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001-es BibID:BIBFORM079007
035-os BibID:(Scopus)85070663061
Első szerző:Oliva, Fabrizio
Cím:Repetitive levosimendan treatment in the management of advanced heart failure / Fabrizio Oliva, Josep Comin-Colet, Francesco Fedele, Friedrich Fruhwald, Finn Gustafsson, Matti Kivikko, Borbély Attila, Gerhard Pölzl, Carsten Tschöpe
Dátum:2018
ISSN:1520-765X
Megjegyzések:Inotropes may be an appropriate treatment for patients with advanced heart failure (AdHF) who remain highly symptomatic despite optimized standard therapies. Objectives for inotrope use in these situations include relief of symptoms and improvement of quality of life, and reduction in unplanned hospitalizations and the costs associated with such episodes. All of these goals must be attained without compromising survival. Encouraging findings with intermittent cycles of intravenous levosimendan have emerged from a range of exploratory studies and from three larger controlled trials (LevoRep, LION-HEART, and LAICA) which offered some evidence of clinical advantage. In these settings, however, obtaining statistically robust data may prove elusive due to the difficulties of endpoint assessment in a complex medical condition with varying presentation and trajectory. Adoption of a composite clinical endpoint evaluated in a hierarchical manner may offer a workable solution to this problem. Such an instrument can explore the proposition that repetitive administration of levosimendan early in the period after discharge from an acute episode of worsening heart failure may be associated with greater subsequent clinical stability vis-a`-vis standard therapy. The use of this methodology to develop a ♭stability score' for each patient means that all participants in such a trial contribute to the overall outcome analysis through one or more of the hierarchical endpoints; this has helpful practical implications for the number of patients needed and the length of follow-up required to generate endpoint data. The LeoDOR study (NCT03437226), outlined in this review, has been designed to explore this new approach to outcome assessment in AdHF.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Intermittent treatment
Repetitive inotrope
Quality of life
Rehospitalization
Outcome
Megjelenés:European Heart Journal Supplements. - 20 : suppl. I (2018), p. I11-I20. -
További szerzők:Comin-Colet, Josep Fedele, Francesco Fruhwald, Friedrich Gustafsson, Finn Kivikko, Matti Borbély Attila (1978-) (kardiológus) Pölzl, Gerhard Tschöpe, Carsten
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001-es BibID:BIBFORM070106
Első szerző:Pölzl, Gerhard
Cím:Repetitive use of levosimendan in advanced heart failure : need for stronger evidence in a field in dire need of a useful therapy / Pölzl Gerhard, Altenberger Johann, Baholli Loant, Beltrán Paola, Borbély Attila, Comin-Colet Josep, Delgado Juan F., Fedele Francesco, Fontana Antonella, Fruhwald Friedrich, Giamouzis Gregory, Giannakoulas George, Garcia-González Martín J., Gustafsson Finn, Kaikkonen Kari, Kivikko Matti, Kubica Jacek, von Lewinski Dirk, Löfman Ida, Malfatto Gabriella, Manito Nicolás, Martínez-Sellés Martin, Masip Josep, Merkely Bela, Morandi Fabrizio, Mølgaard Henning, Oliva Fabrizio, Pantev Emil, Papp Zoltán, Perna Gian Piero, Pfister Roman, Piazza Vito, Bover Ramón, Rangel-Sousa Diego, Recio-Mayoral Alejandro, Reinecke Alexander, Rieth Andreas, Sarapohja Toni, Schmidt Gunter, Seidel Mirko, Störk Stefan, Vrtovec Bojan, Wikström Gerhard, Yerly Patrik, Pollesello Piero
Dátum:2017
ISSN:0167-5273
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:International Journal Of Cardiology. - 243 (2017), p. 389-395. -
További szerzők:Altenberger, Johann Baholli, Loant Beltrán, Paola Borbély Attila (1978-) (kardiológus) Comin-Colet, Josep Delgado, Juan F. Fedele, Francesco Fontana, Antonella Fruhwald, Friedrich Giamouzis, Gregory Giannakoulas, George Garcia-González, Martín J. Gustafsson, Finn Kaikkonen, Kari Kivikko, Matti Kubica, Jacek von Lewinski, Dirk Löfman, Ida Malfatto, Gabriella Manito, Nicolás Martínez-Sellés, Martin Masip, Josep Merkely Béla (1965-) (orvos) Morandi, Fabrizio Mølgaard, Henning Oliva, Fabrizio Pantev, Emil Papp Zoltán (1965-) (kardiológus, élettanász) Perna, Gian Piero Pfister, Roman Piazza, Vito Bover, Ramón Rangel-Sousa, Diego Recio-Mayoral, Alejandro Reinecke, Alexander Rieth, Andreas Sarapohja, Toni Schmidt, Gunter Seidel, Mirko Störk, Stefan Vrtovec, Bojan Wikström, Gerhard Yerly, Patrik Pollesello, Piero
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