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001-es BibID:	BIBFORM090166
Első szerző:	Hágendorn Roland
Cím:	Disturbance of consciousness deteriorates the severity of acute pancreatitis. An international multicentre cohort analyses of 1220 prospectively collected patients / R. Hagendorn, Á. Vincze, F. Izbeki, L. Gajdan, S. Godi, A. Illes, P. Sarlos, N. Farkas, B. Erős, V. Lillik, D. Illes, P. Varjú, K. Marta, I. Török, M. Papp, Z. Vitalis, B. Bod, J. Hamvas, Z. Szepes, T. Takacs, L. Czakó, A. Szentesi, A. Parniczky, P. Hegyi, A. Miko
Dátum:	2020
ISSN:	1424-3903
Megjegyzések:	Purpose: Disturbance of consciousness (DOC) may develop in acute pancreatitis (AP). In clinical practice, it is known that DOC may worsen the patient's condition, but we have no exact data on how DOC affects the outcome of AP. Materials and methods: From the Hungarian Pancreatic Study Groups' AP registry, 1220 cases contained the exact data on DOC. Patients were separated to Non-DOC and DOC, whereas DOC was further divided into non-alcohol related DOC (Non-ALC DOC) and ALC-DOC groups. Statistical analysis was performed by SPSS 24 Software Package. Results: From the 1220 patients, 47 (3.85%) developed DOC, 23 (48.9%) cases were ALC DOC vs. 24 (51.1%) Non-ALC DOC. The incidence of severe AP was higher in the DOC compared to the Non-DOC group (19.15% vs. 5.29%, p<0.001). The mortality was higher in the DOC vs. Non-DOC group (14.89% vs. 1.71%, p<0.001). Length of hospitalization (LOH) was longer in the DOC vs. non-DOC group (Me:11; IQR:8-17 days vs. Me:9; IQR:6-13 days, p?0.049). Patients with ALC DOC developed more frequently moderately-severe AP vs. Non-ALC DOC (43.48% vs. 12.5%), while the incidence of severe AP was significantly higher in Non-ALC vs. ALC DOC group (33.33% vs. 4.35%) (p<0.001). LOH showed tendency to be longer in Non-ALC DOC compared to ALC DOC respectively (Me:13; IQR:7-20 days vs. Me:9.5; IQR:8-15.5 days, p?0.119). Conclusions: DOC during AP is associated with a higher rate of moderate and severe AP and increases the risk of mortality; therefore, the DOC should be closely monitored and prevented in AP.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	Pancreatology. - 20 (2020), p. S25. -
További szerzők:	Vincze Áron Izbéki Ferenc Gajdán László Gódi Szilárd Illés Árpád (1959-) (belgyógyász, haematológus, onkológus) Sarlós Péter Farkas Nelli Erős Bálint Lillik Veronika Illés Dóra Varjú Péter Márta Katalin Török I. Papp Mária (1975-) (belgyógyász, gasztroenterológus) Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Bod Barnabás Hamvas József Szepes Zoltán Takács T. Czakó László Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Hegyi Péter Jenő (belgyógyász) Mikó Alexandra
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM090160
035-os BibID:	(cikkazonosító)1367 (WOS)000626774100081 (Scopus)85099483306
Első szerző:	Hegyi Péter Jr. (belgyógyász)
Cím:	Evidence for diagnosis of early chronic pancreatitis after three episodes of acute pancreatitis : a cross-sectional multicentre international study with experimental animal model / Péter J. Hegyi, Alexandra Soós, Emese Tóth, Attila Ébert, Viktória Venglovecz, Katalin Márta, Péter Mátrai, Alexandra Mikó, Judit Bajor, Patrícia Sarlós, Áron Vincze, Adrienn Halász, Ferenc Izbéki, Zoltán Szepes, László Czakó, György Kovács, Mária Papp, Zsolt Dubravcsik, Márta Varga, József Hamvas, Balázs C. Németh, Melania Macarie, Ali Tüzüm Ince, Elena A. Dubtsova, Mariya A. Kirynkova, Igor E. Khatkov, Tanya Bideeva, Artautas Mickevicius, Elena Ramírez-Maldonado, Ville Sallinen, Bálint Erős, Dániel Pécsi, Andrea Szentesi, Andrea Párniczky, László Tiszlavicz, Péter Hegyi
Dátum:	2021
ISSN:	2045-2322
Megjegyzések:	Abstract Chronic pancreatitis (CP) is an end-stage disease with no specific therapy; therefore, an early diagnosis is of crucial importance. In this study, data from 1315 and 318 patients were analysed from acute pancreatitis (AP) and CP registries, respectively. The population from the AP registry was divided into AP (n = 983), recurrent AP (RAP, n = 270) and CP (n = 62) groups. The prevalence of CP in combination with AP, RAP2, RAP3, RAP4 and RAP5 + was 0%, 1%, 16%, 50% and 47%, respectively, suggesting that three or more episodes of AP is a strong risk factor for CP. Laboratory, imaging and clinical biomarkers highlighted that patients with RAP3 + do not show a significant difference between RAPs and CP. Data from CP registries showed 98% of patients had at least one AP and the average number of episodes was four. We mimicked the human RAPs in a mouse model and found that three or more episodes of AP cause early chronic-like morphological changes in the pancreas. We concluded that three or more attacks of AP with no morphological changes to the pancreas could be considered as early CP (ECP).The new diagnostic criteria for ECP allow the majority of CP patients to be diagnosed earlier. They can be used in hospitals with no additional costs in healthcare.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Scientific Reports. - 11 : 1 (2021), p. 1-14. -
További szerzők:	Soós Alexandra Tóth Emese Ébert Attila Venglovecz Viktória Márta Katalin Mátrai Péter Mikó Alexandra Bajor Judit Sarlós Patrícia Vincze Áron Halász Adrienn Izbéki Ferenc Szepes Zoltán Czakó László Kovács György (1982-) (belgyógyász, gasztroenterológus) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Dubravcsik Zsolt (belgyógyász, gasztroenterológus) Varga Márta Hamvas József Németh Balázs Csaba Macarie, Melania Ince, Ali Tüzün Dubtsova, Elena A. Kirynkova, Mariya A. Khatkov, Igor E. Bideeva, Tanya Mickevicius, Artautas Ramírez-Maldonado, Elena Sallinen, Ville Erős Bálint Pécsi Dániel Szentesi Andrea Párniczky Andrea (gyermekgyógyász) Tiszlavicz László Hegyi Péter Jenő (belgyógyász)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM090171
Első szerző:	Mikó Alexandra
Cím:	Early Phase of Chronic Pancreatitis : results of the First 20 Months of the GOULASH-PLUS Clinical Study / A. Mikó, D. Kato, V. Lillik, L. Gajdán, M. Papp, I. Földi, B. Bodis, N. Faluhelyi, P. Sarlos, Á. Vincze, Z. Szepes, G. Elsayed, P. Mosler, B. Erős, L. Czakó, P. Hegyi
Dátum:	2020
ISSN:	1424-3903
Megjegyzések:	Purpose: Acute pancreatitis (AP) is a severe inflammatory disease that can lead to irreversible complications such as recurrent acute pancreatitis (RAP) and chronic pancreatitis (CP). CP is often diagnosed in an advanced form, though it could be effectively managed at an early stage. However, parameters indicative of early CP are still unknown. We aim to find measurable biomarkers and clinical signs of this early phase through the GOULASH-PLUS follow-up study. Materials and methods: GOULASH-PLUS is a longitudinal study of AP with a 6-year follow-up of patients with a well documented episode of AP. Imaging, physical and laboratory testing is performed annually. To detect endocrine function, blood glucose, HbA1C were measured, and oral glucose tolerance test (OGTT) was performed; exocrine parameters were measured by a stool elastase test. Chi-square test and Fisher exact test were used for statistical analysis. Results: Of the first 133 patients, 57 (43%)were women, 76 (57%)were men, and the average age was 55. 27 (20%) patients had moderate AP, 6 (5%) had severe AP, and 15 (14%) had RAP in the first year. 13 (16%) patients were diagnosed with severe exocrine pancreas insufficiency, 17 (15%) were diagnosed with diabetes and 23 (20%) with impaired glucose tolerance (IGT). Exocrine abnormalities were present in 70% of patients with RAP, compared with only 18% in the group without RAP (p <0.001). There was no difference in endocrine function between RAP and non-RAP groups. Based on OGTT, hyperinsulinemia was detected in IGT and diabetic groups, and endocrine disruption (IGT, DM) was not associated with AP severity. Conclusions: One year after AP, exocrine and endocrine insufficiency can be measured in the majority of patients. In RAP, exocrine abnormalities appear earlier, while the endocrine function is not affected. The development of IGT and DM is independent of the severity of AP.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt folyóiratcikk
Megjelenés:	Pancreatology. - 20 (2020), p. S29. -
További szerzők:	Kató D. Lillik V. Gajdán László Papp Mária (1975-) (belgyógyász, gasztroenterológus) Földi Ildikó (1981-) (orvos) Bódis Beáta Faluhelyi Nándor Sarlós Patrícia Vincze Áron Szepes Zoltán Elsayed, G. Mosler, P. Erős Bálint Czakó László Hegyi Péter Jenő (belgyógyász)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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