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001-es BibID:BIBFORM070110
Első szerző:Altenberger, Johann
Cím:Levosimendan in acute and advanced heart failure : an appraisal of the clinical database and evaluation of its therapeutic applications / Altenberger J., Gustafsson F., Harjola Veli-Pekka, Karason K., Kindgen-Milles D., Kivikko M., Malfatto G., Papp Z., Parissis J., Pollesello P., Pölzl G., Tschöpe C.
Dátum:2018
ISSN:0160-2446
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Journal Of Cardiovascular Pharmacology. - 71 : 3 (2018), p. 129-136. -
További szerzők:Gustafsson, Finn Harjola, Veli-Pekka Karason, Kristian Kindgen-Milles, D. Kivikko, Matti Malfatto, Gabriella Papp Zoltán (1965-) (kardiológus, élettanász) Parissis, John Pollesello, Piero Pölzl, Gerhard Tschöpe, Carsten
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2.

001-es BibID:BIBFORM114410
035-os BibID:(scopus)85169671684
Első szerző:Pölzl, Gerhard
Cím:Repetitive levosimendan infusions for patients with advanced chronic heart failure in the vulnerable post-discharge period : The multinational randomized trial / Pölzl Gerhard, Altenberger Johann, Comín-Colet Josep, Delgado Juan F., Fedele Francesco, García-González Martín Jesús, Gustafsson Finn, Masip Josep, Papp Zoltán, Störk Stefan, Ulmer Hanno, Maier Sarah, Vrtovec Bojan, Wikström Gerhard, Zima Endre, Bauer Axel
Dátum:2023
ISSN:1388-9842 1879-0844
Megjegyzések:Aim: The LeoDOR trial explored the efficacy and safety of intermittent levosimendan therapy in the vulnerable phase following a hospitalization for acute heart failure (HF). Methods and results: In this prospective multicentre, double-blind, two-armed trial, patients with advanced HF were randomized 2:1 at the end of an index hospitalization for acute HF to intermittent levosimendan therapy or matching placebo for 12 weeks. All patients had left ventricular ejection fraction (LVEF) ?30% during index hospitalization. Levosimendan was administered according to centre preference either as 6 h infusion at a rate of 0.2 ?g/kg/min every 2 weeks, or as 24 h infusion at a rate of 0.1 ?g/kg/min every 3 weeks. The primary efficacy assessment after 14 weeks was based on a global rank score consisting of three hierarchical groups. Secondary clinical endpoints included the composite risk of tiers 1 and 2 at 14 and 26 weeks, respectively. Due to the COVID-19 pandemic, the planned number of patients could not be recruited. The final modified intention-to-treat analysis included 145 patients (93 in the combined levosimendan arm, 52 in the placebo arm), which reduced the statistical power to detect a 20% risk reduction in the primary endpoint to 60%. Compared with placebo, intermittent levosimendan had no significant effect on the primary endpoint: the mean rank score was 72.55 for the levosimendan group versus 73.81 for the placebo group (p = 0.863). However, there was a signal towards a higher incidence of the individual clinical components of the primary endpoint in the levosimendan group versus the placebo group both after 14 weeks (hazard ratio [HR] 2.94, 95% confidence interval [CI] 1.12-7.68; p = 0.021) and 26 weeks (HR 1.64, 95% CI 0.87-3.11; p = 0.122). Conclusions: Among patients recently hospitalized with HF and reduced LVEF, intermittent levosimendan therapy did not improve post-hospitalization clinical stability.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:European Journal Of Heart Failure. - [Epub ahead of print] (2023). -
További szerzők:Altenberger, Johann Comin-Colet, Josep Delgado, Juan F. Fedele, Francesco Garcia-González, Martín J. Gustafsson, Finn Masip, Josep Papp Zoltán (1965-) (kardiológus, élettanász) Störk, Stefan Ulmer, Hanno Maier, Sarah Vrtovec, Bojan Wikström, Gerhard Zima Endre (1974-) (kardiológus) Bauer, Axel LeoDOR Investigators
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3.

001-es BibID:BIBFORM090865
Első szerző:Pölzl, Gerhard
Cím:Repetitive levosimendan infusions for patients with advanced chronic heart failure in the vulnerable post-discharge period / Pölzl Gerhard, Allipour Birgani Shadab, Comín-Colet Josep, Delgado Juan F., Fedele Francesco, Garcia-Gonzáles Martín J., Gustafsson Finn, Masip Josep, Papp Zoltán, Störk Stefan, Ulmer Hanno, Vrtovec Bojan, Wikström Gerhard, Altenberger Johann
Dátum:2019
ISSN:2055-5822
Megjegyzések:Hospitalization for acute heart failure (HF) is associated with a substantial morbidity burden and with associated healthcare costs and an increased mortality risk. However, few if any major medical innovations have been witnessed in this area in recent times. Levosimendan is a first-in-class calcium sensitizer and potassium channel opener indicated for the management of acute HF. Experience in several clinical studies has indicated that administration of intravenous levosimendan in intermittent cycles may reduce hospitalization and mortality rates in patients with advanced HF; however, none of those trials were designed or powered to give conclusive insights into that possibility. This paper describes the rationale and protocol of LeoDOR (levosimendan infusions for patients with advanced chronic heart failure), a randomized, double-blind, placebo-controlled, international, multicentre trial that will explore the efficacy and safety of intermittent levosimendan therapy, in addition to optimized standard therapy, in patients following hospitalization for acute HF. Salient features of LeoDOR include the use of two treatment regimens, in order to evaluate the effects of different schedules and doses of levosimendan during a 12 week treatment phase, and the use of a global rank primary endpoint, in which all patients are ranked across three hierarchical groups ranging from time to death or urgent heart transplantation or implantation of a ventricular assist device to time to rehospitalization and, lastly, time-averaged proportional change in N-terminal pro-brain natriuretic peptide. Secondary endpoints include changes in HF symptoms and functional status at 14 weeks.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:ESC heart failure. - 6 : 1 (2019), p. 174-181. -
További szerzők:Allipour Birgani, Shadab Comin-Colet, Josep Delgado, Juan F. Fedele, Francesco Garcia-González, Martín J. Gustafsson, Finn Masip, Josep Papp Zoltán (1965-) (kardiológus, élettanász) Störk, Stefan Ulmer, Hanno Vrtovec, Bojan Wikström, Gerhard Altenberger, Johann
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4.

001-es BibID:BIBFORM070106
Első szerző:Pölzl, Gerhard
Cím:Repetitive use of levosimendan in advanced heart failure : need for stronger evidence in a field in dire need of a useful therapy / Pölzl Gerhard, Altenberger Johann, Baholli Loant, Beltrán Paola, Borbély Attila, Comin-Colet Josep, Delgado Juan F., Fedele Francesco, Fontana Antonella, Fruhwald Friedrich, Giamouzis Gregory, Giannakoulas George, Garcia-González Martín J., Gustafsson Finn, Kaikkonen Kari, Kivikko Matti, Kubica Jacek, von Lewinski Dirk, Löfman Ida, Malfatto Gabriella, Manito Nicolás, Martínez-Sellés Martin, Masip Josep, Merkely Bela, Morandi Fabrizio, Mølgaard Henning, Oliva Fabrizio, Pantev Emil, Papp Zoltán, Perna Gian Piero, Pfister Roman, Piazza Vito, Bover Ramón, Rangel-Sousa Diego, Recio-Mayoral Alejandro, Reinecke Alexander, Rieth Andreas, Sarapohja Toni, Schmidt Gunter, Seidel Mirko, Störk Stefan, Vrtovec Bojan, Wikström Gerhard, Yerly Patrik, Pollesello Piero
Dátum:2017
ISSN:0167-5273
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:International Journal Of Cardiology. - 243 (2017), p. 389-395. -
További szerzők:Altenberger, Johann Baholli, Loant Beltrán, Paola Borbély Attila (1978-) (kardiológus) Comin-Colet, Josep Delgado, Juan F. Fedele, Francesco Fontana, Antonella Fruhwald, Friedrich Giamouzis, Gregory Giannakoulas, George Garcia-González, Martín J. Gustafsson, Finn Kaikkonen, Kari Kivikko, Matti Kubica, Jacek von Lewinski, Dirk Löfman, Ida Malfatto, Gabriella Manito, Nicolás Martínez-Sellés, Martin Masip, Josep Merkely Béla (1965-) (orvos) Morandi, Fabrizio Mølgaard, Henning Oliva, Fabrizio Pantev, Emil Papp Zoltán (1965-) (kardiológus, élettanász) Perna, Gian Piero Pfister, Roman Piazza, Vito Bover, Ramón Rangel-Sousa, Diego Recio-Mayoral, Alejandro Reinecke, Alexander Rieth, Andreas Sarapohja, Toni Schmidt, Gunter Seidel, Mirko Störk, Stefan Vrtovec, Bojan Wikström, Gerhard Yerly, Patrik Pollesello, Piero
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5.

001-es BibID:BIBFORM070112
Első szerző:Seferović, Petar M.
Cím:Organization of heart failure management in European Society of Cardiology member countries : survey of the Heart Failure Association of the European Society of Cardiology in collaboration with the Heart Failure National Societies/Working Groups / Seferović Petar M., Stoerk Stefan, Filippatos Gerasimos, Mareev Viacheslav, Kavoliuniene Ausra, Ristić Arsen D., Ponikowski Piotr, McMurray John, Maggioni Aldol, Ruschitzka Frankl, van Veldhuisen Dirk J., Coats Andrew, Piepoli Massimo, McDonagh Theresa, Riley Jillian, Hoes Arno, Pieske Burkert, Dobrić Milan, Papp Zoltan, Mebazaa Alexandre, Parissis John, Ben Gal Tuvia, Vinereanu Dragos, Brito Dulce, Altenberger Johann, Gatzov Plamen, Milinković Ivan, Hradec Jaromír, Trochu Jean-Noel, Amir Offer, Moura Brenda, Lainscak Mitja, Comin Josep, Wikström Gerhard, Anker Stefan, Committee of National Heart Failure Societies or Working Groups of the Heart Failure Association of the European Society of Cardiology
Dátum:2013
ISSN:1388-9842
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:European Journal Of Heart Failure. - 15 : 9 (2013), p. 947-959. -
További szerzők:Stoerk, Stefan Filippatos, Gerasimos S. Mareev, Vyacheslev Kavoliuniene, Ausra Ristić, Arsen D. Ponikowski, Piotr McMurray, John J. Maggioni, Aldo Ruschitzka, Frank van Veldhuisen, Dirk J. Coats, Andrew Piepoli, Massimo McDonagh, Theresa Riley, Jillian Hoes, Arno Pieske, Burkert Dobrić, Milan Papp Zoltán (1965-) (kardiológus, élettanász) Mebazaa, Alexandre Parissis, John Ben Gal, Tuvia Vinereanu, Dragos Brito, Dulce Altenberger, Johann Gatzov, Plamen Milinković, Ivan Hradec, Jaromír Trochu, Jean-Noel Amir, Offer Moura, Brenda Lainscak, Mitja Comin-Colet, Josep Wikström, Gerhard Anker, Stefan D. Committee of NHFS or WGHFA of the ESC
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