, Adrienn Halász, Ferenc Izbéki, Zoltán Szepes, László Czakó, György Kovács, Mária Papp, Zsolt Dubravcsik, Márta Varga, József Hamvas, Balázs C. Németh, Melania Macarie, Ali Tüzüm Ince, Elena A. Dubtsova, Mariya A. Kirynkova, Igor E. Khatkov, Tanya Bideeva, Artautas Mickevicius, Elena Ramírez-Maldonado, Ville Sallinen, Bálint Erős, Dániel Pécsi, Andrea Szentesi, Andrea Párniczky, László Tiszlavicz, Péter Hegyi
Dátum:2021
ISSN:2045-2322
Megjegyzések:Abstract Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 11 : 1 (2021), p. 1-14. -
További szerzők:Soós Alexandra Tóth Emese Ébert Attila Venglovecz Viktória Márta Katalin Mátrai Péter Mikó Alexandra Bajor Judit Sarlós Patrícia Vincze Áron Halász Adrienn Izbéki Ferenc Szepes Zoltán Czakó László Kovács György (1982-) (belgyógyász, gasztroenterológus) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Dubravcsik Zsolt (belgyógyász, gasztroenterológus) Varga Márta Hamvas József Németh Balázs Csaba Macarie, Melania Ince, Ali Tüzün Dubtsova, Elena A. Kirynkova, Mariya A. Khatkov, Igor E. Bideeva, Tanya Mickevicius, Artautas Ramírez-Maldonado, Elena Sallinen, Ville Erős Bálint Pécsi Dániel Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Tiszlavicz László Hegyi Péter Jenő (belgyógyász)
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7.

001-es BibID:BIBFORM113578
035-os BibID:(Scopus)85165616258
Első szerző:Juhász Márk Félix
Cím:Invalidity of Tokyo guidelines in acute biliary pancreatitis : A multicenter cohort analysis of 944 pancreatitis cases / Juhász Márk Félix, Tóháti Rebeka, Jászai Viktória Adrienn, Molnár Regina, Farkas Nelli, Czakó László, Vincze Áron, Erőss Bálint, Szentesi Andrea, Izbéki Ferenc, Papp Mária, Hegyi Péter, Párniczky Andrea, Hungarian Pancreatic Study Group
Dátum:2023
ISSN:2050-6406 2050-6414
Megjegyzések:Abstract Background There is a noteworthy overlap between the clinical picture of biliary acute pancreatitis (AP) and the 2018 Tokyo guidelines currently used for the diagnosis of cholangitis (AC) and cholecystitis (CC). This can lead to significant antibiotic and endoscopic retrograde cholangiopancreatography (ERCP) overuse. Objectives We aimed to assess the on-admission prevalence of AC/CC according to the 2018 Tokyo guidelines (TG18) in a cohort of biliary AP patients, and its association with antibiotic use, ERCP and clinically relevant endpoints. Methods We conducted a secondary analysis of the Hungarian Pancreatic Study Group's prospective multicenter registry of 2195 AP cases. We grouped and compared biliary cases (n?=?944) based on the on-admission fulfillment of definite AC/CC according to TG18. Aside from antibiotic use, we evaluated mortality, AC/CC/AP severity, ERCP performance and length of hospitalization. We also conducted a literature review discussing each criteria of the TG18 in the context of AP. Results 27.8% of biliary AP cases fulfilled TG18 for both AC and CC, 22.5% for CC only and 20.8% for AC only. Antibiotic use was high (77.4%). About 2/3 of the AC/CC cases were mild, around 10% severe. Mortality was below 1% in mild and moderate AC/CC patients, but considerably higher in severe cases (12.8% and 21.2% in AC and CC). ERCP was performed in 89.3% of AC cases, common bile duct stones were found in 41.1%. Conclusion Around 70% of biliary AP patients fulfilled the TG18 for AC/CC, associated with a high rate of antibiotic use. Mortality in presumed mild or moderate AC/CC is low. Each of the laboratory and clinical criteria are commonly fulfilled in biliary AP, single imaging findings are also unspecific?AP specific diagnostic criteria are needed, as the prevalence of AC/CC are likely greatly overestimated. Randomized trials testing antibiotic use are also warranted.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:United European Gastroenterology Journal. - 11 (2023), p. 767-774. -
További szerzők:Tóháti Rebeka Jászai Viktória Adrienn Molnár Regina Farkas Nelli Czakó László Vincze Áron Erőss Bálint Szentesi Andrea Izbéki Ferenc Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hegyi Péter Jenő (belgyógyász) Párniczky Andrea (gyermekgyógyász) Hungarian Pancreatic Study Group
Pályázati támogatás:FK138929
OTKA
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

8.

001-es BibID:BIBFORM105426
035-os BibID:(scopus)85138835366 (wos)000860477900001 (cikkazonosító)801592
Első szerző:Juhász Márk Félix
Cím:Pancreatic family history does not predict disease progression but connotes alcohol consumption in adolescents and young adults with acute pancreatitis : Analysis of an international cohort of 2,335 patients / Márk Félix Juhász, Nelli Farkas, Andrea Szentesi, Andrzej Wedrychowicz, Andreia Florina Nita, Natália Lásztity, Alexandra Tészás, István Tokodi, Áron Vincze, Bálint Eross, Ferenc Izbéki, László Czakó, Mária Papp, Péter Hegyi, Andrea Párniczky
Dátum:2022
ISSN:2296-858X
Megjegyzések:Background: In pediatric acute pancreatitis (AP), a family history of pancreatic diseases is prognostic for earlier onset of recurrent AP (ARP) and chronic pancreatitis (CP). No evidence supports the same association in adult-onset pancreatitis. Age-specific reasons for familial aggregation are also unclear. We aimed to examine the prognostic role of pancreatic family history for ARP/CP and observe possible underlying mechanisms. Methods: We conducted a secondary analysis of the Hungarian Pancreatic Study Group's (HPSG) multicenter, international, prospective registry of patients with AP, both children and adults. We compared the positive family history and the negative family history of pancreatic diseases, in different age groups, and analyzed trends of accompanying factors. Chi-square and Fisher exact tests were usedResults: We found a higher rate of ARP/CP in the positive pancreatic family history group (33.7 vs. 25.9%, p = 0.018), peaking at 6?17 years. Idiopathic AP peaked in childhood in the positive family history group (75% 0?5 years) and was consistently 20?35% in the negative group. A higher rate of alcohol consumption/smoking was found in the positive groups at 12?17 years (62.5 vs. 15.8%, p = 0.013) and 18?29 years (90.9 vs. 58.1%, p = 0.049). The prevalence of diabetes and hyperlipidemia steadily rose with age in both groups. Conclusion: Positive family history most likely signifies genetic background in early childhood. During adolescence and early adulthood, alcohol consumption and smoking emerge?clinicians should be aware and turn to intervention in such cases. Contrary to current viewpoints, positive pancreatic family history is not a prognostic factor for ARP and CP in adults, so it shouldnot be regarded that way.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Medicine. - 9 (2022), p. 1-8. -
További szerzők:Farkas Nelli Szentesi Andrea Wedrychowicz, Andrzej Nita, Andreia Florina Lásztity Natália (gyermekgyógyász, gasztroenterológus) Tészás Alexandra Tokodi István Vincze Áron Erőss Bálint Izbéki Ferenc Czakó László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hegyi Péter Jr. (belgyógyász) Párniczky Andrea (gyermekgyógyász)
Pályázati támogatás:GINOP-2.3.2-15-2016-00015
GINOP
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

9.

001-es BibID:BIBFORM097905
035-os BibID:(WoS)000784212600006 (Scopus)85118725064
Első szerző:Juhász Márk Félix
Cím:The EFFect of dietary fat content on the recurrence of pancreaTitis (EFFORT) : protocol of a multicenter randomized controlled trial / Juhász Márk Félix, Vereczkei Zsófia, Ocskay Klementina, Szakó Lajos, Farkas Nelli, Szakács Zsolt, Zádori Noémi, Wilschanski Michael, Pandol Stephen J., Joly Francisca, Capurso Gabriele, Arcidiacono Paolo Giorgio, Izbéki Ferenc, Czakó László, Papp Mária, Czopf László, Hegyi Péter Jr., Párniczky Andrea, Hungarian Pancreatic Study Group
Dátum:2022
ISSN:1424-3903
Megjegyzések:Background: Around 20% of patients with acute pancreatitis (AP) will develop acute recurrent pancreatitis (ARP) and 10% will progress to chronic pancreatitis. While interventions to avoid recurrences exist for the two most common causes - abstinence for alcoholic and cholecystectomy for biliary pancreatitis - the are no known preventive measures in idiopathic ARP. Though it is not included in any of the guidelines, a low-fat diet is often recommended. Our aim is to test dietary fat reduction's effect on AP recurrence in a randomized controlled setting, in order to provide high-quality evidence for the validity of such an intervention. Methods, design: Participants with at least 2 episodes of AP in the preceding 2 years of which the last episode was idiopathic will be randomized to one of two diets with different fat contents: a 'reduced fat diet' (15% fat, 65% carbohydrate, 20% protein) and a 'standard healthy diet' (30% fat, 50% carbohydrate, 20% protein; based on WHO recommendations). Participants will be followed-up for 2 years (visits will be scheduled for months 3, 6, 12, 18 and 24) during which they will receive a repeated session of nutritional guidance, complete food frequency questionnaires and data on relapse, mortality, BMI, cardiovascular parameters and serum lipid values will be collected. Discussion: This study will determine the effect of modifying the dietary fat content on AP recurrence, mortality, serum lipids and weight loss in idiopathic cases.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Pancreatology. - 22 : 1 (2022), p. 51-57. -
További szerzők:Vereczkei Zsófia Ocskay Klementina Szakó Lajos Farkas Nelli Szakács Zsolt Zádori Noémi Wilschanski, Michael Pandol, Stephen J. Joly, Francisca Capurso, Gabriele Arcidiacono, Paolo Giorgio Izbéki Ferenc Czakó László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Czopf László Hegyi Péter Jr. (belgyógyász) Párniczky Andrea (gyermekgyógyász) Hungarian Pancreatic Study Group
Pályázati támogatás:GINOP-2.3.2-15-2016-00048
GINOP
EFOP-3.6.2-16-2017-00006
EFOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

10.

001-es BibID:BIBFORM101539
035-os BibID:(Cikkazonosító)7827 (WOS)000795163100024 (Scopus)85130054194 (PMID)35552440
Első szerző:Kiss Szabolcs
Cím:Early prediction of acute necrotizing pancreatitis by artificial intelligence : a prospective cohort-analysis of 2387 cases / Szabolcs Kiss, József Pintér, Roland Molontay, Marcell Nagy, Nelli Farkas, Zoltán Sipos, Péter Fehérvári, László Pecze, Mária Földi, Áron Vincze, Tamás Takács, László Czakó, Ferenc Izbéki, Adrienn Halász, Eszter Boros, József Hamvas, Márta Varga, Artautas Mickevicius, Nándor Faluhelyi, Orsolya Farkas, Szilárd Váncsa, Rita Nagy, Stefania Bunduc, Péter Jenő Hegyi, Katalin Márta, Katalin Borka, Attila Doros, Nóra Hosszúfalusi, László Zubek, Bálint Erőss, Zsolt Molnár, Andrea Párniczky, Péter Hegyi, Andrea Szentesi, Hungarian Pancreatic Study Group
Dátum:2022
ISSN:2045-2322
Megjegyzések:Pancreatic necrosis is a consistent prognostic factor in acute pancreatitis (AP). However, the clinical scores currently in use are either too complicated or require data that are unavailable on admission or lack sufficient predictive value. We therefore aimed to develop a tool to aid in necrosis prediction. The XGBoost machine learning algorithm processed data from 2,387 patients with AP. The confidence of the model was estimated by a bootstrapping method and interpreted via the 10th and the 90th percentiles of the prediction scores. Shapley Additive exPlanations (SHAP) values were calculated to quantify the contribution of each variable provided. Finally, the model was implemented as an online application using the Streamlit Python-based framework. The XGBoost classifier provided an AUC value of 0.757. Glucose, C-reactive protein, alkaline phosphatase, gender and total white blood cell count have the most impact on prediction based on the SHAP values. The relationship between the size of the training dataset and model performance shows that prediction performance can be improved. This study combines necrosis prediction and artificial intelligence. The predictive potential of this model is comparable to the current clinical scoring systems and has several advantages over them.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 12 : 1 (2022), p. 1-1. -
További szerzők:Pintér József (1930-) (urológus) Molontay Roland Nagy Marcell Farkas Nelli Sipos Zoltán (1988-) (vegyész, angol-magyar szakfordító) Fehérvári Péter Pecze László Földi Mária Vincze Áron Takács Tamás (Szeged) Czakó László Izbéki Ferenc Halász Adrienn Boros Eszter Hamvas József Varga Márta Mickevicius, Artautas Faluhelyi Nándor Farkas Orsolya Váncsa Szilárd Nagy Rita Bunduc, Stefania Hegyi Péter Jenő (belgyógyász) Márta Katalin Borka Katalin Doros Attila Hosszúfalusi Nóra Zubek László (1970-) (aneszteziológus és intenzív terápiás, kardiológus, oxyológus) Erőss Bálint Molnár Zsolt (Pécs, aneszteziológus) Párniczky Andrea (gyermekgyógyász) Hegyi Péter (pszichológus) Szentesi Andrea Papp Mária (1975-) (belgyógyász, gasztroenterológus) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Hungarian Pancreatic Study Group
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

11.

001-es BibID:BIBFORM101294
035-os BibID:(cikkazonosító)e842 (wos)000804849400001
Első szerző:Kui Balázs
Cím:EASY-APP : an artificial intelligence model and application for early and easy prediction of severity in acute pancreatitis / Kui Balázs, Pintér József, Molontay Roland, Nagy Marcell, Farkas Nelli, Gede Noémi, Vincze Áron, Bajor Judit, Gódi Szilárd, Czimmer József, Szabó Imre, Illés Anita, Sarlós Patrícia, Hágendorn Roland, Pár Gabriella, Papp Mária, Vitális Zsuzsanna, Kovács György, Fehér Eszter, Földi Ildikó, Izbéki Ferenc, Gajdán László, Fejes Roland, Németh Balázs Csaba, Török Imola, Farkas Hunor, Artautas Mickevicius, Ville Sallinen, Shamil Galeev, Elena Ramirez Maldonado, Párniczky Andrea, Erőss Bálint, Hegyi Péter Jenő, Márta Katalin, Váncsa Szilárd, Sutton Robert, Enrique de-Madaria, Elizabeth Pando, Piero Alberti, Maria José Gómez-Jurado, Alina Tantau, Szentesi Andrea, Hegyi Péter, Hungarian Pancreatic Study Group
Dátum:2022
ISSN:2001-1326
Megjegyzések:Background: Acute pancreatitis (AP) is a potentially severe or even fatal inflammation of the pancreas. Early identification of patients, who are at high risk for developing a severe course of the disease is crucial for preventing organ failure and death. Most of the former predictive scores require many parameters or at least 24 hours to predict the severity, so the early therapeutic window is missing. Methods: The early achievable severity index (EASY) is a registered multicentre, multinational, prospective, observational study (ISRCTN10525246). Clinical parameters were collected from 15 countries and 28 medical centres via eCRF. The predictions were made using machine learning models including Decision Tree, Random Forest, Logistic Regression, SVM, CatBoost, and XGBoost. For the modeling, we used the scikit-learn, xgboost, and catboost Python packages. We have evaluated our models using 4-fold cross-validation and the receiver operating characteristic (ROC) curve, the area under the ROC curve (AUC), and accuracy metrics have been calculated on the union of the test sets of the cross-validation. The most important factors and their contribution to the prediction were identified using a modern tool of explainable artificial intelligence, called SHapley Additive exPlanations (SHAP). Using the XGBoost machine learning algorithm for prediction, the SHAP values for the explanation, and the bootstrapping method for the estimation of confidence we have developed a web application in the Streamlit Python-based framework. Results: The prediction model is based on the international cohort of 1184 patients and a validation cohort of 3543 patients. The best performing model has been an XGBoost classifier with an average AUC score of 0.81 and accuracy of 89.1% and the model is improving with experience. The six most influential features are the respiratory rate, body temperature, abdominal muscular reflex, gender, age, and glucose level. Finally, a free and easy-to-use web application was developed (http://easy-app.org/). Conclusions: The EASY prediction score is a practical tool for identifying patients at high risk for severe acute pancreatitis within hours of hospital admission. The easy-to-use web application is available for clinicians and contributes to the improvement of the model.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
severity prediction
acute pancreatitis
artificial intelligence
Megjelenés:Clinical and Translational Medicine. - 12 : 6 (2022), p. 1-13. -
További szerzők:Pintér József (1930-) (urológus) Molontay Roland Nagy Marcell Farkas Nelli Gede Noémi Vincze Áron Bajor Judit Gódi Szilárd Czimmer József Szabó Imre Illés Anita Sarlós Patrícia Hágendorn Roland Pár Gabriella Papp Mária (1975-) (belgyógyász, gasztroenterológus) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Kovács György (1982-) (belgyógyász, gasztroenterológus) Fehér Eszter Földi Ildikó (1981-) (orvos) Izbéki Ferenc Gajdán László Fejes Roland Németh Balázs Csaba Török Imola Farkas Hunor Mickevicius, Artautas Sallinen, Ville Galeev, Shamil Ramírez-Maldonado, Elena Párniczky Andrea (gyermekgyógyász) Erőss Bálint Hegyi Péter Jenő (belgyógyász) Márta Katalin Váncsa Szilárd Sutton, Robert de-Madaria, Enrique Pando, Elizabeth Alberti, Piero Gómez-Jurado, Maria José Tantau, Alina Szentesi Andrea Hegyi Péter (pszichológus) Hungarian Pancreatic Study Group
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

12.

001-es BibID:BIBFORM084964
Első szerző:Mosztbacher Dóra
Cím:Hypertriglyceridemia-induced acute pancreatitis : a prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases / Mosztbacher Dóra, Hanák Lilla, Farkas Nelli, Szentesi Andrea, Mikó Alexandra, Bajor Judit, Sarlós Patrícia, Czimmer József, Vincze Áron, Hegyi Péter Jenő, Erőss Bálint, Takács Tamás, Czakó László, Németh Balázs Csaba, Izbéki Ferenc, Halász Adrienn, Gajdán László, Hamvas József, Papp Mária, Földi Ildikó, Fehér Krisztina Eszter, Varga Márta, Csefkó Klára, Török Imola, Farkas Hunor Pál, Mickevicius Artautas, Maldonado Elena Ramirez, Sallinen Ville, Novák János, Ince Ali Tüzün, Galeev Shamil, Bod Barnabás, Sümegi János, Pencik Petr, Dubravcsik Zsolt, Illés Dóra, Gódi Szilárd, Kui Balázs, Márta Katalin, Pécsi Dániel, Varjú Péter, Szakács Zsolt, Darvasi Erika, Párniczky Andrea, Hegyi Péter Jr., Hungarian Pancreatic Study Group
Dátum:2020
ISSN:1424-3903
Megjegyzések:Background. Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP). It has been shown that hypertriglyceridemia aggravates the severity and related complications of AP; however, detailed analyses of large cohorts are inadequate and contradictory. Our aim was to investigate the dose-dependent effect of hypertriglyceridemia on AP. Methods. AP patients over 18 years old who underwent triglyceride measurement within the initial three days were included into our cohort analysis from a prospective international, multicenter AP registry operated by the Hungarian Pancreatic Study Group. Data on 716 AP cases were analyzed. Six groups were created based on the highest triglyceride level (<1.7 mmol/l, 1.7?2.19 mmol/l, 2.2?5.59 mmol/l, 5.6?11.29 mmol/l, 11.3?22.59 mmol/l, ?22.6 mmol/l). Results. Hypertriglyceridemia (?1.7 mmol/l) presented in 30.6% of the patients and was significantly and dose- dependently associated with younger age and male gender. In 7.7% of AP cases, hypertriglyceridemia (?11.3 mmol/l) was considered as a causative etiological factor; however, 43.6% of these cases were associated with other etiologies (alcohol and biliary). Hypertriglyceridemia was significantly and dose-dependently related to obesity and diabetes. The rates of local complications, organ failure and maximum CRP level were significantly and dose- dependently raised by hypertriglyceridemia. Triglyceride above 11.3 mmol/l was linked to a significantly higher incidence of moderately severe AP and longer hospital stay, whereas triglyceride over 22.6 mmol/l was significantly associated with severe AP as well. Conclusion. Hypertriglyceridemia dose-dependently aggravates the severity and related complications of AP. Diagnostic workup for hypertriglyceridemia requires better awareness regardless of the etiology of AP.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
acute pancreatitis
hypertriglyceridemia
etiology
cohort
severity
Megjelenés:Pancreatology. - 20 : 4 (2020), p. 608-616. -
További szerzők:Hanák Lilla Farkas Nelli Szentesi Andrea Mikó Alexandra Bajor Judit Sarlós Patrícia Czimmer József Vincze Áron Hegyi Péter Jenő (belgyógyász) Erőss Bálint Takács Tamás (Szeged) Czakó László Németh Balázs Csaba Izbéki Ferenc Halász Adrienn Gajdán László Hamvas József Papp Mária (1975-) (belgyógyász, gasztroenterológus) Földi Ildikó (1981-) (orvos) Fehér Krisztina Eszter Varga Márta Csefkó Klára Török Imola Farkas Hunor Mickevicius, Artautas Maldonado, Elena Ramirez Sallinen, Ville Novák János Ince, Ali Tüzün Galeev, Shamil Bod Barnabás Sümegi János Pencik, Petr Dubravcsik Zsolt (belgyógyász, gasztroenterológus) Illés Dóra Gódi Szilárd Kui Balázs Márta Katalin Pécsi Dániel Varjú Péter Szakács Zsolt Darvasi Erika Párniczky Andrea (gyermekgyógyász) Hegyi Péter Jr. (belgyógyász) Hungarian Pancreatic Study Group
Pályázati támogatás:K131996
OTKA
FK131864
OTKA
FK124632
OTKA
K120335
OTKA
GINOP 2.3.2-15-2016-00048
GINOP
EFOP-3.6.2-16-2017-00006
EFOP
ÚNKP-19-4
ÚNKP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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