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001-es BibID:BIBFORM085501
Első szerző:Hágendorn Roland
Cím:Development of disturbance of consciousness is associated with increased severity in acute pancreatitis / Roland Hágendorn, Áron Vincze, Ferenc Izbéki, László Gajdán, Szilárd Gódi, Anita Illés, Patrícia Sarlós, Nelli Farkas, Bálint Erőss, Veronika Lillik, Dóra Illés, Péter Varjú, Katalin Márta, Imola Török, Mária Papp, Zsuzsanna Vitális, Barnabás Bod, József Hamvas, Zoltán Szepes, Tamás Takács, László Czakó, Zsolt Márton, Andrea Szentesi, Andrea Párniczky, Péter Hegyi, Alexandra Mikó
Dátum:2020
ISSN:1424-3903
Megjegyzések:Background Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient's condition, but we have no exact data on how DOC affects the outcome of AP. Methods From the Hungarian Pancreatic Study Groups' AP registry, 1220 prospectively collected cases were analysed, which contained exact data on DOC, included patients with confusion, delirium, convulsion, and alcohol withdrawal, answering a post hoc defined research question. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC DOC groups. For statistical analysis, independent sample t-test, Mann-Whitney, Chi-squared, or Fisher exact test were used. Results From the 1220 patients, 47 (3.9%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. Analysis between the DOC and Non-DOC groups showed a higher incidence of severe AP (19.2% vs. 5.3%, p<0.001), higher mortality (14.9% vs. 1.7%, p<0.001), and a longer length of hospitalization (LOH) (Me=11; IQR: 8-17 days vs. Me=9; IQR: 6-13 days, p=0.049) respectively. Patients with ALC DOC developed more frequently moderate AP vs. Non-ALC DOC (43.5% vs. 12.5%), while the incidence of severe AP was higher in Non-ALC vs. ALC DOC group (33.3% vs. 4.4%) (p<0.001). LOH showed a tendency to be longer in Non-ALC DOC compared to ALC DOC, respectively (Me:13; IQR:7-20 days vs. Me:9.5; IQR:8-15.5 days, p=0.119). Conclusion DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
disturbance of consciousness
acute pancreatitis
alcohol
delirium
mortality
Megjelenés:Pancreatology. - 20 : 5 (2020), p. 806-812. -
További szerzők:Vincze Áron Izbéki Ferenc Gajdán László Gódi Szilárd Illés Anita Sarlós Patrícia Farkas Nelli Erőss Bálint Lillik Veronika Illés Dóra Varjú Péter Márta Katalin Török Imola Papp Mária (1975-) (belgyógyász, gasztroenterológus) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Bod Barnabás Hamvas József Szepes Zoltán Takács Tamás (Szeged) Czakó László Márton Zsolt Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Hegyi Péter Jenő (belgyógyász) Mikó Alexandra
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM070012
035-os BibID:e015874
Első szerző:Márta Katalin
Cím:High versus low energy administration in the early phase of acute pancreatitis (GOULASH trial) : protocol of a multicentre randomized double-blind clinical trial / Katalin Márta, Anikó Nóra Szabó, Dániel Pécsi, Péter Varjú, Judit Bajor, Szilárd Gódi, Patrícia Sarlós, Alexandra Mikó, Katalin Szemes, Mária Papp, Tamás Tornai, Áron Vincze, Zsolt Márton, Patrícia Anna Vincze, Erzsébet Lankó, Andrea Szentesi, Tímea Molnár, Roland Hagendorn, Faluhelyi Nándor, István Battyáni, Dezső Kelemen, Róbert Papp, Attila Miseta, Verzár Zsófia, Markus M. Lerch, Johan P. Neoptoleomos, Miklós Sain-Tóth, Ole H. Petersen, Peter Hegyi
Dátum:2017
ISSN:2044-6055
Megjegyzések:Introduction. Acute pancreatitis (AP) is an inflammatory disease with no specific therapy. Mitochondrial injury followed by ATP depletion in both acinar and ductal cells is a recently discovered early event in the pathogenesis. Importantly, preclinical research showed that intracellular ATP delivery restores the physiological function of the cells and protects from cell injury suggesting that restoration of energy levels in the pancreas is therapeutically beneficial. Despite several, high quality and experimental observations in this area, no randomized trials have been conducted to date to address the requirements for energy intake in the early phase of AP. Methods/Design. This is a randomized, controlled two-arms double-blind multicentre trial. Patients suffering from AP will be randomly assigned to groups A (30 kcal/kg/day energy administration starting within 24h of hospital admission) or B (low energy administration during the first 72h of hospital admission). Energy will be delivered with nasoenteric tube feeding with additional intravenous glucose supplementation or total parenteral nutrition if necessary. A combination of multi organ failure for more than 48h and mortality is defined as the primary endpoint, whereas several secondary endpoints such as length of hospitalization or pain will be determined to elucidate more detailed differences between the groups. The general feasibility, safety and quality checks required for high quality evidence will be adhered to.Ethics and Dissemination. The study has been approved by the relevant organization, The Scientific and Research Ethics Committee of the Hungarian Medical Research Council (55961- 2/2016/EKU). This study will provide evidence whether early high-energy nutritional support is beneficial in the clinical management of AP. The results of this trial will be published in an open access way and disseminated among medical doctors.Trial registration: The trial has been registered at the ISRCTN (ISRTCN 63827758).
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
acute pancreatitis
energy administration
enteral feeding
randomized clinical trial
Megjelenés:BMJ Open. - 7 : 9 (2017), p. 1-9. -
További szerzők:Szabó Anikó Nóra Pécsi Dániel Varjú Péter Bajor Judit Gódi Szilárd Sarlós Patrícia Mikó Alexandra Szemes Katalin Papp Mária (1975-) (belgyógyász, gasztroenterológus) Tornai Tamás István (1984-) (belgyógyász) Vincze Áron Márton Zsolt Vincze Patrícia Anna Lankó Erzsébet Szentesi Andrea Molnár Tímea Hágendorn Roland Faluhelyi Nándor Battyáni István Kelemen Dezső Papp Róbert Miseta Attila Verzár Zsófia Lerch, Markus M. Neoptoleomos, Johan P. Sain-Tóth, Miklós Petersen, Ole H. Hegyi Péter Jenő (belgyógyász)
Pályázati támogatás:GINOP-2.3.2-15-2016-00015
GINOP
KH-125678
NKFI
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM095975
Első szerző:Nagy Anikó
Cím:Glucose levels show independent and dose-dependent association with worsening acute pancreatitis outcomes: Post-hoc analysis of a prospective, international cohort of 2250 acute pancreatitis cases / Aniko Nagy, Mark Félix Juhász, Anikó Görbe, Alex Váradi, Ferenc Izbéki, Áron Vincze, Patrícia Sarlós, József Czimmer, Zoltán Szepes, Tamás Takács, Mária Papp, Eszter Fehér, József Hamvas, Klaudia Kárász, Imola Török, Davor Stimac, Goran Poropat, Ali Tüzün Ince, Bálint Erőss, Katalin Márta, Dániel Pécsi, Dóra Illés, Szilárd Váncsa, Mária Földi, Nándor Faluhelyi, Orsolya Farkas, Tamás Nagy, Péter Kanizsai, Zsolt Márton, Andrea Szentesi, Péter Hegyi, Andrea Párniczky
Dátum:2021
ISSN:1424-3903
Megjegyzések:Background: Metabolic risk factors, such as obesity, hypertension, and hyperlipidemia are independent risk factors for the development of various complications in acute pancreatitis (AP). Hypertriglyceridemia dose-dependently elicits pancreatotoxicity and worsens the outcomes of AP. The role of hyperglycemia, as a toxic metabolic factor in the clinical course of AP, has not been examined yet. Methods: We analyzed a prospective, international cohort of 2250 AP patients, examining associations between (1) glycosylated hemoglobin (HbA1c), (2) on-admission glucose, (3) peak in-hospital glucose and clinically important outcomes (mortality, severity, complications, length of hospitalization (LOH), maximal C-reactive protein (CRP)). We conducted a binary logistic regression accounting for age, gender, etiology, diabetes, and our examined variables. Receiver Operating Characteristic Curve (ROC) was applied to detect the diagnostic accuracy of the three variables. Results: Both on-admission and peak serum glucose are independently associated with AP severity and mortality, accounting for age, gender, known diabetes and AP etiology. They show a dose-dependen association with severity (p < 0.001 in both), mortality (p < 0.001), LOH (p < 0.001), maximal CRP (p < 0.001), systemic (p < 0.001) and local complications (p < 0.001). Patients with peak glucose >7 mmol/l had a 15 times higher odds for severe AP and a five times higher odds for mortality. We found a trend of increasing HbA1c with increasing LOH (p < 0.001), severity and local complications. Conclusions: On-admission and peak in-hospital glucose are independently and dose-dependently associated with increasing AP severity and mortality. In-hospital laboratory control of glucose and adequate treatment of hyperglycemia are crucial in the management of AP. ? 2021 Published by Elsevier B.V. on behalf of IAP and EPC.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Pancreatology. - 21 : 7 (2021), p. 1237-1246. -
További szerzők:Juhász Márk Félix Görbe Anikó Váradi Alex (1991-) (biológus) Izbéki Ferenc Vincze Áron Sarlós Patrícia Czimmer József Szepes Zoltán Takács Tamás (Szeged) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Fehér Eszter Hamvas József Kárász Klaudia Török Imola Štimac, Davor Poropat, Goran Ince, Ali Tüzün Erőss Bálint Márta Katalin Pécsi Dániel Illés Dóra Váncsa Szilárd Földi Mária Faluhelyi Nándor Farkas Orsolya Nagy Tamás Kanizsai Péter Márton Zsolt Szentesi Andrea Hegyi Péter Jenő (belgyógyász) Párniczky Andrea (gyermekgyógyász)
Pályázati támogatás:EFOP-3.6.2-16-2017-00006
EFOP
Internet cím:Szerző által megadott URL
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4.

001-es BibID:BIBFORM103700
035-os BibID:(scopus)85121564971 (wos)000731322900016 (cikkazonosító)24158
Első szerző:Ocskay Klementina
Cím:Hypoalbuminemia affects one third of acute pancreatitis patients and is independently associated with severity and mortality / Ocskay Klementina, Vinkó Zsófia, Németh Dávid, Szabó László, Bajor Judit, Gódi Szilárd, Sarlós Patrícia, Czakó László, Izbéki Ferenc, Hamvas József, Papp Mária, Varga Márta, Török Imola, Mickevicius Artautas, Sallinen Ville, Maldonado Elena Ramirez, Galeev Shamil, Mikó Alexandra, Erőss Bálint, Imrei Marcell, Hegyi Péter Jenő, Faluhelyi Nándor, Farkas Orsolya, Kanizsai Péter, Miseta Attila, Nagy Tamás, Hágendorn Roland, Márton Zsolt, Szakács Zsolt, Szentesi Andrea, Hegyi Péter, Párniczky Andrea
Dátum:2021
ISSN:2045-2322
Megjegyzések:The incidence and medical costs of acute pancreatitis (AP) are on the rise, and severe cases still have a 30% mortality rate. We aimed to evaluate hypoalbuminemia as a risk factor and the prognostic value of human serum albumin in AP. Data from 2461 patients were extracted from the international, prospective, multicentre AP registry operated by the Hungarian Pancreatic Study Group. Data from patients with albumin measurement in the frst 48 h (n= 1149) and anytime during hospitalization (n= 1272) were analysed. Multivariate binary logistic regression and Receiver Operator Characteristic curve analysis were used. The prevalence of hypoalbuminemia (<35 g/L) was 19% on admission and 35.7% during hospitalization. Hypoalbuminemia dose-dependently increased the risk of severity, mortality, local complications and organ failure and is associated with longer hospital stay. The predictive value of hypoalbuminemia on admission was poor for severity and mortality. Severe hypoalbuminemia (<25 g/L) represented an independent risk factor for severity (OR 48.761; CI 25.276?98.908) and mortality (OR 16.83; CI 8.32?35.13). Albumin loss during AP was strongly associated with severity (p< 0.001) and mortality (p= 0.002). Hypoalbuminemia represents an independent risk factor for severity and mortality in AP, and it shows a dose-dependent relationship with local complications, organ failure and length of stay.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 11 : 1 (2021), p. 1-12. -
További szerzők:Vinkó Zsófia Németh Dávid Szabó László Bajor Judit Gódi Szilárd Sarlós Patrícia Czakó László Izbéki Ferenc Hamvas József Papp Mária (1975-) (belgyógyász, gasztroenterológus) Varga Márta Török Imola Mickevicius, Artautas Sallinen, Ville Maldonado, Elena Ramirez Galeev, Shamil Mikó Alexandra Erőss Bálint Imrei Marcell Hegyi Péter Jenő (belgyógyász) Faluhelyi Nándor Farkas Orsolya Kanizsai Péter Miseta Attila Nagy Tamás Hágendorn Roland Márton Zsolt Szakács Zsolt Szentesi Andrea Hegyi Péter (pszichológus) Párniczky Andrea (gyermekgyógyász)
Pályázati támogatás:EFOP-3.6.2-16-2017-00006
EFOP
GINOP-2.3.2-15-2016-00015
GINOP
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DOI
Intézményi repozitóriumban (DEA) tárolt változat
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5.

001-es BibID:BIBFORM103702
035-os BibID:(cikkazonosító)671917 (scopus)85114319818 (wos)000692562300001
Első szerző:Tod Pál
Cím:Initial Renal Function (eGFR) Is a Prognostic Marker of Severe Acute Pancreatitis : a Cohort-Analysis of 1,224 Prospectively Collected Cases / Tod Pál, Farkas Nelli, Németh Dávid, Szénási Gábor, Vincze Áron, Hágendorn Roland, Czakó László, Illés Dóra, Izbéki Ferenc, Dunás-Varga Veronika, Papp Mária, Hamvas József, Varga Márta, Gombos Katalin, Nagy Tamás, Márton Zsolt, Faluhelyi Nándor, Török Imola, Ince Ali Tüzün, Galeev Shamil, Hegyi Péter Jenő, Szentesi Andrea, Párniczky Andrea, Szakács Zsolt, Hegyi Péter, Hamar Péter
Dátum:2021
ISSN:2296-858X
Megjegyzések:Background: Acute pancreatitis (AP) is a life-threatening disease. We aimed to explore the prognostic relevance of renal function based on estimated glomerular filtration rate (eGFR). Methods: A prospective registry of AP patients was established by the Hungarian Pancreatic Study Group. Data of 1,224 consecutive patients were collected between 2012 and 2017. Patients were divided into 3 groups according to their eGFR measured within 24 h of hospitalization: normal renal function: >90 mL/min, mild to moderate renal functional impairment: 30?90 mL/min and severe renal dysfunction: <30 mL/min. Associations of eGFR with outcome (survival, length of hospitalization, AP severity, blood glucose), inflammatory markers (erythrocyte sedimentation rate, white blood cell count), anemia and organ failure (heart, kidney, liver) were analyzed. Results: Death, longer hospitalization and severe AP, but not the cause of AP, were significantly associated with lower eGFR. The inflammatory markers (CRP, WBC count) but not anemia (Hb, Htk) were closely associated with severe renal dysfunction. Renal function was associated with heart and renal failure but not with other complications of AP such as respiratory failure, local pancreatic complications, diabetes or peptic ulcer. eGFR was not associated with liver damage (ALAT, ?-GT) or liver function (serum bilirubin) although biliary complications, alcohol and metabolic syndrome were the most common etiologies of AP. Tod et al. eGFR in Severe Acute Pancreatitis Conclusions: Our study suggests a useful prognostic value of initial eGFR in AP patients. Even mild eGFR reduction predicted mortality, severity of AP and the length of hospitalization. Thus, precise evaluation of renal function should be considered for assessing AP severity and outcome.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
AP severity and mortality
renal dysfunction
CKD-EPI
EGFR
human retrospective cohort
Megjelenés:Frontiers in Medicine. - 8 (2021), p. 1-10. -
További szerzők:Farkas Nelli Németh Dávid Szénási Gábor Vincze Áron Hágendorn Roland Czakó László Illés Dóra Izbéki Ferenc Dunás-Varga Veronika Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hamvas József Varga Márta Gombos Katalin Nagy Tamás (1977-) (vegyész, orvosi laboratóriumi analitikus) Márton Zsolt Faluhelyi Nándor Török Imola Ince, Ali Tüzün Galeev, Shamil Hegyi Péter Jenő (belgyógyász) Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Szakács Zsolt Hegyi Péter (pszichológus) Hamar Péter
Pályázati támogatás:EFOP-3.6.2-16-2017-00006
EFOP
GINOP-2.3.2-15-2016-00048
GINOP
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DOI
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