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1.
001-es BibID:
BIBFORM088207
Első szerző:
Demcsák Alexandra
Cím:
Acid suppression therapy, gastrointestinal bleeding and infection in acute pancreatitis - An international cohort study / Alexandra Demcsak, Alexandra Soos, Lilla Kincses, Ines Capunge, Georgi Minkov, Mila Kovacheva-Slavova, Radislav Nakov, Dong Wu, Wei Huang, Qing Xia, Lihui Deng, Marcus Hollenbach, Alexander Schneider, Michael Hirth, Orestis Ioannidis, Aron Vincze, Judit Bajor, Patrícia Sarlos, Laszló Czakó, Dora Illés, Ferenc Izbeki, Laszló Gajdán, Maria Papp, Jozsef Hamvas, Marta Varga, Peter Kanizsai, Ernő Bóna, Alexandra Miko, Szilard Váncsa, Márk Félix Juhász, Klementina Ocskay, Erika Darvasi, Emőke Miklós, Balint Erőss, Andrea Szentesi, Andrea Parniczky, Riccardo Casadei, Claudio Ricci, Carlo Ingaldi, Laura Mastrangelo, Elio Jovine, Vincenzo Cennamo, Marco V. Marino, Giedrius Barauskas, Povilas Ignatavicius, Mario Pelaez-Luna, Andrea Soriano Rios, Svetlana Turcan, Eugen Tcaciuc, Ewa Małecka-Panas, Hubert Zatorski, Vitor Nunes, Antonio Gomes, Tiago Cúrdia Gonçalves, Marta Freitas, Júlio Constantino, Milene Sa, Jorge Pereira, Bogdan Mateescu, Gabriel Constantinescu, Vasile Sandru, Ionut Negoi, Cezar Ciubotaru, Valentina Negoita, Stefania Bunduc, Cristian Gheorghe, Sorin Barbu, Alina Tantau, Marcel Tantau, Eugen Dumitru, Andra Iulia Suceveanu, Cristina Tocia, Adriana Gherbon, Andrey Litvin, Natalia Shirinskaya, Yliya Rabotyagova, Mihailo Bezmarevic, Péter Jenő Hegyi, Jimin Han, Juan Armando Rodriguez-Oballe, Isabel Miguel Salas, Eva Pijoan Comas, Daniel de la Iglesia Garcia, Andrea Jardi Cuadrado, Adriano Quiroga Castineira, Yu-Ting Chang, Ming-Chu Chang, Ali Kchaou, Ahmed Tlili, Sabite Kacar, Volkan Gokbulut, Deniz Duman, Haluk Tarik Kani, Engin Altintas, Serge Chooklin, Serhii Chuklin, Amir Gougol, George Papachristou, Peter Hegyi Jr.
Dátum:
2020
ISSN:
1424-3903
Megjegyzések:
Background:Acid suppressing drugs (ASD) are generally used in acute pancreatitis (AP); however, largecohorts are not available to understand their efficiency and safety. Therefore, our aims were to evaluatethe association between the administration of ASDs, the outcome of AP, the frequency of gastrointestinal(GI) bleeding and GI infection in patients with AP.Methods:We initiated an international survey and performed retrospective data analysis on AP patientshospitalized between January 2013 and December 2018.Results:Data of 17,422 adult patients with AP were collected from 59 centers of 23 countries. We foundthat 23.3% of patients received ASDs before and 86.6% during the course of AP. ASDs were prescribed to57.6% of patients at discharge. ASD administration was associated with more severe AP and highermortality. GI bleeding was reported in 4.7% of patients, and it was associated with pancreatitis severity,mortality and ASD therapy. Stool culture test was performed in 6.3% of the patients with 28.4% positiveresults.Clostridium difficilewas the cause of GI infection in 60.5% of cases. Among the patients with GIinfections, 28.9% received ASDs, whereas 24.1% were without any acid suppression treatment. GI infec-tion was associated with more severe pancreatitis and higher mortality.Conclusions:Although ASD therapy is widely used, it is unlikely to have beneficial effects either on theoutcome of AP or on the prevention of GI bleeding during AP. Therefore, ASD therapy should be sub-stantially decreased in the therapeutic management of AP.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Acid suppressing drug
Gastrointestinal bleeding
Gastrointestinal infection
Acute pancreatitis
Proton pump inhibitor
Megjelenés:
Pancreatology. - 20 : 7 (2020), p. 1323-1331. -
További szerzők:
Soós Alexandra
Kincses Lilla
Capunge, Ines
Minkov, Georgi
Kovacheva-Slavova, Mila
Nakov, Radislav
Wu, Dong
Huang, Wei
Xia, Qing
Deng, Lihui
Hollenbach, Marcus
Schneider, Alexander
Hirth, Michael
Ioannidis, Orestis
Vincze Áron
Bajor Judit
Sarlós Patrícia
Czakó László
Illés Dóra
Izbéki Ferenc
Gajdán László
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Hamvas József
Varga Márta
Kanizsai Péter
Bóna Ernő
Mikó Alexandra
Váncsa Szilárd
Juhász Márk Félix
Ocskay Klementina
Darvasi Erika
Miklós Emőke
Erőss Bálint
Szentesi Andrea
Párniczky Andrea (gyermekgyógyász)
Casadei, Riccardo
Ricci, Claudio
Ingaldi, Carlo
Mastrangelo, Laura
Jovine, Elio
Cennamo, Vincenzo
Marino, Marco Vito
Barauskas, Giedrius
Ignatavicius, Povilas
Pelaez-Luna, Mario
Rios, Andrea Soriano
Turcan, Svetlana
Tcaciuc, Eugen
Małecka-Panas, Ewa
Zatorski, Hubert
Nunes, Vitor
Gomes, António Pedro
Gonçalves, Tiago Cúrdia
Freitas, Marta
Constantino, Júlio
Sá, Milene
Pereira, Jorge
Mateescu, Bogdan
Constantinescu, Gabriel
Sandru, Vasile
Negoi, Ionut
Ciubotaru, Cezar
Negoita, Valentina
Bunduc, Stefania
Gheorghe, Cristian
Barbu, Sorin
Tantau, Alina
Tantau, Marcel
Dumitru, Eugen
Suceveanu, Andra Iulia
Tocia, Cristina
Gherbon, Adriana
Litvin, A. Andrey
Shirinskaya, Natalia V.
Rabotyagova, Yliya
Bezmarevic, Mihailo
Hegyi Péter Jenő (belgyógyász)
Han, Jimin
Rodriguez-Oballe, Juan Armando
Salas, Isabel Miguel
Comas, Eva Pijoan
Garcia, Daniel de la Iglesia
Cuadrado, Andrea Jardi
Castiñeira, Adriano Quiroga
Chang, Yu-Ting
Chang, Ming-Chu
Kchaou, Ali
Tlili, Ahmed
Kacar, Sabite
Gökbulut, Volkan
Duman, Deniz
Kani, Haluk Tarik
Altintas, Engin
Chooklin, Serge
Chuklin, Serhii
Gougol, Amir
Papachristou, Georgios I.
Hegyi Péter Jr. (belgyógyász)
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
2.
001-es BibID:
BIBFORM082673
035-os BibID:
(cikkazonosító)1092 (WoS)000483784200001 (Scopus)85072948362
Első szerző:
Farkas Nelli
Cím:
A Multicenter, International Cohort Analysis of 1435 Cases to Support Clinical Trial Design in Acute Pancreatitis / Nelli Farkas, Lilla Hanák, Alexandra Mikó, Judit Bajor, Patrícia Sarlós, József Czimmer, Áron Vincze, Szilárd Gódi, Dániel Pécsi, Péter Varjú, Katalin Márta, Péter Jenő Hegyi, Bálint Erőss, Zsolt Szakács, Tamás Takács, László Czakó, Balázs Németh, Dóra Illés, Balázs Kui, Erika Darvasi, Ferenc Izbéki, Adrienn Halász, Veronika Dunás-Varga, László Gajdán, József Hamvas, Mária Papp, Ildikó Földi, Krisztina Eszter Fehér, Márta Varga, Klára Csefkó, Imola Török, Farkas Hunor-Pál, Artautas Mickevicius, Elena Ramirez Maldonado, Ville Sallinen, János Novák, Ali Tüzün Ince, Shamil Galeev, Barnabás Bod, János Sümegi, Petr Pencik, Attila Szepes, Andrea Szentesi, Andrea Párniczky, Péter Jr. Hegyi, Hungarian Pancreatic Study Group
Dátum:
2019
ISSN:
1664-042X
Megjegyzések:
Background: C-reactive protein level (CRP) and white blood cell count (WBC) have been variably used in clinical trials on acute pancreatitis (AP). We assessed their potential role. Methods: First, we investigated studies which have used CRP or WBC, to describe their current role in trials on AP. Second, we extracted the data of 1435 episodes of AP from our registry. CRP and WBC on admission, within 24 h from the onset of pain and their highest values were analyzed. Descriptive statistical tools as Kruskal?Wallis, Mann? Whitney U, Levene's F tests, Receiver Operating Characteristic (ROC) curve analysis and AUC (Area Under the Curve) with 95% confidence interval (CI) were performed. Results: Our literature review showed extreme variability of CRP used as an inclusion criterion or as a primary outcome or both in past and current trials on AP. In our cohort, CRP levels on admission poorly predicted mortality and severe cases of AP; AUC: 0.669 (CI:0.569?0.770); AUC:0.681 (CI: 0.601?0.761), respectively. CRP levels measured within 24 h from the onset of pain failed to predict mortality or severity; AUC: 0.741 (CI:0.627?0.854); AUC:0.690 (CI:0.586?0.793), respectively. The highest CRP during hospitalization had equally poor predictive accuracy for mortality and severity AUC:0.656 (CI:0.544?0.768); AUC:0.705 (CI:0.640?0.769) respectively. CRP within 24 h from the onset of pain used as an inclusion criterion markedly increased the combined event rate of mortality and severe AP (13% for CRP > 25 mg/l and 28% for CRP > 200 mg/l). Conclusion: CRP within 24 h from the onset of pain as an inclusion criterion elevates event rates and reduces the number of patients required in trials on AP.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
acute pancreatitis
C-reactive protein
white blood cell
trial design
sample size calculation
Megjelenés:
Frontiers in Physiology. - 10 (2019), p. 1-12. -
További szerzők:
Hanák Lilla
Mikó Alexandra
Bajor Judit
Sarlós Patrícia
Czimmer József
Vincze Áron
Gódi Szilárd
Pécsi Dániel
Varjú Péter
Márta Katalin
Hegyi Péter Jenő (belgyógyász)
Erőss Bálint
Szakács Zsolt
Takács Tamás (Szeged)
Czakó László
Németh Balázs Tamás
Illés Dóra
Kui Balázs
Darvasi Erika
Izbéki Ferenc
Halász Adrienn
Dunás-Varga Veronika
Gajdán László
Hamvas József
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Földi Ildikó (1981-) (orvos)
Fehér Krisztina Eszter
Varga Márta
Csefkó Klára
Török Imola
Farkas Hunor
Mickevicius, Artautas
Maldonado, Elena Ramirez
Sallinen, Ville
Novák János
Ince, Ali Tüzün
Galeev, Shamil
Bod Barnabás
Sümegi János
Pencik, Petr
Szepes Attila (Szeged)
Szentesi Andrea
Párniczky Andrea (gyermekgyógyász)
Hegyi Péter Jr. (belgyógyász)
Hungarian Pancreatic Study Group
Pályázati támogatás:
GINOP 2.3.2-15-2016-00048
GINOP
EFOP-3.6.2-16-2017-00006
EFOP
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
3.
001-es BibID:
BIBFORM090166
Első szerző:
Hágendorn Roland
Cím:
Disturbance of consciousness deteriorates the severity of acute pancreatitis. An international multicentre cohort analyses of 1220 prospectively collected patients / R. Hagendorn, Á. Vincze, F. Izbeki, L. Gajdan, S. Godi, A. Illes, P. Sarlos, N. Farkas, B. Erős, V. Lillik, D. Illes, P. Varjú, K. Marta, I. Török, M. Papp, Z. Vitalis, B. Bod, J. Hamvas, Z. Szepes, T. Takacs, L. Czakó, A. Szentesi, A. Parniczky, P. Hegyi, A. Miko
Dátum:
2020
ISSN:
1424-3903
Megjegyzések:
Purpose: Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient's condition, but we have no exact data on how DOC affects the outcome of AP. Materials and methods: From the Hungarian Pancreatic Study Groups' AP registry, 1220 cases contained the exact data on DOC. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC-DOC groups. Statistical analysis was performed by SPSS 24 Software Package. Results: From the 1220 patients, 47 (3.85%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. The incidence of severe AP was higher in the DOC compared to the Non-DOC group (19.15% vs. 5.29%, p<0.001). The mortality was higher in the DOC vs. Non-DOC group (14.89% vs. 1.71%, p<0.001). Length of hospitalization (LOH) was longer in the DOC vs. non-DOC group (Me:11; IQR:8-17 days vs. Me:9; IQR:6-13 days, p?0.049). Patients with ALC DOC developed more frequently moderately-severe AP vs. Non-ALC DOC (43.48% vs. 12.5%), while the incidence of severe AP was significantly higher in Non-ALC vs. ALC DOC group (33.33% vs. 4.35%) (p<0.001). LOH showed tendency to be longer in Non-ALC DOC compared to ALC DOC respectively (Me:13; IQR:7-20 days vs. Me:9.5; IQR:8-15.5 days, p?0.119). Conclusions: DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality; therefore, the DOC should be closely monitored and prevented in AP.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idézhető absztrakt
folyóiratcikk
Megjelenés:
Pancreatology. - 20 (2020), p. S25. -
További szerzők:
Vincze Áron
Izbéki Ferenc
Gajdán László
Gódi Szilárd
Illés Árpád (1959-) (belgyógyász, haematológus, onkológus)
Sarlós Péter
Farkas Nelli
Erős Bálint
Lillik Veronika
Illés Dóra
Varjú Péter
Márta Katalin
Török I.
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus)
Bod Barnabás
Hamvas József
Szepes Zoltán
Takács T.
Czakó László
Szentesi Andrea
Párniczky Andrea (gyermekgyógyász)
Hegyi Péter Jenő (belgyógyász)
Mikó Alexandra
Internet cím:
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
4.
001-es BibID:
BIBFORM085501
Első szerző:
Hágendorn Roland
Cím:
Development of disturbance of consciousness is associated with increased severity in acute pancreatitis / Roland Hágendorn, Áron Vincze, Ferenc Izbéki, László Gajdán, Szilárd Gódi, Anita Illés, Patrícia Sarlós, Nelli Farkas, Bálint Erőss, Veronika Lillik, Dóra Illés, Péter Varjú, Katalin Márta, Imola Török, Mária Papp, Zsuzsanna Vitális, Barnabás Bod, József Hamvas, Zoltán Szepes, Tamás Takács, László Czakó, Zsolt Márton, Andrea Szentesi, Andrea Párniczky, Péter Hegyi, Alexandra Mikó
Dátum:
2020
ISSN:
1424-3903
Megjegyzések:
Background Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient's condition, but we have no exact data on how DOC affects the outcome of AP. Methods From the Hungarian Pancreatic Study Groups' AP registry, 1220 prospectively collected cases were analysed, which contained exact data on DOC, included patients with confusion, delirium, convulsion, and alcohol withdrawal, answering a post hoc defined research question. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC DOC groups. For statistical analysis, independent sample t-test, Mann-Whitney, Chi-squared, or Fisher exact test were used. Results From the 1220 patients, 47 (3.9%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. Analysis between the DOC and Non-DOC groups showed a higher incidence of severe AP (19.2% vs. 5.3%, p<0.001), higher mortality (14.9% vs. 1.7%, p<0.001), and a longer length of hospitalization (LOH) (Me=11; IQR: 8-17 days vs. Me=9; IQR: 6-13 days, p=0.049) respectively. Patients with ALC DOC developed more frequently moderate AP vs. Non-ALC DOC (43.5% vs. 12.5%), while the incidence of severe AP was higher in Non-ALC vs. ALC DOC group (33.3% vs. 4.4%) (p<0.001). LOH showed a tendency to be longer in Non-ALC DOC compared to ALC DOC, respectively (Me:13; IQR:7-20 days vs. Me:9.5; IQR:8-15.5 days, p=0.119). Conclusion DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
disturbance of consciousness
acute pancreatitis
alcohol
delirium
mortality
Megjelenés:
Pancreatology. - 20 : 5 (2020), p. 806-812. -
További szerzők:
Vincze Áron
Izbéki Ferenc
Gajdán László
Gódi Szilárd
Illés Anita
Sarlós Patrícia
Farkas Nelli
Erőss Bálint
Lillik Veronika
Illés Dóra
Varjú Péter
Márta Katalin
Török Imola
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus)
Bod Barnabás
Hamvas József
Szepes Zoltán
Takács Tamás (Szeged)
Czakó László
Márton Zsolt
Szentesi Andrea
Párniczky Andrea (gyermekgyógyász)
Hegyi Péter Jenő (belgyógyász)
Mikó Alexandra
Internet cím:
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
5.
001-es BibID:
BIBFORM083103
Első szerző:
Koncz Balázs
Cím:
LIFEStyle, Prevention and Risk of Acute PaNcreatitis (LIFESPAN) : protocol of a multicentre and multinational observational case-control study / Koncz Balázs, Darvasi Erika, Erdősi Dalma, Szentesi Andrea, Márta Katalin, Erőss Bálint, Pécsi Dániel, Gyöngyi Zoltán, Girán János, Farkas Nelli, Papp Maria, Fehér Eszter, Vitális Zsuzsanna, Janka Tamás, Vincze Áron, Izbéki Ferenc, Dunás-Varga Veronika, Gajdán László, Török Imola, Károly Sándor, Antal Judit, Zádori Noémi, Lerch Markus M., Neoptolemos John, Sahin-Toth Miklos, Petersen Ole H., Hegyi Péter
Dátum:
2020
ISSN:
2044-6055 2044-6055
Megjegyzések:
AbstrACt Introduction Acute pancreatitis (AP) is a life- threatening inflammatory disease of the exocrine pancreas which needs acute hospitalisation. Despite its importance, we have significant lack of knowledge whether the lifestyle factors elevate or decrease the risk of AP or influence the disease outcome. So far, no synthetising study has been carried out examining associations between socioeconomic factors, dietary habits, physical activity, chronic stress, sleep quality and AP. Accordingly, LIFESPAN identifies risk factors of acute pancreatitis and helps to prepare preventive recommendations for lifestyle elements. Methods and analysis LIFESPAN is an observational, multicentre international case?control study. Participating subjects will create case and control groups. The study protocol was designed according to the SPIRIT guideline. Patients in the case group (n=1700) have suffered from AP (alcohol- induced, n=500; biliary, n=500; hypertriglyceridemiainduced, n=200; other, n=500); the control group subjects have no AP in their medical history. Our study will have three major control groups (n=2200): hospital- based (n=500), population- based (n=500) and aetiology- based (alcohol, n=500; biliary, n=500 and hypertriglyceridemia, n=200). All of them will be matched to the case group individually by gender, age and location of residence. Aggregately, 3900 subjects will be enrolled into the study. The study participants will complete a complex questionnaire with the help of a clinical research administrator/study nurse. Analysis methods include analysis of the continuous and categorical values. Ethics and dissemination The study has obtained the relevant ethical approval (54175-2/2018/EKU) and also internationally registered (ISRCTN25940508). After obtaining the final conclusions, we will publish the data to the medical community and will also disseminate our results via open access. trial registration number ISRCTN25940508; Pre- results.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
acute pancreatitis
lifestyle
prevention
Megjelenés:
BMJ Open. - 10 : 1 (2020), p. 1-9. -
További szerzők:
Darvasi Erika
Erdősi Dalma
Szentesi Andrea
Márta Katalin
Erőss Bálint
Pécsi Dániel
Gyöngyi Zoltán
Girán János
Farkas Nelli
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Fehér Eszter
Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus)
Janka Tamás
Vincze Áron
Izbéki Ferenc
Dunás-Varga Veronika
Gajdán László
Török Imola
Károly Sándor
Antal Judit
Zádori Noémi
Lerch, Markus M.
Neoptoleomos, Johan P.
Sahin-Tóth Miklós
Petersen, Ole H.
Hegyi Péter Jenő (belgyógyász)
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
6.
001-es BibID:
BIBFORM101294
035-os BibID:
(cikkazonosító)e842 (wos)000804849400001
Első szerző:
Kui Balázs
Cím:
EASY-APP : an artificial intelligence model and application for early and easy prediction of severity in acute pancreatitis / Kui Balázs, Pintér József, Molontay Roland, Nagy Marcell, Farkas Nelli, Gede Noémi, Vincze Áron, Bajor Judit, Gódi Szilárd, Czimmer József, Szabó Imre, Illés Anita, Sarlós Patrícia, Hágendorn Roland, Pár Gabriella, Papp Mária, Vitális Zsuzsanna, Kovács György, Fehér Eszter, Földi Ildikó, Izbéki Ferenc, Gajdán László, Fejes Roland, Németh Balázs Csaba, Török Imola, Farkas Hunor, Artautas Mickevicius, Ville Sallinen, Shamil Galeev, Elena Ramirez Maldonado, Párniczky Andrea, Erőss Bálint, Hegyi Péter Jenő, Márta Katalin, Váncsa Szilárd, Sutton Robert, Enrique de-Madaria, Elizabeth Pando, Piero Alberti, Maria José Gómez-Jurado, Alina Tantau, Szentesi Andrea, Hegyi Péter, Hungarian Pancreatic Study Group
Dátum:
2022
ISSN:
2001-1326
Megjegyzések:
Background: Acute pancreatitis (AP) is a potentially severe or even fatal inflammation of the pancreas. Early identification of patients, who are at high risk for developing a severe course of the disease is crucial for preventing organ failure and death. Most of the former predictive scores require many parameters or at least 24 hours to predict the severity, so the early therapeutic window is missing. Methods: The early achievable severity index (EASY) is a registered multicentre, multinational, prospective, observational study (ISRCTN10525246). Clinical parameters were collected from 15 countries and 28 medical centres via eCRF. The predictions were made using machine learning models including Decision Tree, Random Forest, Logistic Regression, SVM, CatBoost, and XGBoost. For the modeling, we used the scikit-learn, xgboost, and catboost Python packages. We have evaluated our models using 4-fold cross-validation and the receiver operating characteristic (ROC) curve, the area under the ROC curve (AUC), and accuracy metrics have been calculated on the union of the test sets of the cross-validation. The most important factors and their contribution to the prediction were identified using a modern tool of explainable artificial intelligence, called SHapley Additive exPlanations (SHAP). Using the XGBoost machine learning algorithm for prediction, the SHAP values for the explanation, and the bootstrapping method for the estimation of confidence we have developed a web application in the Streamlit Python-based framework. Results: The prediction model is based on the international cohort of 1184 patients and a validation cohort of 3543 patients. The best performing model has been an XGBoost classifier with an average AUC score of 0.81 and accuracy of 89.1% and the model is improving with experience. The six most influential features are the respiratory rate, body temperature, abdominal muscular reflex, gender, age, and glucose level. Finally, a free and easy-to-use web application was developed (http://easy-app.org/). Conclusions: The EASY prediction score is a practical tool for identifying patients at high risk for severe acute pancreatitis within hours of hospital admission. The easy-to-use web application is available for clinicians and contributes to the improvement of the model.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
severity prediction
acute pancreatitis
artificial intelligence
Megjelenés:
Clinical and Translational Medicine. - 12 : 6 (2022), p. 1-13. -
További szerzők:
Pintér József (1930-) (urológus)
Molontay Roland
Nagy Marcell
Farkas Nelli
Gede Noémi
Vincze Áron
Bajor Judit
Gódi Szilárd
Czimmer József
Szabó Imre
Illés Anita
Sarlós Patrícia
Hágendorn Roland
Pár Gabriella
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus)
Kovács György (1982-) (belgyógyász, gasztroenterológus)
Fehér Eszter
Földi Ildikó (1981-) (orvos)
Izbéki Ferenc
Gajdán László
Fejes Roland
Németh Balázs Csaba
Török Imola
Farkas Hunor
Mickevicius, Artautas
Sallinen, Ville
Galeev, Shamil
Ramírez-Maldonado, Elena
Párniczky Andrea (gyermekgyógyász)
Erőss Bálint
Hegyi Péter Jenő (belgyógyász)
Márta Katalin
Váncsa Szilárd
Sutton, Robert
de-Madaria, Enrique
Pando, Elizabeth
Alberti, Piero
Gómez-Jurado, Maria José
Tantau, Alina
Szentesi Andrea
Hegyi Péter (pszichológus)
Hungarian Pancreatic Study Group
Internet cím:
Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:
Saját polcon:
7.
001-es BibID:
BIBFORM090171
Első szerző:
Mikó Alexandra
Cím:
Early Phase of Chronic Pancreatitis : results of the First 20 Months of the GOULASH-PLUS Clinical Study / A. Mikó, D. Kato, V. Lillik, L. Gajdán, M. Papp, I. Földi, B. Bodis, N. Faluhelyi, P. Sarlos, Á. Vincze, Z. Szepes, G. Elsayed, P. Mosler, B. Erős, L. Czakó, P. Hegyi
Dátum:
2020
ISSN:
1424-3903
Megjegyzések:
Purpose: Acute pancreatitis (AP) is a severe inflammatory disease that can lead to irreversible complications such as recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP). CP is often diagnosed in an advanced form, though it could be effectively managed at an early stage. However, parameters indicative of early CP are still unknown. We aim to find measurable biomarkers and clinical signs of this early phase through the GOULASH-PLUS follow-up study. Materials and methods: GOULASH-PLUS is a longitudinal study of AP with a 6-year follow-up of patients with a well documented episode of AP. Imaging, physical and laboratory testing is performed annually. To detect endocrine function, blood glucose, HbA1C were measured, and oral glucose tolerance test (OGTT) was performed; exocrine parameters were measured by a stool elastase test. Chi-square test and Fisher exact test were used for statistical analysis. Results: Of the first 133 patients, 57 (43%)were women, 76 (57%)were men, and the average age was 55. 27 (20%) patients had moderate AP, 6 (5%) had severe AP, and 15 (14%) had RAP in the first year. 13 (16%) patients were diagnosed with severe exocrine pancreas insufficiency, 17 (15%) were diagnosed with diabetes and 23 (20%) with impaired glucose tolerance (IGT). Exocrine abnormalities were present in 70% of patients with RAP, compared with only 18% in the group without RAP (p <0.001). There was no difference in endocrine function between RAP and non-RAP groups. Based on OGTT, hyperinsulinemia was detected in IGT and diabetic groups, and endocrine disruption (IGT, DM) was not associated with AP severity. Conclusions: One year after AP, exocrine and endocrine insufficiency can be measured in the majority of patients. In RAP, exocrine abnormalities appear earlier, while the endocrine function is not affected. The development of IGT and DM is independent of the severity of AP.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idézhető absztrakt
folyóiratcikk
Megjelenés:
Pancreatology. - 20 (2020), p. S29. -
További szerzők:
Kató D.
Lillik V.
Gajdán László
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Földi Ildikó (1981-) (orvos)
Bódis Beáta
Faluhelyi Nándor
Sarlós Patrícia
Vincze Áron
Szepes Zoltán
Elsayed, G.
Mosler, P.
Erős Bálint
Czakó László
Hegyi Péter Jenő (belgyógyász)
Internet cím:
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
8.
001-es BibID:
BIBFORM078557
035-os BibID:
(cikkazonosító)e025500
Első szerző:
Mikó Alexandra
Cím:
Observational longitudinal multicentre investigation of acute pancreatitis. (GOULASH PLUS) : follow-up of the GOULASH-study, protocol / Alexandra Mikó, Bálint Erőss, Patrícia Sarlós, Péter Hegyi Jr., Katalin Márta, Dániel Pécsi, Áron Vincze, Beáta Bódis, Orsolya Nemes, Nándor Faluhelyi, Orsolya Farkas, Róbert Papp, Dezső Kelemen, Andrea Szentesi, Eszter Hegyi, Mária Papp, László Czakó, Ferenc Izbéki, László Gajdán, János Novák, Miklós Sahin-Tóth, Markus M. Lerch, John P. Neoptolemos, Ole H. Petersen, Péter Hegyi
Dátum:
2019
ISSN:
2044-6055
Megjegyzések:
Background: Acute pancreatitis (AP) is an inflammatory condition, which can lead to late consequences. In 20% of patients recurrent AP (RAP) develops and in 7-12.8% chronic pancreatitis (CP) will occur. However, we do not have sufficient information to establish an evidence-based statement to define early CP, or how to prevent its development. Aim: The aim of this study is to understand the influencing factors and to determine, which parameters should be measured or used as a biomarker to detect the early phase of CP. Methods/Design: This is an observational prospective follow-up study of the GOULASH-trial (ISRTCN 63827758) in which i) all severity of pancreatitis are included, ii) patients receive only therapeutic modalities which are accepted by the EBM guideline, iii) whole blood, serum and plasma are stored in our biobank and iv) large amount of variables are collected and kept in our electronic database including anamnestic data, physical examination, laboratory parameters, imaging, therapy and complications, therefore this fully characterized patient-cohort are well suitable for this longitudinal follow up study. Patients' selection: patients enrolled in the GOULASH study will be offered to join to the longitudinal study. The follow-up will be at 1-2-3-4-5 and 6 years after the episode of AP. Anamnestic data will be collected by questionnaires: i) Diet History Questionnaire ii) SF-36 iii) physical activity questionnaire iv) stress questionnaire. Genetic tests will be performed for the genes associated with CP. The exocrine and endocrine pancreatic, liver and kidney functions will be determined by laboratory tests, stool sample analyses, and imaging. Cost-effectiveness will be analyzed to examine the relationship between events of interest and health-related quality of life or to explore subgroup differences. Conclusion: This study will provide information about the risk factors and influencing factors and measurable parameters of CP.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
acute pancreatitis
follow-up
chronic pancreatitis
risk factor
Megjelenés:
BMJ Open. - 9 : 8 (2019), p. 1-9. -
További szerzők:
Erőss Bálint
Sarlós Patrícia
Hegyi Péter Jr. (belgyógyász)
Márta Katalin
Pécsi Dániel
Vincze Áron
Bódis Beáta
Nemes Orsolya
Faluhelyi Nándor
Farkas Orsolya
Papp Róbert
Kelemen Dezső
Szentesi Andrea
Hegyi Eszter
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Czakó László
Izbéki Ferenc
Gajdán László
Novák János
Sahin-Tóth Miklós
Lerch, Markus M.
Neoptoleomos, Johan P.
Petersen, Ole H.
Hegyi Péter Jenő (belgyógyász)
Internet cím:
Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:
Saját polcon:
9.
001-es BibID:
BIBFORM084964
Első szerző:
Mosztbacher Dóra
Cím:
Hypertriglyceridemia-induced acute pancreatitis : a prospective, multicenter, international cohort analysis of 716 acute pancreatitis cases / Mosztbacher Dóra, Hanák Lilla, Farkas Nelli, Szentesi Andrea, Mikó Alexandra, Bajor Judit, Sarlós Patrícia, Czimmer József, Vincze Áron, Hegyi Péter Jenő, Erőss Bálint, Takács Tamás, Czakó László, Németh Balázs Csaba, Izbéki Ferenc, Halász Adrienn, Gajdán László, Hamvas József, Papp Mária, Földi Ildikó, Fehér Krisztina Eszter, Varga Márta, Csefkó Klára, Török Imola, Farkas Hunor Pál, Mickevicius Artautas, Maldonado Elena Ramirez, Sallinen Ville, Novák János, Ince Ali Tüzün, Galeev Shamil, Bod Barnabás, Sümegi János, Pencik Petr, Dubravcsik Zsolt, Illés Dóra, Gódi Szilárd, Kui Balázs, Márta Katalin, Pécsi Dániel, Varjú Péter, Szakács Zsolt, Darvasi Erika, Párniczky Andrea, Hegyi Péter Jr., Hungarian Pancreatic Study Group
Dátum:
2020
ISSN:
1424-3903
Megjegyzések:
Background. Hypertriglyceridemia is the third most common cause of acute pancreatitis (AP). It has been shown that hypertriglyceridemia aggravates the severity and related complications of AP; however, detailed analyses of large cohorts are inadequate and contradictory. Our aim was to investigate the dose-dependent effect of hypertriglyceridemia on AP. Methods. AP patients over 18 years old who underwent triglyceride measurement within the initial three days were included into our cohort analysis from a prospective international, multicenter AP registry operated by the Hungarian Pancreatic Study Group. Data on 716 AP cases were analyzed. Six groups were created based on the highest triglyceride level (<1.7 mmol/l, 1.7?2.19 mmol/l, 2.2?5.59 mmol/l, 5.6?11.29 mmol/l, 11.3?22.59 mmol/l, ?22.6 mmol/l). Results. Hypertriglyceridemia (?1.7 mmol/l) presented in 30.6% of the patients and was significantly and dose- dependently associated with younger age and male gender. In 7.7% of AP cases, hypertriglyceridemia (?11.3 mmol/l) was considered as a causative etiological factor; however, 43.6% of these cases were associated with other etiologies (alcohol and biliary). Hypertriglyceridemia was significantly and dose-dependently related to obesity and diabetes. The rates of local complications, organ failure and maximum CRP level were significantly and dose- dependently raised by hypertriglyceridemia. Triglyceride above 11.3 mmol/l was linked to a significantly higher incidence of moderately severe AP and longer hospital stay, whereas triglyceride over 22.6 mmol/l was significantly associated with severe AP as well. Conclusion. Hypertriglyceridemia dose-dependently aggravates the severity and related complications of AP. Diagnostic workup for hypertriglyceridemia requires better awareness regardless of the etiology of AP.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
acute pancreatitis
hypertriglyceridemia
etiology
cohort
severity
Megjelenés:
Pancreatology. - 20 : 4 (2020), p. 608-616. -
További szerzők:
Hanák Lilla
Farkas Nelli
Szentesi Andrea
Mikó Alexandra
Bajor Judit
Sarlós Patrícia
Czimmer József
Vincze Áron
Hegyi Péter Jenő (belgyógyász)
Erőss Bálint
Takács Tamás (Szeged)
Czakó László
Németh Balázs Csaba
Izbéki Ferenc
Halász Adrienn
Gajdán László
Hamvas József
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Földi Ildikó (1981-) (orvos)
Fehér Krisztina Eszter
Varga Márta
Csefkó Klára
Török Imola
Farkas Hunor
Mickevicius, Artautas
Maldonado, Elena Ramirez
Sallinen, Ville
Novák János
Ince, Ali Tüzün
Galeev, Shamil
Bod Barnabás
Sümegi János
Pencik, Petr
Dubravcsik Zsolt (belgyógyász, gasztroenterológus)
Illés Dóra
Gódi Szilárd
Kui Balázs
Márta Katalin
Pécsi Dániel
Varjú Péter
Szakács Zsolt
Darvasi Erika
Párniczky Andrea (gyermekgyógyász)
Hegyi Péter Jr. (belgyógyász)
Hungarian Pancreatic Study Group
Pályázati támogatás:
K131996
OTKA
FK131864
OTKA
FK124632
OTKA
K120335
OTKA
GINOP 2.3.2-15-2016-00048
GINOP
EFOP-3.6.2-16-2017-00006
EFOP
ÚNKP-19-4
ÚNKP
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
10.
001-es BibID:
BIBFORM103703
035-os BibID:
(cikkazonosító)2131 (Scopus)85130241509 (WoS)000803398400001
Első szerző:
Nagy Rita
Cím:
In-Hospital Patient Education Markedly Reduces Alcohol Consumption after Alcohol-Induced Acute Pancreatitis / Nagy Rita, Ocskay Klementina, Váradi Alex, Papp Mária, Vitális Zsuzsanna, Izbéki Ferenc, Boros Eszter, Gajdán László, Szentesi Andrea, Erőss Bálint, Hegyi Péter Jenő, Vincze Áron, Bajor Judit, Sarlos Patricia, Mikó Alexandra, Márta Katalin, Pécsi Dániel, Párniczky Andrea, Hegyi Péter
Dátum:
2022
ISSN:
2072-6643
Megjegyzések:
Although excessive alcohol consumption is by far the most frequent cause of recurrent acute pancreatitis (AP) cases, specific therapy is still not well established to prevent recurrence. Generally, psychological therapy (e.g., brief intervention (BI)) is the cornerstone of cessation programs; however, it is not yet widely used in everyday practice. We conducted a post-hoc analysis of a prospectively collected database. Patients suffering from alcohol-induced AP between 2016 and 2021 received 30 min BI by a physician. Patient-reported alcohol consumption, serum gamma-glutamyl-transferase (GGT) level, and mean corpuscular volume (MCV) of red blood cells were collected on admission and at the 1-month follow-up visit to monitor patients' drinking habits. Ninety-nine patients with alcohol-induced AP were enrolled in the study (mean age: 50 ? 11, 89% male). A significant decrease was detected both in mean GGT value (294 ? 251 U/L vs. 103 ? 113 U/L, p < 0.001) and in MCV level (93.7 ? 5.3 U/L vs. 92.1 ? 5.1 U/L, p < 0.001) in patients with elevated on-admission GGT levels. Notably, 79% of the patients (78/99) reported alcohol abstinence at the 1-month control visit. Brief intervention is an effective tool to reduce alcohol consumption and to prevent recurrent AP. Longitudinal randomized clinical studies are needed to identify the adequate structure and frequency of BIs in alcohol-induced AP
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:
Nutrients. - 14 : 10 (2022), p. 1-9. -
További szerzők:
Ocskay Klementina
Váradi Alex (1991-) (biológus)
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus)
Izbéki Ferenc
Boros Eszter
Gajdán László
Szentesi Andrea
Erőss Bálint
Hegyi Péter Jenő (belgyógyász)
Vincze Áron
Bajor Judit
Sarlós Patrícia
Mikó Alexandra
Márta Katalin
Pécsi Dániel
Párniczky Andrea (gyermekgyógyász)
Hegyi Péter (pszichológus)
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
11.
001-es BibID:
BIBFORM100014
035-os BibID:
(cikkazonosító)e050821 (WoS)000739490700018 (Scopus)85122762723
Első szerző:
Ocskay Klementina
Cím:
Recurrent acute pancreatitis prevention by the elimination of alcohol and cigarette smoking (REAPPEAR) : protocol of a randomised controlled trial and a cohort study / Klementina Ocskay, Márk Félix Juhász, Nelli Farkas, Noémi Zádori, Lajos Szakó, Zsolt Szakács, Andrea Szentesi, Bálint Erőss, Emőke Miklós, Antal Zemplényi, Béla Birkás, Árpád Csathó, István Hartung, Tamás Nagy, László Czopf, Ferenc Izbéki, László Gajdán, Mária Papp, László Czakó, Dóra Illés, Marco V. Marino, Antonello Mirabella, Ewa Małecka-Panas, Hubert Zatorski, Yaroslav Susak, Kristina Opalchuk, Gabriele Capurso, Laura Apadula, Cristian Gheorghe, Ionut Adrian Saizu, Ole H. Petersen, Enrique de-Madaria, Jonas Rosendahl, Andrea Párniczky, Péter Hegyi, Hungarian Pancreatic Study Group
Dátum:
2022
ISSN:
2044-6055
Megjegyzések:
Background/objectives Acute recurrent pancreatitis (ARP) due to alcohol and/or tobacco abuse is a preventable disease which lowers quality of life and can lead to chronic pancreatitis. The REAPPEAR study aims to investigate whether a combined patient education and cessation programme for smoking and alcohol prevents ARP. Methods and analysis The REAPPEAR study consists of an international multicentre randomised controlled trial (REAPPEAR-T) testing the efficacy of a cessation programme on alcohol and smoking and a prospective cohort study (REAPPEAR-C) assessing the effects of change in alcohol consumption and smoking (irrespective of intervention). Daily smoker patients hospitalised with alcohol-induced acute pancreatitis (AP) will be enrolled. All patients will receive a standard intervention priorly to encourage alcohol and smoking cessation. Participants will be subjected to laboratory testing, measurement of blood pressure and body mass index and will provide blood, hair and urine samples for later biomarker analysis. Addiction, motivation to change, socioeconomic status and quality of life will be evaluated with questionnaires. In the trial, patients will be randomised either to the cessation programme with 3-monthly visits or to the control group with annual visits. Participants of the cessation programme will receive a brief intervention at every visit with direct feedback on their alcohol consumption based on laboratory results. The primary endpoint will be the composite of 2-year all-cause recurrence rate of AP and/ or 2-year all-cause mortality. The cost-effectiveness of the cessation programme will be evaluated. An estimated 182 participants will be enrolled per group to the REAPPEAR-T with further enrolment to the cohort. Ethics and dissemination The study was approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (40394-10/2020/ EÜIG), all local ethical approvals are in place. Results will be disseminated at conferences and in peer-reviewed journals. Trial registration number NCT04647097
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:
BMJ Open. - 12 : 1 (2022), p. 1-9. -
További szerzők:
Juhász Márk Félix
Farkas Nelli
Zádori Noémi
Szakó Lajos
Szakács Zsolt
Szentesi Andrea
Erőss Bálint
Miklós Emőke
Zemplényi Antal
Birkás Béla
Csathó Árpád
Hartung István
Nagy Tamás (1977-) (vegyész, orvosi laboratóriumi analitikus)
Czopf László
Izbéki Ferenc
Gajdán László
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Czakó László
Illés Dóra
Marino, Marco Vito
Mirabella, Antonello
Małecka-Panas, Ewa
Zatorski, Hubert
Susak, Yaroslav Mykhailovych
Opalchuk, Kristina
Capurso, Gabriele
Apadula, Laura
Gheorghe, Cristian
Saizu, Ionut Adrian
Petersen, Ole H.
de-Madaria, Enrique
Rosendahl, Jonas
Párniczky Andrea (gyermekgyógyász)
Hegyi Péter Jenő (belgyógyász)
Hungarian Pancreatic Study Group
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
12.
001-es BibID:
BIBFORM079249
Első szerző:
Párniczky Andrea (gyermekgyógyász)
Cím:
Antibiotic therapy in acute pancreatitis : from global overuse to evidence based recommendations / Andrea Parniczky, Tamas Lantos, Eszter Margit Toth, Zsolt Szakacs, Szilard Godi, Roland Hagendorn, Dora Illes, Balazs Koncz, Katalin Marta, Alexandra Miko, Dora Mosztbacher, Balazs Csaba Nemeth, Daniel Pecsi, Aniko Szabo, Akos Szücs, Peter Varjú, Andrea Szentesi, Erika Darvasi, Balint Eross, Ferenc Izbeki, Laszlo Gajdan, Adrienn Halasz, Aron Vincze, Imre Szabo, Gabriella Par, Judit Bajor, Patrícia Sarlos, Jozsef Czimmer, Jozsef Hamvas, Tamas Takacs, Zoltan Szepes, Laszlo Czako, Marta Varga, Janos Novak, Barnabas Bod, Attila Szepes, Janos Sümegi, Maria Papp, Csaba Gog, Imola Torok, Wei Huang, Qing Xia, Ping Xue, Weiqin Li, Weiwei Chen, Natalia V. Shirinskaya, Vladimir L. Poluektov, Anna V. Shirinskaya, Péter Jenő Hegyi, Marian Batovský, Juan Armando Rodriguez-Oballe, Isabel Miguel Salas, Javier Lopez-Diaz, J. Enrique Dominguez-Munoz, Xavier Molero, Elizabeth Pando, María Lourdes Ruiz-Rebollo, Beatriz Burgueno-Gomez, Yu-Ting Chang, Ming-Chu Chang, Ajay Sud, Danielle Moore, Robert Sutton, Amir Gougol, Georgios I. Papachristou, Yaroslav Mykhailovych Susak, Illia Olehovych Tiuliukin, Antonio Pedro Gomes, Maria Jesus Oliveira, David Joao Aparício, Marcel Tantau, Floreta Kurti, Mila Kovacheva-Slavova, Stephanie-Susanne Stecher, Julia Mayerle, Goran Poropat, Kshaunish Das, Marco Vito Marino, Gabriele Capurso, Ewa Małecka-Panas, Hubert Zatorski, Anita Gasiorowska, Natalia Fabisiak, Piotr Ceranowicz, Beata Kusnierz-Cabala, Joana Rita Carvalho, Samuel Raimundo Fernandes, Jae Hyuck Chang, Eun Kwang Choi, Jimin Han, Sara Bertilsson, Hanaz Jumaa, Gabriel Sandblom, Sabite Kacar, Minas Baltatzis, Aliaksandr Vladimir Varabei, Vizhynis Yeshy, Serge Chooklin, Andriy Kozachenko, Nikolay Veligotsky, Peter Jr. Hegyi, Hungarian Pancreatic Study Group
Dátum:
2019
ISSN:
1424-3903
Megjegyzések:
Background: Unwarranted administration of antibiotics in acute pancreatitis presents a global challenge. The clinical reasoning behind the misuse is poorly understood. Our aim was to investigate current clinical practices and develop recommendations that guide clinicians in prescribing antibiotic treatment in acute pancreatitis. Methods: Four methods were used. 1) Systematic data collection was performed to summarize current evidence; 2) a retrospective questionnaire was developed to understand the current global clinical practice; 3) five years of prospectively collected data were analysed to identify the clinical parameters used by medical teams in the decision making process, and finally; 4) the UpToDate Grading of Rec- ommendations, Assessment, Development and Evaluation (GRADE) system was applied to provide evi- dence based recommendations for healthcare professionals. Results: The systematic literature search revealed no consensus on the start of AB therapy in patients with no bacterial culture test. Retrospective data collection on 9728 patients from 22 countries indicated a wide range (31e82%) of antibiotic use frequency in AP. Analysis of 56 variables from 962 patients showed that clinicians initiate antibiotic therapy based on increased WBC and/or elevated CRP, lipase and amylase levels. The above mentioned four laboratory parameters showed no association with infection in the early phase of acute pancreatitis. Instead, procalcitonin levels proved to be a better biomarker of early infection. Patients with suspected infection because of fever had no benefit from antibiotic therapy. Conclusions: The authors formulated four consensus statements to urge reduction of unjustified anti- biotic treatment in acute pancreatitis and to use procalcitonin rather than WBC or CRP as biomarkers to guide decision-making.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Acute pancreatitis
Antibiotic
Guideline
Recommendation
Infection
Megjelenés:
Pancreatology. - 19 : 4 (2019), p. 488-499. -
További szerzők:
Lantos Tamás
Tóth Eszter Margit
Szakács Zsolt
Gódi Szilárd
Hágendorn Roland
Illés Dóra
Koncz Balázs
Márta Katalin
Mikó Alexandra
Mosztbacher Dóra
Németh Balázs Csaba
Pécsi Dániel
Szabó Anikó
Szűcs Ákos (sebész)
Varjú Péter
Szentesi Andrea
Darvasi Erika
Erőss Bálint
Izbéki Ferenc
Gajdán László
Halász Adrienn
Vincze Áron
Szabó Imre (1952-) (orvos)
Pár Gabriella
Bajor Judit
Sarlós Patrícia
Czimmer József
Hamvas József
Takács Tamás (Szeged)
Szepes Zoltán
Czakó László
Varga Márta
Novák János
Bod Barnabás
Szepes Attila
Sümegi János
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Góg Csaba
Török Imola
Huang, Wei
Xia, Qing
Xue, Ping
Li, Weiqin
Chen, Weiwei
Shirinskaya, Natalia V.
Poluektov, Vladimir L.
Shirinskaya, Anna V.
Hegyi Péter Jenő (belgyógyász)
Bátovský, Marian
Rodriguez-Oballe, Juan Armando
Salas, Isabel Miguel
Lopez-Diaz, Javier
Dominguez-Munoz, J. Enrique
Molero, Xavier
Pando, Elizabeth
Ruiz-Rebollo, María Lourdes
Burgueño-Gómez, Beatriz
Chang, Yu-Ting
Chang, Ming-Chu
Sud, Ajay
Moore, Danielle
Sutton, Robert
Gougol, Amir
Papachristou, Georgios I.
Susak, Yaroslav Mykhailovych
Tiuliukin, Illia Olehovych
Gomes, António Pedro
Oliveira, Maria Jesus
Aparício, David João
Tantau, Marcel
Kurti, Floreta
Kovacheva-Slavova, Mila
Stecher, Stephanie-Susanne
Mayerle, Julia
Poropat, Goran
Das, Kshaunish
Marino, Marco Vito
Capurso, Gabriele
Małecka-Panas, Ewa
Zatorski, Hubert
Gasiorowska, Anita
Fabisiak, Natalia
Ceranowicz, Piotr
Kuśnierz-Cabala, Beata
Carvalho, Joana Rita
Fernandes, Samuel Raimundo
Chang, Jae Hyuck
Choi, Eun Kwang
Han, Jimin
Bertilsson, Sara
Jumaa, Hanaz
Sandblom, Gabriel
Kacar, Sabite
Baltatzis, Minas
Varabei, Aliaksandr Vladimir
Yeshy, Vizhynis
Chooklin, Serge
Kozachenko, Andriy
Veligotsky, Nikolay
Hegyi Péter Jr. (belgyógyász)
Hungarian Pancreatic Study Group
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