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001-es BibID:	BIBFORM088207
Első szerző:	Demcsák Alexandra
Cím:	Acid suppression therapy, gastrointestinal bleeding and infection in acute pancreatitis - An international cohort study / Alexandra Demcsak, Alexandra Soos, Lilla Kincses, Ines Capunge, Georgi Minkov, Mila Kovacheva-Slavova, Radislav Nakov, Dong Wu, Wei Huang, Qing Xia, Lihui Deng, Marcus Hollenbach, Alexander Schneider, Michael Hirth, Orestis Ioannidis, Aron Vincze, Judit Bajor, Patrícia Sarlos, Laszló Czakó, Dora Illés, Ferenc Izbeki, Laszló Gajdán, Maria Papp, Jozsef Hamvas, Marta Varga, Peter Kanizsai, Ernő Bóna, Alexandra Miko, Szilard Váncsa, Márk Félix Juhász, Klementina Ocskay, Erika Darvasi, Emőke Miklós, Balint Erőss, Andrea Szentesi, Andrea Parniczky, Riccardo Casadei, Claudio Ricci, Carlo Ingaldi, Laura Mastrangelo, Elio Jovine, Vincenzo Cennamo, Marco V. Marino, Giedrius Barauskas, Povilas Ignatavicius, Mario Pelaez-Luna, Andrea Soriano Rios, Svetlana Turcan, Eugen Tcaciuc, Ewa Małecka-Panas, Hubert Zatorski, Vitor Nunes, Antonio Gomes, Tiago Cúrdia Gonçalves, Marta Freitas, Júlio Constantino, Milene Sa, Jorge Pereira, Bogdan Mateescu, Gabriel Constantinescu, Vasile Sandru, Ionut Negoi, Cezar Ciubotaru, Valentina Negoita, Stefania Bunduc, Cristian Gheorghe, Sorin Barbu, Alina Tantau, Marcel Tantau, Eugen Dumitru, Andra Iulia Suceveanu, Cristina Tocia, Adriana Gherbon, Andrey Litvin, Natalia Shirinskaya, Yliya Rabotyagova, Mihailo Bezmarevic, Péter Jenő Hegyi, Jimin Han, Juan Armando Rodriguez-Oballe, Isabel Miguel Salas, Eva Pijoan Comas, Daniel de la Iglesia Garcia, Andrea Jardi Cuadrado, Adriano Quiroga Castineira, Yu-Ting Chang, Ming-Chu Chang, Ali Kchaou, Ahmed Tlili, Sabite Kacar, Volkan Gokbulut, Deniz Duman, Haluk Tarik Kani, Engin Altintas, Serge Chooklin, Serhii Chuklin, Amir Gougol, George Papachristou, Peter Hegyi Jr.
Dátum:	2020
ISSN:	1424-3903
Megjegyzések:	Background:Acid suppressing drugs (ASD) are generally used in acute pancreatitis (AP); however, largecohorts are not available to understand their efficiency and safety. Therefore, our aims were to evaluatethe association between the administration of ASDs, the outcome of AP, the frequency of gastrointestinal(GI) bleeding and GI infection in patients with AP.Methods:We initiated an international survey and performed retrospective data analysis on AP patientshospitalized between January 2013 and December 2018.Results:Data of 17,422 adult patients with AP were collected from 59 centers of 23 countries. We foundthat 23.3% of patients received ASDs before and 86.6% during the course of AP. ASDs were prescribed to57.6% of patients at discharge. ASD administration was associated with more severe AP and highermortality. GI bleeding was reported in 4.7% of patients, and it was associated with pancreatitis severity,mortality and ASD therapy. Stool culture test was performed in 6.3% of the patients with 28.4% positiveresults.Clostridium difficilewas the cause of GI infection in 60.5% of cases. Among the patients with GIinfections, 28.9% received ASDs, whereas 24.1% were without any acid suppression treatment. GI infec-tion was associated with more severe pancreatitis and higher mortality.Conclusions:Although ASD therapy is widely used, it is unlikely to have beneficial effects either on theoutcome of AP or on the prevention of GI bleeding during AP. Therefore, ASD therapy should be sub-stantially decreased in the therapeutic management of AP.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Acid suppressing drug Gastrointestinal bleeding Gastrointestinal infection Acute pancreatitis Proton pump inhibitor
Megjelenés:	Pancreatology. - 20 : 7 (2020), p. 1323-1331. -
További szerzők:	Soós Alexandra Kincses Lilla Capunge, Ines Minkov, Georgi Kovacheva-Slavova, Mila Nakov, Radislav Wu, Dong Huang, Wei Xia, Qing Deng, Lihui Hollenbach, Marcus Schneider, Alexander Hirth, Michael Ioannidis, Orestis Vincze Áron Bajor Judit Sarlós Patrícia Czakó László Illés Dóra Izbéki Ferenc Gajdán László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Hamvas József Varga Márta Kanizsai Péter Bóna Ernő Mikó Alexandra Váncsa Szilárd Juhász Márk Félix Ocskay Klementina Darvasi Erika Miklós Emőke Erőss Bálint Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Casadei, Riccardo Ricci, Claudio Ingaldi, Carlo Mastrangelo, Laura Jovine, Elio Cennamo, Vincenzo Marino, Marco Vito Barauskas, Giedrius Ignatavicius, Povilas Pelaez-Luna, Mario Rios, Andrea Soriano Turcan, Svetlana Tcaciuc, Eugen Małecka-Panas, Ewa Zatorski, Hubert Nunes, Vitor Gomes, António Pedro Gonçalves, Tiago Cúrdia Freitas, Marta Constantino, Júlio Sá, Milene Pereira, Jorge Mateescu, Bogdan Constantinescu, Gabriel Sandru, Vasile Negoi, Ionut Ciubotaru, Cezar Negoita, Valentina Bunduc, Stefania Gheorghe, Cristian Barbu, Sorin Tantau, Alina Tantau, Marcel Dumitru, Eugen Suceveanu, Andra Iulia Tocia, Cristina Gherbon, Adriana Litvin, A. Andrey Shirinskaya, Natalia V. Rabotyagova, Yliya Bezmarevic, Mihailo Hegyi Péter Jenő (belgyógyász) Han, Jimin Rodriguez-Oballe, Juan Armando Salas, Isabel Miguel Comas, Eva Pijoan Garcia, Daniel de la Iglesia Cuadrado, Andrea Jardi Castiñeira, Adriano Quiroga Chang, Yu-Ting Chang, Ming-Chu Kchaou, Ali Tlili, Ahmed Kacar, Sabite Gökbulut, Volkan Duman, Deniz Kani, Haluk Tarik Altintas, Engin Chooklin, Serge Chuklin, Serhii Gougol, Amir Papachristou, Georgios I. Hegyi Péter Jr. (belgyógyász)
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001-es BibID:	BIBFORM100014
035-os BibID:	(cikkazonosító)e050821 (WoS)000739490700018 (Scopus)85122762723
Első szerző:	Ocskay Klementina
Cím:	Recurrent acute pancreatitis prevention by the elimination of alcohol and cigarette smoking (REAPPEAR) : protocol of a randomised controlled trial and a cohort study / Klementina Ocskay, Márk Félix Juhász, Nelli Farkas, Noémi Zádori, Lajos Szakó, Zsolt Szakács, Andrea Szentesi, Bálint Erőss, Emőke Miklós, Antal Zemplényi, Béla Birkás, Árpád Csathó, István Hartung, Tamás Nagy, László Czopf, Ferenc Izbéki, László Gajdán, Mária Papp, László Czakó, Dóra Illés, Marco V. Marino, Antonello Mirabella, Ewa Małecka-Panas, Hubert Zatorski, Yaroslav Susak, Kristina Opalchuk, Gabriele Capurso, Laura Apadula, Cristian Gheorghe, Ionut Adrian Saizu, Ole H. Petersen, Enrique de-Madaria, Jonas Rosendahl, Andrea Párniczky, Péter Hegyi, Hungarian Pancreatic Study Group
Dátum:	2022
ISSN:	2044-6055
Megjegyzések:	Background/objectives Acute recurrent pancreatitis (ARP) due to alcohol and/or tobacco abuse is a preventable disease which lowers quality of life and can lead to chronic pancreatitis. The REAPPEAR study aims to investigate whether a combined patient education and cessation programme for smoking and alcohol prevents ARP. Methods and analysis The REAPPEAR study consists of an international multicentre randomised controlled trial (REAPPEAR-T) testing the efficacy of a cessation programme on alcohol and smoking and a prospective cohort study (REAPPEAR-C) assessing the effects of change in alcohol consumption and smoking (irrespective of intervention). Daily smoker patients hospitalised with alcohol-induced acute pancreatitis (AP) will be enrolled. All patients will receive a standard intervention priorly to encourage alcohol and smoking cessation. Participants will be subjected to laboratory testing, measurement of blood pressure and body mass index and will provide blood, hair and urine samples for later biomarker analysis. Addiction, motivation to change, socioeconomic status and quality of life will be evaluated with questionnaires. In the trial, patients will be randomised either to the cessation programme with 3-monthly visits or to the control group with annual visits. Participants of the cessation programme will receive a brief intervention at every visit with direct feedback on their alcohol consumption based on laboratory results. The primary endpoint will be the composite of 2-year all-cause recurrence rate of AP and/ or 2-year all-cause mortality. The cost-effectiveness of the cessation programme will be evaluated. An estimated 182 participants will be enrolled per group to the REAPPEAR-T with further enrolment to the cohort. Ethics and dissemination The study was approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (40394-10/2020/ EÜIG), all local ethical approvals are in place. Results will be disseminated at conferences and in peer-reviewed journals. Trial registration number NCT04647097
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	BMJ Open. - 12 : 1 (2022), p. 1-9. -
További szerzők:	Juhász Márk Félix Farkas Nelli Zádori Noémi Szakó Lajos Szakács Zsolt Szentesi Andrea Erőss Bálint Miklós Emőke Zemplényi Antal Birkás Béla Csathó Árpád Hartung István Nagy Tamás (1977-) (vegyész, orvosi laboratóriumi analitikus) Czopf László Izbéki Ferenc Gajdán László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Czakó László Illés Dóra Marino, Marco Vito Mirabella, Antonello Małecka-Panas, Ewa Zatorski, Hubert Susak, Yaroslav Mykhailovych Opalchuk, Kristina Capurso, Gabriele Apadula, Laura Gheorghe, Cristian Saizu, Ionut Adrian Petersen, Ole H. de-Madaria, Enrique Rosendahl, Jonas Párniczky Andrea (gyermekgyógyász) Hegyi Péter Jenő (belgyógyász) Hungarian Pancreatic Study Group
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