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001-es BibID:	BIBFORM040583
Első szerző:	Velden, Jolanda, van der
Cím:	Myosin light chain composition in non-failing donor and end-stage failing human ventricular myocardium / van der Velden J., Papp Z., Boontje N. M., Zaremba R., de Jong J. W., Janssen P. M. L., Hasenfuss G., Stienen G. J. M.
Dátum:	2003
ISSN:	0065-2598
Megjegyzések:	The increased Ca(2+)-responsiveness in end-stage human heart failure cannot be attributed to contractile protein isoform changes, but rather is the complex resultant of changes in degree of phosphorylation of VLC-2 and TnI. Despite the decreased basal level of VLC-2 phosphorylation the response to VLC-2 dephosphorylation is enhanced in failing myocytes, which might result from differences in endogenous phosphorylation of thin and thick filament proteins between donor and failing hearts. Taken together decreased VLC-2 phosphorylation in end-stage human heart failure might represent a compensatory process leading to an improvement of myocardial contractility by opposing the detrimental effects of increased Ca(2+)-responsiveness of force and impaired Ca(2+)-handling on diastolic function.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Advances in Experimental Medicine and Biology. - 538 (2003), p. 3-15. -
További szerzők:	Papp Zoltán (1965-) (kardiológus, élettanász) Boontje, Nicky M. Zaremba, Ruud de Jong, J. W. Janssen, P. M. L. Hasenfuß, Gerd Stienen, Ger J. M.
Internet cím:	DOI
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