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1.
001-es BibID:
BIBFORM097905
035-os BibID:
(WoS)000784212600006 (Scopus)85118725064
Első szerző:
Juhász Márk Félix
Cím:
The EFFect of dietary fat content on the recurrence of pancreaTitis (EFFORT) : protocol of a multicenter randomized controlled trial / Juhász Márk Félix, Vereczkei Zsófia, Ocskay Klementina, Szakó Lajos, Farkas Nelli, Szakács Zsolt, Zádori Noémi, Wilschanski Michael, Pandol Stephen J., Joly Francisca, Capurso Gabriele, Arcidiacono Paolo Giorgio, Izbéki Ferenc, Czakó László, Papp Mária, Czopf László, Hegyi Péter Jr., Párniczky Andrea, Hungarian Pancreatic Study Group
Dátum:
2022
ISSN:
1424-3903
Megjegyzések:
Background: Around 20% of patients with acute pancreatitis (AP) will develop acute recurrent pancreatitis (ARP) and 10% will progress to chronic pancreatitis. While interventions to avoid recurrences exist for the two most common causes - abstinence for alcoholic and cholecystectomy for biliary pancreatitis - the are no known preventive measures in idiopathic ARP. Though it is not included in any of the guidelines, a low-fat diet is often recommended. Our aim is to test dietary fat reduction's effect on AP recurrence in a randomized controlled setting, in order to provide high-quality evidence for the validity of such an intervention. Methods, design: Participants with at least 2 episodes of AP in the preceding 2 years of which the last episode was idiopathic will be randomized to one of two diets with different fat contents: a 'reduced fat diet' (15% fat, 65% carbohydrate, 20% protein) and a 'standard healthy diet' (30% fat, 50% carbohydrate, 20% protein; based on WHO recommendations). Participants will be followed-up for 2 years (visits will be scheduled for months 3, 6, 12, 18 and 24) during which they will receive a repeated session of nutritional guidance, complete food frequency questionnaires and data on relapse, mortality, BMI, cardiovascular parameters and serum lipid values will be collected. Discussion: This study will determine the effect of modifying the dietary fat content on AP recurrence, mortality, serum lipids and weight loss in idiopathic cases.
Tárgyszavak:
Orvostudományok
Egészségtudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:
Pancreatology. - 22 : 1 (2022), p. 51-57. -
További szerzők:
Vereczkei Zsófia
Ocskay Klementina
Szakó Lajos
Farkas Nelli
Szakács Zsolt
Zádori Noémi
Wilschanski, Michael
Pandol, Stephen J.
Joly, Francisca
Capurso, Gabriele
Arcidiacono, Paolo Giorgio
Izbéki Ferenc
Czakó László
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Czopf László
Hegyi Péter Jr. (belgyógyász)
Párniczky Andrea (gyermekgyógyász)
Hungarian Pancreatic Study Group
Pályázati támogatás:
GINOP-2.3.2-15-2016-00048
GINOP
EFOP-3.6.2-16-2017-00006
EFOP
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
2.
001-es BibID:
BIBFORM100014
035-os BibID:
(cikkazonosító)e050821 (WoS)000739490700018 (Scopus)85122762723
Első szerző:
Ocskay Klementina
Cím:
Recurrent acute pancreatitis prevention by the elimination of alcohol and cigarette smoking (REAPPEAR) : protocol of a randomised controlled trial and a cohort study / Klementina Ocskay, Márk Félix Juhász, Nelli Farkas, Noémi Zádori, Lajos Szakó, Zsolt Szakács, Andrea Szentesi, Bálint Erőss, Emőke Miklós, Antal Zemplényi, Béla Birkás, Árpád Csathó, István Hartung, Tamás Nagy, László Czopf, Ferenc Izbéki, László Gajdán, Mária Papp, László Czakó, Dóra Illés, Marco V. Marino, Antonello Mirabella, Ewa Małecka-Panas, Hubert Zatorski, Yaroslav Susak, Kristina Opalchuk, Gabriele Capurso, Laura Apadula, Cristian Gheorghe, Ionut Adrian Saizu, Ole H. Petersen, Enrique de-Madaria, Jonas Rosendahl, Andrea Párniczky, Péter Hegyi, Hungarian Pancreatic Study Group
Dátum:
2022
ISSN:
2044-6055
Megjegyzések:
Background/objectives Acute recurrent pancreatitis (ARP) due to alcohol and/or tobacco abuse is a preventable disease which lowers quality of life and can lead to chronic pancreatitis. The REAPPEAR study aims to investigate whether a combined patient education and cessation programme for smoking and alcohol prevents ARP. Methods and analysis The REAPPEAR study consists of an international multicentre randomised controlled trial (REAPPEAR-T) testing the efficacy of a cessation programme on alcohol and smoking and a prospective cohort study (REAPPEAR-C) assessing the effects of change in alcohol consumption and smoking (irrespective of intervention). Daily smoker patients hospitalised with alcohol-induced acute pancreatitis (AP) will be enrolled. All patients will receive a standard intervention priorly to encourage alcohol and smoking cessation. Participants will be subjected to laboratory testing, measurement of blood pressure and body mass index and will provide blood, hair and urine samples for later biomarker analysis. Addiction, motivation to change, socioeconomic status and quality of life will be evaluated with questionnaires. In the trial, patients will be randomised either to the cessation programme with 3-monthly visits or to the control group with annual visits. Participants of the cessation programme will receive a brief intervention at every visit with direct feedback on their alcohol consumption based on laboratory results. The primary endpoint will be the composite of 2-year all-cause recurrence rate of AP and/ or 2-year all-cause mortality. The cost-effectiveness of the cessation programme will be evaluated. An estimated 182 participants will be enrolled per group to the REAPPEAR-T with further enrolment to the cohort. Ethics and dissemination The study was approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (40394-10/2020/ EÜIG), all local ethical approvals are in place. Results will be disseminated at conferences and in peer-reviewed journals. Trial registration number NCT04647097
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:
BMJ Open. - 12 : 1 (2022), p. 1-9. -
További szerzők:
Juhász Márk Félix
Farkas Nelli
Zádori Noémi
Szakó Lajos
Szakács Zsolt
Szentesi Andrea
Erőss Bálint
Miklós Emőke
Zemplényi Antal
Birkás Béla
Csathó Árpád
Hartung István
Nagy Tamás (1977-) (vegyész, orvosi laboratóriumi analitikus)
Czopf László
Izbéki Ferenc
Gajdán László
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Czakó László
Illés Dóra
Marino, Marco Vito
Mirabella, Antonello
Małecka-Panas, Ewa
Zatorski, Hubert
Susak, Yaroslav Mykhailovych
Opalchuk, Kristina
Capurso, Gabriele
Apadula, Laura
Gheorghe, Cristian
Saizu, Ionut Adrian
Petersen, Ole H.
de-Madaria, Enrique
Rosendahl, Jonas
Párniczky Andrea (gyermekgyógyász)
Hegyi Péter Jenő (belgyógyász)
Hungarian Pancreatic Study Group
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
3.
001-es BibID:
BIBFORM079249
Első szerző:
Párniczky Andrea (gyermekgyógyász)
Cím:
Antibiotic therapy in acute pancreatitis : from global overuse to evidence based recommendations / Andrea Parniczky, Tamas Lantos, Eszter Margit Toth, Zsolt Szakacs, Szilard Godi, Roland Hagendorn, Dora Illes, Balazs Koncz, Katalin Marta, Alexandra Miko, Dora Mosztbacher, Balazs Csaba Nemeth, Daniel Pecsi, Aniko Szabo, Akos Szücs, Peter Varjú, Andrea Szentesi, Erika Darvasi, Balint Eross, Ferenc Izbeki, Laszlo Gajdan, Adrienn Halasz, Aron Vincze, Imre Szabo, Gabriella Par, Judit Bajor, Patrícia Sarlos, Jozsef Czimmer, Jozsef Hamvas, Tamas Takacs, Zoltan Szepes, Laszlo Czako, Marta Varga, Janos Novak, Barnabas Bod, Attila Szepes, Janos Sümegi, Maria Papp, Csaba Gog, Imola Torok, Wei Huang, Qing Xia, Ping Xue, Weiqin Li, Weiwei Chen, Natalia V. Shirinskaya, Vladimir L. Poluektov, Anna V. Shirinskaya, Péter Jenő Hegyi, Marian Batovský, Juan Armando Rodriguez-Oballe, Isabel Miguel Salas, Javier Lopez-Diaz, J. Enrique Dominguez-Munoz, Xavier Molero, Elizabeth Pando, María Lourdes Ruiz-Rebollo, Beatriz Burgueno-Gomez, Yu-Ting Chang, Ming-Chu Chang, Ajay Sud, Danielle Moore, Robert Sutton, Amir Gougol, Georgios I. Papachristou, Yaroslav Mykhailovych Susak, Illia Olehovych Tiuliukin, Antonio Pedro Gomes, Maria Jesus Oliveira, David Joao Aparício, Marcel Tantau, Floreta Kurti, Mila Kovacheva-Slavova, Stephanie-Susanne Stecher, Julia Mayerle, Goran Poropat, Kshaunish Das, Marco Vito Marino, Gabriele Capurso, Ewa Małecka-Panas, Hubert Zatorski, Anita Gasiorowska, Natalia Fabisiak, Piotr Ceranowicz, Beata Kusnierz-Cabala, Joana Rita Carvalho, Samuel Raimundo Fernandes, Jae Hyuck Chang, Eun Kwang Choi, Jimin Han, Sara Bertilsson, Hanaz Jumaa, Gabriel Sandblom, Sabite Kacar, Minas Baltatzis, Aliaksandr Vladimir Varabei, Vizhynis Yeshy, Serge Chooklin, Andriy Kozachenko, Nikolay Veligotsky, Peter Jr. Hegyi, Hungarian Pancreatic Study Group
Dátum:
2019
ISSN:
1424-3903
Megjegyzések:
Background: Unwarranted administration of antibiotics in acute pancreatitis presents a global challenge. The clinical reasoning behind the misuse is poorly understood. Our aim was to investigate current clinical practices and develop recommendations that guide clinicians in prescribing antibiotic treatment in acute pancreatitis. Methods: Four methods were used. 1) Systematic data collection was performed to summarize current evidence; 2) a retrospective questionnaire was developed to understand the current global clinical practice; 3) five years of prospectively collected data were analysed to identify the clinical parameters used by medical teams in the decision making process, and finally; 4) the UpToDate Grading of Rec- ommendations, Assessment, Development and Evaluation (GRADE) system was applied to provide evi- dence based recommendations for healthcare professionals. Results: The systematic literature search revealed no consensus on the start of AB therapy in patients with no bacterial culture test. Retrospective data collection on 9728 patients from 22 countries indicated a wide range (31e82%) of antibiotic use frequency in AP. Analysis of 56 variables from 962 patients showed that clinicians initiate antibiotic therapy based on increased WBC and/or elevated CRP, lipase and amylase levels. The above mentioned four laboratory parameters showed no association with infection in the early phase of acute pancreatitis. Instead, procalcitonin levels proved to be a better biomarker of early infection. Patients with suspected infection because of fever had no benefit from antibiotic therapy. Conclusions: The authors formulated four consensus statements to urge reduction of unjustified anti- biotic treatment in acute pancreatitis and to use procalcitonin rather than WBC or CRP as biomarkers to guide decision-making.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Acute pancreatitis
Antibiotic
Guideline
Recommendation
Infection
Megjelenés:
Pancreatology. - 19 : 4 (2019), p. 488-499. -
További szerzők:
Lantos Tamás
Tóth Eszter Margit
Szakács Zsolt
Gódi Szilárd
Hágendorn Roland
Illés Dóra
Koncz Balázs
Márta Katalin
Mikó Alexandra
Mosztbacher Dóra
Németh Balázs Csaba
Pécsi Dániel
Szabó Anikó
Szűcs Ákos (sebész)
Varjú Péter
Szentesi Andrea
Darvasi Erika
Erőss Bálint
Izbéki Ferenc
Gajdán László
Halász Adrienn
Vincze Áron
Szabó Imre (1952-) (orvos)
Pár Gabriella
Bajor Judit
Sarlós Patrícia
Czimmer József
Hamvas József
Takács Tamás (Szeged)
Szepes Zoltán
Czakó László
Varga Márta
Novák János
Bod Barnabás
Szepes Attila
Sümegi János
Papp Mária (1975-) (belgyógyász, gasztroenterológus)
Góg Csaba
Török Imola
Huang, Wei
Xia, Qing
Xue, Ping
Li, Weiqin
Chen, Weiwei
Shirinskaya, Natalia V.
Poluektov, Vladimir L.
Shirinskaya, Anna V.
Hegyi Péter Jenő (belgyógyász)
Bátovský, Marian
Rodriguez-Oballe, Juan Armando
Salas, Isabel Miguel
Lopez-Diaz, Javier
Dominguez-Munoz, J. Enrique
Molero, Xavier
Pando, Elizabeth
Ruiz-Rebollo, María Lourdes
Burgueño-Gómez, Beatriz
Chang, Yu-Ting
Chang, Ming-Chu
Sud, Ajay
Moore, Danielle
Sutton, Robert
Gougol, Amir
Papachristou, Georgios I.
Susak, Yaroslav Mykhailovych
Tiuliukin, Illia Olehovych
Gomes, António Pedro
Oliveira, Maria Jesus
Aparício, David João
Tantau, Marcel
Kurti, Floreta
Kovacheva-Slavova, Mila
Stecher, Stephanie-Susanne
Mayerle, Julia
Poropat, Goran
Das, Kshaunish
Marino, Marco Vito
Capurso, Gabriele
Małecka-Panas, Ewa
Zatorski, Hubert
Gasiorowska, Anita
Fabisiak, Natalia
Ceranowicz, Piotr
Kuśnierz-Cabala, Beata
Carvalho, Joana Rita
Fernandes, Samuel Raimundo
Chang, Jae Hyuck
Choi, Eun Kwang
Han, Jimin
Bertilsson, Sara
Jumaa, Hanaz
Sandblom, Gabriel
Kacar, Sabite
Baltatzis, Minas
Varabei, Aliaksandr Vladimir
Yeshy, Vizhynis
Chooklin, Serge
Kozachenko, Andriy
Veligotsky, Nikolay
Hegyi Péter Jr. (belgyógyász)
Hungarian Pancreatic Study Group
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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