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1.

001-es BibID:BIBFORM077074
Első szerző:Bajor Judit
Cím:HLA-DQ2 homozygosis increases tTGA levels at diagnosis but does not influence the clinical phenotype of celiac disease : a multicenter study / Bajor Judit, Szakacs Zsolt, Juhasz Mark, Papp Maria, Kocsis Dorottya, Szegedi Eva, Foldi Ildiko, Farkas Nelli, Hegyi Peter, Vincze Aron
Dátum:2019
ISSN:1744-3121 1744-313X
Megjegyzések:Background and purpose: Magnitude of gluten-specific T-cell responses in celiac disease might be dependent on HLA-DQ2 gene dose. We aimed to investigate the effects of HLA-DQB1*02 allele dose on clinical outcomes. Methods: We reviewed the charts of all celiac patients attending to three Hungarian university clinics after 1997 and included those patients, who 1) were diagnosed with celiac disease, 2) underwent high resolution HLA-typing, and 3) were ?18 years at the time of data collection. HLA typing was performed to determine DQB1*02 allele dose. Patients were divided into risk groups by DQB1*02 allele dose, as follows: high-, intermediate-, and low-risk groups corresponded to a double, single, and zero doses, respectively. We used ANOVA and Person's chi-squared test to explore association between HLA-risk and clinical variables. Results: 727 celiac patients attended the clinics but only 105 (14.4%) patients were eligible for inclusion. High, intermediate, and low HLA-risk patients comprised 35.3%, 52.3%, and 12.3% of the study population, respectively. Double dose of HLADQB1*02 was more frequent in patient with high tTGA level (> 10 times the upper limit of normal) (p=0.045). Gene dose was not associated with younger age at diagnosis (p=0.549), gender (p=0.739), more severe diagnostic histology (p=0.318), more frequent classical presentation (p=0.846), anemia (p=0.611), metabolic bone disease (p=0.374), dermatitis herpetiformis (p=0.381), and autoimmune diseases (p=0.837). Conclusions: Our study shows a significant gene dose effect in terms of tTGA level at diagnosis, but no significant association between HLA-DQB1*02 allele dose and the clinical outcomes in celiac disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:International Journal of Immunogenetics. - 46 : 2 (2019), p. 74-81. -
További szerzők:Szakács Zsolt Juhász Márk Félix Papp Mária (1975-) (belgyógyász, gasztroenterológus) Kocsis Dorottya Szegedi Éva Földi Ildikó (1981-) (orvos) Farkas Nelli Hegyi Péter Jenő (belgyógyász) Vincze Áron
Pályázati támogatás:ÚNKP-17-3-II
ÚNKP
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2.

001-es BibID:BIBFORM088207
Első szerző:Demcsák Alexandra
Cím:Acid suppression therapy, gastrointestinal bleeding and infection in acute pancreatitis - An international cohort study / Alexandra Demcsak, Alexandra Soos, Lilla Kincses, Ines Capunge, Georgi Minkov, Mila Kovacheva-Slavova, Radislav Nakov, Dong Wu, Wei Huang, Qing Xia, Lihui Deng, Marcus Hollenbach, Alexander Schneider, Michael Hirth, Orestis Ioannidis, Aron Vincze, Judit Bajor, Patrícia Sarlos, Laszló Czakó, Dora Illés, Ferenc Izbeki, Laszló Gajdán, Maria Papp, Jozsef Hamvas, Marta Varga, Peter Kanizsai, Ernő Bóna, Alexandra Miko, Szilard Váncsa, Márk Félix Juhász, Klementina Ocskay, Erika Darvasi, Emőke Miklós, Balint Erőss, Andrea Szentesi, Andrea Parniczky, Riccardo Casadei, Claudio Ricci, Carlo Ingaldi, Laura Mastrangelo, Elio Jovine, Vincenzo Cennamo, Marco V. Marino, Giedrius Barauskas, Povilas Ignatavicius, Mario Pelaez-Luna, Andrea Soriano Rios, Svetlana Turcan, Eugen Tcaciuc, Ewa Małecka-Panas, Hubert Zatorski, Vitor Nunes, Antonio Gomes, Tiago Cúrdia Gonçalves, Marta Freitas, Júlio Constantino, Milene Sa, Jorge Pereira, Bogdan Mateescu, Gabriel Constantinescu, Vasile Sandru, Ionut Negoi, Cezar Ciubotaru, Valentina Negoita, Stefania Bunduc, Cristian Gheorghe, Sorin Barbu, Alina Tantau, Marcel Tantau, Eugen Dumitru, Andra Iulia Suceveanu, Cristina Tocia, Adriana Gherbon, Andrey Litvin, Natalia Shirinskaya, Yliya Rabotyagova, Mihailo Bezmarevic, Péter Jenő Hegyi, Jimin Han, Juan Armando Rodriguez-Oballe, Isabel Miguel Salas, Eva Pijoan Comas, Daniel de la Iglesia Garcia, Andrea Jardi Cuadrado, Adriano Quiroga Castineira, Yu-Ting Chang, Ming-Chu Chang, Ali Kchaou, Ahmed Tlili, Sabite Kacar, Volkan Gokbulut, Deniz Duman, Haluk Tarik Kani, Engin Altintas, Serge Chooklin, Serhii Chuklin, Amir Gougol, George Papachristou, Peter Hegyi Jr.
Dátum:2020
ISSN:1424-3903
Megjegyzések:Background:Acid suppressing drugs (ASD) are generally used in acute pancreatitis (AP); however, largecohorts are not available to understand their efficiency and safety. Therefore, our aims were to evaluatethe association between the administration of ASDs, the outcome of AP, the frequency of gastrointestinal(GI) bleeding and GI infection in patients with AP.Methods:We initiated an international survey and performed retrospective data analysis on AP patientshospitalized between January 2013 and December 2018.Results:Data of 17,422 adult patients with AP were collected from 59 centers of 23 countries. We foundthat 23.3% of patients received ASDs before and 86.6% during the course of AP. ASDs were prescribed to57.6% of patients at discharge. ASD administration was associated with more severe AP and highermortality. GI bleeding was reported in 4.7% of patients, and it was associated with pancreatitis severity,mortality and ASD therapy. Stool culture test was performed in 6.3% of the patients with 28.4% positiveresults.Clostridium difficilewas the cause of GI infection in 60.5% of cases. Among the patients with GIinfections, 28.9% received ASDs, whereas 24.1% were without any acid suppression treatment. GI infec-tion was associated with more severe pancreatitis and higher mortality.Conclusions:Although ASD therapy is widely used, it is unlikely to have beneficial effects either on theoutcome of AP or on the prevention of GI bleeding during AP. Therefore, ASD therapy should be sub-stantially decreased in the therapeutic management of AP.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Acid suppressing drug
Gastrointestinal bleeding
Gastrointestinal infection
Acute pancreatitis
Proton pump inhibitor
Megjelenés:Pancreatology. - 20 : 7 (2020), p. 1323-1331. -
További szerzők:Soós Alexandra Kincses Lilla Capunge, Ines Minkov, Georgi Kovacheva-Slavova, Mila Nakov, Radislav Wu, Dong Huang, Wei Xia, Qing Deng, Lihui Hollenbach, Marcus Schneider, Alexander Hirth, Michael Ioannidis, Orestis Vincze Áron Bajor Judit Sarlós Patrícia Czakó László Illés Dóra Izbéki Ferenc Gajdán László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hamvas József Varga Márta Kanizsai Péter Bóna Ernő Mikó Alexandra Váncsa Szilárd Juhász Márk Félix Ocskay Klementina Darvasi Erika Miklós Emőke Erőss Bálint Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Casadei, Riccardo Ricci, Claudio Ingaldi, Carlo Mastrangelo, Laura Jovine, Elio Cennamo, Vincenzo Marino, Marco Vito Barauskas, Giedrius Ignatavicius, Povilas Pelaez-Luna, Mario Rios, Andrea Soriano Turcan, Svetlana Tcaciuc, Eugen Małecka-Panas, Ewa Zatorski, Hubert Nunes, Vitor Gomes, António Pedro Gonçalves, Tiago Cúrdia Freitas, Marta Constantino, Júlio Sá, Milene Pereira, Jorge Mateescu, Bogdan Constantinescu, Gabriel Sandru, Vasile Negoi, Ionut Ciubotaru, Cezar Negoita, Valentina Bunduc, Stefania Gheorghe, Cristian Barbu, Sorin Tantau, Alina Tantau, Marcel Dumitru, Eugen Suceveanu, Andra Iulia Tocia, Cristina Gherbon, Adriana Litvin, A. Andrey Shirinskaya, Natalia V. Rabotyagova, Yliya Bezmarevic, Mihailo Hegyi Péter Jenő (belgyógyász) Han, Jimin Rodriguez-Oballe, Juan Armando Salas, Isabel Miguel Comas, Eva Pijoan Garcia, Daniel de la Iglesia Cuadrado, Andrea Jardi Castiñeira, Adriano Quiroga Chang, Yu-Ting Chang, Ming-Chu Kchaou, Ali Tlili, Ahmed Kacar, Sabite Gökbulut, Volkan Duman, Deniz Kani, Haluk Tarik Altintas, Engin Chooklin, Serge Chuklin, Serhii Gougol, Amir Papachristou, Georgios I. Hegyi Péter Jr. (belgyógyász)
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3.

001-es BibID:BIBFORM061703
035-os BibID:(WoS)000370276800004 (Scopus)85020318416
Első szerző:Gecse Krisztina B.
Cím:Efficacy And Safety Of The Biosimilar Infliximab CT-P13 Treatment In Inflammatory Bowel Diseases : a Prospective, Multicentre, Nationwide Cohort / Krisztina B. Gecse, Barbara D. Lovász, Klaudia Farkas, János Banai, László Bene, Beáta Gasztonyi, Petra Anna Golovics, Tünde Kristóf, László Lakatos, Ágnes Anna Csontos, Márk Juhász, Ferenc Nagy, Károly Palatka, Mária Papp, Árpád Patai, Lilla Lakner, Ágnes Salamon, Tamás Szamosi, Zoltán Szepes, Gábor T. Tóth, Áron Vincze, Balázs Szalay, Tamás Molnár Péter, L. Lakatos
Dátum:2016
ISSN:1873-9946
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Crohns & Colitis. - 10 : 2 (2016), p. 133-140. -
További szerzők:Lovász Barbara Dorottya Farkas Klaudia Banai János Bene László (Budapest) Gasztonyi Beáta Golovics Petra Anna Kristóf Tünde Lakatos László (Veszprém) Csontos Ágnes Anna Juhász Márk Félix Nagy Ferenc (orvos Szeged) Palatka Károly (1961-) (belgyógyász, gasztroenterológus) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Patai Árpád (belgyógyász) Lakner Lilla Salamon Ágnes (orvos Szekszárd) Szamosi Tamás Szepes Zoltán Tóth Gábor Tamás Vincze Áron Szalay Balázs Molnár Tamás (orvos Szeged) Lakatos Péter (Semmelweis Egyetem)
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4.

001-es BibID:BIBFORM113578
035-os BibID:(Scopus)85165616258
Első szerző:Juhász Márk Félix
Cím:Invalidity of Tokyo guidelines in acute biliary pancreatitis : A multicenter cohort analysis of 944 pancreatitis cases / Juhász Márk Félix, Tóháti Rebeka, Jászai Viktória Adrienn, Molnár Regina, Farkas Nelli, Czakó László, Vincze Áron, Erőss Bálint, Szentesi Andrea, Izbéki Ferenc, Papp Mária, Hegyi Péter, Párniczky Andrea, Hungarian Pancreatic Study Group
Dátum:2023
ISSN:2050-6406 2050-6414
Megjegyzések:Abstract Background There is a noteworthy overlap between the clinical picture of biliary acute pancreatitis (AP) and the 2018 Tokyo guidelines currently used for the diagnosis of cholangitis (AC) and cholecystitis (CC). This can lead to significant antibiotic and endoscopic retrograde cholangiopancreatography (ERCP) overuse. Objectives We aimed to assess the on-admission prevalence of AC/CC according to the 2018 Tokyo guidelines (TG18) in a cohort of biliary AP patients, and its association with antibiotic use, ERCP and clinically relevant endpoints. Methods We conducted a secondary analysis of the Hungarian Pancreatic Study Group's prospective multicenter registry of 2195 AP cases. We grouped and compared biliary cases (n?=?944) based on the on-admission fulfillment of definite AC/CC according to TG18. Aside from antibiotic use, we evaluated mortality, AC/CC/AP severity, ERCP performance and length of hospitalization. We also conducted a literature review discussing each criteria of the TG18 in the context of AP. Results 27.8% of biliary AP cases fulfilled TG18 for both AC and CC, 22.5% for CC only and 20.8% for AC only. Antibiotic use was high (77.4%). About 2/3 of the AC/CC cases were mild, around 10% severe. Mortality was below 1% in mild and moderate AC/CC patients, but considerably higher in severe cases (12.8% and 21.2% in AC and CC). ERCP was performed in 89.3% of AC cases, common bile duct stones were found in 41.1%. Conclusion Around 70% of biliary AP patients fulfilled the TG18 for AC/CC, associated with a high rate of antibiotic use. Mortality in presumed mild or moderate AC/CC is low. Each of the laboratory and clinical criteria are commonly fulfilled in biliary AP, single imaging findings are also unspecific?AP specific diagnostic criteria are needed, as the prevalence of AC/CC are likely greatly overestimated. Randomized trials testing antibiotic use are also warranted.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:United European Gastroenterology Journal. - 11 (2023), p. 767-774. -
További szerzők:Tóháti Rebeka Jászai Viktória Adrienn Molnár Regina Farkas Nelli Czakó László Vincze Áron Erőss Bálint Szentesi Andrea Izbéki Ferenc Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hegyi Péter Jenő (belgyógyász) Párniczky Andrea (gyermekgyógyász) Hungarian Pancreatic Study Group
Pályázati támogatás:FK138929
OTKA
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5.

001-es BibID:BIBFORM105426
035-os BibID:(scopus)85138835366 (wos)000860477900001 (cikkazonosító)801592
Első szerző:Juhász Márk Félix
Cím:Pancreatic family history does not predict disease progression but connotes alcohol consumption in adolescents and young adults with acute pancreatitis : Analysis of an international cohort of 2,335 patients / Márk Félix Juhász, Nelli Farkas, Andrea Szentesi, Andrzej Wedrychowicz, Andreia Florina Nita, Natália Lásztity, Alexandra Tészás, István Tokodi, Áron Vincze, Bálint Eross, Ferenc Izbéki, László Czakó, Mária Papp, Péter Hegyi, Andrea Párniczky
Dátum:2022
ISSN:2296-858X
Megjegyzések:Background: In pediatric acute pancreatitis (AP), a family history of pancreatic diseases is prognostic for earlier onset of recurrent AP (ARP) and chronic pancreatitis (CP). No evidence supports the same association in adult-onset pancreatitis. Age-specific reasons for familial aggregation are also unclear. We aimed to examine the prognostic role of pancreatic family history for ARP/CP and observe possible underlying mechanisms. Methods: We conducted a secondary analysis of the Hungarian Pancreatic Study Group's (HPSG) multicenter, international, prospective registry of patients with AP, both children and adults. We compared the positive family history and the negative family history of pancreatic diseases, in different age groups, and analyzed trends of accompanying factors. Chi-square and Fisher exact tests were usedResults: We found a higher rate of ARP/CP in the positive pancreatic family history group (33.7 vs. 25.9%, p = 0.018), peaking at 6?17 years. Idiopathic AP peaked in childhood in the positive family history group (75% 0?5 years) and was consistently 20?35% in the negative group. A higher rate of alcohol consumption/smoking was found in the positive groups at 12?17 years (62.5 vs. 15.8%, p = 0.013) and 18?29 years (90.9 vs. 58.1%, p = 0.049). The prevalence of diabetes and hyperlipidemia steadily rose with age in both groups. Conclusion: Positive family history most likely signifies genetic background in early childhood. During adolescence and early adulthood, alcohol consumption and smoking emerge?clinicians should be aware and turn to intervention in such cases. Contrary to current viewpoints, positive pancreatic family history is not a prognostic factor for ARP and CP in adults, so it shouldnot be regarded that way.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Medicine. - 9 (2022), p. 1-8. -
További szerzők:Farkas Nelli Szentesi Andrea Wedrychowicz, Andrzej Nita, Andreia Florina Lásztity Natália (gyermekgyógyász, gasztroenterológus) Tészás Alexandra Tokodi István Vincze Áron Erőss Bálint Izbéki Ferenc Czakó László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hegyi Péter Jr. (belgyógyász) Párniczky Andrea (gyermekgyógyász)
Pályázati támogatás:GINOP-2.3.2-15-2016-00015
GINOP
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6.

001-es BibID:BIBFORM097905
035-os BibID:(WoS)000784212600006 (Scopus)85118725064
Első szerző:Juhász Márk Félix
Cím:The EFFect of dietary fat content on the recurrence of pancreaTitis (EFFORT) : protocol of a multicenter randomized controlled trial / Juhász Márk Félix, Vereczkei Zsófia, Ocskay Klementina, Szakó Lajos, Farkas Nelli, Szakács Zsolt, Zádori Noémi, Wilschanski Michael, Pandol Stephen J., Joly Francisca, Capurso Gabriele, Arcidiacono Paolo Giorgio, Izbéki Ferenc, Czakó László, Papp Mária, Czopf László, Hegyi Péter Jr., Párniczky Andrea, Hungarian Pancreatic Study Group
Dátum:2022
ISSN:1424-3903
Megjegyzések:Background: Around 20% of patients with acute pancreatitis (AP) will develop acute recurrent pancreatitis (ARP) and 10% will progress to chronic pancreatitis. While interventions to avoid recurrences exist for the two most common causes - abstinence for alcoholic and cholecystectomy for biliary pancreatitis - the are no known preventive measures in idiopathic ARP. Though it is not included in any of the guidelines, a low-fat diet is often recommended. Our aim is to test dietary fat reduction's effect on AP recurrence in a randomized controlled setting, in order to provide high-quality evidence for the validity of such an intervention. Methods, design: Participants with at least 2 episodes of AP in the preceding 2 years of which the last episode was idiopathic will be randomized to one of two diets with different fat contents: a 'reduced fat diet' (15% fat, 65% carbohydrate, 20% protein) and a 'standard healthy diet' (30% fat, 50% carbohydrate, 20% protein; based on WHO recommendations). Participants will be followed-up for 2 years (visits will be scheduled for months 3, 6, 12, 18 and 24) during which they will receive a repeated session of nutritional guidance, complete food frequency questionnaires and data on relapse, mortality, BMI, cardiovascular parameters and serum lipid values will be collected. Discussion: This study will determine the effect of modifying the dietary fat content on AP recurrence, mortality, serum lipids and weight loss in idiopathic cases.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Pancreatology. - 22 : 1 (2022), p. 51-57. -
További szerzők:Vereczkei Zsófia Ocskay Klementina Szakó Lajos Farkas Nelli Szakács Zsolt Zádori Noémi Wilschanski, Michael Pandol, Stephen J. Joly, Francisca Capurso, Gabriele Arcidiacono, Paolo Giorgio Izbéki Ferenc Czakó László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Czopf László Hegyi Péter Jr. (belgyógyász) Párniczky Andrea (gyermekgyógyász) Hungarian Pancreatic Study Group
Pályázati támogatás:GINOP-2.3.2-15-2016-00048
GINOP
EFOP-3.6.2-16-2017-00006
EFOP
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7.

001-es BibID:BIBFORM061367
035-os BibID:(scopus)84952919716 (wos)000369955100003
Első szerző:Kocsis Dorottya
Cím:Intestinalis zsírsavkötő fehérje : az enterocytakárosodás markere akut és krónikus gasztroenterológiai kórképekben / Kocsis Dorottya, Papp Mária, Tornai Tamás, Tulassay Zsolt, Herszényi László, Tóth Miklós, Juhász Márk
Dátum:2016
Megjegyzések:Az intestinalis zsírsavkötő fehérje a zsírsavkötő fehérjék családjába tartozó, a vékony- és vastagbél enterocytáinakcitoszoljában termelődő, kis molekulasúlyú fehérje. Az enterocytasejtek membránintegritásának megbomlását követőenmegjelenik a szisztémás keringésben, és a vesék glomerularis szűrőjén keresztül kiválasztódik a vizeletbe. A szerzők akut és krónikus enterocytakárosodással járó gastrointestinalis kórképekben az intestinalis zsírsavkötő fehérje biomarkerként való használatával kapcsolatos vizsgálatokat tekintik át.
Tárgyszavak:Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban
folyóiratcikk
intestinalis zsírsavkötő fehérje
nekrotizáló enterocolitis
akut mesenterialis ischaemia
coeliakia
gyulladásos bélbetegség
bakteriális transzlokáció
Megjelenés:Orvosi Hetilap. - 157 : 2 (2016), p. 59-64. -
További szerzők:Papp Mária (1975-) (belgyógyász, gasztroenterológus) Tornai Tamás István (1984-) (belgyógyász) Tulassay Zsolt (1944-) (belgyógyász, gasztroenterológus) Herszényi László Tóth Miklós (Budapest) Juhász Márk Félix
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8.

001-es BibID:BIBFORM095975
Első szerző:Nagy Anikó
Cím:Glucose levels show independent and dose-dependent association with worsening acute pancreatitis outcomes: Post-hoc analysis of a prospective, international cohort of 2250 acute pancreatitis cases / Aniko Nagy, Mark Félix Juhász, Anikó Görbe, Alex Váradi, Ferenc Izbéki, Áron Vincze, Patrícia Sarlós, József Czimmer, Zoltán Szepes, Tamás Takács, Mária Papp, Eszter Fehér, József Hamvas, Klaudia Kárász, Imola Török, Davor Stimac, Goran Poropat, Ali Tüzün Ince, Bálint Erőss, Katalin Márta, Dániel Pécsi, Dóra Illés, Szilárd Váncsa, Mária Földi, Nándor Faluhelyi, Orsolya Farkas, Tamás Nagy, Péter Kanizsai, Zsolt Márton, Andrea Szentesi, Péter Hegyi, Andrea Párniczky
Dátum:2021
ISSN:1424-3903
Megjegyzések:Background: Metabolic risk factors, such as obesity, hypertension, and hyperlipidemia are independent risk factors for the development of various complications in acute pancreatitis (AP). Hypertriglyceridemia dose-dependently elicits pancreatotoxicity and worsens the outcomes of AP. The role of hyperglycemia, as a toxic metabolic factor in the clinical course of AP, has not been examined yet. Methods: We analyzed a prospective, international cohort of 2250 AP patients, examining associations between (1) glycosylated hemoglobin (HbA1c), (2) on-admission glucose, (3) peak in-hospital glucose and clinically important outcomes (mortality, severity, complications, length of hospitalization (LOH), maximal C-reactive protein (CRP)). We conducted a binary logistic regression accounting for age, gender, etiology, diabetes, and our examined variables. Receiver Operating Characteristic Curve (ROC) was applied to detect the diagnostic accuracy of the three variables. Results: Both on-admission and peak serum glucose are independently associated with AP severity and mortality, accounting for age, gender, known diabetes and AP etiology. They show a dose-dependen association with severity (p < 0.001 in both), mortality (p < 0.001), LOH (p < 0.001), maximal CRP (p < 0.001), systemic (p < 0.001) and local complications (p < 0.001). Patients with peak glucose >7 mmol/l had a 15 times higher odds for severe AP and a five times higher odds for mortality. We found a trend of increasing HbA1c with increasing LOH (p < 0.001), severity and local complications. Conclusions: On-admission and peak in-hospital glucose are independently and dose-dependently associated with increasing AP severity and mortality. In-hospital laboratory control of glucose and adequate treatment of hyperglycemia are crucial in the management of AP. ? 2021 Published by Elsevier B.V. on behalf of IAP and EPC.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Pancreatology. - 21 : 7 (2021), p. 1237-1246. -
További szerzők:Juhász Márk Félix Görbe Anikó Váradi Alex (1991-) (biológus) Izbéki Ferenc Vincze Áron Sarlós Patrícia Czimmer József Szepes Zoltán Takács Tamás (Szeged) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Fehér Eszter Hamvas József Kárász Klaudia Török Imola Štimac, Davor Poropat, Goran Ince, Ali Tüzün Erőss Bálint Márta Katalin Pécsi Dániel Illés Dóra Váncsa Szilárd Földi Mária Faluhelyi Nándor Farkas Orsolya Nagy Tamás Kanizsai Péter Márton Zsolt Szentesi Andrea Hegyi Péter Jenő (belgyógyász) Párniczky Andrea (gyermekgyógyász)
Pályázati támogatás:EFOP-3.6.2-16-2017-00006
EFOP
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

9.

001-es BibID:BIBFORM100014
035-os BibID:(cikkazonosító)e050821 (WoS)000739490700018 (Scopus)85122762723
Első szerző:Ocskay Klementina
Cím:Recurrent acute pancreatitis prevention by the elimination of alcohol and cigarette smoking (REAPPEAR) : protocol of a randomised controlled trial and a cohort study / Klementina Ocskay, Márk Félix Juhász, Nelli Farkas, Noémi Zádori, Lajos Szakó, Zsolt Szakács, Andrea Szentesi, Bálint Erőss, Emőke Miklós, Antal Zemplényi, Béla Birkás, Árpád Csathó, István Hartung, Tamás Nagy, László Czopf, Ferenc Izbéki, László Gajdán, Mária Papp, László Czakó, Dóra Illés, Marco V. Marino, Antonello Mirabella, Ewa Małecka-Panas, Hubert Zatorski, Yaroslav Susak, Kristina Opalchuk, Gabriele Capurso, Laura Apadula, Cristian Gheorghe, Ionut Adrian Saizu, Ole H. Petersen, Enrique de-Madaria, Jonas Rosendahl, Andrea Párniczky, Péter Hegyi, Hungarian Pancreatic Study Group
Dátum:2022
ISSN:2044-6055
Megjegyzések:Background/objectives Acute recurrent pancreatitis (ARP) due to alcohol and/or tobacco abuse is a preventable disease which lowers quality of life and can lead to chronic pancreatitis. The REAPPEAR study aims to investigate whether a combined patient education and cessation programme for smoking and alcohol prevents ARP. Methods and analysis The REAPPEAR study consists of an international multicentre randomised controlled trial (REAPPEAR-T) testing the efficacy of a cessation programme on alcohol and smoking and a prospective cohort study (REAPPEAR-C) assessing the effects of change in alcohol consumption and smoking (irrespective of intervention). Daily smoker patients hospitalised with alcohol-induced acute pancreatitis (AP) will be enrolled. All patients will receive a standard intervention priorly to encourage alcohol and smoking cessation. Participants will be subjected to laboratory testing, measurement of blood pressure and body mass index and will provide blood, hair and urine samples for later biomarker analysis. Addiction, motivation to change, socioeconomic status and quality of life will be evaluated with questionnaires. In the trial, patients will be randomised either to the cessation programme with 3-monthly visits or to the control group with annual visits. Participants of the cessation programme will receive a brief intervention at every visit with direct feedback on their alcohol consumption based on laboratory results. The primary endpoint will be the composite of 2-year all-cause recurrence rate of AP and/ or 2-year all-cause mortality. The cost-effectiveness of the cessation programme will be evaluated. An estimated 182 participants will be enrolled per group to the REAPPEAR-T with further enrolment to the cohort. Ethics and dissemination The study was approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (40394-10/2020/ EÜIG), all local ethical approvals are in place. Results will be disseminated at conferences and in peer-reviewed journals. Trial registration number NCT04647097
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:BMJ Open. - 12 : 1 (2022), p. 1-9. -
További szerzők:Juhász Márk Félix Farkas Nelli Zádori Noémi Szakó Lajos Szakács Zsolt Szentesi Andrea Erőss Bálint Miklós Emőke Zemplényi Antal Birkás Béla Csathó Árpád Hartung István Nagy Tamás (1977-) (vegyész, orvosi laboratóriumi analitikus) Czopf László Izbéki Ferenc Gajdán László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Czakó László Illés Dóra Marino, Marco Vito Mirabella, Antonello Małecka-Panas, Ewa Zatorski, Hubert Susak, Yaroslav Mykhailovych Opalchuk, Kristina Capurso, Gabriele Apadula, Laura Gheorghe, Cristian Saizu, Ionut Adrian Petersen, Ole H. de-Madaria, Enrique Rosendahl, Jonas Párniczky Andrea (gyermekgyógyász) Hegyi Péter Jenő (belgyógyász) Hungarian Pancreatic Study Group
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

10.

001-es BibID:BIBFORM094178
035-os BibID:(WOS)000727779500019 (Scopus)85106978919
Első szerző:Szakó Lajos
Cím:Early occurrence of pseudocysts in acute pancreatitis - A multicenter international cohort analysis of 2275 cases / Lajos Szakó, Noémi Gede, Alex Váradi, Benedek Tinusz, Nóra Vörhendi, Dóra Mosztbacher, Áron Vincze, Tamás Takács, László Czakó, Ferenc Izbéki, László Gajdán, Veronika Dunás-Varga, József Hamvas, Mária Papp, Krisztina Eszter Fehér, Márta Varga, Artautas Mickevicius, Imola Török, Klementina Ocskay, Márk Félix Juhász, Szilárd Váncsa, Nándor Faluhelyi, Orsolya Farkas, Attila Miseta, András Vereczkei, Alexandra Mikó, Péter Jenő Hegyi, Andrea Szentesi, Andrea Párniczky, Bálint Erőss, Péter Hegyi
Dátum:2021
ISSN:1424-3903
Megjegyzések:BACKGROUND Pseudocysts being the most frequent local complications of acute pancreatitis (AP) have substantial effect on the disease course, hospitalization and quality of life of the patient. Our study aimed to understand the effects of pre existing (OLD-P) and newly developed (NEW-P) pseudocysts on AP. METHODS Data were extracted from the Acute Pancreatitis Registry organized by the Hungarian Pancreatic Study Group (HPSG). 2275 of 2461 patients had uploaded information concerning pancreatic morphology assessed by imaging technique. Patients were divided into "no pseudocyst" (NO-P) group, "old pseudocyst" (OLD-P) group, or "newly developed pseudocyst" (NEW-P) groups. RESULTS The median time of new pseudocyst development was nine days from hospital admission and eleven days from the beginning of the abdominal pain. More NEW-P cases were severe (15.9% vs 4.7% in the NO-P group p<0.001), with longer length of hospitalization (LoH) (median: 14 days versus 8 days, p<0.001), and were associated with several changed laboratory parameters. OLD-P was associated with male gender (72.2% vs. 56.1%, p=0.0014), alcoholic etiology (35.2% vs. 19.8% in the NO-P group), longer hospitalization (median: 10 days, p<0.001), a previous episode of AP (p<0.001), pre-existing diagnosis of chronic pancreatitis (CP) (p<0.001), current smoking (p<0.001), and increased alcohol consumption (unit/week) (p=0.014). CONCLUSION Most of the new pseudocysts develop within two weeks. Newly developing pseudocysts are associated with a more severe disease course and increased length of hospitalization. Pre-existing pseudocysts are associated with higher alcohol consumption and smoking. Because CP is more frequently associated with a pre-existing pseudocyst, these patients need closer attention after AP.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Pancreatology. - 21 : 6 (2021), p. 1161-1172. -
További szerzők:Gede Noémi Váradi Alex (1991-) (biológus) Tinusz Benedek Vörhendi Nóra Mosztbacher Dóra Vincze Áron Takács Tamás (Szeged) Czakó László Izbéki Ferenc Gajdán László Dunás-Varga Veronika Hamvas József Papp Mária (1975-) (belgyógyász, gasztroenterológus) Fehér Krisztina Eszter Varga Márta Mickevicius, Artautas Török Imola Ocskay Klementina Juhász Márk Félix Váncsa Szilárd Faluhelyi Nándor Farkas Orsolya Miseta Attila Vereczkei András Mikó Alexandra Hegyi Péter Jr. (belgyógyász) Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Erőss Bálint Hegyi Péter Jenő (belgyógyász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

11.

001-es BibID:BIBFORM113553
035-os BibID:(scopus)85153309480 (wos)000973548200001
Első szerző:Váncsa Szilárd
Cím:Metabolic-associated fatty liver disease is associated with acute pancreatitis with more severe course : Post hoc analysis of a prospectively collected international registry / Váncsa Szilárd, Sipos Zoltán, Váradi Alex, Nagy Rita, Ocskay Klementina, Juhász Félix Márk, Márta Katalin, Teutsch Brigitta, Mikó Alexandra, Hegyi Péter Jenő, Vincze Áron, Izbéki Ferenc, Czakó László, Papp Mária, Hamvas József, Varga Márta, Török Imola, Mickevicius Artautas, Erőss Bálint, Párniczky Andrea, Szentesi Andrea, Pár Gabriella, Hegyi Péter, Hungarian Pancreatic Study Group
Dátum:2023
ISSN:2050-6406 2050-6414
Megjegyzések:Introduction - Non?alcoholic fatty liver disease (NAFLD) is a proven risk factor for acute pancreatitis (AP). However, NAFLD has recently been redefined as metabolic?associated fatty liver disease (MAFLD). In this post hoc analysis, we quantified the effect of MAFLD on the outcomes of AP. Methods - We identified our patients from the multicentric, prospective International Acute Pancreatitis Registry of the Hungarian Pancreatic Study Group. Next, we compared AP patients with and without MAFLD and the individual components of MAFLD regarding in?hospital mortality and AP severity based on the revised Atlanta classification. Lastly, we calculated odds ratios (ORs) with 95% confidence intervals (CIs) using multivariate logistic regression analysis. Results - MAFLD had a high prevalence in AP, 39% (801/2053). MAFLD increased the odds of moderate?to?severe AP (OR = 1.43, CI: 1.09?1.89). However, the odds of in?hospital mortality (OR = 0.89, CI: 0.42?1.89) and severe AP (OR = 1.70, CI: 0.97?3.01) were not higher in the MAFLD group. Out of the three diagnostic criteria of MAFLD, the highest odds of severe AP was in the group based on metabolic risk abnormalities (OR = 2.68, CI: 1.39?5.09). In addition, the presence of one, two, and three diagnostic criteria dose?dependently increased the odds of moderate?to?severe AP (OR = 1.23, CI: 0.88?1.70, OR = 1.38, CI: 0.93?2.04, and OR = 3.04, CI: 1.63?5.70, respectively) and severe AP (OR = 1.13, CI: 0.54?2.27, OR = 2.08, CI: 0.97?4.35, and OR = 4.76, CI: 1.50?15.4, respectively). Furthermore, in patients with alcohol abuse and aged ?60 years, the effect of MAFLD became insignificant. Conclusions - MAFLD is associated with AP severity, which varies based on the components of its diagnostic criteria. Furthermore, MAFLD shows a dose? dependent effect on the outcomes of AP.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:United European Gastroenterology Journal. - 11 : 4 (2023), p. 371-382. -
További szerzők:Sipos Zoltán (1988-) (vegyész, angol-magyar szakfordító) Váradi Alex (1991-) (biológus) Nagy Rita Ocskay Klementina Juhász Márk Félix Márta Katalin Teutsch Brigitta Mikó Alexandra Hegyi Péter Jenő (belgyógyász) Vincze Áron Izbéki Ferenc Czakó László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hamvas József Varga Márta Török Imola Mickevicius, Artautas Erőss Bálint Párniczky Andrea (gyermekgyógyász) Szentesi Andrea Pár Gabriella Hegyi Péter (pszichológus) Hungarian Pancreatic Study Group
Pályázati támogatás:ÚNKP?22?3?II
Egyéb
ÚNKP?22?3?I
Egyéb
ÚNKP?22?5
Egyéb
ÚNKP?22?4?II
Egyéb
FK131864
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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