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1.

001-es BibID:BIBFORM049771
Első szerző:Bodnár Dóra (molekuláris biológus)
Cím:Hypermuscular mice with mutation in the myostatin gene display altered calcium signaling / Dóra Bodnár, Nikolett Geyer, Olga Ruzsnavszky, Tamás Oláh, Bence Hegyi, Mónika Sztretye, János Fodor, Beatrix Dienes, Ágnes Balogh, Zoltán Papp, László Szabó, Géza Müller, László Csernoch, Péter Szentesi
Dátum:2014
ISSN:0022-3751
Megjegyzések:Myostatin, a member of the transforming growth factor β family, is a potent negative regulator of skeletal muscle growth, as myostatin-deficient mice show a great increase in muscle mass. Yet the physical performance of these animals is reduced. As an explanation for this, alterations in the steps in excitation-contraction coupling were hypothesized and tested for in mice with the 12 bp deletion in the propeptide region of the myostatin precursor (MstnCmpt-dl1Abc or Cmpt). In voluntary wheel running, control C57BL/6 mice performed better than the mutant animals in both maximal speed and total distance covered. Despite the previously described lower specific force of Cmpt animals, the pCa-force relationship, determined on chemically permeabilized fibre segments, did not show any significant difference between the two mouse strains. While resting intracellular Ca2+ concentration ([Ca2+]i) measured on single intact flexor digitorum brevis (FDB) muscle fibres using Fura-2 AM was similar to control (72.0 ± 1.7 vs. 78.1 ± 2.9 nm, n = 38 and 45), the amplitude of KCl-evoked calcium transients was smaller (360 ± 49 vs. 222 ± 45 nm, n = 22) in the mutant strain. Similar results were obtained using tetanic stimulation and Rhod-2 AM, which gave calcium transients that were smaller (2.42 ± 0.11 vs. 2.06 ± 0.10 F/F0, n = 14 and 13, respectively) on Cmpt mice. Sarcoplasmic reticulum (SR) calcium release flux calculated from these transients showed a reduced peak (23.7 ± 3.0 vs. 15.8 ± 2.1 mMs-1) and steady level (5.7 ± 0.7 vs. 3.7 ± 0.5 mm s-1) with no change in the peak-to-steady ratio. The amplitude and spatial spread of calcium release events detected on permeabilized FDB fibres were also significantly smaller in mutant mice. These results suggest that reduced SR calcium release underlies the reduced muscle force in Cmpt animals.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
EC coupling
skeletal muscle
calcium release
myostatin
Molekuláris Medicina
Doktori iskola
Megjelenés:Journal of Physiology-London. - 592 : 6 (2014), p. 1353-1365. -
További szerzők:Geyer Nikolett Ruzsnavszky Olga (1983-) (élettanász) Oláh Tamás (1983-) (élettanász) Hegyi Bence (1987-) (élettanász) Sztretye Mónika (1981-) (élettanász, elektrofiziológus) Fodor János (1973-) (élettanász, biotechnológus) Dienes Beatrix (1972-) (élettanász, molekuláris biológus) Balogh Ágnes (1984-) (kardiológus) Papp Zoltán (1965-) (kardiológus, élettanász) Szabó László Müller Géza Csernoch László (1961-) (élettanász) Szentesi Péter (1967-) (élettanász)
Pályázati támogatás:NN-107765
OTKA
TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
A harántcsíkolt izom kontrakció molekuláris szabályozása
TÁMOP-4.2.2/B-10/1-2010-0024
TÁMOP
Molekuláris Orvostudomány Doktori Iskola
TÁMOP-4.2.2.A-11/1/KONV-2012-0025
TÁMOP
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2.

001-es BibID:BIBFORM065595
Első szerző:Papp Zoltán (kardiológus, élettanász)
Cím:Rebuttal from Zoltán Papp, Attila Borbély and Walter J. Paulus / Zoltan Papp, Attila Borbely, Walter J. Paulus
Dátum:2014
ISSN:0022-3751
Tárgyszavak:Orvostudományok Elméleti orvostudományok hozzászólás
Megjelenés:Journal Of Physiology-London. - 592 : 3 (2014), p. 421-422. -
További szerzők:Borbély Attila (1978-) (kardiológus) Paulus, Walter J.
Pályázati támogatás:Health-2010 MEDIA-261409
FP7
TÁMOP-4.2.2.A-11/1/KONV-2012-0045
TÁMOP
Kardiológia Kutatócsoport
4.2.4. A/2?11?1?2012?0001
TÁMOP
K 109083
OTKA
PD 108614
OTKA
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3.

001-es BibID:BIBFORM050070
Első szerző:Papp Zoltán (kardiológus, élettanász)
Cím:CrossTalk opposing view : the late sodium current is not an important player in the development of diastolic heart failure (heart failure with a preserved ejection fraction) / Zoltán Papp, Attila Borbély, Walter J. Paulus
Dátum:2014
ISSN:0022-3751
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Physiology-London. - 592 : 3 (2014), p. 415-417. -
További szerzők:Borbély Attila (1978-) (kardiológus) Walter J. Paulus (kutató orvos)
Pályázati támogatás:MEDIA-261409
FP7
TÁMOP-4.2.2.A-11/1/KONV-2012-0045
TÁMOP
K 109083
OTKA
PD 108614
OTKA
TÁMOP 4.2.4. A/2-11-1-2012-0001
TÁMOP
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4.

001-es BibID:BIBFORM040571
Első szerző:Papp Zoltán (kardiológus, élettanász)
Cím:Two components of [Ca2+]i-activated Cl- current during large [Ca2+]i transients in single rabbit heart Purkinje cells / Papp Z., Sipido K. R., Callewaert G., Carmeliet E.
Dátum:1995
Megjegyzések:1. Single Purkinje cells, enzymatically isolated from rabbit ventricle, were studied under whole-cell voltage clamp conditions and internally perfused with the fluorescent Ca2+ indicator fura-2(100 microM). 2. Ca2+ release from the sarcoplasmic reticulum was either induced by external application of caffeine or occurred spontaneously in Ca2+i-overloaded cells. Membrane currents accompanying these Ca(2+)-release signals were studied at steady membrane potentials. 3. [Ca2+]i transients were accompanied by transient membrane currents. In the absence of Na(+)-Ca2+ exchange, two current components could be observed. The first component peaked well before the [Ca2+]i transient (Ifast) and relaxed before peak [Ca2+]i. The second component, on the other hand, peaked at the time when [Ca2+]i was maximal (Islow). 4. In symmetrical Cl- solutions both current components had a reversal potential close to O mV. A reduction of external or internal [Cl-] shifted this reversal potential in accordance with the change of the Cl- equilibrium potential. 5. Each [Ca2+]i transient was accompanied by Ifast. Properties of Ifast suggest that this current component is the [Ca2+]i-dependent Cl- current, ICl(Ca), previously observed during depolarizing pulses. 6. Islow was only detected in cells that displayed a large [Ca2+]i transient with or without elevated resting [Ca2+]i. 7. It is concluded that during large [Ca2+]i transients a slow component of ICl(Ca) can be activated. This second component may arise from the same channel population as the previously described fast component and be related to the presence of spatial and temporal inhomogeneities of [Ca2+]i. Alternatively, this current component may arise from a different Cl- channel population with a different Ca2+ sensitivity.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Physiology 483 : Pt2 (1995), p. 319-330. -
További szerzők:Sipido, Karin R. Callewaert, Geert Carmeliet, Edward
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5.

001-es BibID:BIBFORM040579
Első szerző:Papp Zoltán (kardiológus, élettanász)
Cím:The mechanism of the force enhancement by MgADP under simulated ischaemic conditions in rat cardiac myocytes / Papp, Z., Szabo, A., Barends, J. P., Stienen, G. J. M.
Dátum:2002
ISSN:0022-3751
Megjegyzések:In this study, the effects of MgADP and/or MgATP on the Ca2+ -dependent and Ca2+ -independent contractile force restoration were determined in order to identify the origin of the tonic force increase (i.e. ischaemic contracture) which develops during advanced stages of ischaemia. Experiments were performed at 15 degrees C during simulated ischaemic conditions in Triton-skinned right ventricular myocytes from rats. In the presence of 5 mM MgATP the maximal Ca2+ -dependent force (P(o)) of 39 +/- 2 kN m(-2) (mean +/- S.E.M.) under control conditions (pH 7.0, 15 mM phosphocreatine (CP)) decreased to 8 +/- 1 % during simulated ischaemia (pH 6.2, 30 mM inorganic phosphate (P(i)), without CP). This change was accompanied by a major reduction in Ca2+ sensitivity (pCa(50) 4.10 vs. 5.62). Substitution of MgADP for MgATP restored isometric force production and its Ca2+ sensitivity (pCa(50) 4.74 at 4 mM MgADP and 1 mM MgATP). In addition, it shifted the MgATP threshold concentration of Ca2+ -independent force development to higher levels in a concentration-dependent manner. However, Ca2+ -independent force was facilitated less by MgADP than Ca2+ -dependent force. The MgADP-induced increase in force was accompanied by marked reductions in the velocity of unloaded shortening and the rate of tension redevelopment. These data and simulations using a model of cross-bridge kinetics suggest that the ischaemic force is not a consequence of a reduction in intracellular MgATP concentration, but identify MgADP as a key modulator of the cross-bridge cycle under simulated ischaemic conditions in cardiac muscle, with a much lower inhibition constant (0.012 +/- 0.003 mM) than in skeletal muscle. Therefore, MgADP has a high potential to stabilize the force-generating cross-bridge state and to facilitate the development of ischaemic contracture, possibly involving a Ca2+ activation process in the ischaemic myocardium.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Physiology-London. - 543 : 1 (2002), p. 177-189. -
További szerzők:Szabó Ágnes Barends, J. P. Stienen, Ger J. M.
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6.

001-es BibID:BIBFORM070105
Első szerző:Patsalos, Andreas
Cím:In situ macrophage phenotypic transition is affected by altered cellular composition prior to acute sterile muscle injury / Patsalos Andreas, Pap Attila, Varga Tamas, Trencsenyi Gyorgy, Contreras Gerardo Alvarado, Garai Ildiko, Papp Zoltan, Dezso Balazs, Pintye Eva, Nagy Laszlo
Dátum:2017
ISSN:0022-3751
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Physiology-London 595 : 17 (2017), p. 5815-5842. -
További szerzők:Pap Attila (1980-) (biológus) Varga Tamás (1971-) (biológus) Trencsényi György (1978-) (biológus, biokémikus, molekuláris biológus) Contreras, Gerardo Alvarado (1978-) (orvos) Garai Ildikó (1966-) (radiológus) Papp Zoltán (1965-) (kardiológus, élettanász) Dezső Balázs (1951-) (pathológus) Pintye Éva (1955-) (fizikus) Nagy László (1966-) (molekuláris sejtbiológus, biokémikus)
Pályázati támogatás:K100196
OTKA
K111941
OTKA
K116855
OTKA
'NR-NET' ITN PITN-GA2013-606806
FP7
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7.

001-es BibID:BIBFORM086626
035-os BibID:(WoS)000553612900013 (Scopus)85086370101
Első szerző:Reil, Jan-Christian
Cím:CaMKII Activity Contributes to Homeometric Autoregulation of the Heart : a Novel Mechanism for the Anrep Effect / Jan-Christian Reil, Gert-Hinrich Reil, Árpád Kovács, Vasco Sequeira, Mark T. Waddingham, Maria Lodi, Melissa Herwig, Shahrooz Ghaderi, Michael M. Kreusser, Zoltán Papp, Niels Voigt, Dobromir Dobrev, Svenja Meyhöfer, Harald F. Langer, Lars S. Maier, Dominik Linz, Andreas Mügge, Mathias Hohl, Paul Steendijk, Nazha Hamdani
Dátum:2020
ISSN:0022-3751 1469-7793
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Journal of Physiology-London. - 598 : 15 (2020), p. 3129-3153. -
További szerzők:Reil, Gert-Hinrich Kovács Árpád (1986-) (kardiológus) Sequeira, Vasco Waddingham, Mark T. Lódi Mária (1991-) Herwig, Melissa Ghaderi, Shahrooz Kreusser, Michael M. Papp Zoltán (1965-) (kardiológus, élettanász) Voigt, Niels Dobrev, Dobromir Meyhöfer, Svenja Langer, Harald F. Maier, Lars S. Linz, Dominik Mügge, Andreas Hohl, Mathias (kutató orvos) Steendijk, Paul Hamdani, Nazha
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8.

001-es BibID:BIBFORM040576
Első szerző:Stienen, Ger J. M.
Cím:Influence of inorganic phosphate and pH on sarcoplasmic reticular ATPase in skinned muscle fibres of Xenopus laevis / Stienen G. J., Papp Z., Zaremba R.
Dátum:1999
Megjegyzések:1. The influence of 30 mM inorganic phosphate (Pi) and pH (6.2-7.4) on the rate of ATP utilization was determined in mechanically skinned bundles of myofibrils from the iliofibularis muscle of Xenopus laevis at approximately 5 C. 2. BDM (2,3-butanedione monoxime; 10 mM) depressed isometric force production and actomyosin (AM) ATPase activity equally. Therefore sarcoplasmic reticular (SR) ATPase activity could be determined by extrapolation of the total ATPase activity to zero force. 3. The SR ATPase activity without added Pi at pH 7.1 was 42 +/- 2 % of the total ATPase activity. Addition of 30 mM Pi reduced SR ATPase activity slightly, by 9 +/- 5 %, and depressed force by 62 +/- 2 % and AM ATPase activity by 21 +/- 6 %. 4. At pH 6.2, force, SR ATPase activity and AM ATPase activity were reduced by 21 +/- 5, 61 +/- 5 and 10 +/- 4 % of their respective values at pH 7.1. 5. The SR ATPase activity at 30 mM Pi and pH 6.2 was reduced markedly to 20 +/- 6 % of the value under control conditions, suggesting that the maximum rate of Ca2+ uptake during muscle fatigue was strongly depressed. This reduction was larger than expected on the basis of the effects of Pi and pH alone.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal of Physiology. - 518 : Pt3 (1999), p. 735-744. -
További szerzők:Papp Zoltán (1965-) (kardiológus, élettanász) Zaremba, Ruud
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9.

001-es BibID:BIBFORM040569
Első szerző:Stienen, Ger J. M.
Cím:Mechanical properties of skinned rabbit psoas and soleus muscle fibres during lengthening: effects of phosphate and Ca2+ / G. J. M. Stienen, P. G. A. Versteeg, Z. Papp, G. Elzinga
Dátum:1992
Megjegyzések:1. Mechanical properties of permeabilized single fibres from rabbit psoas and soleus muscle were determined by measuring the length responses due to abrupt changes in load and the force responses due to isovelocity length changes at different phosphate and Ca2+ concentrations. 2. The length responses due to abrupt increases in load from psoas fibres showed a rapid lengthening during the change in load followed by a phase of lengthening during which the velocity gradually decreased. In soleus fibres an abrupt lengthening during the change in load was followed by a phase of lengthening during which the velocity remained constant or decreased slightly for increases in load to less than 1.45 of the isometric force (F0). For larger increases in load the velocity during this later phase first increased and thereafter decreased. 3. The initial force-velocity curve, derived from the early part of the isotonic responses after the change in load, as well as the late force-velocity curve derived from the force level attained during isovelocity length changes, were sensitive to phosphate. Phosphate caused a shift of the absolute force-velocity curves of both psoas and soleus fibres towards lower values of force. In psoas fibres, the relative force-velocity curves derived by normalization of the force level to the force developed isometrically was shifted by phosphate to smaller velocities. In soleus fibres, the initial velocity at low and intermediate relative loads (less than 1.75 F0) was increased by phosphate but at higher loads it decreased, while the late force-velocity curve showed an overall decrease in velocity. 4. The force responses during isovelocity lengthening of psoas fibres showed an early rapid increase in force followed by a slow rise in force. The position of this break point in force was sensitive to the phosphate concentration. In soleus fibres, the force responses without phosphate showed an overshoot followed by a slow rise in force. The overshoot diminished with increasing phosphate concentration. 5. Phosphate and Ca2+ affected the force responses in psoas and soleus fibres in different ways. When the isometric starting levels were the same, force during and after the length change at submaximal activation was always less than at maximal activation in the presence of 15 mM-phosphate. 6. The changes in the mechanical performance during lengthening caused by phosphate in psoas as well as in soleus fibres, are in agreement with a decrease in the average force per attached crossbridge
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:The Journal of Physiology 451 (1992), p. 503-523. -
További szerzők:Versteeg, P. G. A. Papp Zoltán (1965-) (kardiológus, élettanász) Elzinga, G.
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