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001-es BibID:	BIBFORM061109
Első szerző:	Balog Márta
Cím:	Sex-specific chronic stress response at the level of adrenal gland modifies sexual hormone and leptin receptors / Marta Balog, Milan Miljanović, Senka Blažetić, Irena Labak, Vedrana Ivić, Barbara Viljetić, Attila Borbely, Zoltán Papp, Robert Blažeković, Sandor G. Vari, Miklós Fagyas, Marija Heffer
Dátum:	2015
ISSN:	0353-9504
Megjegyzések:	AimTo compare cardiometabolic risk-related biochemical markers and sexual hormone and leptin receptors in the adrenal gland of rat males, non-ovariectomized females (NON-OVX), and ovariectomized females (OVX) under chronic stress.MethodsForty six 16-week-old Sprague-Dawley rats were divided into male, NON-OVX, and OVX group and exposed to chronic stress or kept as controls. Weight, glucose tolerance test (GTT), serum concentration of glucose, and cholesterol were measured. Adrenal glands were collected at the age of 28 weeks and immunohistochemical staining against estrogen beta (ER?), progesterone (PR), testosterone (AR), and leptin (Ob-R) receptors was performed.ResultsBody weight, GTT, serum cholesterol, and glucose changed in response to stress as expected and validated the applied stress protocol. Stressed males had significantly higher number of ER? receptors in comparison to control group (P?=?0.028). Stressed NON-OVX group had significantly decreased AR in comparison to control group (P?=?0.007). The levels of PR did not change in any consistent pattern. The levels of Ob-R increased upon stress in all groups, but the significant difference was reached only in the case of stressed OVX group compared to control (P?=?0.033).ConclusionChronic stress response was sex specific. OVX females had similar biochemical parameters as males. Changes upon chronic stress in adrenal gland were related to a decrease in testosterone receptor in females and increase in estrogen receptor in males.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban chronic stress Leptin sexual hormone
Megjelenés:	Croatian Medical Journal. - 56 : 2 (2015), p. 104-113. -
További szerzők:	Miljanović, Milan Blažetić, Senka Labak, Irena Ivić, Vedrana Viljetić, Barbara Borbély Attila (1978-) (kardiológus) Papp Zoltán (1965-) (kardiológus, élettanász) Blazeković, Robert Vári Sándor G. Fagyas Miklós (1984-) (orvos) Heffer, Marija
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001-es BibID:	BIBFORM054413
Első szerző:	Kalász Judit (molekuláris biológus)
Cím:	Single acute stress-induced progesterone and ovariectomy alter cardiomyocyte contractile function in female rats / Judit Kalász, Enikő Pásztor Tóth, Beáta Bódi, Miklós Fagyas, Attila Tóth, Bhattoa Harjit Pal, Sándor G. Vári, Marta Balog, Senka Blažetić, Marija Heffer, Zoltán Papp, Attila Borbély
Dátum:	2014
ISSN:	0353-9504
Megjegyzések:	AIM:To assess how ovarian-derived sex hormones (in particular progesterone) modify the effects of single acute stress on the mechanical and biochemical properties of left ventricular cardiomyocytes in the rat.METHODS:Non-ovariectomized (control, n=8) and ovariectomized (OVX, n=8) female rats were kept under normal conditions or were exposed to stress (control-S, n=8 and OVX-S, n=8). Serum progesterone levels were measured using a chemiluminescent immunoassay. Left ventricular myocardial samples were used for isometric force measurements and protein analysis. Ca(2+)-dependent active force (Factive), Ca(2+)-independent passive force (Fpassive), and Ca(2+)-sensitivity of force production were determined in single, mechanically isolated, permeabilized cardiomyocytes. Stress- and ovariectomy-induced alterations in myofilament proteins (myosin-binding protein C [MyBP-C], troponin I [TnI], and titin) were analyzed by sodium dodecyl sulfate gel electrophoresis using protein and phosphoprotein stainings.RESULTS:Serum progesterone levels were significantly increased in stressed rats (control-S, 35.6?4.8 ng/mL and OVX-S, 21.9?4.0 ng/mL) compared to control (10?2.9 ng/mL) and OVX (2.8?0.5 ng/mL) groups. Factive was higher in the OVX groups (OVX, 25.9?3.4 kN/m(2) and OVX-S, 26.3?3.0 kN/m(2)) than in control groups (control, 16.4?1.2 kN/m(2) and control-S, 14.4?0.9 kN/m(2)). Regarding the potential molecular mechanisms, Factive correlated with MyBP-C phosphorylation, while myofilament Ca(2+)-sensitivity inversely correlated with serum progesterone levels when the mean values were plotted for all animal groups. Fpassive was unaffected by any treatment.CONCLUSION:Stress increases ovary-independent synthesis and release of progesterone, which may regulate Ca(2+)-sensitivity of force production in left ventricular cardiomyocytes. Stress and female hormones differently alter Ca(2+)-dependent cardiomyocyte contractile force production, which may have pathophysiological importance during stress conditions affecting postmenopausal women.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban stress, progesteron, cardiomyocytes
Megjelenés:	Croatian Medical Journal. - 55 : 3 (2014), p. 239-249. -
További szerzők:	Pásztorné Tóth Enikő (1966-) (laboratóriumi analitikus) Bódi Beáta (1989-) (molekuláris biológus) Fagyas Miklós (1984-) (orvos) Tóth Attila (1971-) (biológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Vári Sándor G. Balog Márta Blažetić, Senka Heffer, Marija Papp Zoltán (1965-) (kardiológus, élettanász) Borbély Attila (1978-) (kardiológus)
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