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1.
001-es BibID:
BIBFORM090166
Első szerző:
Hágendorn Roland
Cím:
Disturbance of consciousness deteriorates the severity of acute pancreatitis. An international multicentre cohort analyses of 1220 prospectively collected patients / R. Hagendorn, Á. Vincze, F. Izbeki, L. Gajdan, S. Godi, A. Illes, P. Sarlos, N. Farkas, B. Erős, V. Lillik, D. Illes, P. Varjú, K. Marta, I. Török, M. Papp, Z. Vitalis, B. Bod, J. Hamvas, Z. Szepes, T. Takacs, L. Czakó, A. Szentesi, A. Parniczky, P. Hegyi, A. Miko
Dátum:
2020
ISSN:
1424-3903
Megjegyzések:
Purpose: Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient's condition, but we have no exact data on how DOC affects the outcome of AP. Materials and methods: From the Hungarian Pancreatic Study Groups' AP registry, 1220 cases contained the exact data on DOC. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC-DOC groups. Statistical analysis was performed by SPSS 24 Software Package. Results: From the 1220 patients, 47 (3.85%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. The incidence of severe AP was higher in the DOC compared to the Non-DOC group (19.15% vs. 5.29%, p<0.001). The mortality was higher in the DOC vs. Non-DOC group (14.89% vs. 1.71%, p<0.001). Length of hospitalization (LOH) was longer in the DOC vs. non-DOC group (Me:11; IQR:8-17 days vs. Me:9; IQR:6-13 days, p?0.049). Patients with ALC DOC developed more frequently moderately-severe AP vs. Non-ALC DOC (43.48% vs. 12.5%), while the incidence of severe AP was significantly higher in Non-ALC vs. ALC DOC group (33.33% vs. 4.35%) (p<0.001). LOH showed tendency to be longer in Non-ALC DOC compared to ALC DOC respectively (Me:13; IQR:7-20 days vs. Me:9.5; IQR:8-15.5 days, p?0.119). Conclusions: DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality; therefore, the DOC should be closely monitored and prevented in AP.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idézhető absztrakt
folyóiratcikk
Megjelenés:
Pancreatology. - 20 (2020), p. S25. -
További szerzők:
Vincze Áron
Izbéki Ferenc
Gajdán László
Gódi Szilárd
Illés Árpád (1959-) (belgyógyász, haematológus, onkológus)
Sarlós Péter
Farkas Nelli
Erős Bálint
Lillik Veronika
Illés Dóra
Varjú Péter
Márta Katalin
Török I.
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus)
Bod Barnabás
Hamvas József
Szepes Zoltán
Takács T.
Czakó László
Szentesi Andrea
Párniczky Andrea (gyermekgyógyász)
Hegyi Péter Jenő (belgyógyász)
Mikó Alexandra
Internet cím:
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
2.
001-es BibID:
BIBFORM085501
Első szerző:
Hágendorn Roland
Cím:
Development of disturbance of consciousness is associated with increased severity in acute pancreatitis / Roland Hágendorn, Áron Vincze, Ferenc Izbéki, László Gajdán, Szilárd Gódi, Anita Illés, Patrícia Sarlós, Nelli Farkas, Bálint Erőss, Veronika Lillik, Dóra Illés, Péter Varjú, Katalin Márta, Imola Török, Mária Papp, Zsuzsanna Vitális, Barnabás Bod, József Hamvas, Zoltán Szepes, Tamás Takács, László Czakó, Zsolt Márton, Andrea Szentesi, Andrea Párniczky, Péter Hegyi, Alexandra Mikó
Dátum:
2020
ISSN:
1424-3903
Megjegyzések:
Background Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient's condition, but we have no exact data on how DOC affects the outcome of AP. Methods From the Hungarian Pancreatic Study Groups' AP registry, 1220 prospectively collected cases were analysed, which contained exact data on DOC, included patients with confusion, delirium, convulsion, and alcohol withdrawal, answering a post hoc defined research question. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC DOC groups. For statistical analysis, independent sample t-test, Mann-Whitney, Chi-squared, or Fisher exact test were used. Results From the 1220 patients, 47 (3.9%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. Analysis between the DOC and Non-DOC groups showed a higher incidence of severe AP (19.2% vs. 5.3%, p<0.001), higher mortality (14.9% vs. 1.7%, p<0.001), and a longer length of hospitalization (LOH) (Me=11; IQR: 8-17 days vs. Me=9; IQR: 6-13 days, p=0.049) respectively. Patients with ALC DOC developed more frequently moderate AP vs. Non-ALC DOC (43.5% vs. 12.5%), while the incidence of severe AP was higher in Non-ALC vs. ALC DOC group (33.3% vs. 4.4%) (p<0.001). LOH showed a tendency to be longer in Non-ALC DOC compared to ALC DOC, respectively (Me:13; IQR:7-20 days vs. Me:9.5; IQR:8-15.5 days, p=0.119). Conclusion DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
disturbance of consciousness
acute pancreatitis
alcohol
delirium
mortality
Megjelenés:
Pancreatology. - 20 : 5 (2020), p. 806-812. -
További szerzők:
Vincze Áron
Izbéki Ferenc
Gajdán László
Gódi Szilárd
Illés Anita
Sarlós Patrícia
Farkas Nelli
Erőss Bálint
Lillik Veronika
Illés Dóra
Varjú Péter
Márta Katalin
Török Imola
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus)
Bod Barnabás
Hamvas József
Szepes Zoltán
Takács Tamás (Szeged)
Czakó László
Márton Zsolt
Szentesi Andrea
Párniczky Andrea (gyermekgyógyász)
Hegyi Péter Jenő (belgyógyász)
Mikó Alexandra
Internet cím:
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
3.
001-es BibID:
BIBFORM101294
035-os BibID:
(cikkazonosító)e842 (wos)000804849400001
Első szerző:
Kui Balázs
Cím:
EASY-APP : an artificial intelligence model and application for early and easy prediction of severity in acute pancreatitis / Kui Balázs, Pintér József, Molontay Roland, Nagy Marcell, Farkas Nelli, Gede Noémi, Vincze Áron, Bajor Judit, Gódi Szilárd, Czimmer József, Szabó Imre, Illés Anita, Sarlós Patrícia, Hágendorn Roland, Pár Gabriella, Papp Mária, Vitális Zsuzsanna, Kovács György, Fehér Eszter, Földi Ildikó, Izbéki Ferenc, Gajdán László, Fejes Roland, Németh Balázs Csaba, Török Imola, Farkas Hunor, Artautas Mickevicius, Ville Sallinen, Shamil Galeev, Elena Ramirez Maldonado, Párniczky Andrea, Erőss Bálint, Hegyi Péter Jenő, Márta Katalin, Váncsa Szilárd, Sutton Robert, Enrique de-Madaria, Elizabeth Pando, Piero Alberti, Maria José Gómez-Jurado, Alina Tantau, Szentesi Andrea, Hegyi Péter, Hungarian Pancreatic Study Group
Dátum:
2022
ISSN:
2001-1326
Megjegyzések:
Background: Acute pancreatitis (AP) is a potentially severe or even fatal inflammation of the pancreas. Early identification of patients, who are at high risk for developing a severe course of the disease is crucial for preventing organ failure and death. Most of the former predictive scores require many parameters or at least 24 hours to predict the severity, so the early therapeutic window is missing. Methods: The early achievable severity index (EASY) is a registered multicentre, multinational, prospective, observational study (ISRCTN10525246). Clinical parameters were collected from 15 countries and 28 medical centres via eCRF. The predictions were made using machine learning models including Decision Tree, Random Forest, Logistic Regression, SVM, CatBoost, and XGBoost. For the modeling, we used the scikit-learn, xgboost, and catboost Python packages. We have evaluated our models using 4-fold cross-validation and the receiver operating characteristic (ROC) curve, the area under the ROC curve (AUC), and accuracy metrics have been calculated on the union of the test sets of the cross-validation. The most important factors and their contribution to the prediction were identified using a modern tool of explainable artificial intelligence, called SHapley Additive exPlanations (SHAP). Using the XGBoost machine learning algorithm for prediction, the SHAP values for the explanation, and the bootstrapping method for the estimation of confidence we have developed a web application in the Streamlit Python-based framework. Results: The prediction model is based on the international cohort of 1184 patients and a validation cohort of 3543 patients. The best performing model has been an XGBoost classifier with an average AUC score of 0.81 and accuracy of 89.1% and the model is improving with experience. The six most influential features are the respiratory rate, body temperature, abdominal muscular reflex, gender, age, and glucose level. Finally, a free and easy-to-use web application was developed (http://easy-app.org/). Conclusions: The EASY prediction score is a practical tool for identifying patients at high risk for severe acute pancreatitis within hours of hospital admission. The easy-to-use web application is available for clinicians and contributes to the improvement of the model.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
severity prediction
acute pancreatitis
artificial intelligence
Megjelenés:
Clinical and Translational Medicine. - 12 : 6 (2022), p. 1-13. -
További szerzők:
Pintér József (1930-) (urológus)
Molontay Roland
Nagy Marcell
Farkas Nelli
Gede Noémi
Vincze Áron
Bajor Judit
Gódi Szilárd
Czimmer József
Szabó Imre
Illés Anita
Sarlós Patrícia
Hágendorn Roland
Pár Gabriella
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus)
Kovács György (1982-) (belgyógyász, gasztroenterológus)
Fehér Eszter
Földi Ildikó (1981-) (orvos)
Izbéki Ferenc
Gajdán László
Fejes Roland
Németh Balázs Csaba
Török Imola
Farkas Hunor
Mickevicius, Artautas
Sallinen, Ville
Galeev, Shamil
Ramírez-Maldonado, Elena
Párniczky Andrea (gyermekgyógyász)
Erőss Bálint
Hegyi Péter Jenő (belgyógyász)
Márta Katalin
Váncsa Szilárd
Sutton, Robert
de-Madaria, Enrique
Pando, Elizabeth
Alberti, Piero
Gómez-Jurado, Maria José
Tantau, Alina
Szentesi Andrea
Hegyi Péter (pszichológus)
Hungarian Pancreatic Study Group
Internet cím:
Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:
Saját polcon:
4.
001-es BibID:
BIBFORM070012
035-os BibID:
e015874
Első szerző:
Márta Katalin
Cím:
High versus low energy administration in the early phase of acute pancreatitis (GOULASH trial) : protocol of a multicentre randomized double-blind clinical trial / Katalin Márta, Anikó Nóra Szabó, Dániel Pécsi, Péter Varjú, Judit Bajor, Szilárd Gódi, Patrícia Sarlós, Alexandra Mikó, Katalin Szemes, Mária Papp, Tamás Tornai, Áron Vincze, Zsolt Márton, Patrícia Anna Vincze, Erzsébet Lankó, Andrea Szentesi, Tímea Molnár, Roland Hagendorn, Faluhelyi Nándor, István Battyáni, Dezső Kelemen, Róbert Papp, Attila Miseta, Verzár Zsófia, Markus M. Lerch, Johan P. Neoptoleomos, Miklós Sain-Tóth, Ole H. Petersen, Peter Hegyi
Dátum:
2017
ISSN:
2044-6055
Megjegyzések:
Introduction. Acute pancreatitis (AP) is an inflammatory disease with no specific therapy. Mitochondrial injury followed by ATP depletion in both acinar and ductal cells is a recently discovered early event in the pathogenesis. Importantly, preclinical research showed that intracellular ATP delivery restores the physiological function of the cells and protects from cell injury suggesting that restoration of energy levels in the pancreas is therapeutically beneficial. Despite several, high quality and experimental observations in this area, no randomized trials have been conducted to date to address the requirements for energy intake in the early phase of AP. Methods/Design. This is a randomized, controlled two-arms double-blind multicentre trial. Patients suffering from AP will be randomly assigned to groups A (30 kcal/kg/day energy administration starting within 24h of hospital admission) or B (low energy administration during the first 72h of hospital admission). Energy will be delivered with nasoenteric tube feeding with additional intravenous glucose supplementation or total parenteral nutrition if necessary. A combination of multi organ failure for more than 48h and mortality is defined as the primary endpoint, whereas several secondary endpoints such as length of hospitalization or pain will be determined to elucidate more detailed differences between the groups. The general feasibility, safety and quality checks required for high quality evidence will be adhered to.Ethics and Dissemination. The study has been approved by the relevant organization, The Scientific and Research Ethics Committee of the Hungarian Medical Research Council (55961- 2/2016/EKU). This study will provide evidence whether early high-energy nutritional support is beneficial in the clinical management of AP. The results of this trial will be published in an open access way and disseminated among medical doctors.Trial registration: The trial has been registered at the ISRCTN (ISRTCN 63827758).
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
acute pancreatitis
energy administration
enteral feeding
randomized clinical trial
Megjelenés:
BMJ Open. - 7 : 9 (2017), p. 1-9. -
További szerzők:
Szabó Anikó Nóra
Pécsi Dániel
Varjú Péter
Bajor Judit
Gódi Szilárd
Sarlós Patrícia
Mikó Alexandra
Szemes Katalin
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Tornai Tamás István (1984-) (belgyógyász)
Vincze Áron
Márton Zsolt
Vincze Patrícia Anna
Lankó Erzsébet
Szentesi Andrea
Molnár Tímea
Hágendorn Roland
Faluhelyi Nándor
Battyáni István
Kelemen Dezső
Papp Róbert
Miseta Attila
Verzár Zsófia
Lerch, Markus M.
Neoptoleomos, Johan P.
Sain-Tóth, Miklós
Petersen, Ole H.
Hegyi Péter Jenő (belgyógyász)
Pályázati támogatás:
GINOP-2.3.2-15-2016-00015
GINOP
KH-125678
NKFI
Internet cím:
Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:
Saját polcon:
5.
001-es BibID:
BIBFORM103700
035-os BibID:
(scopus)85121564971 (wos)000731322900016 (cikkazonosító)24158
Első szerző:
Ocskay Klementina
Cím:
Hypoalbuminemia affects one third of acute pancreatitis patients and is independently associated with severity and mortality / Ocskay Klementina, Vinkó Zsófia, Németh Dávid, Szabó László, Bajor Judit, Gódi Szilárd, Sarlós Patrícia, Czakó László, Izbéki Ferenc, Hamvas József, Papp Mária, Varga Márta, Török Imola, Mickevicius Artautas, Sallinen Ville, Maldonado Elena Ramirez, Galeev Shamil, Mikó Alexandra, Erőss Bálint, Imrei Marcell, Hegyi Péter Jenő, Faluhelyi Nándor, Farkas Orsolya, Kanizsai Péter, Miseta Attila, Nagy Tamás, Hágendorn Roland, Márton Zsolt, Szakács Zsolt, Szentesi Andrea, Hegyi Péter, Párniczky Andrea
Dátum:
2021
ISSN:
2045-2322
Megjegyzések:
The incidence and medical costs of acute pancreatitis (AP) are on the rise, and severe cases still have a 30% mortality rate. We aimed to evaluate hypoalbuminemia as a risk factor and the prognostic value of human serum albumin in AP. Data from 2461 patients were extracted from the international, prospective, multicentre AP registry operated by the Hungarian Pancreatic Study Group. Data from patients with albumin measurement in the frst 48 h (n= 1149) and anytime during hospitalization (n= 1272) were analysed. Multivariate binary logistic regression and Receiver Operator Characteristic curve analysis were used. The prevalence of hypoalbuminemia (<35 g/L) was 19% on admission and 35.7% during hospitalization. Hypoalbuminemia dose-dependently increased the risk of severity, mortality, local complications and organ failure and is associated with longer hospital stay. The predictive value of hypoalbuminemia on admission was poor for severity and mortality. Severe hypoalbuminemia (<25 g/L) represented an independent risk factor for severity (OR 48.761; CI 25.276?98.908) and mortality (OR 16.83; CI 8.32?35.13). Albumin loss during AP was strongly associated with severity (p< 0.001) and mortality (p= 0.002). Hypoalbuminemia represents an independent risk factor for severity and mortality in AP, and it shows a dose-dependent relationship with local complications, organ failure and length of stay.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:
Scientific Reports. - 11 : 1 (2021), p. 1-12. -
További szerzők:
Vinkó Zsófia
Németh Dávid
Szabó László
Bajor Judit
Gódi Szilárd
Sarlós Patrícia
Czakó László
Izbéki Ferenc
Hamvas József
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Varga Márta
Török Imola
Mickevicius, Artautas
Sallinen, Ville
Maldonado, Elena Ramirez
Galeev, Shamil
Mikó Alexandra
Erőss Bálint
Imrei Marcell
Hegyi Péter Jenő (belgyógyász)
Faluhelyi Nándor
Farkas Orsolya
Kanizsai Péter
Miseta Attila
Nagy Tamás
Hágendorn Roland
Márton Zsolt
Szakács Zsolt
Szentesi Andrea
Hegyi Péter (pszichológus)
Párniczky Andrea (gyermekgyógyász)
Pályázati támogatás:
EFOP-3.6.2-16-2017-00006
EFOP
GINOP-2.3.2-15-2016-00015
GINOP
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
6.
001-es BibID:
BIBFORM079249
Első szerző:
Párniczky Andrea (gyermekgyógyász)
Cím:
Antibiotic therapy in acute pancreatitis : from global overuse to evidence based recommendations / Andrea Parniczky, Tamas Lantos, Eszter Margit Toth, Zsolt Szakacs, Szilard Godi, Roland Hagendorn, Dora Illes, Balazs Koncz, Katalin Marta, Alexandra Miko, Dora Mosztbacher, Balazs Csaba Nemeth, Daniel Pecsi, Aniko Szabo, Akos Szücs, Peter Varjú, Andrea Szentesi, Erika Darvasi, Balint Eross, Ferenc Izbeki, Laszlo Gajdan, Adrienn Halasz, Aron Vincze, Imre Szabo, Gabriella Par, Judit Bajor, Patrícia Sarlos, Jozsef Czimmer, Jozsef Hamvas, Tamas Takacs, Zoltan Szepes, Laszlo Czako, Marta Varga, Janos Novak, Barnabas Bod, Attila Szepes, Janos Sümegi, Maria Papp, Csaba Gog, Imola Torok, Wei Huang, Qing Xia, Ping Xue, Weiqin Li, Weiwei Chen, Natalia V. Shirinskaya, Vladimir L. Poluektov, Anna V. Shirinskaya, Péter Jenő Hegyi, Marian Batovský, Juan Armando Rodriguez-Oballe, Isabel Miguel Salas, Javier Lopez-Diaz, J. Enrique Dominguez-Munoz, Xavier Molero, Elizabeth Pando, María Lourdes Ruiz-Rebollo, Beatriz Burgueno-Gomez, Yu-Ting Chang, Ming-Chu Chang, Ajay Sud, Danielle Moore, Robert Sutton, Amir Gougol, Georgios I. Papachristou, Yaroslav Mykhailovych Susak, Illia Olehovych Tiuliukin, Antonio Pedro Gomes, Maria Jesus Oliveira, David Joao Aparício, Marcel Tantau, Floreta Kurti, Mila Kovacheva-Slavova, Stephanie-Susanne Stecher, Julia Mayerle, Goran Poropat, Kshaunish Das, Marco Vito Marino, Gabriele Capurso, Ewa Małecka-Panas, Hubert Zatorski, Anita Gasiorowska, Natalia Fabisiak, Piotr Ceranowicz, Beata Kusnierz-Cabala, Joana Rita Carvalho, Samuel Raimundo Fernandes, Jae Hyuck Chang, Eun Kwang Choi, Jimin Han, Sara Bertilsson, Hanaz Jumaa, Gabriel Sandblom, Sabite Kacar, Minas Baltatzis, Aliaksandr Vladimir Varabei, Vizhynis Yeshy, Serge Chooklin, Andriy Kozachenko, Nikolay Veligotsky, Peter Jr. Hegyi, Hungarian Pancreatic Study Group
Dátum:
2019
ISSN:
1424-3903
Megjegyzések:
Background: Unwarranted administration of antibiotics in acute pancreatitis presents a global challenge. The clinical reasoning behind the misuse is poorly understood. Our aim was to investigate current clinical practices and develop recommendations that guide clinicians in prescribing antibiotic treatment in acute pancreatitis. Methods: Four methods were used. 1) Systematic data collection was performed to summarize current evidence; 2) a retrospective questionnaire was developed to understand the current global clinical practice; 3) five years of prospectively collected data were analysed to identify the clinical parameters used by medical teams in the decision making process, and finally; 4) the UpToDate Grading of Rec- ommendations, Assessment, Development and Evaluation (GRADE) system was applied to provide evi- dence based recommendations for healthcare professionals. Results: The systematic literature search revealed no consensus on the start of AB therapy in patients with no bacterial culture test. Retrospective data collection on 9728 patients from 22 countries indicated a wide range (31e82%) of antibiotic use frequency in AP. Analysis of 56 variables from 962 patients showed that clinicians initiate antibiotic therapy based on increased WBC and/or elevated CRP, lipase and amylase levels. The above mentioned four laboratory parameters showed no association with infection in the early phase of acute pancreatitis. Instead, procalcitonin levels proved to be a better biomarker of early infection. Patients with suspected infection because of fever had no benefit from antibiotic therapy. Conclusions: The authors formulated four consensus statements to urge reduction of unjustified anti- biotic treatment in acute pancreatitis and to use procalcitonin rather than WBC or CRP as biomarkers to guide decision-making.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Acute pancreatitis
Antibiotic
Guideline
Recommendation
Infection
Megjelenés:
Pancreatology. - 19 : 4 (2019), p. 488-499. -
További szerzők:
Lantos Tamás
Tóth Eszter Margit
Szakács Zsolt
Gódi Szilárd
Hágendorn Roland
Illés Dóra
Koncz Balázs
Márta Katalin
Mikó Alexandra
Mosztbacher Dóra
Németh Balázs Csaba
Pécsi Dániel
Szabó Anikó
Szűcs Ákos (sebész)
Varjú Péter
Szentesi Andrea
Darvasi Erika
Erőss Bálint
Izbéki Ferenc
Gajdán László
Halász Adrienn
Vincze Áron
Szabó Imre (1952-) (orvos)
Pár Gabriella
Bajor Judit
Sarlós Patrícia
Czimmer József
Hamvas József
Takács Tamás (Szeged)
Szepes Zoltán
Czakó László
Varga Márta
Novák János
Bod Barnabás
Szepes Attila
Sümegi János
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Góg Csaba
Török Imola
Huang, Wei
Xia, Qing
Xue, Ping
Li, Weiqin
Chen, Weiwei
Shirinskaya, Natalia V.
Poluektov, Vladimir L.
Shirinskaya, Anna V.
Hegyi Péter Jenő (belgyógyász)
Bátovský, Marian
Rodriguez-Oballe, Juan Armando
Salas, Isabel Miguel
Lopez-Diaz, Javier
Dominguez-Munoz, J. Enrique
Molero, Xavier
Pando, Elizabeth
Ruiz-Rebollo, María Lourdes
Burgueño-Gómez, Beatriz
Chang, Yu-Ting
Chang, Ming-Chu
Sud, Ajay
Moore, Danielle
Sutton, Robert
Gougol, Amir
Papachristou, Georgios I.
Susak, Yaroslav Mykhailovych
Tiuliukin, Illia Olehovych
Gomes, António Pedro
Oliveira, Maria Jesus
Aparício, David João
Tantau, Marcel
Kurti, Floreta
Kovacheva-Slavova, Mila
Stecher, Stephanie-Susanne
Mayerle, Julia
Poropat, Goran
Das, Kshaunish
Marino, Marco Vito
Capurso, Gabriele
Małecka-Panas, Ewa
Zatorski, Hubert
Gasiorowska, Anita
Fabisiak, Natalia
Ceranowicz, Piotr
Kuśnierz-Cabala, Beata
Carvalho, Joana Rita
Fernandes, Samuel Raimundo
Chang, Jae Hyuck
Choi, Eun Kwang
Han, Jimin
Bertilsson, Sara
Jumaa, Hanaz
Sandblom, Gabriel
Kacar, Sabite
Baltatzis, Minas
Varabei, Aliaksandr Vladimir
Yeshy, Vizhynis
Chooklin, Serge
Kozachenko, Andriy
Veligotsky, Nikolay
Hegyi Péter Jr. (belgyógyász)
Hungarian Pancreatic Study Group
Internet cím:
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DOI
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Saját polcon:
7.
001-es BibID:
BIBFORM103702
035-os BibID:
(cikkazonosító)671917 (scopus)85114319818 (wos)000692562300001
Első szerző:
Tod Pál
Cím:
Initial Renal Function (eGFR) Is a Prognostic Marker of Severe Acute Pancreatitis : a Cohort-Analysis of 1,224 Prospectively Collected Cases / Tod Pál, Farkas Nelli, Németh Dávid, Szénási Gábor, Vincze Áron, Hágendorn Roland, Czakó László, Illés Dóra, Izbéki Ferenc, Dunás-Varga Veronika, Papp Mária, Hamvas József, Varga Márta, Gombos Katalin, Nagy Tamás, Márton Zsolt, Faluhelyi Nándor, Török Imola, Ince Ali Tüzün, Galeev Shamil, Hegyi Péter Jenő, Szentesi Andrea, Párniczky Andrea, Szakács Zsolt, Hegyi Péter, Hamar Péter
Dátum:
2021
ISSN:
2296-858X
Megjegyzések:
Background: Acute pancreatitis (AP) is a life-threatening disease. We aimed to explore the prognostic relevance of renal function based on estimated glomerular filtration rate (eGFR). Methods: A prospective registry of AP patients was established by the Hungarian Pancreatic Study Group. Data of 1,224 consecutive patients were collected between 2012 and 2017. Patients were divided into 3 groups according to their eGFR measured within 24 h of hospitalization: normal renal function: >90 mL/min, mild to moderate renal functional impairment: 30?90 mL/min and severe renal dysfunction: <30 mL/min. Associations of eGFR with outcome (survival, length of hospitalization, AP severity, blood glucose), inflammatory markers (erythrocyte sedimentation rate, white blood cell count), anemia and organ failure (heart, kidney, liver) were analyzed. Results: Death, longer hospitalization and severe AP, but not the cause of AP, were significantly associated with lower eGFR. The inflammatory markers (CRP, WBC count) but not anemia (Hb, Htk) were closely associated with severe renal dysfunction. Renal function was associated with heart and renal failure but not with other complications of AP such as respiratory failure, local pancreatic complications, diabetes or peptic ulcer. eGFR was not associated with liver damage (ALAT, ?-GT) or liver function (serum bilirubin) although biliary complications, alcohol and metabolic syndrome were the most common etiologies of AP. Tod et al. eGFR in Severe Acute Pancreatitis Conclusions: Our study suggests a useful prognostic value of initial eGFR in AP patients. Even mild eGFR reduction predicted mortality, severity of AP and the length of hospitalization. Thus, precise evaluation of renal function should be considered for assessing AP severity and outcome.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
AP severity and mortality
renal dysfunction
CKD-EPI
EGFR
human retrospective cohort
Megjelenés:
Frontiers in Medicine. - 8 (2021), p. 1-10. -
További szerzők:
Farkas Nelli
Németh Dávid
Szénási Gábor
Vincze Áron
Hágendorn Roland
Czakó László
Illés Dóra
Izbéki Ferenc
Dunás-Varga Veronika
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Hamvas József
Varga Márta
Gombos Katalin
Nagy Tamás (1977-) (vegyész, orvosi laboratóriumi analitikus)
Márton Zsolt
Faluhelyi Nándor
Török Imola
Ince, Ali Tüzün
Galeev, Shamil
Hegyi Péter Jenő (belgyógyász)
Szentesi Andrea
Párniczky Andrea (gyermekgyógyász)
Szakács Zsolt
Hegyi Péter (pszichológus)
Hamar Péter
Pályázati támogatás:
EFOP-3.6.2-16-2017-00006
EFOP
GINOP-2.3.2-15-2016-00048
GINOP
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