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001-es BibID:BIBFORM088207
Első szerző:Demcsák Alexandra
Cím:Acid suppression therapy, gastrointestinal bleeding and infection in acute pancreatitis - An international cohort study / Alexandra Demcsak, Alexandra Soos, Lilla Kincses, Ines Capunge, Georgi Minkov, Mila Kovacheva-Slavova, Radislav Nakov, Dong Wu, Wei Huang, Qing Xia, Lihui Deng, Marcus Hollenbach, Alexander Schneider, Michael Hirth, Orestis Ioannidis, Aron Vincze, Judit Bajor, Patrícia Sarlos, Laszló Czakó, Dora Illés, Ferenc Izbeki, Laszló Gajdán, Maria Papp, Jozsef Hamvas, Marta Varga, Peter Kanizsai, Ernő Bóna, Alexandra Miko, Szilard Váncsa, Márk Félix Juhász, Klementina Ocskay, Erika Darvasi, Emőke Miklós, Balint Erőss, Andrea Szentesi, Andrea Parniczky, Riccardo Casadei, Claudio Ricci, Carlo Ingaldi, Laura Mastrangelo, Elio Jovine, Vincenzo Cennamo, Marco V. Marino, Giedrius Barauskas, Povilas Ignatavicius, Mario Pelaez-Luna, Andrea Soriano Rios, Svetlana Turcan, Eugen Tcaciuc, Ewa Małecka-Panas, Hubert Zatorski, Vitor Nunes, Antonio Gomes, Tiago Cúrdia Gonçalves, Marta Freitas, Júlio Constantino, Milene Sa, Jorge Pereira, Bogdan Mateescu, Gabriel Constantinescu, Vasile Sandru, Ionut Negoi, Cezar Ciubotaru, Valentina Negoita, Stefania Bunduc, Cristian Gheorghe, Sorin Barbu, Alina Tantau, Marcel Tantau, Eugen Dumitru, Andra Iulia Suceveanu, Cristina Tocia, Adriana Gherbon, Andrey Litvin, Natalia Shirinskaya, Yliya Rabotyagova, Mihailo Bezmarevic, Péter Jenő Hegyi, Jimin Han, Juan Armando Rodriguez-Oballe, Isabel Miguel Salas, Eva Pijoan Comas, Daniel de la Iglesia Garcia, Andrea Jardi Cuadrado, Adriano Quiroga Castineira, Yu-Ting Chang, Ming-Chu Chang, Ali Kchaou, Ahmed Tlili, Sabite Kacar, Volkan Gokbulut, Deniz Duman, Haluk Tarik Kani, Engin Altintas, Serge Chooklin, Serhii Chuklin, Amir Gougol, George Papachristou, Peter Hegyi Jr.
Dátum:2020
ISSN:1424-3903
Megjegyzések:Background:Acid suppressing drugs (ASD) are generally used in acute pancreatitis (AP); however, largecohorts are not available to understand their efficiency and safety. Therefore, our aims were to evaluatethe association between the administration of ASDs, the outcome of AP, the frequency of gastrointestinal(GI) bleeding and GI infection in patients with AP.Methods:We initiated an international survey and performed retrospective data analysis on AP patientshospitalized between January 2013 and December 2018.Results:Data of 17,422 adult patients with AP were collected from 59 centers of 23 countries. We foundthat 23.3% of patients received ASDs before and 86.6% during the course of AP. ASDs were prescribed to57.6% of patients at discharge. ASD administration was associated with more severe AP and highermortality. GI bleeding was reported in 4.7% of patients, and it was associated with pancreatitis severity,mortality and ASD therapy. Stool culture test was performed in 6.3% of the patients with 28.4% positiveresults.Clostridium difficilewas the cause of GI infection in 60.5% of cases. Among the patients with GIinfections, 28.9% received ASDs, whereas 24.1% were without any acid suppression treatment. GI infec-tion was associated with more severe pancreatitis and higher mortality.Conclusions:Although ASD therapy is widely used, it is unlikely to have beneficial effects either on theoutcome of AP or on the prevention of GI bleeding during AP. Therefore, ASD therapy should be sub-stantially decreased in the therapeutic management of AP.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Acid suppressing drug
Gastrointestinal bleeding
Gastrointestinal infection
Acute pancreatitis
Proton pump inhibitor
Megjelenés:Pancreatology. - 20 : 7 (2020), p. 1323-1331. -
További szerzők:Soós Alexandra Kincses Lilla Capunge, Ines Minkov, Georgi Kovacheva-Slavova, Mila Nakov, Radislav Wu, Dong Huang, Wei Xia, Qing Deng, Lihui Hollenbach, Marcus Schneider, Alexander Hirth, Michael Ioannidis, Orestis Vincze Áron Bajor Judit Sarlós Patrícia Czakó László Illés Dóra Izbéki Ferenc Gajdán László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hamvas József Varga Márta Kanizsai Péter Bóna Ernő Mikó Alexandra Váncsa Szilárd Juhász Márk Félix Ocskay Klementina Darvasi Erika Miklós Emőke Erőss Bálint Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Casadei, Riccardo Ricci, Claudio Ingaldi, Carlo Mastrangelo, Laura Jovine, Elio Cennamo, Vincenzo Marino, Marco Vito Barauskas, Giedrius Ignatavicius, Povilas Pelaez-Luna, Mario Rios, Andrea Soriano Turcan, Svetlana Tcaciuc, Eugen Małecka-Panas, Ewa Zatorski, Hubert Nunes, Vitor Gomes, António Pedro Gonçalves, Tiago Cúrdia Freitas, Marta Constantino, Júlio Sá, Milene Pereira, Jorge Mateescu, Bogdan Constantinescu, Gabriel Sandru, Vasile Negoi, Ionut Ciubotaru, Cezar Negoita, Valentina Bunduc, Stefania Gheorghe, Cristian Barbu, Sorin Tantau, Alina Tantau, Marcel Dumitru, Eugen Suceveanu, Andra Iulia Tocia, Cristina Gherbon, Adriana Litvin, A. Andrey Shirinskaya, Natalia V. Rabotyagova, Yliya Bezmarevic, Mihailo Hegyi Péter Jenő (belgyógyász) Han, Jimin Rodriguez-Oballe, Juan Armando Salas, Isabel Miguel Comas, Eva Pijoan Garcia, Daniel de la Iglesia Cuadrado, Andrea Jardi Castiñeira, Adriano Quiroga Chang, Yu-Ting Chang, Ming-Chu Kchaou, Ali Tlili, Ahmed Kacar, Sabite Gökbulut, Volkan Duman, Deniz Kani, Haluk Tarik Altintas, Engin Chooklin, Serge Chuklin, Serhii Gougol, Amir Papachristou, Georgios I. Hegyi Péter Jr. (belgyógyász)
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2.

001-es BibID:BIBFORM097905
035-os BibID:(WoS)000784212600006 (Scopus)85118725064
Első szerző:Juhász Márk Félix
Cím:The EFFect of dietary fat content on the recurrence of pancreaTitis (EFFORT) : protocol of a multicenter randomized controlled trial / Juhász Márk Félix, Vereczkei Zsófia, Ocskay Klementina, Szakó Lajos, Farkas Nelli, Szakács Zsolt, Zádori Noémi, Wilschanski Michael, Pandol Stephen J., Joly Francisca, Capurso Gabriele, Arcidiacono Paolo Giorgio, Izbéki Ferenc, Czakó László, Papp Mária, Czopf László, Hegyi Péter Jr., Párniczky Andrea, Hungarian Pancreatic Study Group
Dátum:2022
ISSN:1424-3903
Megjegyzések:Background: Around 20% of patients with acute pancreatitis (AP) will develop acute recurrent pancreatitis (ARP) and 10% will progress to chronic pancreatitis. While interventions to avoid recurrences exist for the two most common causes - abstinence for alcoholic and cholecystectomy for biliary pancreatitis - the are no known preventive measures in idiopathic ARP. Though it is not included in any of the guidelines, a low-fat diet is often recommended. Our aim is to test dietary fat reduction's effect on AP recurrence in a randomized controlled setting, in order to provide high-quality evidence for the validity of such an intervention. Methods, design: Participants with at least 2 episodes of AP in the preceding 2 years of which the last episode was idiopathic will be randomized to one of two diets with different fat contents: a 'reduced fat diet' (15% fat, 65% carbohydrate, 20% protein) and a 'standard healthy diet' (30% fat, 50% carbohydrate, 20% protein; based on WHO recommendations). Participants will be followed-up for 2 years (visits will be scheduled for months 3, 6, 12, 18 and 24) during which they will receive a repeated session of nutritional guidance, complete food frequency questionnaires and data on relapse, mortality, BMI, cardiovascular parameters and serum lipid values will be collected. Discussion: This study will determine the effect of modifying the dietary fat content on AP recurrence, mortality, serum lipids and weight loss in idiopathic cases.
Tárgyszavak:Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Pancreatology. - 22 : 1 (2022), p. 51-57. -
További szerzők:Vereczkei Zsófia Ocskay Klementina Szakó Lajos Farkas Nelli Szakács Zsolt Zádori Noémi Wilschanski, Michael Pandol, Stephen J. Joly, Francisca Capurso, Gabriele Arcidiacono, Paolo Giorgio Izbéki Ferenc Czakó László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Czopf László Hegyi Péter Jr. (belgyógyász) Párniczky Andrea (gyermekgyógyász) Hungarian Pancreatic Study Group
Pályázati támogatás:GINOP-2.3.2-15-2016-00048
GINOP
EFOP-3.6.2-16-2017-00006
EFOP
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM117409
035-os BibID:(cikkazonosító)22109 (Scopus)85179741758
Első szerző:Nagy Rita
Cím:Discharge protocol in acute pancreatitis : an international survey and cohort analysis / Rita Nagy, Klementina Ocskay, Zoltán Sipos, Mária Papp, Péter Hegyi
Dátum:2023
ISSN:2045-2322
Megjegyzések:There are several overlapping clinical practice guidelines in acute pancreatitis (AP), however, none of them contains suggestions on patient discharge. The Hungarian Pancreatic Study Group (HPSG) has recently developed a laboratory data and symptom-based discharge protocol which needs to be validated. (1) A survey was conducted involving all members of the International Association of Pancreatology (IAP) to understand the characteristics of international discharge protocols. (2) We investigated the safety and efectiveness of the HPSG-discharge protocol. According to our international survey, 87.5% (49/56) of the centres had no discharge protocol. Patients discharged based on protocols have a signifcantly shorter median length of hospitalization (LOH) (7 (5;10) days vs. 8 (5;12) days) p < 0.001), and a lower rate of readmission due to recurrent AP episodes (p= 0.005). There was no diference in median discharge CRP level among the international cohorts (p= 0.586). HPSG-protocol resulted in the shortest LOH (6 (5;9) days) and highest median CRP (35.40 (13.78; 68.40) mg/l). Safety was confrmed by the low rate of readmittance (n= 35; 5%). Discharge protocol is necessary in AP. The discharge protocol used in this study is the frst clinically proven protocol. Developing and testifying further protocols are needed to better standardize patients' care.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Acute pancreatitis
Megjelenés:Scientific Reports. - 13 : 1 (2023), p. 1-10. -
További szerzők:Ocskay Klementina Sipos Zoltán (1988-) (vegyész, angol-magyar szakfordító) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hegyi Péter Jenő (belgyógyász)
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM103703
035-os BibID:(cikkazonosító)2131 (Scopus)85130241509 (WoS)000803398400001
Első szerző:Nagy Rita
Cím:In-Hospital Patient Education Markedly Reduces Alcohol Consumption after Alcohol-Induced Acute Pancreatitis / Nagy Rita, Ocskay Klementina, Váradi Alex, Papp Mária, Vitális Zsuzsanna, Izbéki Ferenc, Boros Eszter, Gajdán László, Szentesi Andrea, Erőss Bálint, Hegyi Péter Jenő, Vincze Áron, Bajor Judit, Sarlos Patricia, Mikó Alexandra, Márta Katalin, Pécsi Dániel, Párniczky Andrea, Hegyi Péter
Dátum:2022
ISSN:2072-6643
Megjegyzések:Although excessive alcohol consumption is by far the most frequent cause of recurrent acute pancreatitis (AP) cases, specific therapy is still not well established to prevent recurrence. Generally, psychological therapy (e.g., brief intervention (BI)) is the cornerstone of cessation programs; however, it is not yet widely used in everyday practice. We conducted a post-hoc analysis of a prospectively collected database. Patients suffering from alcohol-induced AP between 2016 and 2021 received 30 min BI by a physician. Patient-reported alcohol consumption, serum gamma-glutamyl-transferase (GGT) level, and mean corpuscular volume (MCV) of red blood cells were collected on admission and at the 1-month follow-up visit to monitor patients' drinking habits. Ninety-nine patients with alcohol-induced AP were enrolled in the study (mean age: 50 ? 11, 89% male). A significant decrease was detected both in mean GGT value (294 ? 251 U/L vs. 103 ? 113 U/L, p < 0.001) and in MCV level (93.7 ? 5.3 U/L vs. 92.1 ? 5.1 U/L, p < 0.001) in patients with elevated on-admission GGT levels. Notably, 79% of the patients (78/99) reported alcohol abstinence at the 1-month control visit. Brief intervention is an effective tool to reduce alcohol consumption and to prevent recurrent AP. Longitudinal randomized clinical studies are needed to identify the adequate structure and frequency of BIs in alcohol-induced AP
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Nutrients. - 14 : 10 (2022), p. 1-9. -
További szerzők:Ocskay Klementina Váradi Alex (1991-) (biológus) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Izbéki Ferenc Boros Eszter Gajdán László Szentesi Andrea Erőss Bálint Hegyi Péter Jenő (belgyógyász) Vincze Áron Bajor Judit Sarlós Patrícia Mikó Alexandra Márta Katalin Pécsi Dániel Párniczky Andrea (gyermekgyógyász) Hegyi Péter (pszichológus)
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5.

001-es BibID:BIBFORM103700
035-os BibID:(scopus)85121564971 (wos)000731322900016 (cikkazonosító)24158
Első szerző:Ocskay Klementina
Cím:Hypoalbuminemia affects one third of acute pancreatitis patients and is independently associated with severity and mortality / Ocskay Klementina, Vinkó Zsófia, Németh Dávid, Szabó László, Bajor Judit, Gódi Szilárd, Sarlós Patrícia, Czakó László, Izbéki Ferenc, Hamvas József, Papp Mária, Varga Márta, Török Imola, Mickevicius Artautas, Sallinen Ville, Maldonado Elena Ramirez, Galeev Shamil, Mikó Alexandra, Erőss Bálint, Imrei Marcell, Hegyi Péter Jenő, Faluhelyi Nándor, Farkas Orsolya, Kanizsai Péter, Miseta Attila, Nagy Tamás, Hágendorn Roland, Márton Zsolt, Szakács Zsolt, Szentesi Andrea, Hegyi Péter, Párniczky Andrea
Dátum:2021
ISSN:2045-2322
Megjegyzések:The incidence and medical costs of acute pancreatitis (AP) are on the rise, and severe cases still have a 30% mortality rate. We aimed to evaluate hypoalbuminemia as a risk factor and the prognostic value of human serum albumin in AP. Data from 2461 patients were extracted from the international, prospective, multicentre AP registry operated by the Hungarian Pancreatic Study Group. Data from patients with albumin measurement in the frst 48 h (n= 1149) and anytime during hospitalization (n= 1272) were analysed. Multivariate binary logistic regression and Receiver Operator Characteristic curve analysis were used. The prevalence of hypoalbuminemia (<35 g/L) was 19% on admission and 35.7% during hospitalization. Hypoalbuminemia dose-dependently increased the risk of severity, mortality, local complications and organ failure and is associated with longer hospital stay. The predictive value of hypoalbuminemia on admission was poor for severity and mortality. Severe hypoalbuminemia (<25 g/L) represented an independent risk factor for severity (OR 48.761; CI 25.276?98.908) and mortality (OR 16.83; CI 8.32?35.13). Albumin loss during AP was strongly associated with severity (p< 0.001) and mortality (p= 0.002). Hypoalbuminemia represents an independent risk factor for severity and mortality in AP, and it shows a dose-dependent relationship with local complications, organ failure and length of stay.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 11 : 1 (2021), p. 1-12. -
További szerzők:Vinkó Zsófia Németh Dávid Szabó László Bajor Judit Gódi Szilárd Sarlós Patrícia Czakó László Izbéki Ferenc Hamvas József Papp Mária (1975-) (belgyógyász, gasztroenterológus) Varga Márta Török Imola Mickevicius, Artautas Sallinen, Ville Maldonado, Elena Ramirez Galeev, Shamil Mikó Alexandra Erőss Bálint Imrei Marcell Hegyi Péter Jenő (belgyógyász) Faluhelyi Nándor Farkas Orsolya Kanizsai Péter Miseta Attila Nagy Tamás Hágendorn Roland Márton Zsolt Szakács Zsolt Szentesi Andrea Hegyi Péter (pszichológus) Párniczky Andrea (gyermekgyógyász)
Pályázati támogatás:EFOP-3.6.2-16-2017-00006
EFOP
GINOP-2.3.2-15-2016-00015
GINOP
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Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM100014
035-os BibID:(cikkazonosító)e050821 (WoS)000739490700018 (Scopus)85122762723
Első szerző:Ocskay Klementina
Cím:Recurrent acute pancreatitis prevention by the elimination of alcohol and cigarette smoking (REAPPEAR) : protocol of a randomised controlled trial and a cohort study / Klementina Ocskay, Márk Félix Juhász, Nelli Farkas, Noémi Zádori, Lajos Szakó, Zsolt Szakács, Andrea Szentesi, Bálint Erőss, Emőke Miklós, Antal Zemplényi, Béla Birkás, Árpád Csathó, István Hartung, Tamás Nagy, László Czopf, Ferenc Izbéki, László Gajdán, Mária Papp, László Czakó, Dóra Illés, Marco V. Marino, Antonello Mirabella, Ewa Małecka-Panas, Hubert Zatorski, Yaroslav Susak, Kristina Opalchuk, Gabriele Capurso, Laura Apadula, Cristian Gheorghe, Ionut Adrian Saizu, Ole H. Petersen, Enrique de-Madaria, Jonas Rosendahl, Andrea Párniczky, Péter Hegyi, Hungarian Pancreatic Study Group
Dátum:2022
ISSN:2044-6055
Megjegyzések:Background/objectives Acute recurrent pancreatitis (ARP) due to alcohol and/or tobacco abuse is a preventable disease which lowers quality of life and can lead to chronic pancreatitis. The REAPPEAR study aims to investigate whether a combined patient education and cessation programme for smoking and alcohol prevents ARP. Methods and analysis The REAPPEAR study consists of an international multicentre randomised controlled trial (REAPPEAR-T) testing the efficacy of a cessation programme on alcohol and smoking and a prospective cohort study (REAPPEAR-C) assessing the effects of change in alcohol consumption and smoking (irrespective of intervention). Daily smoker patients hospitalised with alcohol-induced acute pancreatitis (AP) will be enrolled. All patients will receive a standard intervention priorly to encourage alcohol and smoking cessation. Participants will be subjected to laboratory testing, measurement of blood pressure and body mass index and will provide blood, hair and urine samples for later biomarker analysis. Addiction, motivation to change, socioeconomic status and quality of life will be evaluated with questionnaires. In the trial, patients will be randomised either to the cessation programme with 3-monthly visits or to the control group with annual visits. Participants of the cessation programme will receive a brief intervention at every visit with direct feedback on their alcohol consumption based on laboratory results. The primary endpoint will be the composite of 2-year all-cause recurrence rate of AP and/ or 2-year all-cause mortality. The cost-effectiveness of the cessation programme will be evaluated. An estimated 182 participants will be enrolled per group to the REAPPEAR-T with further enrolment to the cohort. Ethics and dissemination The study was approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (40394-10/2020/ EÜIG), all local ethical approvals are in place. Results will be disseminated at conferences and in peer-reviewed journals. Trial registration number NCT04647097
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:BMJ Open. - 12 : 1 (2022), p. 1-9. -
További szerzők:Juhász Márk Félix Farkas Nelli Zádori Noémi Szakó Lajos Szakács Zsolt Szentesi Andrea Erőss Bálint Miklós Emőke Zemplényi Antal Birkás Béla Csathó Árpád Hartung István Nagy Tamás (1977-) (vegyész, orvosi laboratóriumi analitikus) Czopf László Izbéki Ferenc Gajdán László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Czakó László Illés Dóra Marino, Marco Vito Mirabella, Antonello Małecka-Panas, Ewa Zatorski, Hubert Susak, Yaroslav Mykhailovych Opalchuk, Kristina Capurso, Gabriele Apadula, Laura Gheorghe, Cristian Saizu, Ionut Adrian Petersen, Ole H. de-Madaria, Enrique Rosendahl, Jonas Párniczky Andrea (gyermekgyógyász) Hegyi Péter Jenő (belgyógyász) Hungarian Pancreatic Study Group
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7.

001-es BibID:BIBFORM094178
035-os BibID:(WOS)000727779500019 (Scopus)85106978919
Első szerző:Szakó Lajos
Cím:Early occurrence of pseudocysts in acute pancreatitis - A multicenter international cohort analysis of 2275 cases / Lajos Szakó, Noémi Gede, Alex Váradi, Benedek Tinusz, Nóra Vörhendi, Dóra Mosztbacher, Áron Vincze, Tamás Takács, László Czakó, Ferenc Izbéki, László Gajdán, Veronika Dunás-Varga, József Hamvas, Mária Papp, Krisztina Eszter Fehér, Márta Varga, Artautas Mickevicius, Imola Török, Klementina Ocskay, Márk Félix Juhász, Szilárd Váncsa, Nándor Faluhelyi, Orsolya Farkas, Attila Miseta, András Vereczkei, Alexandra Mikó, Péter Jenő Hegyi, Andrea Szentesi, Andrea Párniczky, Bálint Erőss, Péter Hegyi
Dátum:2021
ISSN:1424-3903
Megjegyzések:BACKGROUND Pseudocysts being the most frequent local complications of acute pancreatitis (AP) have substantial effect on the disease course, hospitalization and quality of life of the patient. Our study aimed to understand the effects of pre existing (OLD-P) and newly developed (NEW-P) pseudocysts on AP. METHODS Data were extracted from the Acute Pancreatitis Registry organized by the Hungarian Pancreatic Study Group (HPSG). 2275 of 2461 patients had uploaded information concerning pancreatic morphology assessed by imaging technique. Patients were divided into "no pseudocyst" (NO-P) group, "old pseudocyst" (OLD-P) group, or "newly developed pseudocyst" (NEW-P) groups. RESULTS The median time of new pseudocyst development was nine days from hospital admission and eleven days from the beginning of the abdominal pain. More NEW-P cases were severe (15.9% vs 4.7% in the NO-P group p<0.001), with longer length of hospitalization (LoH) (median: 14 days versus 8 days, p<0.001), and were associated with several changed laboratory parameters. OLD-P was associated with male gender (72.2% vs. 56.1%, p=0.0014), alcoholic etiology (35.2% vs. 19.8% in the NO-P group), longer hospitalization (median: 10 days, p<0.001), a previous episode of AP (p<0.001), pre-existing diagnosis of chronic pancreatitis (CP) (p<0.001), current smoking (p<0.001), and increased alcohol consumption (unit/week) (p=0.014). CONCLUSION Most of the new pseudocysts develop within two weeks. Newly developing pseudocysts are associated with a more severe disease course and increased length of hospitalization. Pre-existing pseudocysts are associated with higher alcohol consumption and smoking. Because CP is more frequently associated with a pre-existing pseudocyst, these patients need closer attention after AP.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Pancreatology. - 21 : 6 (2021), p. 1161-1172. -
További szerzők:Gede Noémi Váradi Alex (1991-) (biológus) Tinusz Benedek Vörhendi Nóra Mosztbacher Dóra Vincze Áron Takács Tamás (Szeged) Czakó László Izbéki Ferenc Gajdán László Dunás-Varga Veronika Hamvas József Papp Mária (1975-) (belgyógyász, gasztroenterológus) Fehér Krisztina Eszter Varga Márta Mickevicius, Artautas Török Imola Ocskay Klementina Juhász Márk Félix Váncsa Szilárd Faluhelyi Nándor Farkas Orsolya Miseta Attila Vereczkei András Mikó Alexandra Hegyi Péter Jr. (belgyógyász) Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Erőss Bálint Hegyi Péter Jenő (belgyógyász)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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8.

001-es BibID:BIBFORM113553
035-os BibID:(scopus)85153309480 (wos)000973548200001
Első szerző:Váncsa Szilárd
Cím:Metabolic-associated fatty liver disease is associated with acute pancreatitis with more severe course : Post hoc analysis of a prospectively collected international registry / Váncsa Szilárd, Sipos Zoltán, Váradi Alex, Nagy Rita, Ocskay Klementina, Juhász Félix Márk, Márta Katalin, Teutsch Brigitta, Mikó Alexandra, Hegyi Péter Jenő, Vincze Áron, Izbéki Ferenc, Czakó László, Papp Mária, Hamvas József, Varga Márta, Török Imola, Mickevicius Artautas, Erőss Bálint, Párniczky Andrea, Szentesi Andrea, Pár Gabriella, Hegyi Péter, Hungarian Pancreatic Study Group
Dátum:2023
ISSN:2050-6406 2050-6414
Megjegyzések:Introduction - Non?alcoholic fatty liver disease (NAFLD) is a proven risk factor for acute pancreatitis (AP). However, NAFLD has recently been redefined as metabolic?associated fatty liver disease (MAFLD). In this post hoc analysis, we quantified the effect of MAFLD on the outcomes of AP. Methods - We identified our patients from the multicentric, prospective International Acute Pancreatitis Registry of the Hungarian Pancreatic Study Group. Next, we compared AP patients with and without MAFLD and the individual components of MAFLD regarding in?hospital mortality and AP severity based on the revised Atlanta classification. Lastly, we calculated odds ratios (ORs) with 95% confidence intervals (CIs) using multivariate logistic regression analysis. Results - MAFLD had a high prevalence in AP, 39% (801/2053). MAFLD increased the odds of moderate?to?severe AP (OR = 1.43, CI: 1.09?1.89). However, the odds of in?hospital mortality (OR = 0.89, CI: 0.42?1.89) and severe AP (OR = 1.70, CI: 0.97?3.01) were not higher in the MAFLD group. Out of the three diagnostic criteria of MAFLD, the highest odds of severe AP was in the group based on metabolic risk abnormalities (OR = 2.68, CI: 1.39?5.09). In addition, the presence of one, two, and three diagnostic criteria dose?dependently increased the odds of moderate?to?severe AP (OR = 1.23, CI: 0.88?1.70, OR = 1.38, CI: 0.93?2.04, and OR = 3.04, CI: 1.63?5.70, respectively) and severe AP (OR = 1.13, CI: 0.54?2.27, OR = 2.08, CI: 0.97?4.35, and OR = 4.76, CI: 1.50?15.4, respectively). Furthermore, in patients with alcohol abuse and aged ?60 years, the effect of MAFLD became insignificant. Conclusions - MAFLD is associated with AP severity, which varies based on the components of its diagnostic criteria. Furthermore, MAFLD shows a dose? dependent effect on the outcomes of AP.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:United European Gastroenterology Journal. - 11 : 4 (2023), p. 371-382. -
További szerzők:Sipos Zoltán (1988-) (vegyész, angol-magyar szakfordító) Váradi Alex (1991-) (biológus) Nagy Rita Ocskay Klementina Juhász Márk Félix Márta Katalin Teutsch Brigitta Mikó Alexandra Hegyi Péter Jenő (belgyógyász) Vincze Áron Izbéki Ferenc Czakó László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hamvas József Varga Márta Török Imola Mickevicius, Artautas Erőss Bálint Párniczky Andrea (gyermekgyógyász) Szentesi Andrea Pár Gabriella Hegyi Péter (pszichológus) Hungarian Pancreatic Study Group
Pályázati támogatás:ÚNKP?22?3?II
Egyéb
ÚNKP?22?3?I
Egyéb
ÚNKP?22?5
Egyéb
ÚNKP?22?4?II
Egyéb
FK131864
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